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Last update 31 Dec 2025
BZDS-1901
Last update 31 Dec 2025
Overview
Basic Info
Drug Type Autologous CAR-T |
Synonyms alfaPD1MSLNCAR T cell therapy, alphaPD1MSLNCAR T cell therapy, Autocrine PD1 antibody targets mesothelin chimeric antigen receptor T cells (Shanghai Cell Therapy Group) + [7] |
Target |
Action inhibitors |
Mechanism MSLN inhibitors(Mesothelin inhibitors), PD-1 inhibitors(Programmed cell death protein 1 inhibitors), Immunologic cytotoxicity |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
Regulation- |
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Related
4
Clinical Trials associated with BZDS-1901NCT05944185
Phase I/II Study of ?PD1-MSLN-CAR T Cells in MSLN-positive Advanced Solid Tumors
NCT05089266
Study of ?PD1-MSLN-CAR T Cells to Evaluate the Safety, Tolerability, and Effectiveness for Patients With MSLN-positive Advanced Solid Tumors.
NCT04489862
An Exploratory Study of MSLN-CAR T Cells Secreting PD-1 Nanobodies for the Treatment of MSLN-positive Advanced Solid Tumors
100 Clinical Results associated with BZDS-1901
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100 Translational Medicine associated with BZDS-1901
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100 Patents (Medical) associated with BZDS-1901
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100 Deals associated with BZDS-1901
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced Malignant Solid Neoplasm | Phase 2 | China | 01 Sep 2023 | |
| Mesothelin positive Solid Tumors | Phase 2 | China | 01 Sep 2023 | |
| Mesothelioma | Phase 2 | China | - | |
| Mesothelin positive Neoplasms | Phase 1 | China | 25 Dec 2023 | |
| Bile Duct Neoplasms | Phase 1 | China | 30 Oct 2020 | |
| Non-Small Cell Lung Cancer | Phase 1 | China | 13 May 2020 | |
| Colorectal Cancer | Phase 1 | China | 26 Mar 2020 | |
| Ovarian Cancer | Phase 1 | China | 26 Mar 2020 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 1 | Malignant Mesothelioma of Peritoneum | Malignant Pleural Mesothelioma MSLN Expression | PD-L1 Expression | 11 | emhyabymfb(ywiioqkdqk) = cffnochjdu wpszzrywes (jmqxhqcbyk ) View more | Positive | 14 Apr 2023 | ||
NEWS Manual  | Phase 1 | 10 | aPD1-mesCAR-T | fycvtdjcvw(xltlsxoyoy) = mdgvgwaukd vodlzpajbw (vyusehkxys ) View more | Positive | 06 Jun 2022 |
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