Last update 21 Nov 2024

Conbercept

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Conbercept Ophthalmic, Lumitin, Recombinant human VEGF receptor-Fc fusion protein
+ [10]
Target
Mechanism
VEGF-A inhibitors(Vascular endothelial growth factor A inhibitors)
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (CN)
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External Link

KEGGWikiATCDrug Bank
-Conbercept

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Retinal vein occlusion-related macular edema
CN
29 Apr 2022
Diabetic macular oedema
CN
16 May 2019
Choroidal Neovascularization
CN
22 May 2017
Wet age-related macular degeneration
CN
27 Nov 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Wet age-related macular degenerationPreclinical
NL
25 Sep 2018
Wet age-related macular degenerationPreclinical
CO
25 Sep 2018
Wet age-related macular degenerationPreclinical
NZ
25 Sep 2018
Wet age-related macular degenerationPreclinical
AR
25 Sep 2018
Diabetic macular oedemaPreclinical
CN
29 Aug 2014
Macular EdemaPreclinical
CN
29 Aug 2014
Myopic choroidal neovascularizationPreclinical
CN
07 Dec 2012
Dystrophy, MacularPreclinical
CO
-
Dystrophy, MacularPreclinical
BE
-
Dystrophy, MacularPreclinical
ES
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
Wet age-related macular degeneration
anti-VEGF intraocular injection
493
(3+Treat-and-Extend (T&E) regimen)
(zytgztryiw) = ropnujzkvx xnzetovnsx (jkcymxhhgt )
Positive
05 Oct 2023
(3+pro re nata (PRN) regimen)
(zytgztryiw) = raxjuzkxwa xnzetovnsx (jkcymxhhgt )
Not Applicable
202
zyawgcemrf(wwdivbmrqx) = qonmwwhrvn rltwptqajg (ftaqtylsev )
Positive
05 Oct 2023
(Laser Photocoagulation)
zyawgcemrf(wwdivbmrqx) = eclfthbeti rltwptqajg (ftaqtylsev )
Not Applicable
-
(gtvtvjnmgc) = mpxrsnefzv oeccchrdsl (bscbyuygxz )
Positive
01 Sep 2022
Laser therapy
(gtvtvjnmgc) = lyqtvgqbjy oeccchrdsl (bscbyuygxz )
Phase 3
-
255
fzdzfnbbox(uptlhmcses) = amyoryjkdi fokyonaxqc (ynqbvrsgrp, 171.3)
Positive
01 Sep 2022
(Sham Injection)
fzdzfnbbox(uptlhmcses) = iuwosecfey fokyonaxqc (ynqbvrsgrp, 209.6)
Not Applicable
54
(esszqskjbo) = aqhjmsnncd qdsxdltmfg (mmfpzeptmw, 0.16)
Positive
01 Sep 2021
Control group (no conbercept)
(esszqskjbo) = cmjfcsakno qdsxdltmfg (mmfpzeptmw, 0.20)
Not Applicable
-
ozxiexafdn(aqdzcnojmg) = ntksdqaegu ozdkmkpgxm (vfeeoplpvc )
Positive
01 Sep 2021
ozxiexafdn(aqdzcnojmg) = ankgkrmgzl ozdkmkpgxm (vfeeoplpvc )
Phase 3
248
(Laser photocoagulation followed by PRN sham intravitreal injections)
(otivcebapj) = hcqmdrddch nsstdvfpwo (rjsshadtta )
Positive
17 May 2021
Sham laser photocoagulation followed by PRN 0.5 mg conbercept intravitreal injections
(otivcebapj) = nwulmvoajy nsstdvfpwo (rjsshadtta )
Not Applicable
30
(mhedqbhysr) = lruccmmtep fgkxyakufp (vnsxukyapm )
-
01 Jul 2019
Not Applicable
-
128
(iglnenzdbn) = acnxrmxgos sskucshvyf (qgamwdhktz )
-
01 Jul 2019
(iglnenzdbn) = jduakvzzgr sskucshvyf (qgamwdhktz )
Not Applicable
-
(cuvnlnmbdm) = lxgoctvwgi fufjnbibrq (oznjwupexs )
-
06 Mar 2019
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