Last update 20 Mar 2025

Forodesine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol, 1,4-Dideoxy-4-aza-1-(S)-(9-deazahypoxanthin-9-yl)-D-ribitol, FDS
+ [10]
Target
Action
inhibitors
Mechanism
PNP inhibitors(Purine nucleoside phosphorylase inhibitors), Immunosuppressants
Active Organization
Drug Highest PhaseApproved
First Approval Date
Japan (31 Mar 2017),
RegulationOrphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC11H15ClN4O4
InChIKeyWEIAMZKHBCLFOG-QPAIBFMUSA-N
CAS Registry284490-13-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
Japan
31 Mar 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Lymphocytic LeukemiaPhase 2
United States
01 Jun 2005
CD19-positive B-cell acute lymphoblastic leukemiaPhase 2
United States
01 Sep 2004
Precursor B-Cell Lymphoblastic Leukemia-LymphomaPhase 2
United States
01 Sep 2004
T-Cell LeukemiaPhase 2
Georgia
01 Mar 2004
T-Cell LeukemiaPhase 2
United States
01 Mar 2004
CD30-Positive recurrent or refractory Cutaneous T-Cell LymphomaPhase 2
United States
01 Feb 2003
Cutaneous T-Cell LymphomaPhase 1
United States
01 Jul 2007
Cutaneous T-Cell LymphomaPhase 1
Finland
01 Jul 2007
Cutaneous T-Cell LymphomaPhase 1
United Kingdom
01 Jul 2007
Recurrent T Lymphoblastic LymphomaPhase 1
United States
01 Jul 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
48
(syjruiujiv) = ekgvftlusd tluqummejw (dpunvpympa, 14 - 38)
Positive
01 Jan 2019
Phase 1/2
44
(tzqyacdobp) = rnwbpvxfau cwudyzursr (vcrhqwzsrm, 12.0 - 35.3)
Positive
20 May 2016
Phase 2
144
(pxtdwajnci) = mptkwpmans jhzdebmfvm (eiawvssbsa )
-
01 Sep 2014
Not Applicable
64
(rnggtarocp) = cfnulzgclb rsbqklrxss (kncxqfinnd )
-
20 May 2009
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Approval

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Regulation

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