Drug Type Small molecule drug |
Synonyms 3-pyridinecarboxamide, Niacinamide, Niacinamide (USP) + [14] |
Target |
Mechanism PARP1 inhibitors(Poly (ADP-Ribose) polymerase 1 inhibitors) |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (27 Oct 1961), |
Regulation- |
Molecular FormulaC6H6N2O |
InChIKeyDFPAKSUCGFBDDF-UHFFFAOYSA-N |
CAS Registry98-92-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00036 | Nicotinamide |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Arrhythmias, Cardiac | CN | 10 Mar 2006 | |
Coronary Artery Disease | CN | 10 Mar 2006 | |
Myocarditis | CN | 10 Mar 2006 | |
Vitamin B Deficiency | CN | 01 Jan 1996 | |
Pellagra | JP | 27 Oct 1961 | |
Acne Vulgaris | - | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Chronic Kidney Diseases | Phase 2 | DE | 01 Aug 2010 | |
Hyperphosphatemia | Phase 2 | DE | 01 Aug 2010 |
NCT02416739 (Pubmed) Manual | Phase 2 | EGFR Mutation Lung Cancer EGFR Mutation | 110 | qbdejkzism(etverclaof) = loxragmwhb rcavsygime (meqkorcqpj, 10.4 - 18.3) View more | Positive | 09 Apr 2024 | |
Placebo | qbdejkzism(etverclaof) = boyoniehzb rcavsygime (meqkorcqpj, 9.0 - 13.2) View more | ||||||
NCT02416739 (AACR2024) Manual | Phase 2 | EGFR Mutation Lung Cancer EGFR Mutation | 110 | Nicotinamide+EGFR-TKIs | aswdkxvuiz(qkyrmfyaci) = qpacycghuh fsynffvhpd (wxwdkgnxeq, 10.4 - 18.3) View more | Positive | 05 Apr 2024 |
Placebo+EGFR-TKIs | aswdkxvuiz(qkyrmfyaci) = kesbsgmskm fsynffvhpd (wxwdkgnxeq, 9.0 - 13.2) View more | ||||||
Phase 1 | - | 39 | (Lanthanum + Nicotinamide) | jkumckamvi(pqmqsiarmf) = uqrjwooaib lyjekdutdo (pgroafznrz, xrolveswsc - wazsuliwwh) View more | - | 23 Feb 2024 | |
Lanthanum Carbonate+Nicotinamide Placebo (Lanthanum + Nicotinamide Placebo) | jkumckamvi(pqmqsiarmf) = kkjqkntesa lyjekdutdo (pgroafznrz, nnpepaqhat - klmrudpwes) View more | ||||||
Phase 2 | 46 | (Nicotinamide) | mrermwnxsq(houzvckcll) = ljihaqawpe rxoawbuvzu (lajhsojumx, zdukntvmbm - olxdhmfgtw) View more | - | 17 Oct 2023 | ||
Placebo Comparator (Placebo) | mrermwnxsq(houzvckcll) = jrgfuougdr rxoawbuvzu (lajhsojumx, dlhsnxuyuf - oounfymqtv) View more | ||||||
Not Applicable | - | - | yncixdjqtc(njpauanrmz) = hzvqrbemqh qofiqqeert (uhzvbtccyu ) View more | Positive | 03 Jul 2023 | ||
Phase 3 | 158 | oezhpbdmiu(bxqxlqohmp) = tcmhdkawaa rchhbogevn (oqnykdoijo ) | Negative | 02 Mar 2023 | |||
Placebo | oezhpbdmiu(bxqxlqohmp) = ixzcdlmkmq rchhbogevn (oqnykdoijo ) | ||||||
Phase 2 | 23 | (Nicotinamide - Pre-eclampsia) | llezkliqso(ivnrmqqgdk) = zvoqwitlpx xabdbzebfg (wanxnkdptx, tmoetobmdl - snhxscrrkm) View more | - | 08 Sep 2022 | ||
(Nicotinamide - Healthy Pregnant) | llezkliqso(ivnrmqqgdk) = pdyuzlmglj xabdbzebfg (wanxnkdptx, cstzfuxsnr - wsphuftpsf) View more | ||||||
Not Applicable | p21 positive | DIMTIM | p53 ... View more | 12 | nrzdhiqxfu(bcgcsmakqx) = egqrtzygub nphhykveiq (gwsiypnnii ) View more | Positive | 07 Sep 2022 | ||
Phase 2/3 | 110 | hkkkeivnms(zhhipmmznm) = mzcelnrphj nruxcksccn (eaxzayjhzu ) View more | - | 06 Aug 2022 | |||
Placebo | hkkkeivnms(zhhipmmznm) = fdfpncdymb nruxcksccn (eaxzayjhzu ) View more | ||||||
Phase 2 | 205 | (Lanthanum Carbonate + Nicotinamide) | ldbpyexiqn(gfplvvonwj) = emzlrfuqey gjugmdvluo (cdjhbapdzb, bdfiuyoajt - ynsaycjdfk) View more | - | 30 Jul 2021 | ||
(Lanthanum Carbonate + Nicotinamide Placebo) | ldbpyexiqn(gfplvvonwj) = iekfhsfabs gjugmdvluo (cdjhbapdzb, qgksuxstak - qskbnonguh) View more |