A Clinical study to evaluate the Safety and efficacy of hyaluronic acid injection containing stromal vascular fraction extracted from adipose tissue of patients with enophthalmos

Start Date31 Jan 2025

Sponsor / Collaborator

Bundang CHA Hospital

CTRI/2024/11/077456

/ Not yet recruitingNot ApplicableIIT

Effectiveness of 0.1 percent Hyaluronic Acid with 0.2 percent Chlorhexidine Mouthrinse or 0.2 percent Chlorhexidine Mouthrinse alone as adjunct to scaling and root planing on clinical parameters and salivary aspartate aminotransferase marker in Periodontitis : A Prospective randomized observer blinded study - NIL

Start Date10 Dec 2024

Sponsor / Collaborator

Dr. Reddy's Laboratories Ltd.

IRCT20091012002576N49

/ RecruitingPhase 2/3IIT

Comparisons the effect of hyaluronic acid injection in prevention of adhesions after hysteroscopy septoplasty

Start Date22 Oct 2024

Sponsor / Collaborator

Tehran University of Medical Sciences

100 Clinical Results associated with Hyaluronic acid

100 Translational Medicine associated with Hyaluronic acid

100 Patents (Medical) associated with Hyaluronic acid

7,732

Literatures (Medical) associated with Hyaluronic acid

31 Dec 2025·ANNALS OF MEDICINE

The predictive value of hyaluronic acid for the severity and prognosis of COVID-19: a retrospective multicenter cohort study

Article

Author: Yuan, Xiaochun ; Cui, Guangqing ; Pan, Chun ; Mu, Genhua ; Xu, Jingyuan ; Zhang, Jialong ; Zhang, Yanjie

BACKGROUND:

The aim of this study was to elucidate the relationship between HA levels and clinical outcomes, including disease severity and prognosis.

METHODS:

A retrospective multicenter cohort analysis was conducted across three medical centers in China from September 2022 to February 2023. Patients with positive nucleic acid for the novel coronavirus were included in the study. The primary endpoint is 28-day mortality.The severity was assessed by the 'Diagnosis and Treatment Plan for Novel Coronavirus Pneumonia (Trial Version 9)'. Analyses assessed HA correlation with severity (Kendall), predictive value for mortality (logistic regression, ROC, Delong test), and survival differences (KM analysis using a Youden index-derived HA cutoff).

RESULTS:

A total of 862 patients (median age 72; 58.47% male) were included in the study, of whom 108 died. Non-survivors were older, more men, lower BMI, and more complicatinos. The overall median HA level was 121.65 ng/ml, significantly higher in non-survivors(p < 0.001). Kendall correlation analysis revealed a significant correlation between HA level and COVID-19 severity (correlation coefficient: 0.365, p < 0.001). Our preliminary analysis revealed positive correlations between HA and D-dimer and chest CT. In logistic regression models, HA was an independent predictor of 28-day mortality(p = 0.001). The AUROC for HA was 0.840 (95% CI: 0.806-0.974). The cut-off value was 141.65 ng/ml (sensitivity 61.27%, specificity 91.67%). KM survival analysis showed that patients with HA levels higher than 141.65 ng/ml had a significantly lower survival probability(p < 0.001).

CONCLUSION:

HA may potentially function as a biomarker for COVID-19 and could provide a vital reference for the clinical treatment.

31 Dec 2025·Future Science OA

Polymeric nanoparticles-based targeted delivery of drugs and bioactive compounds for arthritis management

Review

Author: Vaidya, Anuradha ; Ravindran, Selvan ; Dixit, Tanu

This review explores the potential of polymeric nanoparticles (PNPs) as targeted drug delivery systems for arthritic treatment, overcoming the limitations of the present therapy. A thorough literature search was conducted on the databases PubMed, Scopus, and Web of Science to find published articles on the use of polymeric nanoparticles in the treatment of arthritis. This includes synthesis methods, mechanisms in drug delivery, and applications of PNPs. Polymeric nanoparticles showed excellent promise in the management of arthritis through enhanced stability of drugs, controlled and sustained drug release, and reduced systemic side effects. Some of the highlighted biocompatible and targeting capabilities of natural and synthetic polymers include chitosan, hyaluronic acid, and PLGA. Bioactive compounds such as curcumin and resveratrol delivered by PNPs enhanced therapeutic efficacy in preclinical arthritis models. Despite their promise, challenges such as rapid clearance and manufacturing scalability remain critical barriers. Polymeric nanoparticles offer a transformative approach to arthritis management by enabling targeted, sustained, and safe drug delivery. Translation into clinical applications would thus require developments in nanoparticle design, personalized medicine, and scalable production techniques.

31 Dec 2025·ANNALS OF MEDICINE

Comparative efficacy of platelet-rich plasma injection vs ultrasound-guided hyaluronic acid injection in the rehabilitation of hip osteoarthritis: an observational study

Article

Author: Bian, Guangjun ; Zhao, Wei ; Zhang, Li

BACKGROUND:

Intra-articular platelet-rich plasma (PRP) injections have been the subject of extensive study in knee osteoarthritis (OA), yet their effectiveness in hip OA has not been explored.

