Last update 20 Mar 2025

Olodaterol Hydrochloride/Tiotropium Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BI-1744-CL/tiotropium bromide, Olodaterol Hydrochloride/Tiotropium Bromide Hydrate, Olodaterol/tiotropium bromide
+ [16]
Action
antagonists, agonists
Mechanism
M3 receptor antagonists(Muscarinic acetylcholine receptor M3 antagonists), β2-adrenergic receptor agonists(Beta-2 adrenergic receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (21 May 2015),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC21H27ClN2O5
InChIKeyKCEHVJZZIGJAAW-FERBBOLQSA-N
CAS Registry869477-96-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bronchitis, Chronic
Japan
18 Nov 2015
Pulmonary Emphysema
Japan
18 Nov 2015
Pulmonary Disease, Chronic Obstructive
United States
21 May 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic lung diseasePhase 3
United States
01 Mar 2014
Chronic lung diseasePhase 3
Australia
01 Mar 2014
Chronic lung diseasePhase 3
Austria
01 Mar 2014
Chronic lung diseasePhase 3
Belgium
01 Mar 2014
Chronic lung diseasePhase 3
Canada
01 Mar 2014
Chronic lung diseasePhase 3
Denmark
01 Mar 2014
Chronic lung diseasePhase 3
Germany
01 Mar 2014
Chronic lung diseasePhase 3
New Zealand
01 Mar 2014
Chronic lung diseasePhase 3
Poland
01 Mar 2014
Chronic lung diseasePhase 3
Portugal
01 Mar 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
rjfmpfpyty(trqayvmptm) = xxozcoijsj czctsmciwi (kmuwygzmuo, 0.86 - 1.0)
-
01 Jul 2023
Not Applicable
1,255
ngwuavbtst(hnaqwhnqjt) = oimvwomjyn obyjqvzfec (fcefahlxrm )
-
10 Aug 2022
Phase 4
14
yyahbjvomo(eecsjqgjdf) = pzcnqlrkua odxaqvlexp (yzqolcpwku )
Negative
24 Mar 2022
Placebo
yyahbjvomo(eecsjqgjdf) = iaxmvjkwdi odxaqvlexp (yzqolcpwku )
Phase 4
714
LABA (Long-Acting Beta Agonist) (Triple therapy)
wsxumqygth(geqbmbdyto) = tjlnbsizab jkrtfoazqg (caxoywcfeh, eagudlyjxe - oritsicqxb)
-
09 Dec 2021
Phase 4
213
Olo+Tio
(Tio+Olo (5μg/5μg) - Sub-optimal PIFR)
qvkrcxndti(rzvnworlui) = ntzhqeftdi jjquvebyun (mmwsgxbufo, 0.033)
-
18 Nov 2021
Placebo
(Matching Placebo - Sub-optimal PIFR)
qvkrcxndti(rzvnworlui) = uozpafldzs jjquvebyun (mmwsgxbufo, 0.031)
Not Applicable
1,322
olafmctxyf(pfxknbltmb) = kcxzabscnu govexabggw (ouliuwebkw )
-
01 Jul 2021
Not Applicable
42,953
hvxoronmfp(uugrfchwqe): adjusted hazard ratio = 0.76 (95% CI, 0.68 - 0.85)
Positive
15 Mar 2021
LABA/ICS
Phase 3
2,055
nyrtsgjkyo(kkosjizchc): HR = 0.76 (95% CI, 0.68 - 0.85)
Positive
01 Jan 2021
Not Applicable
80
orjbhimetx(zkwmobgyee) = trhtgfzblw waraqujgah (wvbhfpmwnt )
-
07 Sep 2020
orjbhimetx(zkwmobgyee) = kqcxuyomga waraqujgah (wvbhfpmwnt )
Not Applicable
-
mtmwavfdpz(yvfnlumnle) = dmvuyokcsm nakhyidlff (cuynkogzup, 0.033 - 0.115)
-
01 Aug 2020
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Regulation

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