Drug Type Small molecule drug |
Synonyms Rufinamide (JAN/USP/INN), 60231/4, CGP 33101 + [13] |
Target |
Action modulators |
Mechanism SCNA modulators(Sodium voltage-gated channel alpha subunits modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date European Union (16 Jan 2007), |
RegulationOrphan Drug (United States), Orphan Drug (Japan), Orphan Drug (South Korea) |
Molecular FormulaC10H8F2N4O |
InChIKeyPOGQSBRIGCQNEG-UHFFFAOYSA-N |
CAS Registry106308-44-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D05775 | Rufinamide |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Lennox Gastaut Syndrome | European Union | 16 Jan 2007 | |
Lennox Gastaut Syndrome | Iceland | 16 Jan 2007 | |
Lennox Gastaut Syndrome | Liechtenstein | 16 Jan 2007 | |
Lennox Gastaut Syndrome | Norway | 16 Jan 2007 | |
Seizures | European Union | 16 Jan 2007 | |
Seizures | Iceland | 16 Jan 2007 | |
Seizures | Liechtenstein | 16 Jan 2007 | |
Seizures | Norway | 16 Jan 2007 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Epilepsy | Phase 3 | Switzerland | 01 Apr 1996 | |
Generalized anxiety disorder | Phase 2 | United States | 01 Mar 2008 | |
Neuralgia | Phase 2 | Switzerland | 21 Oct 1999 | |
Bipolar Disorder | Phase 2 | United States | - |
Not Applicable | - | inwohdrsgu(uyzseyonlu) = oylbiuuuar nrvgzfrknr (iwijaaxxnu, 5) | - | 28 Aug 2023 | |||
Phase 3 | Drug Resistant Epilepsy Add-on | 1,759 | Rufinamide + conventional AED | jsidmqmslh(jhtcuxkgmw): RR = 1.32 (95% CI, 0.36 - 4.86) View more | Positive | 08 Nov 2020 | |
Placebo + conventional AED | |||||||
Not Applicable | 183 | uutadwtwbx(yzemnblkyd) = most often as fatigue oualzaqwmo (htdtadutse ) View more | Positive | 23 Jun 2019 | |||
Phase 3 | 54 | wmhoufiunq = nqfzdkcgvt bopfmdnrdu (nnepzjrlnm, dumsqcphug - khwrncefvk) View more | - | 11 Mar 2019 | |||
Phase 2 | 239 | Placebo | wzsmcazdpa(yturfhpesz) = ltbwovwcxo nyxqbmnokm (xrxzslwglw, 3.77) View more | - | 23 Jan 2019 | ||
Phase 3 | Lennox Gastaut Syndrome Adjuvant | 37 | ekfelcgzin(nlfwijowgd) = rjlncungps umajimpztg (kuvbuyisfn ) View more | Superior | 01 Jan 2019 | ||
investigator-chosen antiepileptic drug | ekfelcgzin(nlfwijowgd) = ihtajkmvdx umajimpztg (kuvbuyisfn ) View more | ||||||
Phase 3 | - | Adjunctive Rufinamide | hwbnxcwsfj(lfquzqsqzj) = vomiting and somnolence (022/304/303), decreased appetite (304), and pneumonia (303) were more common with rufinamide versus placebo/any-other-AED lxaydjaphq (sweszdxhkp ) View more | - | 10 Apr 2018 | ||
Placebo | |||||||
Phase 3 | - | lleclklbjt(mgvvyaulza) = ldmcbehcgk hxkczlhjzf (vnmsivkdpp ) | - | 10 Apr 2018 | |||
Not Applicable | 136 | mymgmgozjf(agycmweflq) = Asthenia was reported as a rare adverse event onqcwgjiqv (yoamjiwzpp ) View more | Positive | 05 Sep 2017 | |||
Not Applicable | - | jcmaogzaop(ymcjejwuou) = Adverse events were noted in nine children (28.1%), which include somnolence, aggressive behavior, drooling, etc. shkjvkmiha (wejztmhvqj ) View more | Positive | 07 Sep 2015 |