OBJECTIVE:

To assess and evaluate the therapeutic effectiveness of autologous PRP and hyaluronic acid (HA) in treating hip OA.

METHODS:

Intra-articular injections were administered to 150 patients with hip osteoarthritis, and the patients were divided into two groups: PRP and HA. The evaluation of clinical outcomes was conducted using the Harris Hip Score (HHS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Visual Analogue Scale (VAS) at 3, 6, and 12 months. Outcomes were compared using regression analysis, repeated measure ANOVA, and Pearson correlation test.

RESULTS:

The PRP group showed greater improvements in all scores (p < 0.05) compared to HA. PRP injection significantly reduced VAS and WOMAC scores [VAS score (MD 2.238, 95% CI 0.065-3.21) and WOMAC score (MD 1.033, 95% CI 0.06-1.526)], while HHS score increased (MD 1.02, 95% CI 0.06-1.126). IL-10 and VAS score showed a moderate correlation in the PRP group (r = 0.591). While statistical significance is indicated by the results, it is suggested that the changes in scores are small and may not be representative of any clinical significance.

CONCLUSION:

It has been demonstrated by the findings of this study that pain and joint discomfort may be decreased by the administration of PRP injections, which may aid in the management of hip OA. However, there was no clinical difference between PRP and HA treatments.

