Evaluation of the effect of polyphenol (hydroxytyrosol) intake on cognitive function in middle-aged and elderly people - Evaluation of the effect of hydroxytyrosol intake on cognitive function

Start Date01 Jan 2022

Sponsor / Collaborator

University of Tsukuba

NCT04899791 / CompletedNot Applicable

Positive Effects of Daily Consumption of Bread Enriched With Hydroxytyrosol on the Results of a 12-week Dietary Intervention on Subjects With Type 2 Diabetes Mellitus and Overweight/ Obesity

Hydroxytyrosol is a phenolic compound drawn from the olive tree and its leaves as a by-product obtained from the manufacturing of olive oil and has antioxidant and antidiabetic effects. The use of HT extract in food products is a good strategy to improve their nutritional quality. However, this extract has a strong odour and flavour, so it is important to be encapsulated for the odour and flavour to be covered up. The purpose of the study is to investigate the effects of regular consumption of bread enriched with HT on biochemical parameters (blood glucose and cholesterol levels).

Start Date24 May 2021

Sponsor / Collaborator

Harokopio University of Athens

[+1]

NCT04725955 / CompletedNot Applicable

Postprandial Responses of Healthy Subjects to Wheat Bread Enriched With Encapsulated Hydroxytyrosol

The amelioration of postprandial glucose and insulin responses to bread is of great importance since it may have significant beneficial effects on health. A number of studies have shown that hydroxytyrosol may have positive metabolic effects. However, this compound presents high hydrophilicity which constitutes the major barrier to its potential application in foods. Microencapsulation arises as a technological strategy to protect it and increase its stability. Alpha-cyclodextrin besides being a great carrier molecule, seems to also be beneficial to postprandial glucose levels. Enrichment of bread with encapsulated hydroxytyrosol could examine potential postprandial benefits.
Ten healthy normoglycemic subjects will participate in the study and will be provided with either a solution of glucose (reference food) or white wheat bread or wheat bread enriched with a-cyclodextrin or wheat bread enriched with hydroxytyrosol encapsulated in a-cyclodextrin, with 1-week intervals in amounts that yielded 50 g of available carbohydrates. Venous blood samples will be collected before consumption and at 30, 45, 60, 90, 120 and 180 min postprandially. Postprandial glucose, insulin and appetite-related hormone responses as well as glycemic index (GI) and subjective appetite ratings will be evaluated.

Start Date31 Jan 2021

Sponsor / Collaborator

Harokopio University of Athens

[+1]

100 Clinical Results associated with Hydroxytyrosol

100 Translational Medicine associated with Hydroxytyrosol

100 Patents (Medical) associated with Hydroxytyrosol

1,040

Literatures (Medical) associated with Hydroxytyrosol

01 Jul 2024·Neural regeneration research

Hydroxytyrosol and Parkinson's disease: protective actions against alpha-synuclein toxicity

Article

Author: Espinosa-Oliva, Ana M ; Hornedo-Ortega, Ruth

01 Mar 2024·Cryobiology

Evaluation of the effects of hydroxytyrosol on human sperm parameters during cryopreservation

Article

Author: Baharsaadi, Mojtaba ; Halvaei, Iman ; Hezavehei, Maryam ; Shahverdi, Abdolhossein

Human sperm cryopreservation is a routine procedure in assisted reproductive technology, but it has detrimental effects on different sperm parameters due to oxidative stress. Our objective was to assess the impacts of hydroxytyrosol (HT), as an antioxidant, on human sperm parameters following cryopreservation. In the first phase, 20 normal human semen samples were cryopreserved using the rapid freezing method with different concentrations of HT including 0, 50, 100, 150, and 200 μg/mL. In the second phase, 20 normal semen samples were collected and cryopreserved with 50 and 100 μg/mL HT. The beneficial effects of HT were determined by evaluation of motility (computer-assisted sperm analysis; CASA), viability (Eosin-nigrosine stain), DNA integrity (sperm chromatic dispersion test, SCD), reactive oxygen species (DCF and DHE staining by flowcytometry) lipid peroxidation (malondialdehyde, MDA test) and mitochondrial membrane potential (JC1 staining by flowcytometry) of sperm after cryopreservation. After thawing, sperm motility had an increasing trend in 50 and 100 μg/mL HT groups in comparison with other groups, althought the difference was not significant. However, sperm viability was significantly increased at 50 and 100 μg/mL HT. Our data also showed that sperm DNA fragmentation was significantly decreased after thawing at 100 μg/mL in comparison with 0 and 50 μg/mL HT. However, the level of intracellular reactive oxygen species, lipid peroxidation and mitochondrial membrane potential were not significantly different between groups. Our results showed that HT may have protective effects on the viability and DNA integrity of human sperm during the freezing-thawing process.

