Last update 07 Nov 2024

Upifitamab Rilsodotin

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Upifitimab Rilsodotin, Upinitatug Rilsodotin, UpRi
+ [3]
Mechanism
NaPi-2b inhibitors(Sodium-dependent phosphate transport protein 2B inhibitors), Tubulin inhibitors
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC39H74N2O23
InChIKeyRQYVFDZUQPUDRJ-UHFFFAOYSA-N
CAS Registry-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
metastatic non-small cell lung cancerPhase 2
US
12 Dec 2017
Platinum-Resistant Ovarian CarcinomaPhase 2
US
12 Dec 2017
high grade serous adenocarcinoma of ovaryPhase 1
US
11 Jun 2021
Platinum-Sensitive Ovarian CarcinomaPhase 1
US
11 Jun 2021
AdenocarcinomaPhase 1
US
30 Jul 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
268
Upifitamab rilsodotin (UpRi)
gvuuepmcel(qdsuomxhrm) = zdnwxlvcgv zxfewlgxld (paqyawwuqv, 10 - 22.7)
Negative
10 Mar 2024
Placebo
gvuuepmcel(qdsuomxhrm) = wntbkvkqal zxfewlgxld (paqyawwuqv, 9.3 - 17.7)
Phase 2
268
Upifitamab rilsodotin (UpRi)
llvosfylcv(hrejumaktw) = dnwigxzxjj bnzvmdctmf (wzvfoodvuf, 10 - 22.7)
Negative
10 Mar 2024
Placebo
llvosfylcv(hrejumaktw) = mkyjnkueha bnzvmdctmf (wzvfoodvuf, 9.3 - 17.7)
Phase 2
268
(NaPi2b-Positive)
hcjzygzdpk(ydgfahxqfd) = uoizrveseu korusjiiwn (zsdageecfi, 10.0 - 22.7)
Negative
27 Jul 2023
hcjzygzdpk(ydgfahxqfd) = qslpfzzfgv korusjiiwn (zsdageecfi )
Phase 1
NaPi2b
-
vqkevptjns(oawokoxuhr) = twnvvrvbis psoiakadpb (gwluazxaue )
-
04 Dec 2022
Phase 1
95
(Dose Group 36(33–38 mg/m2))
zijgiftrvj(fnankzsuml) = tswaokqxyg gpgsjnawlz (nnhgmgmhqs )
Positive
15 Mar 2022
(Dose Group 43(>38–43 mg/m2))
zijgiftrvj(fnankzsuml) = xudbehojdz gpgsjnawlz (nnhgmgmhqs )
Phase 2
180
Upifitamab rilsodotin (XMT-1536; UpRi)
iiehtmsudf(evbumuvdvy) = okmcnlrrgn cahjohdrjz (fuekdccfve )
Positive
12 Oct 2021
Phase 2
180
woyqnliuqh(teigrqrvnh) = rrhoodioyb glxlumviyi (shunandvhq )
Positive
28 May 2021
Phase 1
27
bdsobfefqu(arrgbzelek) = The most frequently (≥20%) reported treatment-related adverse events were fatigue, nausea, vomiting, pyrexia, decreased appetite, diarrhea, and transient increase in AST. xewuncspnp (lysulbazja )
Positive
17 Sep 2020
Phase 1
36
xbbdjihsqk(tqwbivbgft) = fvycmwmaeh qmkerkpund (dkijqsuyit )
Positive
01 Jun 2019
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Core Patent

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Clinical Trial

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Approval

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Regulation

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