Delving into the Latest Updates on Azadirachta indica Extract with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms

Neem

Target-

Action-

Mechanism-

Therapeutic Areas

Mouth and Tooth Diseases

Active Indication

Periodontitis

Inactive Indication-

Originator Organization

Ain Shams University

Active Organization

Ain Shams University

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Acute hepatitis, characterized by rapid onset and high mortality, can result from infections, toxins, and other factors. However, current treatment options have significant side effects, necessitating further research into alternative therapies. This study investigated the extraction method of neem extract and found that its ethanolic extract effectively reduced mortality and decreased ALT and AST levels in mice serum, improving liver pathology. HPLC analysis identified azadirachtin and nimbolide in the extract. It also downregulated NF-κB, NLRP3, and p62 levels, while upregulating Lc3B and Atg5 levels. Experiments in Atg5 knockout mice showed that the absence of Atg5 weakened the extract's efficacy in reducing liver damage and inflammation and affected the extent of NLRP3 protein downregulation. However, it did not affect the extract's ability to reduce NF-κB. Overall, the ethanolic extract of neem leaves primarily modulates the inflammatory response through the NF-κB signaling pathway. The extract's efficacy in reducing NLRP3 is associated with autophagy. These discoveries offer a new theoretical basis for the role of neem in treating acute hepatitis.

18 Dec 2024·Cureus

Uncovering the Role of Indian Medicinal Botanicals in COVID-19 Prevention and Management: A Review

Review

Author: S, Vinayaka K ; Ammu Joseph, Renju ; Shrivastava, Ruchita ; Karra, Theresa ; Vasudeo Damodar, Sarwade ; Mishra, Jyotsana ; Rao, D Meena S ; Gajendra Bagal, Jalindarnath

Indian traditional medicine, based on Ayurveda and Siddha, has become one of the global searches for complementary approaches to conventional interventions during the COVID-19 pandemic. This review presents the antiviral, immune-boosting, and anti-inflammatory properties of some medicinal key plants such as Tulsi (Ocimum sanctum), Neem (Azadirachta indica), Ashwagandha (Withania somnifera), Amla (Emblica officinalis), and Giloy (Tinospora cordifolia). Tulsi appears to inhibit viral replication, Neem increases immune cell synthesis, while Ashwagandha regulates inflammation and stress responses. Vitamin C-rich Amla increases immune defense while also providing protection against oxidative stress and Giloy modulates immune response and its activity, acting as an overall resilience against infection. However, the clinical integration of these plants into mainstream healthcare is hindered by the absence of robust clinical trials, standardization of phytochemicals, and the absence of global standard protocols. In order to establish safety and efficacy, substantial research is needed, including large-scale randomized clinical trials and sophisticated bioinformatics techniques. Indian medicinal plants provide innovative, sustainable, and holistic solutions to global health crises, such as the COVID-19 pandemic, by bridging traditional knowledge with modern scientific frameworks.

01 Dec 2024·Journal of dentistry (Shiraz, Iran)

Evaluation of the Effect of Applying Chitosan, Neem, Tulsi, Aloe vera, and Chlorhexidine Solutions on the Shear Bond Strength of Composite to Dentin.

Article

Author: Sharafeddin, Farahnaz ; Aghaei, Fatemeh

Statement of the ProblemDentin adhesion is challenging and needs modifications. Newly introduced nature-derived materials may be a useful solution in improving dentin adhesion. The use of natural antimicrobial agents for pretreating prepared dentin surfaces before restoration has become of interest.PurposeThe present study investigated the effect of natural compounds on the shear bond strength (SBS) of resin composite adhesively bonded to dentin.Materials and MethodSixty extracted human molar teeth were randomly divided into six groups (n= 10); Group I: two-step etch and rinse adhesive system, Adper Single Bond 2 (SB₂) (experimental control), Group II: 2.5% Chitosan+etch+SB₂, Group III: 15% Neem (Azadirachta indica)+etch+SB₂, Group IV: 15% Tulsi (Ocimum sanctum)+etch+SB₂, Group V: 2% Aloe vera+etch+SB₂, and group VI: 2% Chlorhexidine (CHX)+etch+SB₂. Resin composite (Z350, 3M ESPE USA) was placed over the prepared dentin surfaces and was light cured. Data analysis was performed using One-way ANOVA and post hoc Tukey's test (p< 0.05).ResultsNeem specimens showed the highest mean SBS, statistically greater than the control (p= 0.042). Other experimental groups showed no significant differences in SBS comparison to the control. The mean SBS values of 2.5% Chitosan, 15% Neem, 15% Tulsi, and 2% Aloe vera were significantly higher than 2% CHX (p= 0.046, p= 0.001, p= 0.010 and p= 0.002 respectively).ConclusionDentin pretreatment with Neem may improve the bond strength of a two-step etch and rinse adhesive system. The application of Chitosan, Tulsi, Aloe vera, and CHX did not demonstrate significantly different SBS values from that of the Control, although CHX was lower.

100 Deals associated with Azadirachta indica Extract

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Periodontitis	Phase 2	Egypt	Ain Shams University	01 Sep 2021

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01898091 (OM, CTgov)	Phase 2	Neoplasms \| radiation oral mucositis	50	Placebo Mouthrinse+Neem Mouthrinse (Neem Mouthrinse)	hxpehxyjif(cikuueicbl) = qjynuuhiah wwxtzkutkb (tydkcoqrze, eehpczmzsn - mhclyeqyon) View more	-	06 Mar 2017
				Placebo Mouthrinse (Placebo Mouthrinse)	hxpehxyjif(cikuueicbl) = zlowqkovxt wwxtzkutkb (tydkcoqrze, wtqfqorweu - iqbbcabibv) View more