01 Mar 2024·Food chemistry

Boric acids decorated polymers with Au nanoparticle anchor assisted laser desorption/ionization for qualitive and quantitative analysis of hydroxytyrosol in red wines

Article

Author: Yan, Yinghua ; Huang, Xiaohui ; Wang, Baichun ; Fang, Xiang ; Zhai, Rui ; Ding, Chuan-Fan ; Dai, Xinhua

Hydroxytyrosol possesses a variety of biological and pharmacological activities that are beneficial to human health. However, the methodologies for its detection always suffered from problems. In this work, the gold nanoparticle modified polymer decorated with boric acids (pMBA/VPBA@Au) was synthesized and used both as the adsorbent and matrix to enrich and ionize small molecule substances through surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). The pMBA/VPBA@Au displayed a low detection limit (8 × 10^-6 M) and high selectivity (1:100) for the enrichment of hydroxytyrosol, and the linear correlation curve between the concentration of hydroxytyrosol and the intensity of MS had a good correlation (10^-4-10^-2 M, R² = 0.997). Additionally, the pMBA/VPBA@Au was used to quantify hydroxytyrosol in red wines, and the contents were 0.053-0.094 μg/mL. In general, a simple and novel method for the detection of hydroxytyrosol by SALDI-MS using boric acid functionalized polymer was developed for the first time, showing a good practical application value.

News (Medical) associated with Hydroxytyrosol

05 Mar 2024

·www.prnewswire.com

Study Illustrates Zeropollution's Enhancing Skin's Resilience to Environmental Damage

