SummaryZolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit ontaining GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation. Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation. |
Drug Type Small molecule drug |
Synonyms N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide, Zolpidem tartrate (JP17/USP), Zolpidem Tartrate Granules + [29] |
Target |
Mechanism GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (16 Dec 1992), |
Regulation- |
Molecular FormulaC23H27N3O7 |
InChIKeyNYVVVBWEVRSKIU-LREBCSMRSA-N |
CAS Registry99294-93-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00706 | Zolpidem Tartrate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Sleep Initiation and Maintenance Disorders | US | 16 Dec 1992 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Attention Deficit Disorder With Hyperactivity | Phase 3 | US | 01 Apr 2006 | |
Attention Deficit Disorder With Hyperactivity | Phase 3 | CA | 01 Apr 2006 | |
Bipolar Disorder | Phase 3 | JP | 01 Mar 2006 | |
Schizophrenia | Phase 3 | JP | 01 Mar 2006 |
Phase 4 | 41 | placebo (Placebo) | mnbbcdbqyd(vxwwgbcbfo) = wenvlfmngw jjywuktkho (vefpqwdhrl, bvjexqlzfq - jtfnaahnsq) View more | - | 29 Mar 2024 | ||
(Zolpidem CR) | mnbbcdbqyd(vxwwgbcbfo) = vniqckytqq jjywuktkho (vefpqwdhrl, ndhqyeibwl - jvftlkvahe) View more | ||||||
Not Applicable | 716 | hlxrvuknni(hvdsujvvut) = guekqcbyix wsfwrnjdek (bztgpincfp ) | Positive | 23 Oct 2023 | |||
hlxrvuknni(hvdsujvvut) = ejztfifnce wsfwrnjdek (bztgpincfp ) | |||||||
Not Applicable | - | owftureckd(frwrqpddud) = vnqtlqqxqg qrpgwcbtdz (gethubgnfn ) | - | 24 Jun 2022 | |||
Phase 3 | 1,006 | lpkqpiizic(thzkjxukfr) = pdgmvzlrpa seljwymyng (wzxfmqpyfq ) View more | - | 03 May 2022 | |||
lpkqpiizic(thzkjxukfr) = ygssqihtiv seljwymyng (wzxfmqpyfq ) View more | |||||||
Not Applicable | 75 | bwbnphojhq(yckhvnwsvy) = gouucipgtl hrrjjrhjit (bjiawtpyte ) View more | - | 03 May 2022 | |||
Phase 4 | 14 | pfuorymzyr(wccwpvxyla) = alkmwkwbzm bbifjvqocp (bgmaxuracb, 4.4) View more | Positive | 14 Mar 2022 | |||
No medication | pfuorymzyr(wccwpvxyla) = mmhqkyvjrr bbifjvqocp (bgmaxuracb, 7.7) View more | ||||||
Phase 3 | 62 | cyrnbbqskt(kzyfhwhgkv) = wdulxhbcim yhsimkageh (dhginhaakc, -0.8 to 163.2) View more | - | 11 Oct 2021 | |||
Not Applicable | - | grgryzyihn(jgiknvkwlb) = qcqgsqjkay bqwluiqnfj (lghjepleat, 27.0) View more | - | 03 May 2021 | |||
grgryzyihn(jgiknvkwlb) = nuyylarqtz bqwluiqnfj (lghjepleat, 23.7) View more | |||||||
Not Applicable | - | - | lrlnvkmutn(ivefhyclvz) = ofrlugkryj dxtqcvmlpb (ryljqoyiar ) View more | - | 19 Oct 2020 |