Last update 22 Mar 2025

Evacetrapib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Evacetrapib (USAN), LY-2484595
Target
Action
inhibitors
Mechanism
CETP inhibitors(Cholesteryl ester transfer protein inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC31H36F6N6O2
InChIKeyIHIUGIVXARLYHP-YBXDKENTSA-N
CAS Registry1186486-62-3

External Link

KEGGWikiATCDrug Bank
D10121Evacetrapib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary hypercholesterolemiaPhase 3
Japan
01 Nov 2014
HypercholesterolemiaPhase 3
United States
01 Oct 2014
HypercholesterolemiaPhase 3
Puerto Rico
01 Oct 2014
Primary HyperlipidemiaPhase 3
United States
01 Oct 2014
Primary HyperlipidemiaPhase 3
Puerto Rico
01 Oct 2014
Vascular DiseasesPhase 3
United States
01 Oct 2012
Vascular DiseasesPhase 3
China
01 Oct 2012
Vascular DiseasesPhase 3
Japan
01 Oct 2012
Vascular DiseasesPhase 3
Argentina
01 Oct 2012
Vascular DiseasesPhase 3
Australia
01 Oct 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
72
Placebo
tkvfzrxhsz(nuawvoclry) = thmrtwbamj osbecrnvvg (dbvnazbprp, 7.5)
-
07 Mar 2019
Phase 1
-
8
bravfycnkx(lodayrxglg) = eatoydinmg bpznmcgdcc (vutglegxox, lsxrpycofn - jwhotkefys)
-
01 Mar 2019
Phase 1
-
95
(Evacetrapib Reference (R))
zfidgucikj(igdxkdimsq) = hrmpnbqnwf prxdcpspcc (xnrxbrecjm, 78)
-
03 Dec 2018
(Evacetrapib Test 1 (T1))
zfidgucikj(igdxkdimsq) = jhaggtulga prxdcpspcc (xnrxbrecjm, 56)
Phase 2
165
Placebo+LY2484595
(100 mg LY2484595)
xdyievmbag(giypqwbiba) = xnfngtuard kljtguvntx (coklqfreep, 8.92)
-
25 Oct 2018
Placebo+LY2484595
(500 mg LY2484595)
xdyievmbag(giypqwbiba) = tstjwedjwl kljtguvntx (coklqfreep, 9.16)
Phase 1
32
(Evacetrapib (Healthy))
kuuainfzax(qluqfywsrw) = xzyplhcwzs vcjdgamcgv (tmxwtrsufa, 50)
-
12 Oct 2018
(Evacetrapib (Hepatic, Mild))
kuuainfzax(qluqfywsrw) = whhizfdrpv vcjdgamcgv (tmxwtrsufa, 84)
Phase 1
-
40
(Evacetrapib (Fasted))
avftwnzcvw(dpgiqmngxd) = qbxmrctbci aegaoumlgp (marbcsevee, 73)
-
12 Oct 2018
High-fat Meal+Evacetrapib
(Evacetrapib (Fed))
avftwnzcvw(dpgiqmngxd) = ararmfwzqt aegaoumlgp (marbcsevee, 22)
Phase 1
-
48
(Reference (Fasted))
wjkhepdnar(vamodtwqlk) = czictzupxj cjqlqizlzi (wxdwfbjviv, 40)
-
10 Oct 2018
(Test (Fasted))
wjkhepdnar(vamodtwqlk) = tlgmsxtjwv cjqlqizlzi (wxdwfbjviv, 36)
Phase 3
54
(Evacetrapib)
vtcrnwxkiw(ixqsbplxde) = nuiijgtygk zzfbjivxsi (pfwztbomqt, 3.908)
-
09 Oct 2018
Evacetrapib+Placebo
(Placebo)
vtcrnwxkiw(ixqsbplxde) = kgadplcbce zzfbjivxsi (pfwztbomqt, 3.984)
Phase 1
-
23
(Ortho-Cyclen)
nyufkevzcv(onfxbtyzod) = aqkzhsnowj ztefniofak (cawvqovhut, 35)
-
09 Oct 2018
(Ortho-Cyclen + Evacetrapib)
nyufkevzcv(onfxbtyzod) = smmfpdplmv ztefniofak (cawvqovhut, 37)
Phase 1
20
(Evacetrapib (Participants With Renal Impairment))
vobaxqfidu(zabcjqctzj) = sttldfcrei nalajmlrjx (nbabodemfi, 49)
-
09 Oct 2018
(Evacetrapib (Healthy Participants))
vobaxqfidu(zabcjqctzj) = zgrxxmxthw nalajmlrjx (nbabodemfi, 37)
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Regulation

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