New research reveals botanical blend's enhancement of complexion by inhibiting pollution-induced damage and inflammation. MADRID, March 5, 2024 /PRNewswire/ -- A new, preclinical study highlights the abilities of a beauty-from-within botanical-blend Zeropollution® to shield skin from the adverse effects of city pollution, especially from free radical damage on a cellular level. Continue Reading Study Illustrates Zeropollution’s Enhancing Skin’s Resilience to Environmental Damage (PRNewsfoto/Monteloeder, S.L.) Formulated by nutraceutical company Monteloeder, S.L., a subsidiary of SuanNutra, Zeropollution harnesses a medley of botanical extracts that includes lemon verbena (Lippia citriodora), rosemary (Rosmarinus officinalis), olive, (Olea europaea), and Japanese pagoda tree (Sophora japonica). This patented multi-herbal cosmeceutical has been crafted to synergistically strengthen the skin's protective barrier against environmental insults through an "inside out" approach. Living in a toxic world, people are becoming more mindful of the health consequences posed by air pollution, ultraviolet light, and chemicals not only upon skin function but also on overall wellbeing. Pollutants affect the skin on several levels. They can alter the skin barrier and skin microflora and increases oxidative stress, damaging and disrupting DNA. The study led by Laurent Peno-Mazzarino was published in the Journal of Current Issues in Molecular Biology in January 2024. Positive outcomes were observed in both ex vivo human skin explants and in in vitro models using human epidermal cells exposed to pollutants, including heavy metals and diesel particles condensed into an urban dust. These are the main components of "city pollution" particulates found in nearly every urban environment. The outcomes revealed several mechanisms of action underlying the protective effect of Zeropollution, including marked reductions in lipid peroxidation induced by pollutants. This encompasses reactive molecules generated by factors such as UV radiation, pollution, and other environmental stressors that can damage cells and tissues. By only the third day of the study total inhibition of these molecules was observed. The formula effectively suppressed the inflammatory response triggered by environmental pollution. Specifically, IL1-α inflammatory markers were reduced by almost 90%. Zeropollution also significantly reduced pollutant-induced production of reactive oxygen species (ROS) in human endothelial cells and lung tissue cells. In this study, Zeropollution successfully counteracted the adverse effects of urban dust on the heart rate of zebra fish embryos. Moreover, it demonstrated abilities to inhibit the overactivation of the aryl hydrocarbon receptor (AhR), another biological pathway of the pollutant stress response that causes inflammation and skin damage. "This study underscores its beneficial effects on guarding the skin from pollution as supported by in vitro models," enthuses Nuria Caturla, PhD, Chief R&D Officer for Monteloeder. "While results of previous clinical studies endorsed Zeropollution's antioxidant and anti-aging effects, this preclinical research delves deeper into the botanical compound's molecular mechanisms." "Zeropollution possesses profound antioxidant and protective properties, as proven by its ability to reduce free-radical damage, inflammation and lipid peroxidation, while also offering protection against heavy metals," adds Caturla. In a previous clinical trial on 100 women volunteers living in polluted urban zones, supplementation with Zeropollution was linked to increased skin elasticity and firmness, strengthened skin barrier function, and skin radiance. Antioxidant status measured was also improved. "The botanical blend was uniquely crafted to fortify the skin's natural defences against external insults and nourish it from within," continues Caturla. "This study unveils Zeropollution's antioxidant potential beyond skin health, suggesting cardiopulmonary and endothelial benefits. This broadens its application spectrum beyond nutricosmetics and aligns with the consumer belief that help for a beautiful complexion can emanate from the inside." The proprietary formula comprises a polyphenol-enriched herbal blend containing a diverse array of phytochemical compounds sourced from various botanicals. This design is inspired by extensive scientific literature advocating that the use of multiple antioxidants as opposed to a high dose of a single antioxidant could be more effective owed to their complementary or synergistic effects. Zeropollution is built around the company's prized lemon verbena ingredient which stars in many of Monteloeder's portfolio of branded botanical formulations. The formula is standardized to several active compounds and quantified by HPLC-DAD analysis. These include hydroxytyrosol, verbascoside, oleuropein, rosemary diterpenes, and quercetin. All of which possess antioxidant and anti-inflammatory properties. Zeropollution's composition houses verbascosides derived from lemon verbena with a specific role in safeguarding pulmonary cells by enhancing the activity of antioxidant enzymes while inhibiting activity of inflammatory mediators and signaling pathways. Zeropollution can be delivered in various formats, including "shots," soft gels, capsules, effervescent tablets, as well as in functional foods and beverages. Designed to be taken internally, Zeropollution is tailored for all beauty-from-within applications, responding to consumer demand for holistic solutions that embrace the fusion of beauty, health, and wellness. Visit us at SupplySide East, April 16-17, booth #4327 About Monteloeder: Monteloeder contributes cutting-edge innovation and scientific rigor to the development of botanical health ingredients, featuring proprietary patented products supported by clinical studies. The company's portfolio has garnered international accolades in Health & Wellness, Women's Health, and Beauty from Within. Monteloeder is a subsidiary of SUANNUTRA, which boasts a rich heritage of more than 125 years of combined experience in the European nutraceutical sector. For more information, contact: Company contact: Monteloeder, S.L., a subsidiary of SuanNutra Mariana Ortega Product Manager E-mail: [email protected] Website: Photo - SOURCE Monteloeder, S.L.

