Last update 01 Nov 2024

HS-10370

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
KRAS G12C
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Therapeutic Areas
NeoplasmsRespiratory Diseases
Active Indication
Advanced Malignant Solid NeoplasmKRAS G12C mutation Solid TumorsAdvanced Lung Non-Small Cell Carcinoma
Inactive Indication-
Originator Organization
Jiangsu Hansoh Pharmaceutical Co. Ltd.Jiangsu Hansoh Pharmaceutical Co. Ltd.
Active Organization
Jiangsu Hansoh Pharmaceutical Co. Ltd.Jiangsu Hansoh Pharmaceutical Co. Ltd.
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

4
Clinical Trials associated with HS-10370
NCT06594874 / Not yet recruitingPhase 1
A Phase Ib Study Evaluating the Safety, Tolerability , Pharmacokinetics and Activity of HS-10370 in Addition to Other Anti-cancer Therapies in Participants with KRAS G12C Mutation Advanced Solid Tumors
NCT05367778 / RecruitingPhase 1/2
A Phase 1/2, Open-label, Multicenter Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of HS-10370 Monotherapy in Patients with Advanced Solid Tumors
CTR20220710 / RecruitingPhase 1
HS-10370在晚期实体瘤患者中的安全性、耐受性、药代动力学和有效性的I/II期临床研究
[Translation] Phase I/II clinical study of the safety, tolerability, pharmacokinetics and efficacy of HS-10370 in patients with advanced solid tumors
100 Clinical Results associated with HS-10370
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100 Translational Medicine associated with HS-10370
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100 Patents (Medical) associated with HS-10370
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100 Deals associated with HS-10370
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
CN
Jiangsu Hansoh Pharmaceutical Co. Ltd.Jiangsu Hansoh Pharmaceutical Co. Ltd.
03 Jun 2022
KRAS G12C mutation Solid TumorsPhase 1
CN
Jiangsu Hansoh Pharmaceutical Co. Ltd.Jiangsu Hansoh Pharmaceutical Co. Ltd.
31 Oct 2024
Advanced Lung Non-Small Cell CarcinomaPhase 1
CN
Jiangsu Hansoh Pharmaceutical Co. Ltd.Jiangsu Hansoh Pharmaceutical Co. Ltd.
26 Aug 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT05367778 (HS-10370-101, AACR2024)
ManualManual
Phase 1
KRAS G12C mutation Solid Tumors
55
(tnfnwcjzry) = ybdmendhix zndaogyrjy (gxafnbuzjw )
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Positive
05 Apr 2024
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Approval

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Regulation

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