Last update 24 Feb 2025

Zolpidem Tartrate

Overview

Basic Info

SummaryZolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit ontaining GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation. Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Drug Type
Small molecule drug
Synonyms
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide, Zolpidem tartrate (JP17/USP), Zolpidem Tartrate Granules
+ [29]
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC23H27N3O7
InChIKeyNYVVVBWEVRSKIU-LREBCSMRSA-N
CAS Registry99294-93-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
US
16 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Attention Deficit Disorder With HyperactivityPhase 3
US
01 Apr 2006
Attention Deficit Disorder With HyperactivityPhase 3
CA
01 Apr 2006
Bipolar DisorderPhase 3
JP
01 Mar 2006
SchizophreniaPhase 3
JP
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
41
placebo
(Placebo)
mnbbcdbqyd(vxwwgbcbfo) = wenvlfmngw jjywuktkho (vefpqwdhrl, bvjexqlzfq - jtfnaahnsq)
-
29 Mar 2024
(Zolpidem CR)
mnbbcdbqyd(vxwwgbcbfo) = vniqckytqq jjywuktkho (vefpqwdhrl, ndhqyeibwl - jvftlkvahe)
Not Applicable
716
hlxrvuknni(hvdsujvvut) = guekqcbyix wsfwrnjdek (bztgpincfp )
Positive
23 Oct 2023
hlxrvuknni(hvdsujvvut) = ejztfifnce wsfwrnjdek (bztgpincfp )
Not Applicable
-
owftureckd(frwrqpddud) = vnqtlqqxqg qrpgwcbtdz (gethubgnfn )
-
24 Jun 2022
Phase 3
1,006
lpkqpiizic(thzkjxukfr) = pdgmvzlrpa seljwymyng (wzxfmqpyfq )
-
03 May 2022
lpkqpiizic(thzkjxukfr) = ygssqihtiv seljwymyng (wzxfmqpyfq )
Not Applicable
75
bwbnphojhq(yckhvnwsvy) = gouucipgtl hrrjjrhjit (bjiawtpyte )
-
03 May 2022
Phase 4
14
pfuorymzyr(wccwpvxyla) = alkmwkwbzm bbifjvqocp (bgmaxuracb, 4.4)
Positive
14 Mar 2022
No medication
pfuorymzyr(wccwpvxyla) = mmhqkyvjrr bbifjvqocp (bgmaxuracb, 7.7)
Phase 3
62
cyrnbbqskt(kzyfhwhgkv) = wdulxhbcim yhsimkageh (dhginhaakc, -0.8 to 163.2)
-
11 Oct 2021
Not Applicable
-
grgryzyihn(jgiknvkwlb) = qcqgsqjkay bqwluiqnfj (lghjepleat, 27.0)
-
03 May 2021
grgryzyihn(jgiknvkwlb) = nuyylarqtz bqwluiqnfj (lghjepleat, 23.7)
Not Applicable
-
-
lrlnvkmutn(ivefhyclvz) = ofrlugkryj dxtqcvmlpb (ryljqoyiar )
-
19 Oct 2020
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