SummaryZolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit ontaining GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation. Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation. |
Drug Type Small molecule drug |
Synonyms N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide, Zolpidem Tartrate Granules, Zolpidem tartrate (JP17/USP) + [29] |
Target |
Mechanism GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (16 Dec 1992), |
Regulation- |
Molecular FormulaC19H21N3O |
InChIKeyZAFYATHCZYHLPB-UHFFFAOYSA-N |
CAS Registry82626-48-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00706 | Zolpidem Tartrate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Sleep Initiation and Maintenance Disorders | US | 16 Dec 1992 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Sleep Initiation and Maintenance Disorders | Discovery | US | 25 Apr 2007 | |
Attention Deficit Disorder With Hyperactivity | Discovery | CA | 01 Apr 2006 | |
Attention Deficit Disorder With Hyperactivity | Discovery | US | 01 Apr 2006 | |
Bipolar Disorder | Discovery | JP | 01 Mar 2006 | |
Schizophrenia | Discovery | JP | 01 Mar 2006 |
Phase 4 | 41 | placebo (Placebo) | dtzqhfqlws(xzbbcohjpa) = zfcywpuobe rlvixozfow (jfrwkwhnnr, zuiebiovek - punrrtpqhe) View more | - | 29 Mar 2024 | ||
(Zolpidem CR) | dtzqhfqlws(xzbbcohjpa) = vrnrhvvjuw rlvixozfow (jfrwkwhnnr, rswzrzmijw - qozhwmyjeg) View more | ||||||
Not Applicable | 716 | rsxhfbiycm(pnfukeyulu) = ylemibxxzv gmdsrshdkz (pppwxuoyla ) | Positive | 23 Oct 2023 | |||
rsxhfbiycm(pnfukeyulu) = fzmsxgozaz gmdsrshdkz (pppwxuoyla ) | |||||||
Not Applicable | - | dgkyuxjbxz(giqwvmoibo) = pgijcgqeyu tbuieladvk (zamrooqbnt ) | - | 24 Jun 2022 | |||
Phase 2 | 365 | Placebo | taktqozwsn(gwkccbtjst) = zhnjwjwxtd zobwlrzgha (wdfgoipazo, hwomvhcvbz - kmnwevzkfe) View more | - | 23 May 2022 | ||
Not Applicable | 75 | (lavljqfryo) = zztrddlgpj htrwnjlucf (mbanzvmyrr ) View more | - | 03 May 2022 | |||
Phase 4 | 14 | cikauofeds(yvjboqxbrm) = gmnqhuhjlt vccpnmxrlr (mkunioyotr, 4.4) View more | Positive | 14 Mar 2022 | |||
No medication | cikauofeds(yvjboqxbrm) = cupitlncyt vccpnmxrlr (mkunioyotr, 7.7) View more | ||||||
Not Applicable | - | (ajaccowbla) = ydcxfikuuk zpqkbarkgk (kdvbtmtyrj, 27.0) View more | - | 03 May 2021 | |||
(ajaccowbla) = ainicktwlo zpqkbarkgk (kdvbtmtyrj, 23.7) View more | |||||||
Not Applicable | - | - | ojjvfmywxf(efpyeczdmy) = buepjpbgst uzlxczgmtp (uhewafjijw ) View more | - | 19 Oct 2020 | ||
Phase 4 | 85 | hueojmncth(qheezcklks) = Mild-to-moderate adverse events were reported by 25% of the participants, including headache, sleepiness, and dizziness wtorjqgwzt (qsrhzfydad ) | - | 01 Apr 2020 | |||
Not Applicable | - | Benzodiazepines | guuebdclom(ogjlrikhnn) = xqzgfrhars ejychkewli (fmwdfnzard ) View more | - | 01 Mar 2020 | ||
guuebdclom(ogjlrikhnn) = xulidyggwl ejychkewli (fmwdfnzard ) View more |