Clinical Result

21 Jul 2023

·www.prnewswire.com

Gundry MD® Polyphenol-Rich Olive Oil™ Celebrates Over 2 Million Units Sold

Gundry MD Polyphenol-Rich Olive Oil, a Supercharged Extra Virgin Olive Oil Providing Comprehensive Support For a Healthy Heart, Radiant Skin, and Resilient Muscles LOS ANGELES, July 21, 2023 /PRNewswire/ -- Gundry MD has now sold over 2 million units of one of its best-selling products, Gundry MD Polyphenol-Rich Olive Oil. Inspired by Dr. Steven Gundry, a pioneer in nutrition and world-renowned heart surgeon, this one-of-a-kind olive oil is enriched with an impressive 30-fold increase in polyphenol content compared to standard "store-bought" olive oils. With this boost in polyphenol content, the Gundry MD olive oil offers extra support for smooth skin, a healthy heart, and strong muscles.* Continue Reading Gundry MD Polyphenol-Rich Olive Oil is a strong and tasty olive oil infused with hydroxytyrosol, a naturally occurring polyphenol renowned for its exceptional ability to combat free radicals in the body. With an extraordinary concentration of hydroxytyrosol, boasting up to 30 times more than regular olive oils, and fortified with potent antioxidant properties, Gundry MD Polyphenol-Rich Olive Oil delivers a wide array of benefits that surpass those found in conventional olive oil. What is Gundry MD Polyphenol-Rich Olive Oil? Gundry MD Polyphenol-Rich Olive Oil is a strong and tasty olive oil infused with hydroxytyrosol, a naturally occurring polyphenol renowned for its exceptional ability to combat free radicals in the body. With an extraordinary concentration of hydroxytyrosol, boasting up to 30 times more than regular olive oils, and fortified with potent antioxidant properties, Gundry MD Polyphenol-Rich Olive Oil delivers a wide array of benefits that surpass those found in conventional olive oil. It helps provide comprehensive support for the immune system, supports brain health, supports a healthy heart and arteries, and helps encourage blood flow throughout the body. The abundance of antioxidants and additional polyphenols present in this oil aids the body in combating harmful compounds that can lead to fatigue and weakness. Incorporating Gundry MD Polyphenol-Rich Olive Oil into your daily routine is simple. As recommended by Dr. Gundry, you can enjoy it straight as a daily shot or sprinkle it over your meals as a delectable topping to help nourish a healthy heart, maintain optimal blood pressure and blood sugar levels, promote smoother skin, and support the immune system.* Where to Purchase Gundry MD Polyphenol-Rich Olive Oil Gundry MD Polyphenol-Rich Olive Oil can be purchased on the GundryMD website for $49.95 with a 90-day purchase-price guarantee. Suggested Use of Gundry MD Polyphenol-Rich Olive Oil For optimal consumption, take 1 or more tablespoons of Gundry MD Polyphenol-Rich Olive Oil daily. Enjoy it straight or incorporate it into various culinary delights such as salad dressings, yogurt, cooked vegetables, protein dishes, or Dr. Gundry's famous green smoothie for a delightful and healthful addition. Due to its high-quality and potent nutritional content, this olive oil is designed to be used as topper and not for cooking. Make a salad dressing with it: A fantastic method to balance the peppery flavor of the oil is by combining it with balsamic vinegar. Create your own balsamic vinaigrette by mixing equal parts of Gundry MD Polyphenol-Rich Olive Oil and balsamic vinegar, adding a pinch of sea salt, and a teaspoon of Dijon mustard. Use it in a sauce: Gundry MD Polyphenol-Rich Olive Oil can be used in many sauces including pesto. To make it, simply incorporate half a cup of basil or parsley, a quarter cup of toasted pine nuts, a quarter cup of grated parmesan, a clove of garlic, and approximately a quarter cup of Gundry MD Polyphenol-Rich Olive Oil into a food processor or blender then blend the ingredients until well combined. About Gundry MD Founded in 2015, Gundry MD is dedicated to providing cutting-edge solutions to its users by using science-backed ingredients that can offer a boost in metabolism, all-day energy, smooth, easy digestion, and a youthful-feeling mind and body. These amazing results all begin with feeding your body powerful health-boosting nutrients like polyphenols. Based on his many years of nutrition research, Dr. Gundry helps create every Gundry MD product. Best-selling Gundry MD products include Total Restore, Bio Complete 3, Energy Renew, and Polyphenol-Rich Olive Oil. All Gundry MD products come with a 90-day purchase price guarantee if you are not satisfied. For more information, visit or @gundrymd on Instagram and Facebook. About Dr. Gundry Founder of Gundry MD, Dr. Steven Gundry is a pioneer in nutrition and one of the world's top cardiothoracic surgeons, as well as medical director at The International Heart and Lung Institute and The Centers for Restorative Medicine in Beverly Hills, Palm Springs, and Santa Barbara, California. He has spent the past 25 years helping people restore their health by optimizing nutrition and lifestyle choices. Steven Gundry MD is also the host of the health podcast, The Dr. Gundry Podcast, and author of four New York Times best-selling books including The Plant Paradox™ which details his famous lectin-free or Plant Paradox diet. For more information, visit , the Dr. Gundry YouTube channel, @drstevengundry on Instagram, and @drgundry on TikTok. *All individuals are unique. Your results can and will vary. Press contact: Ashley Beenen [email protected] SOURCE Gundry MD

20 Mar 2023

·druggenius.com

By-product of Olive Oil Helps Exercise Performance & Hasten Recovery, Study Shows

