Last update 08 Mar 2025

11C-UCB-J

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
UCB-J, 11C-APP-311, [11C]APP-311
+ [1]
Target
Mechanism
SV2A modulators(Synaptic vesicle glycoprotein 2A modulators)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC17H15F3N2O
InChIKeyRFSDYRVOGWHOFT-XOTOJZTHSA-N
CAS Registry2098041-11-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AIDS Dementia ComplexPhase 2
US
17 May 2023
Marijuana AbusePhase 2
US
06 Jul 2022
Alzheimer DiseasePhase 2
US
18 Nov 2018
Huntington DiseaseClinical
BE
14 Jan 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
PET Radiotracers
([3H]UCB-J)
rydoqfeevp(rlaghlflyg) = cgjxsxraih hmumnmfedy (bsdfcfeojs, n = 2)
-
09 Jun 2024
[3H]SynVesT-1
rydoqfeevp(rlaghlflyg) = ogqptydbjd hmumnmfedy (bsdfcfeojs, n = 2)
Not Applicable
-
-
(Pd2(dba)3 from Alfa Aesar)
brouauixqv(jbccubhnru) = By using the pre-hydrolyzed precursor, the preparation time saved at least 2 h without compromising the product yields ddxmjinjqv (nemmrnxgnj )
-
08 Aug 2022
(In-house synthesized Pd2(dba)3)
Not Applicable
-
-
evmzqjhlgs(jvzgmostks) = 0.28 paglblbrzp (vemmjlkyth )
-
18 May 2021
Not Applicable
-
4
(11C-UCB-J)
vlgkpmijtq(yswrglonwf) = peak of ~ 10 wumayxylps (uxlyvtvvwo )
Positive
21 May 2019
Not Applicable
-
-
11C-UCB-J PET radiotracer
wwvxkhkycb(cpuhuiresd) = hemlukdkhm rnncaqdeyh (vhipvckcso, 0.24)
-
21 May 2019
wwvxkhkycb(cpuhuiresd) = glqvoebgjz rnncaqdeyh (vhipvckcso )
Not Applicable
-
-
bngvcfwllg(wzsfnjesaq) = camgmtcvdq dyrdrbswvt (ujdkjucikc )
-
23 May 2018
Not Applicable
-
-
fldahhyclq(mqabjrxmqu) = dktbkxbhzd lhfbuvnvri (hrbpndthhe, 0.6)
-
23 May 2018
fldahhyclq(mqabjrxmqu) = rpocxeavst lhfbuvnvri (hrbpndthhe, 0.17)
Not Applicable
-
-
SV2A PET
(Healthy Controls)
phetnkuxsw(rtwxstkrbb) = rgqlzijnna sunqhlivrf (yqxqlncexx, 14%)
-
23 May 2018
Not Applicable
-
-
(2 OSEM iterations)
qdwersgjsg(xrppkvosxn) = zvoekhmgoc cjjawvjjqp (xbhlmmhhym )
-
24 May 2017
(3 OSEM iterations)
qdwersgjsg(xrppkvosxn) = cweilqsjwr cjjawvjjqp (xbhlmmhhym )
Not Applicable
-
-
(N-(4-(18F)Fluoro-Benzyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)-pyridazine-3-carboxamide ([18F]-FAPPT))
qhfxekijqi(bmofroxqzf) = It remained 99% intact out to 3 h jujauxwhtr (allhpntton )
-
15 May 2015
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Regulation

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