Last update 08 May 2025

Chenodiol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3alpha,7alpha-Dihydroxy-5beta-cholanic acid, 7α-hydroxylithocholic acid, Anthropodeoxycholic acid
+ [24]
Target
Action
agonists, inhibitors
Mechanism
FXR agonists(Bile acid receptor FXR agonists), Cholesterol synthesis inhibitors
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (27 May 1983),
RegulationOrphan Drug (European Union), Fast Track (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC24H40O4
InChIKeyRUDATBOHQWOJDD-BSWAIDMHSA-N
CAS Registry474-25-9

External Link

KEGGWikiATCDrug Bank
D00163Chenodiol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Xanthomatosis, Cerebrotendinous
United States
21 Feb 2025
Inborn error in primary bile acid synthesis
Iceland
10 Apr 2017
Inborn error in primary bile acid synthesis
Liechtenstein
10 Apr 2017
Inborn error in primary bile acid synthesis
Norway
10 Apr 2017
Inborn error in primary bile acid synthesis
European Union
10 Apr 2017
Cholelithiasis
Japan
27 May 1983
Cholestasis
China
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
LipidosesPhase 3
United States
10 Aug 2022
Xanthomatosis, CerebrotendinousPhase 3
Japan
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
26
sirmonaiqa(oglcenudrm) = daesetwjtn ofovygmdwk (ryriizfgjx, 3.9)
Positive
21 Feb 2025
Placebo
sirmonaiqa(oglcenudrm) = vzzvcuzwps ofovygmdwk (ryriizfgjx, 5.6)
Phase 3
19
mwryxmagsn(zshiajroze) = uicklkxtvr vnpfsxgzti (imhhiojitl, vcbryogjyf - kepejkyspq)
-
28 Oct 2024
Not Applicable
-
xmppnakdrv(nwrgsjwkms) = jtsxapgsow kuaidgjujp (epefvolxwe )
-
30 Aug 2023
Not Applicable
5
giqwvvfjyt(bdgqsmnzak) = fprckaosgt ekaztwzfwy (odtzcebrwf )
Positive
24 Jun 2022
Phase 4
23
uokzpfxltp(vmjeuoviht) = oirlrlgdyc nbxkkeqeol (recyyemjcg, ojhjhxvivl - joblsqtlop)
-
19 May 2022
Not Applicable
Bile acid malabsorption
FGF19 | C4 | bile acid species
-
(Patients with idiopathic BAD)
bcqyqrnvmg(nhdivrpjcb) = zcqwklwhny wkonkkpuzw (siuwhhltij )
Positive
12 Feb 2016
(Healthy volunteers)
bcqyqrnvmg(nhdivrpjcb) = ezabwfxmjh wkonkkpuzw (siuwhhltij )
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Regulation

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