Olive oil is a healthy fat loved and known for its deliciousness and wide versatility. It has also been linked to a truckload of health benefits . Now, a recent study adds to olive’s exceptional health perks, finding that its natural byproduct, gotten during production, has potential benefits for those who exercise. Researchers found that the natural by-product, olive fruit water, had good antioxidant properties and supported exercise. The study was conducted by scientists at Anglia Ruskin University and the results were published in the journal Nutrients . (function(v,d,o,ai){ai=d.createElement("script");ai.defer=true;ai.async=true;ai.src=v.location.protocol+o;d.head.appendChild(ai);})(window, document, "//a.vdo.ai/core/v-druggenius/vdo.ai.js"); window.vdo_ai_ = window.vdo_ai_ || {}; window.vdo_ai_.dimensions = window.vdo_ai_.dimensions || []; vdo_ai_.dimensions.push( [ "v-druggenius", "dim1", "/news/by-product-of-olive-oil-helps-exercise-performance-hasten-recovery-study-shows/" ] ); vdo_ai_.dimensions.push( [ "v-druggenius", "dim2", "439155" ] ); vdo_ai_.dimensions.push( [ "v-druggenius", "dim3", "" ] ); vdo_ai_.dimensions.push( [ "v-druggenius", "dim4", "organic" ] ); This is the first study to carry out an investigation into the benefits of the commercially available polyphenol-rich olive fruit water in exercise among recreationally active people. Olive fruit water is easily obtained during the production of olive oil. Olives contain polyphenols , which possess antioxidant properties. Emerging during the olive picking season, this commercially available polyphenol-rich drink, called OliPhenolia (OliP) contains different phenolic compounds and is especially rich in hydroxytyrosol. Polyphenol is also found in some fruits and vegetables including beets and cherries, which are also popularly known for their exercise benefits. Researchers enrolled over 29 participants above the age of 21 who were recreationally active (that is, those who performed approximately three exercise sessions each week) for the study. They were given either OliPhenolia or a placebo that was matched for both taste and appearance to take for 16 straight days. Participants were provided with 32 jars of OliPhenolia and told to drink two jars every day for 16 days. The team ensured adherence by making sure the participants returned the empty jar along with any full one at the end of the trial. Their results revealed that consuming OliPhenolia for 16 days at a stretch caused a positive impact on various key markers of running performance. In addition to that, they observed that drinking OliPhenolia significantly boosted both respiratory levels at the beginning of exercise as well as oxygen consumption and running efficiency at low levels of intensity (lactate threshold 1) Furthermore, respiratory parameters at a higher intensity (lactate threshold 2) were largely unaffected by OliPhenolia, but perceived exertion, that is, how hard the participants felt like their body was working, was boosted by the drink. They also found a significant boost in acute recovery following a gradual increase in exercise intensity over time (incremental exercise). The researchers report that OliPhenolia is relatively safe as there were no cases or reports of adverse reactions throughout the intervention. This olive fruit water is typically overlooked and is usually disposed of during the production of olive oil. Researchers came across a company in Italy called Fattoria La Vialla, that converts this wastewater and use it as a form of dietary supplement. Above all, their finding which explored the usefulness and relevance of this olive fruit water in the exercise field shows that 16 days of supplementation with OliPhenolia is largely beneficial for aerobic workouts, even at submaximal levels. “We now intend to carry out further research at Anglia Ruskin University to corroborate these findings,” says lead author Dr. Justin Roberts. “We are also looking to investigate whether this product can be used for marathon training and recovery, as well as test its effectiveness in suppressing inflammation associated with exercise.”

Clinical Result

100 Deals associated with Hydroxytyrosol

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KEGG	Wiki	ATC	Drug Bank
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Indication	Highest Phase	Country/Location	Organization	Date
Breast Cancer	Phase 3	-	The Methodist Hospitals, Inc.	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02068092 (CTgov)	Phase 2/3	Breast Cancer	51	Hydroxytyrosol	rlhvrhyjjs(trvshuojbv) = zmhlsoyagi whitxcveqp (kheuazqnvi, cdrizjebkq - lmmyecjloe) View more	-	10 Oct 2023
ESC2023	Not Applicable	Coronary Artery Disease	30	Olive extract enriched with hydroxytyrosol	skpifikbbg(aydbnectog) = rzougmchbu ibzvozhptd (jvvfarphvv ) View more	-	26 Aug 2023
				Olive extract enriched with hydroxytyrosol	skpifikbbg(aydbnectog) = venuazilqd ibzvozhptd (jvvfarphvv ) View more
EASD2019	Not Applicable	Weight Loss	-	15mg of HXT daily	cgiowjcrgr(dsuymgawlp) = dkgzgxorwt oilmjacjdl (cwnuvjhkdm, 1.06) View more	Positive	19 Sep 2019
				5mg of HXT daily	cgiowjcrgr(dsuymgawlp) = hajxvplhza oilmjacjdl (cwnuvjhkdm, 0.99) View more

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