News (Medical) associated with Hyaluronic acid

31 Jul 2025

·news.abbvie.com

AbbVie Reports Second-Quarter 2025 Financial Results

Corporate News Reports Second-Quarter Diluted EPS of $0.52 on a GAAP Basis, a Decrease of 32.5 Percent; Adjusted Diluted EPS of $2.97, an Increase of 12.1 Percent; These Results Include an Unfavorable Impact of $0.42 Per Share Related to Acquired IPR&D and Milestones Expense Delivers Second-Quarter Net Revenues of $15.423 Billion, an Increase of 6.6 Percent on a Reported Basis or 6.5 Percent on an Operational Basis Second-Quarter Global Net Revenues from the Immunology Portfolio Were $7.631 Billion, an Increase of 9.5 Percent on a Reported Basis, or 9.2 Percent on an Operational Basis; Global Skyrizi Net Revenues Were $4.423 Billion; Global Rinvoq Net Revenues Were $2.028 Billion; Global Humira Net Revenues Were $1.180 Billion Second-Quarter Global Net Revenues from the Neuroscience Portfolio Were $2.683 Billion, an Increase of 24.2 Percent on a Reported Basis, or 24.0 Percent on an Operational Basis; Global Vraylar Net Revenues Were $900 Million; Global Botox Therapeutic Net Revenues Were $928 Million; Combined Global Ubrelvy and Qulipta Net Revenues Were $605 Million Second-Quarter Global Net Revenues from the Oncology Portfolio Were $1.676 Billion, an Increase of 2.6 Percent on a Reported Basis, or 2.4 Percent on an Operational Basis; Global Imbruvica Net Revenues Were $754 Million; Global Venclexta Net Revenues Were $691 Million; Global Elahere Net Revenues Were $159 Million Second-Quarter Global Net Revenues from the Aesthetics Portfolio Were $1.279 Billion, a Decrease of 8.1 Percent on a Reported Basis, or 8.0 Percent on an Operational Basis; Global Botox Cosmetic Net Revenues Were $692 Million; Global Juvederm Net Revenues Were $260 Million Raises 2025 Adjusted Diluted EPS Guidance Range from $11.67 - $11.87 to $11.88 - $12.08, which Includes an Unfavorable Impact of $0.55 Per Share Related to Acquired IPR&D and Milestones Expense Incurred Year-To-Date Through the Second Quarter 2025 NORTH CHICAGO, Ill., July 31, 2025 /PRNewswire/ -- AbbVie (NYSE:ABBV) announced financial results for the second quarter ended June 30, 2025. "AbbVie delivered another outstanding quarter with strong performance from our diversified growth platform. We also made meaningful pipeline progress with several regulatory approvals, encouraging clinical data and strategic investments in promising external innovation," said Robert A. Michael, chairman and chief executive officer, AbbVie. "We're entering the second half of the year with substantial momentum and are once again raising our full-year outlook." Second-Quarter Results Worldwide net revenues were $15.423 billion, an increase of 6.6 percent on a reported basis, or 6.5 percent on an operational basis. Global net revenues from the immunology portfolio were $7.631 billion, an increase of 9.5 percent on a reported basis, or 9.2 percent on an operational basis. Global Skyrizi net revenues were $4.423 billion, an increase of 62.2 percent on a reported basis, or 61.8 percent on an operational basis. Global Rinvoq net revenues were $2.028 billion, an increase of 41.8 percent on a reported basis, or 41.2 percent on an operational basis. Global Humira net revenues were $1.180 billion, a decrease of 58.1 percent on a reported basis, or 58.2 percent on an operational basis. Global net revenues from the neuroscience portfolio were $2.683 billion, an increase of 24.2 percent on a reported basis, or 24.0 percent on an operational basis. Global Vraylar net revenues were $900 million, an increase of 16.3 percent. Global Botox Therapeutic net revenues were $928 million, an increase of 14.1 percent on a reported basis, or 14.2 percent on an operational basis. Global Ubrelvy net revenues were $338 million, an increase of 47.1 percent on a reported basis, or 47.2 percent on an operational basis. Global Qulipta net revenues were $267 million, an increase of 77.5 percent on a reported basis, or 76.9 percent on an operational basis. Global net revenues from the oncology portfolio were $1.676 billion, an increase of 2.6 percent on a reported basis, or 2.4 percent on an operational basis. Global Imbruvica net revenues were $754 million, a decrease of 9.5 percent. Global Venclexta net revenues were $691 million, an increase of 8.5 percent on a reported basis, or 8.3 percent on an operational basis. Global Elahere net revenues were $159 million, an increase of 24.2 percent on a reported basis, or 23.7 percent on an operational basis. Global net revenues from the aesthetics portfolio were $1.279 billion, a decrease of 8.1 percent on a reported basis, or 8.0 percent on an operational basis. Global Botox Cosmetic net revenues were $692 million, a decrease of 5.0 percent on a reported basis, or 4.9 percent on an operational basis. Global Juvederm net revenues were $260 million, a decrease of 24.0 percent. On a GAAP basis, gross margin in the second quarter was 71.8 percent. The adjusted gross margin was 84.4 percent. On a GAAP basis, selling, general and administrative (SG&A) expense was 21.1 percent of net revenues. The adjusted SG&A expense was 21.0 percent of net revenues. On a GAAP basis, research and development (R&D) expense was 13.8 percent of net revenues. The adjusted R&D expense was 13.7 percent of net revenues. Acquired IPR&D and milestones expense was 5.3 percent of net revenues. On a GAAP basis, operating margin in the second quarter was 31.7 percent. The adjusted operating margin was 44.3 percent. Net