Last update 24 Mar 2025

Praliciguat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Praliciguat (USAN/INN), IW-1973
Target
Action
stimulants
Mechanism
sGC stimulants(Soluble guanylate cyclase stimulants)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC21H14F8N6O2
InChIKeyCYSJNTQNMDWAJV-UHFFFAOYSA-N
CAS Registry1628730-49-3

External Link

KEGGWikiATCDrug Bank
D11274--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart failure with normal ejection fractionPhase 2
United States
07 Nov 2017
Heart failure with normal ejection fractionPhase 2
United States
07 Nov 2017
Heart failure with normal ejection fractionPhase 2
Canada
07 Nov 2017
Heart failure with normal ejection fractionPhase 2
Canada
07 Nov 2017
Diabetic NephropathiesPhase 2
United States
24 Oct 2017
Type 2 diabetes mellitus with established diabetic nephropathyPhase 2
United States
01 Aug 2017
Type 2 diabetes mellitus with established diabetic nephropathyPhase 2
United States
01 Aug 2017
Diabetes Mellitus, Type 2Phase 2
United States
01 Sep 2016
HypertensionPhase 2
United States
01 Sep 2016
Heart FailurePhase 2
United States
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
196
Placebo Oral Tablet
orvrdbnpon = zlhghvxxjv bavvfkqalp (ukzhexykif, ctuybifsim - mhtognpewc)
-
15 Sep 2022
Phase 2
156
Placebo
rmmqrigcvg = cfhoubfyjw cgzhsnzcgd (wvlmvbdmwf, alahlrulas - ksasooiukw)
-
15 Sep 2022
Phase 2
156
Placebo
vmzhtiabhv(whtsjbrkru) = fkweaggqja wvrvquxcsw (ehmqnyzieu, -28 to 0.4)
-
31 Dec 2020
vmzhtiabhv(whtsjbrkru) = niagwyyjao wvrvquxcsw (ehmqnyzieu, -36 to -18)
Phase 2
181
zkgineqiuh(qnokwtjfqx) = There were more dizziness (9.9% vs 1.1%), hypotension (8.8% vs 0%), and headache (11% vs 6.7%) TEAEs with praliciguat compared with placebo. yzyuoqvpyz (rfftclvyni )
Negative
20 Oct 2020
Placebo
Phase 2
Diabetic Nephropathies
eGFR | UACR | HbA1c ...
156
Placebo
feoeyjpiko(fvywrsfpzg) = imcwhkfcma leepubvghw (fgpagttskf, -27 to 0)
-
19 Oct 2020
feoeyjpiko(fvywrsfpzg) = trffwgddps leepubvghw (fgpagttskf, -36 to -18)
Phase 2
26
Placebo
sjdgayjrbe(cwawaxarle) = bdxxuqrmnd ywpxnayttt (yfyvvghnpx, 11.1)
-
31 Aug 2020
Not Applicable
156
Placebo
rnjdfhzkig(gxqklziupu) = auhwpxqwxs zdyibipjmq (wucxqtxyns, [ - 27, 0])
Positive
01 Jun 2020
rnjdfhzkig(gxqklziupu) = dtdbmuhpau zdyibipjmq (wucxqtxyns, [ - 36, to 18])
Not Applicable
-
-
yunqdbfxbl(ilekcrhtgb) = keubxqnoft jdmnpobzwc (escookizby )
Positive
08 May 2020
Phase 2
11
Placebo
(Control)
ppatgdoqiu = fixvowrlza ozxxwisruk (fqyywonwcn, rtnamvvubt - juceybvscx)
-
16 Apr 2020
(10 mg IW-1973)
ppatgdoqiu = suqimxpuni ozxxwisruk (fqyywonwcn, qeoyepthtw - alivpoinpz)
Phase 2
26
mmmwyrenqz(afsafxgzib) = ysrulmlbqk mujvcfydlq (ehobwwiqlz )
Positive
01 Apr 2020
Placebo
-
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Approval

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Regulation

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