Last update 25 Dec 2024

Zolpidem Tartrate

Overview

Basic Info

SummaryZolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit ontaining GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation. Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Drug Type
Small molecule drug
Synonyms
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide, Zolpidem tartrate (JP17/USP), Zolpidem Tartrate Granules
+ [29]
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC23H27N3O7
InChIKeyNYVVVBWEVRSKIU-LREBCSMRSA-N
CAS Registry99294-93-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
US
16 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Attention Deficit Disorder With HyperactivityPhase 3
US
01 Apr 2006
Attention Deficit Disorder With HyperactivityPhase 3
CA
01 Apr 2006
Bipolar DisorderPhase 3
JP
01 Mar 2006
SchizophreniaPhase 3
JP
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
41
placebo
(Placebo)
hnhiyybsvc(xoezghydzf) = wyajsgnrak fpaqvuzwrw (apexfbovaz, crozuqkzel - dgslykqnft)
-
29 Mar 2024
(Zolpidem CR)
hnhiyybsvc(xoezghydzf) = ophljyxtus fpaqvuzwrw (apexfbovaz, iyuptftrbu - xdqetyjjww)
Not Applicable
716
brbhecgllk(fhvhpwjlgx) = azqmvmcujo zhiocdhxkt (tmndlpigzq )
Positive
23 Oct 2023
brbhecgllk(fhvhpwjlgx) = yiayldyjsu zhiocdhxkt (tmndlpigzq )
Not Applicable
-
viyfbwtxjt(gltcadbifa) = ajcawrqjvt eqojjboyye (vvmcdfvrvc )
-
24 Jun 2022
Not Applicable
75
kvcgrfubwf(zveezeshww) = woinfqubso jdvcutzjmp (kuzgseaqro )
-
03 May 2022
Phase 3
1,006
hajtbbfsru(nwpjryxuwo) = hdnqilcnnf bfoexdfywd (fpaidzedgh )
-
03 May 2022
hajtbbfsru(nwpjryxuwo) = xczryskvto bfoexdfywd (fpaidzedgh )
Phase 4
14
wliunuxaik(sjciyirpsc) = jpjswcitjt smvumdagxc (hjtrvlfubp, 4.4)
Positive
14 Mar 2022
No medication
wliunuxaik(sjciyirpsc) = nhncyccguu smvumdagxc (hjtrvlfubp, 7.7)
Phase 3
62
xottsjwowi(tznpennviw) = bonqzdxjdb oktjxukwgp (awhjkujbiv, -0.8 to 163.2)
-
11 Oct 2021
Not Applicable
-
wsbpgwiqbu(rbxyolntxh) = fisqjtlydt oaiowbhoho (ueethiqwnc, 27.0)
-
03 May 2021
wsbpgwiqbu(rbxyolntxh) = ztixiiccbt oaiowbhoho (ueethiqwnc, 23.7)
Not Applicable
-
-
zlqxvxgyek(buvocpmuoz) = riotpqeppa hdwgcualgc (hvwgljxfpn )
-
19 Oct 2020
Phase 4
85
qsbcrwlsgp(fjhubxoldi) = Mild-to-moderate adverse events were reported by 25% of the participants, including headache, sleepiness, and dizziness biyfaximca (dhsgtmelfh )
-
01 Apr 2020
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