interest expense was $678 million. On a GAAP basis, the tax rate in the quarter was 39.4 percent. The adjusted tax rate was 16.2 percent. Diluted EPS in the second quarter was $0.52 on a GAAP basis. Adjusted diluted EPS, excluding specified items, was $2.97. These results include an unfavorable impact of $0.42 per share related to acquired IPR&D and milestones expense. Global Skyrizi net revenues were $4.423 billion, an increase of 62.2 percent on a reported basis, or 61.8 percent on an operational basis. Global Rinvoq net revenues were $2.028 billion, an increase of 41.8 percent on a reported basis, or 41.2 percent on an operational basis. Global Humira net revenues were $1.180 billion, a decrease of 58.1 percent on a reported basis, or 58.2 percent on an operational basis. Global Vraylar net revenues were $900 million, an increase of 16.3 percent. Global Botox Therapeutic net revenues were $928 million, an increase of 14.1 percent on a reported basis, or 14.2 percent on an operational basis. Global Ubrelvy net revenues were $338 million, an increase of 47.1 percent on a reported basis, or 47.2 percent on an operational basis. Global Qulipta net revenues were $267 million, an increase of 77.5 percent on a reported basis, or 76.9 percent on an operational basis. Global Imbruvica net revenues were $754 million, a decrease of 9.5 percent. Global Venclexta net revenues were $691 million, an increase of 8.5 percent on a reported basis, or 8.3 percent on an operational basis. Global Elahere net revenues were $159 million, an increase of 24.2 percent on a reported basis, or 23.7 percent on an operational basis. Global Botox Cosmetic net revenues were $692 million, a decrease of 5.0 percent on a reported basis, or 4.9 percent on an operational basis. Global Juvederm net revenues were $260 million, a decrease of 24.0 percent. Note: "Operational" comparisons are presented at constant currency rates that reflect comparative local currency net revenues at the prior year's foreign exchange rates. Recent Events AbbVie announced the U.S. Food and Drug Administration (FDA) approved Rinvoq (upadacitinib) as the first oral Janus Kinase (JAK) inhibitor approved for the treatment of adults with giant cell arteritis (GCA). The approval was supported by data from the pivotal Phase 3 SELECT-GCA trial, which met the primary endpoint of sustained remission and key secondary endpoints. This marks the ninth approved indication for Rinvoq in the U.S., across rheumatology, gastroenterology and dermatology. AbbVie announced positive topline results from the first of two pivotal studies in the Phase 3 UP-AA clinical program evaluating the safety and efficacy of Rinvoq in adult and adolescent patients with severe alopecia areata (AA). In the study, Rinvoq achieved the primary endpoint, demonstrating that 44.6% and 54.3% of patients with severe AA treated with Rinvoq 15mg and 30mg, respectively, reached 80% or more scalp hair coverage at week 24 as defined by the severity of alopecia tool (SALT) score ≤20. Key secondary endpoints, including improvements in eyebrows and eyelashes, as well as the percentage of subjects with 90% or more scalp coverage (SALT ≤10) and complete scalp hair coverage (SALT=0) at Week 24, were also met. Rinvoq's safety profile in AA was generally consistent with that in approved indications, and no new safety signals were identified in this study. AbbVie and Capstan Therapeutics, a clinical-stage biotechnology company dedicated to advancing in vivo engineering of cells through RNA delivery using targeted lipid nanoparticles (tLNPs), announced a definitive agreement under which AbbVie will acquire Capstan. The transaction includes CPTX2309, a potential first-in-class in vivo tLNP anti-CD19 CAR-T therapy candidate, currently in Phase 1 development for the treatment of B cell-mediated autoimmune diseases. Additionally, AbbVie will acquire Capstan's proprietary tLNP platform technology designed to deliver RNA payloads, such as mRNA, capable of engineering specific cell types in vivo. AbbVie announced new data from its Phase 3 TEMPLE head-to-head study evaluating the tolerability, safety and efficacy of Qulipta (atogepant) compared to topiramate for the preventive treatment of migraine in adult patients with a history of four or more migraine days per month. In the study, Qulipta met the primary endpoint of fewer treatment discontinuations attributed to adverse events versus topiramate, and all six secondary endpoints achieved statistical significance for superiority versus topiramate, demonstrating clinical efficacy. Full results from the TEMPLE study will be presented at an upcoming medical meeting. AbbVie announced that Emrelis (telisotuzumab vedotin-tllv) was granted accelerated approval by the FDA for the treatment of adult patients with locally advanced or metastatic, non-squamous non-small cell lung cancer (NSCLC) with high c-Met protein overexpression who have received a prior systemic therapy. Emrelis is the first treatment approved for previously treated advanced NSCLC patients with high c-Met protein overexpression, a population that often faces poor prognosis and has limited treatment options. AbbVie announced the submission of a supplemental New Drug Application (sNDA) to the FDA for Venclexta (venetoclax) and acalabrutinib combination therapy for the treatment of chronic lymphocytic leukemia (CLL). This combination therapy has potential to be the first all oral, fixed-duration regimen for previously untreated patients with CLL. The submission