Delving into the Latest Updates on NT-004(NewGen) with Synapse

Overview

Basic Info

Drug Type

Chemical drugs

Synonyms-

Target

EGFR x HER2

Action

antagonists

Mechanism

EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), HER2 antagonists(Receptor tyrosine-protein kinase erbB-2 antagonists)

Therapeutic Areas

Neoplasms

Active Indication-

Inactive Indication

Neoplasms

Originator Organization

Jiangsu Kanion Pharmaceutical Co., Ltd.

Active Organization-

Inactive Organization

NewGen Therapeutics, Inc.

License Organization-

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

A 28-year-old female with polycystic ovary syndrome (PCOS) and a history of primary infertility for eight years underwent in vitro maturation (IVM) at Wardha. The patient’s clinical profile revealed elevated levels of anti-Müllerian hormone (AMH) levels, a high luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio, and ultrasound findings consistent with PCOS. After mild ovarian stimulation, 12 immature oocytes were retrieved and cultured in Neurotrophin-4 (NT-4) enriched IVM medium. A total of eight oocytes matured to the metaphase II stage, with seven achieving fertilization via intracytoplasmic sperm injection (ICSI). Out of the fertilized oocytes, five developed into high-quality blastocysts. The patient received an optimized endometrial preparation protocol, including metformin, estradiol, cabergoline, and L-arginine supplementation. Following frozen embryo transfer, pregnancy was confirmed by positive beta-human chorionic gonadotropin (β-hCG) levels and ultrasound. This study highlights IVM’s potential to mitigate ovarian hyperstimulation syndrome (OHSS) risks while achieving high success rates in PCOS patients. The inclusion of NT-4 in maturation media significantly improved oocyte quality, fertilization rates, and blastocyst development. These findings underscore IVM as a promising assisted reproductive technology (ART) approach, offering enhanced safety and efficacy for fertility treatment in PCOS patients.

01 Jan 2014·Neural regeneration researchQ2 · MEDICINE

Neuronal cell death and regeneration in diseases associated with advanced glycation end-products accumulation

Q2 · MEDICINE

ArticleOA

Author: Bikbova, Guzel ; Oshitari, Toshiyuki ; Yamamoto, Shuichi

This article describes on effect of low dose AGEs on neurite regeneration in isolated rat retinas and to estimate the regenerative effects of neurotrophin-4 (NT-4) in AGEs exposed retinas.Results shows that low concentration of AGEs, e.g., 10 μg/mL, induces neuronal apoptosis in the ganglion cell layer (GCL) and decreases the number of regenerated neuritis.Retinal neuronal death in AGE-BSA exposed rat retinas was correlated with the increased expression of active-form of caspase-9 and AIF.The neuroprotective and regenerative effects of NT-4 are correlated with the reduction of AIF and caspase-9 expression.

01 Mar 2011·Fertility and sterilityQ2 · MEDICINE

Neurotrophin 4 enhances in vitro follicular assembly in human fetal ovaries

Q2 · MEDICINE

Article

Author: Jacob Farhi ; Ronit Abir ; Roni Garor ; Benjamin Fisch ; Haim Pinkas ; Yoav Peled

OBJECTIVE:

To investigate the in vitro effect of neurotrophin 4 (NT-4) on follicular assembly in human fetal ovaries.

DESIGN:

Human ovarian tissue from fetuses at 19-20 gestational weeks was placed in organ culture for two weeks with NT-4. Control groups were cultured with a neutralizing antibody against NT-4.

SETTING:

Infertility unit at an university-affiliated tertiary medical center.

PATIENT(S):

Four patients who underwent pregnancy terminations at 19-20 gestational weeks.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Histologic findings of follicular assembly.

RESULT(S):

Follicular assembly was significantly increased in the specimens cultured with NT-4 than in the uncultured specimens, the samples cultured without NT-4, and samples cultured with the neutralizing antibody. In the second week of culture, additional follicular assembly was promoted in the presence of 100 ng/mL NT-4 but not with 10 ng/mL NT-4.

CONCLUSION(S):

This is the first report showing that NT-4 seems to promote human follicular assembly in fetal ovaries, probably in a dose-dependent manner. Follicular assembly is regulated by multiple signals, and additional studies on the effects of other growth factors in combination with NT-4 are warranted.

100 Deals associated with NT-004(NewGen)

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