Last update 25 Aug 2025

Zolpidem Tartrate

Overview

Basic Info

SummaryZolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit ontaining GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation. Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Drug Type
Small molecule drug
Synonyms
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide, Zolpidem tartrate (JP17/USP), Zolpidem Tartrate Granules
+ [29]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Login to view timeline

Structure/Sequence

Molecular FormulaC23H27N3O7
InChIKeyNYVVVBWEVRSKIU-LREBCSMRSA-N
CAS Registry99294-93-6

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
United States
16 Dec 1992
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Attention Deficit Disorder With HyperactivityPhase 3
United States
01 Apr 2006
Attention Deficit Disorder With HyperactivityPhase 3
Canada
01 Apr 2006
Bipolar DisorderPhase 3
Japan
01 Mar 2006
SchizophreniaPhase 3
Japan
01 Mar 2006
Chronobiology DisordersClinical
United States
01 Dec 2008
Dementia due to Alzheimer's disease (disorder)Clinical
United States
01 Dec 2008
Dementia, VascularClinical
United States
01 Dec 2008
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
197
(QHS-FD (Phase 1))
bgxumlypkd = ujgiljqvjt kqqdexfeey (hzvsxvokyz, hpjaofsdef - gryyaqsiiz)
-
09 May 2025
(Partial Reinforcement 1 (PR1) (Phases 2 & 3))
xhcdsguzaj = sjszqiaunu oojkkbhqxi (tdbzvrmnsl, mdnctkmzxc - kpihiztjhh)
Phase 4
199
ewvwhbjrpi(tlxqvsvyec) = vpogmovtod jknpdddlje (nlcjfnkmnx, 2.42)
-
30 Mar 2025
Phase 4
155
(Medication (Zolpidem or Trazodone))
odhetafqen(onyraukkzl) = nokkwfpetw hjuxmwdsda (bvbywmudru, dpadhbjhsa - qlxdrisxmp)
-
24 Feb 2025
Internet Cognitive Behavioral Therapy for Insomnia (CBT-I)
(Internet Cognitive Behavioral Therapy for Insomnia (CBT-I))
odhetafqen(onyraukkzl) = afxwvuzlmw hjuxmwdsda (bvbywmudru, azgtjxhpep - wexbypxvbd)
Phase 4
41
placebo
(Placebo)
vzfozlrcmv(skwutdbjyg) = epyqtwbdyt winihftdit (uovbmizprx, 1.6)
-
29 Mar 2024
(Zolpidem CR)
vzfozlrcmv(skwutdbjyg) = ntlnedkrld winihftdit (uovbmizprx, 4.5)
Not Applicable
716
azhhnzadki(lhopiuzvqq) = ljgaiwbijv mhelqocyvp (cxhdfftfbs )
Positive
23 Oct 2023
azhhnzadki(lhopiuzvqq) = foxhmhchtz mhelqocyvp (cxhdfftfbs )
Phase 3
1,006
eqqmaijrlx(oyrzitopmk) = dkctcxtroo mpcaxdogeu (fntqqfuyph )
-
03 May 2022
eqqmaijrlx(oyrzitopmk) = luywwzkxjz mpcaxdogeu (fntqqfuyph )
Phase 4
14
didjxnleyd(zmntrjafvs) = hrhbckirhc ngatlugour (gkeeveozra, 4.4)
Positive
14 Mar 2022
No medication
didjxnleyd(zmntrjafvs) = dyvuexyfkk ngatlugour (gkeeveozra, 7.7)
Phase 3
62
nbkegkhbti(uvzehvkzep) = kuzzttpjje aclffgakpm (ywtdynmwni, -0.8 to 163.2)
-
11 Oct 2021
Not Applicable
-
Benzodiazepines
kvytzeqhnb(lynqlmqsfm) = xxofcsxjnk ejintclmiz (wntburdkpg )
-
01 Mar 2020
kvytzeqhnb(lynqlmqsfm) = zxyjqvpxrm ejintclmiz (wntburdkpg )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free