is supported by data from the Phase 3 AMPLIFY trial which demonstrated that the combination regimen of Venclexta and acalabrutinib improved progression-free survival (PFS) compared to standard chemoimmunotherapy in previously untreated patients with CLL. At the American Society of Clinical Oncology (ASCO) Annual Meeting, AbbVie presented key data that showcased significant progress across AbbVie's robust oncology pipeline, in a range of difficult-to-treat solid tumors and blood cancers. Highlights included new data from AbbVie's novel investigational antibody-drug conjugates (ADCs) telisotuzumab adizutecan (ABBV-400, Temab-A) in advanced NSCLC, ABBV-706 in high-grade neuroendocrine neoplasms (NENs) and pivekimab sunirine (PVEK) in blastic plasmacytoid dendritic cell neoplasm (BPDCN). AbbVie announced the global Phase 3 VERONA trial evaluating Venclexta (venetoclax) in combination with azacitidine in the treatment of newly diagnosed higher-risk myelodysplastic syndrome (MDS) did not meet the primary endpoint of overall survival. No new safety signals were observed and results from the trial will be available in a future medical congress and/or publication. AbbVie and Ichnos Glenmark Innovation (IGI) announced an exclusive licensing agreement for IGI's lead investigational asset, ISB 2001, which is being investigated for the treatment of oncology and autoimmune diseases. ISB 2001 is a first-in-class trispecific T-cell engager currently in Phase 1 development for relapsed/refractory (r/r) multiple myeloma (MM). AbbVie announced the FDA approved a label expansion for Mavyret (glecaprevir/pibrentasvir), an oral pangenotypic direct acting antiviral (DAA) therapy. Mavyret is the first oral eight-week pangenotypic treatment option approved for people with acute or chronic hepatitis C virus (HCV). With this approval, providers can now treat HCV patients immediately at the time of diagnosis. AbbVie and ADARx Pharmaceuticals, a late clinical-stage biotechnology company developing next-generation RNA therapeutics, announced a collaboration and license option agreement to develop small interfering RNA (siRNA) therapeutics across multiple disease areas. The collaboration will leverage AbbVie's expertise in biotherapeutic drug development and commercialization with ADARx's proprietary RNA technology to advance next-generation siRNA therapies across neuroscience, immunology and oncology. Full-Year 2025 Outlook AbbVie is raising its adjusted diluted EPS guidance for the full year 2025 from $11.67 - $11.87 to $11.88 - $12.08, which includes an unfavorable impact of $0.55 per share related to acquired IPR&D and milestones expense incurred year-to-date through the second quarter 2025. The company's 2025 adjusted diluted EPS guidance excludes any impact from acquired IPR&D and milestones that may be incurred beyond the second quarter of 2025, as both cannot be reliably forecasted. About AbbVie AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, neuroscience, oncology, and eye care - and products and services across our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X (formerly Twitter), Facebook, Instagram, YouTube or LinkedIn. Conference Call AbbVie will host an investor conference call today at 8:00 a.m. Central Time to discuss our second-quarter performance. The call will be webcast through AbbVie's Investor Relations website at investors.abbvie.com. An archived edition of the call will be available after 11:00 a.m. Central Time. Non-GAAP Financial Results Financial results for 2025 and 2024 are presented on both a reported and a non-GAAP basis. Reported results were prepared in accordance with GAAP and include all revenue and expenses recognized during the period. Non-GAAP results adjust for certain non-cash items and for factors that are unusual or unpredictable, and exclude those costs, expenses, and other specified items presented in the reconciliation tables later in this release. AbbVie's management believes non-GAAP financial measures provide useful information to investors regarding AbbVie's results of operations and assist management, analysts and investors in evaluating the performance of the business. Non-GAAP financial measures should be considered in addition to, and not as a substitute for, measures of financial performance prepared in accordance with GAAP. Forward-Looking Statements Some statements in this news release are, or may be considered, forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995. The words "believe," "expect," "anticipate," "project" and similar expressions and uses of future or conditional verbs, generally identify forward-looking statements. AbbVie cautions that these forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those expressed or implied in the forward-looking statements. Such risks and uncertainties include, but are not limited to, challenges to intellectual property, competition from other products, difficulties inherent in the research and development process, adverse litigation or government action, changes to laws and regulations applicable to our industry, the impact of global macroeconomic factors, such as economic downturns or uncertainty, international conflict, trade disputes and tariffs, and other uncertainties and risks associated with global business operations. Additional information about the economic, competitive, governmental, technological and other factors that may affect AbbVie's operations is set forth in Item 1A, "Risk Factors," of AbbVie's 2024 Annual Report on Form 10-K, which has