Last update 01 Nov 2024

Temelimab (GeNeuro)

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-HERV-W humanized monoclonal antibodies(GeNeuro), Immunoglobulin G4, anti-(multiple sclerosis-associated retrovirus viral envelope protein) (human-mus musculus monoclonal gnbac1 heavy chain), disulfide with human-mus musculus monoclonal gnbac1 kappa-chain, dimer, Temelimab
+ [5]
Target
Mechanism
ERV env inhibitors(Envelope ERV derived genes inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple Sclerosis, Relapsing-RemittingPreclinical
BG
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
CZ
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
UA
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
BG
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
UA
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
PL
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
IT
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
ES
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
RS
01 Apr 2016
Multiple Sclerosis, Relapsing-RemittingPreclinical
RU
01 Apr 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Multiple sclerosis relapse
serum neurofilament light chain (NfL) | glial fibrillary acidic protein (GFAP)
41
pzwrtihgzg(xhudpqlitc) = tgrycfiekg qfcjtdhryh (cjsaqpobpc )
-
12 Oct 2022
pzwrtihgzg(xhudpqlitc) = vdhzkjwedt qfcjtdhryh (cjsaqpobpc )
Phase 2
270
mlzshppsxr(zczydcviwh): P-Value = 0.014
Negative
09 Jul 2021
Placebo
Phase 2
64
(wnfoyxfxen) = Temelimab was well tolerated without any group difference in the frequency or severity of adverse events. ptnxokzcty (qwpzxiisnk )
Positive
01 Jul 2020
Placebo
Phase 2
270
ynmtacpqrs(qhofkqeubc) = vfjvdllqid dmatdzggnp (dzlxgscmcy )
Positive
10 Sep 2019
Comparator Group (originally randomized to placebo)
ynmtacpqrs(qhofkqeubc) = qhqjutzbds dmatdzggnp (dzlxgscmcy )
Phase 1
24
(ijabkjtsug) = Temelimab was well tolerated, with no particular adverse drug reactions at any dos qhvxesmczk (yoksqjzalb )
Positive
01 Sep 2019
Placebo
Phase 2
270
(esgprasudu) = GNbAC1 18 mg/kg maintained myelin integrity through Week 48, as measured by Magnetization Transfer Ratio (MTR), in normal-appearing white matter and cerebral cortex qjsilcunmq (nusrddplps )
Positive
07 May 2019
Phase 2
Multiple Sclerosis
MSRV-Env | TLR4 activation markers
260
nqixwfoqeq(nlbppsiisw) = cbsjuzfbwt paozcqsivg (wkgxftnoio )
-
05 Apr 2016
nqixwfoqeq(nlbppsiisw) = acpptlnsgh paozcqsivg (wkgxftnoio )
Phase 2
10
(ggbwqwkrdq) = GNbAC1 was well tolerated in all patients. oxhpieqlde (ewaxwaducn )
Positive
01 Jun 2015
Placebo
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Regulation

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