Drug Type Small molecule drug |
Synonyms (R)-(3-(2'-cyclopropyl-3-(hydroxymethyl)-[1,1'-biphenyl]-4-yl) pyrrolidin-1-yl)(5-fluoropyridin-2-yl)methanone, KM 001 (Kamari Pharma), KM001 + [1] |
Target |
Mechanism TRPV3 antagonists(Transient receptor potential cation channel subfamily V member 3 channel antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
RegulationOrphan Drug (EU), Orphan Drug (US) |
Start Date06 Mar 2023 |
Sponsor / Collaborator |
Start Date17 Jul 2022 |
Sponsor / Collaborator |
Start Date24 May 2022 |
Sponsor / Collaborator Kamari Pharma Ltd. [+1] |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Keratosis Palmoplantaris Papulosa | Phase 1 | IL | 17 Jul 2022 | |
Pachyonychia Congenita | Phase 1 | IL | 17 Jul 2022 | |
Neurodermatitis | Phase 1 | DE | 24 May 2022 | |
Pruritus | Phase 1 | DE | 24 May 2022 |
Study | Phase | Population | Analyzed Enrollment | Group | Results | Evaluation | Publication Date |
---|
NCT05435638 (Biospace) Manual | Phase 1 | 15 | KM-001 1% cream (UK) | gpkfluwjzk(cjhzvwqpit) = vtnmnotpwd xwdvzdqjwl (hgxqvfypeg, 52.9-97.8) View more | Positive | 17 May 2024 | |
KM-001 1% cream (Israel) | gpkfluwjzk(cjhzvwqpit) = ybfwxlheob xwdvzdqjwl (hgxqvfypeg, 48.7-97.4) |