been filed with the Securities and Exchange Commission, as updated by its Quarterly Reports on Form 10-Q and in other documents that AbbVie subsequently files with the Securities and Exchange Commission that update, supplement or supersede such information. AbbVie undertakes no obligation, and specifically declines, to release publicly any revisions to forward-looking statements as a result of subsequent events or developments, except as required by law. Media: Investors: Gabby Tarbert Liz Shea (224) 244-0111 (847) 935-2211 Todd Bosse (847) 936-1182 Jeffrey Byrne (847) 938-2923 AbbVie Inc. Key Product Revenues Quarter Ended June 30, 2025 (Unaudited) % Change vs. 2Q24 Net Revenues (in millions) Reported Operationala U.S. Int'l. Total U.S. Int'l. Total Int'l. Total NET REVENUES $11,762 $3,661 $15,423 5.9 % 9.1 % 6.6 % 8.4 % 6.5 % Immunology 6,097 1,534 7,631 6.7 22.3 9.5 20.7 9.2 Skyrizi 3,843 580 4,423 64.3 49.7 62.2 47.2 61.8 Rinvoq 1,452 576 2,028 42.7 39.6 41.8 37.5 41.2 Humira 802 378 1,180 (66.0) (16.8) (58.1) (17.2) (58.2) Neuroscience 2,333 350 2,683 23.2 30.6 24.2 28.7 24.0 Vraylar 898 2 900 16.2 72.8 16.3 76.8 16.3 Botox Therapeutic 775 153 928 15.9 5.7 14.1 6.0 14.2 Ubrelvy 330 8 338 46.5 73.9 47.1 76.7 47.2 Qulipta 237 30 267 62.8 >100.0 77.5 >100.0 76.9 Vyalev 22 76 98 n/m >100.0 >100.0 >100.0 >100.0 Duodopa 20 77 97 (13.6) (13.7) (13.7) (16.3) (15.7) Other Neuroscience 51 4 55 (11.4) (23.3) (12.3) (21.3) (12.2) Oncology 1,026 650 1,676 (1.0) 8.7 2.6 8.3 2.4 Imbruvicab 543 211 754 (8.9) (11.2) (9.5) (11.2) (9.5) Venclexta 321 370 691 7.4 9.5 8.5 9.1 8.3 Elahere 138 21 159 8.0 n/m 24.2 n/m 23.7 Epkinlyc 22 48 70 57.4 >100.0 93.9 >100.0 92.3 Other Oncology 2 — 2 n/m n/m n/m n/m n/m Aesthetics 797 482 1,279 (7.8) (8.5) (8.1) (8.3) (8.0) Botox Cosmetic 410 282 692 (8.7) 0.9 (5.0) 1.2 (4.9) Juvederm Collection 105 155 260 (23.6) (24.4) (24.0) (24.4) (24.0) Other Aesthetics 282 45 327 1.6 5.8 2.2 6.4 2.3 Eye Care 226 288 514 (5.7) (2.4) (3.9) (1.5) (3.4) Ozurdex 30 95 125 (12.6) 5.8 0.6 4.4 (0.4) Lumigan/Ganfort 52 51 103 19.9 (15.4) (0.8) (15.2) (0.7) Alphagan/Combigan — 36 36 (91.6) (3.1) (25.6) (0.2) (23.5) Other Eye Care 144 106 250 (4.3) (1.7) (3.2) 0.9 (2.1) Other Key Products 835 202 1,037 11.2 (4.4) 7.8 (5.8) 7.5 Mavyret 184 191 375 9.7 (5.1) 1.6 (6.5) 0.8 Creon 404 — 404 8.4 n/m 8.4 n/m 8.4 Linzess/Constella 247 11 258 17.4 10.8 17.1 10.3 17.1 a "Operational" comparisons are presented at constant currency rates that reflect comparative local currency net revenues at the prior year's foreign exchange rates. b Reflects profit sharing for Imbruvica international revenues. c Epkinly U.S. revenues reflect profit sharing. International revenues reflect product revenues as well as profit sharing from certain international territories. n/m = not meaningful AbbVie Inc. Key Product Revenues Six Months Ended June 30, 2025 (Unaudited) % Change vs. 6M24 Net Revenues (in millions) Reported Operationala U.S. Int'l. Total U.S. Int'l. Total Int'l. Total NET REVENUES $21,741 $7,025 $28,766 7.9 % 6.0 % 7.4 % 8.3 % 8.0 % Immunology 10,980 2,915 13,895 11.3 17.9 12.6 20.4 13.1 Skyrizi 6,762 1,086 7,848 69.2 46.9 65.8 49.6 66.2 Rinvoq 2,672 1,074 3,746 53.3 37.6 48.5 40.1 49.3 Humira 1,546 755 2,301 (62.6) (20.8) (54.7) (18.4) (54.3) Neuroscience 4,305 660 4,965 19.3 27.4 20.3 29.8 20.6 Vraylar 1,661 4 1,665 13.4 41.8 13.5 47.4 13.5 Botox Therapeutic 1,498 296 1,794 17.0 5.2 14.9 8.6 15.5 Ubrelvy 563 15 578 33.0 46.7 33.3 51.2 33.4 Qulipta 409 51 460 49.5 >100.0 63.6 >100.0 63.6 Vyalev 28 133 161 n/m >100.0 >100.0 >100.0 >100.0 Duodopa 40 153 193 (16.6) (14.9) (15.2) (14.0) (14.5) Other Neuroscience 106 8 114 (10.4) (12.7) (10.5) (8.1) (10.2) Oncology 2,053 1,256 3,309 2.4 7.1 4.2 9.1 5.0 Imbruvicab 1,072 420 1,492 (11.1) (9.7) (10.7) (9.7) (10.7) Venclexta 633 723 1,356 9.1 7.8 8.4 11.3 10.3 Elahere 303 35 338 57.5 n/m 75.5 n/m 75.5 Epkinlyc 43 78 121 61.8 >100.0 92.1 >100.0 93.3 Other Oncology 2 — 2 n/m n/m n/m n/m n/m Aesthetics 1,437 944 2,381 (12.3) (5.6) (9.8) (3.6) (9.0) Botox Cosmetic 705 543 1,248 (15.9) 3.7 (8.4) 5.8 (7.6) Juvederm Collection 180 311 491 (25.9) (21.5) (23.2) (19.8) (22.2) Other Aesthetics 552 90 642 (1.0) 11.7 0.6 14.5 0.9 Eye Care 447 573 1,020 (4.2) (5.3) (4.8) (1.8) (2.8) Ozurdex 60 188 248 (12.4) 0.8 (2.8) 2.7 (1.4) Lumigan/Ganfort 100 109 209 39.4 (11.0) 7.5 (7.7) 9.6 Alphagan/Combigan 26 70 96 (3.6) (13.1) (10.6) (8.5) (7.2) Other Eye Care 261 206 467 (12.8) (4.4) (9.3) 0.3 (7.3) Other Key Products 1,471 375 1,846 2.5 (12.0) (0.8) (10.4) (0.4) Mavyret 326 355 681 4.9 (12.8) (5.1) (11.2) (4.2) Creon 759 — 759 15.4 n/m 15.4 n/m 15.4 Linzess/Constella 386 20 406 (17.4) 7.0 (16.5) 9.7 (16.4) a "Operational" comparisons are presented at constant currency rates that reflect comparative local currency net revenues at the prior year's foreign exchange rates. b Reflects profit sharing for Imbruvica international revenues. c Epkinly U.S. revenues reflect profit sharing. International revenues reflect product revenues as well as profit sharing from certain international territories. n/m = not meaningful AbbVie Inc. Consolidated Statements of Earnings (Unaudited) (in millions, except per share data) Second Quarter Ended June 30 Six Months Ended June 30 2025 2024 2025 2024 Net revenues $ 15,423 $ 14,462 $ 28,766 $ 26,772 Cost of products sold 4,346 4,202 8,348 8,296 Selling, general and administrative 3,253 3,377 6,546 6,692 Research and development 2,131 1,948 4,198 3,887 Acquired IPR&D and milestones 823 937 1,071 1,101 Other operating income (24) — (24) — Total operating costs and expenses 10,529 10,464 20,139 19,976 Operating earnings 4,894 3,998 8,627 6,796 Interest expense, net 678 506 1,305 959 Net foreign exchange loss 23 1 27 5 Other expense, net 2,639 1,345 4,080 1,931 Earnings before income tax expense 1,554 2,146 3,215 3,901 Income tax expense 613 773 985 1,156 Net earnings 941 1,373 2,230 2,745 Net earnings attributable to noncontrolling interest 3 3 6 6 Net earnings attributable to AbbVie Inc. $ 938 $ 1,370 $ 2,224 $ 2,739 Diluted earnings per share attributable to AbbVie Inc. $ 0.52 $ 0.77 $ 1.24 $ 1.53 Adjusted diluted earnings per sharea $ 2.97 $ 2.65 $ 5.43 $ 4.96 Weighted-average diluted shares outstanding 1,771 1,771 1,772 1,772 a Refer to the Reconciliation of GAAP Reported to Non-GAAP Adjusted Information for further details. AbbVie Inc. Reconciliation of GAAP Reported to Non-GAAP Adjusted Information (Unaudited) 1. Specified items impacted results as follows: Quarter Ended June 30, 2025 (in millions, except per share data) Earnings Diluted Pre-tax After-taxa EPS As reported (GAAP) $ 1,554 $ 938 $ 0.52 Adjusted for specified items: Intangible asset amortization 1,864 1,571 0.89 Change in fair value of contingent consideration 2,795 2,709 1.53 Other 91 60 0.03 As adjusted (non-GAAP) $ 6,304 $ 5,278 $ 2.97 a Represents net earnings attributable to AbbVie Inc. Specified items reflect the impact of applicable statutory tax rates. Reported GAAP earnings and adjusted non-GAAP earnings for the three months ended June 30, 2025 included acquired IPR&Dand milestone expense of $823 million on a pre-tax and $737 million on an after-tax basis, representing an unfavorable impact of $0.42 to both diluted EPS and adjusted diluted EPS. 2. The impact of the specified items by line item was as follows: Quarter Ended June 30, 2025 (in millions) Cost ofproducts sold SG&A R&D Other operatingincome Other expense,net As reported (GAAP) $ 4,346 $ 3,253 $ 2,131 $ (24) $ 2,639 Adjusted for specified items: Intangible asset amortization (1,864) — — — — Change in fair value of contingent consideration — — — — (2,795) Other (69) (14) (16) 24 (16) As adjusted (non-GAAP) $ 2,413 $ 3,239 $ 2,115 $ — $ (172) 3. The adjusted tax rate for the second quarter of 2025 was 16.2 percent, as detailed below: Quarter Ended June 30, 2025 (dollars in millions) Pre-tax earnings Income taxes Tax rate As reported (GAAP) $ 1,554 $ 613 39.4 % Specified items 4,750 410 8.6 % As adjusted (non-GAAP) $ 6,304 $ 1,023 16.2 % AbbVie Inc. Reconciliation of GAAP Reported to Non-GAAP Adjusted Information (Unaudited) 1. Specified items impacted results as follows: Quarter Ended June 30, 2024 (in millions, except per share data) Earnings Diluted Pre-tax After-taxa EPS As reported (GAAP) $ 2,146 $ 1,370 $ 0.77 Adjusted for specified items: Intangible asset amortization 1,947 1,651 0.93 Acquisition and integration costs 145 125 0.07 Change in fair value of contingent consideration 1,476 1,438 0.81 Other 90 126 0.07 As adjusted (non-GAAP) $ 5,804 $ 4,710 $ 2.65 a Represents net earnings attributable to AbbVie Inc. Specified items reflect the impact of applicable statutory tax rates. Acquisition and integration costs primarily reflect costs related to the ImmunoGen acquisition. Reported GAAP earnings and adjusted non-GAAP earnings for the three months ended June 30, 2024 included acquired IPR&Dand milestone expense of $937 million on a pre-tax and $924 million on an after-tax basis, representing an unfavorable impactof $0.52 to both diluted EPS and adjusted diluted EPS. 2. The impact of the specified items by line item was as follows: Quarter Ended June 30, 2024 (in millions) Cost of products sold SG&A R&D Other expense,net As reported (GAAP) $ 4,202 $ 3,377 $ 1,948 $ 1,345 Adjusted for specified items: Intangible asset amortization (1,947) — — — Acquisition and integration costs (79) (35) (31) — Change in fair value of contingent consideration — — — (1,476) Other (41) (27) — (22) As adjusted (non-GAAP) $ 2,135 $ 3,315 $ 1,917 $ (153) 3. The adjusted tax rate for the second quarter of 2024 was 18.8 percent, as detailed below: Quarter Ended June 30, 2024 (dollars in millions) Pre-tax earnings Income taxes Tax rate As reported (GAAP) $ 2,146 $ 773 36.0 % Specified items 3,658 318 8.7 % As adjusted(non-GAAP) $ 5,804 $ 1,091 18.8 % AbbVie Inc. Reconciliation of GAAP Reported to Non-GAAP Adjusted Information (Unaudited) 1. Specified items impacted results as follows: Six Months Ended June 30, 2025 (in millions, except per share data) Earnings Diluted Pre-tax After-taxa EPS As reported (GAAP) $ 3,215 $ 2,224 $ 1.24 Adjusted for specified items: Intangible asset amortization 3,722 3,145 1.78 Change in fair value of contingent consideration 4,313 4,186 2.36 Other 153 93 0.05 As adjusted (non-GAAP) $ 11,403 $ 9,648 $ 5.43 a Represents net earnings attributable to AbbVie Inc. Specified items reflect the impact of applicable statutory tax rates. Reported GAAP earnings and adjusted non-GAAP earnings for the six months ended June 30, 2025 included acquired IPR&D and milestones expense of $1.1 billion on a pre-tax and $975 million on an after-tax basis, representing an unfavorable impactof $0.55 to both diluted EPS and adjusted diluted EPS. 2. The impact of the specified items by line item was as follows: Six Months Ended June 30, 2025 (in millions) Cost of products sold SG&A R&D Otheroperating income Other expense,net As reported (GAAP) $ 8,348 $ 6,546 $ 4,198 $ (24) $ 4,080 Adjusted for specified items: Intangible asset amortization (3,722) — — — — Change in fair value of contingent consideration — — — — (4,313) Other (97) (27) (32) 24 (21) As adjusted (non-GAAP) $ 4,529 $ 6,519 $ 4,166 $ — $ (254) 3. The adjusted tax rate for the first six months of 2025 was 15.3 percent, as detailed below: Six Months Ended June 30, 2025 (dollars in millions) Pre-tax earnings Income taxes Tax rate As reported (GAAP) $ 3,215 $ 985 30.6 % Specified items 8,188 764 9.3 % As adjusted (non-GAAP) $ 11,403 $ 1,749 15.3 % AbbVie Inc. Reconciliation of GAAP Reported to Non-GAAP Adjusted Information (Unaudited) 1. Specified items impacted results as follows: Six Months Ended June 30, 2024 (in millions, except per share data) Earnings Diluted Pre-tax After-taxa EPS As reported (GAAP) $ 3,901 $ 2,739 $ 1.53 Adjusted for specified items: Intangible asset amortization 3,838 3,254 1.84 Acquisition and integration costs 656 611 0.34 Change in fair value of contingent consideration 2,136 2,081 1.17 Other 111 145 0.08 As adjusted (non-GAAP) $ 10,642 $ 8,830 $ 4.96 a Represents net earnings attributable to AbbVie Inc. Specified items reflect the impact of applicable statutory tax rates. Acquisition and integration costs primarily reflect costs related to the ImmunoGen acquisition. Reported GAAP earnings and adjusted non-GAAP earnings for the six months ended June 30, 2024 included acquired IPR&Dand milestones expense of $1.1 billion on a pre-tax and after-tax basis, representing an unfavorable impact of $0.60 to bothdiluted EPS and adjusted diluted EPS. 2. The impact of the specified items by line item was as follows: Six Months Ended June 30, 2024 (in millions) Cost of productssold SG&A R&D Interestexpense, net Otherexpense, net As reported (GAAP) $ 8,296 $ 6,692 $ 3,887 $ 959 $ 1,931 Adjusted for specified items: Intangible asset amortization (3,838) — — — — Acquisition and integration costs (158) (315) (159) (24) — Change in fair value of contingent consideration — — — — (2,136) Other (57) (30) — — (24) As adjusted (non-GAAP) $ 4,243 $ 6,347 $ 3,728 $ 935 $ (229) 3. The adjusted tax rate for the first six months of 2024 was 17.0 percent, as detailed below: Six Months Ended June 30, 2024 (dollars in millions) Pre-tax earnings Income taxes Tax rate As reported (GAAP) $ 3,901 $ 1,156 29.6 % Specified items 6,741 650 9.6 % As adjusted (non-GAAP) $ 10,642 $ 1,806 17.0 % SOURCE AbbVie For more information Contact us » Subscribe for email alerts Sign up Subscription management We also welcome the opportunity to hear from you in these social channels, but remember we work in a highly-regulated industry with unique legal considerations. Before engaging, please read and adhere to our established community guidelines for each channel. View our social media channel guidelines » AbbVie.com | Site Map | Terms of Use | Privacy Notice | Consumer Health Data Privacy Notice | Cookies Settings | Your Privacy Choices Copyright © 2025 AbbVie Inc. North Chicago, Illinois, U.S.A. Unless otherwise specified, all product names appearing in this Internet site are trademarks owned by or licensed to AbbVie Inc., its subsidiaries or affiliates. No use of any AbbVie trademark, trade name, or trade dress in this site may be made without the prior written authorization of AbbVie Inc., except to identify the product or services of the company. YOU ARE ABOUT TO LEAVE FOR A 3RD PARTY WEBSITE Notice The "Yes" link below will take you out of the AbbVie family of websites. Links which take you out of the AbbVie worldwide websites are not under the control of AbbVie, and AbbVie is not responsible for the contents of any such site or any further links from such site. AbbVie is providing these links to you only as a convenience and the inclusion of any link does not imply endorsement of the linked site by AbbVie. The Internet site that you have requested may not be optimized to your screen size. Do you wish to leave this site? These cookies are necessary for the website to function and cannot be switched off in our systems. They may be set by us or by third party providers whose services we have added to our pages. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy or language preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not work. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They may be set by us or by third party providers whose services we have added to our pages. They help us to know which pages are the most and least popular and see how visitors move around the site. If you do not allow these cookies we will not be able to monitor our site’s performance or learn how to make it better but the site will still work. Anonymous Performance Cookies Switch Label label These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They may be set by us or by third party providers whose services we have added to our pages. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not be able to monitor our site’s performance or learn how to make it better. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They may be set by us or by third party providers whose services we have added to our pages. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not be able to monitor our site’s performance or learn how to make it better. These cookies may be set through our site by our advertising partners. They may be used by those companies to build a profile of your interests and show you relevant adverts on other sites. They do not store directly personal information, but are based on uniquely identifying your browser and internet device. If you do not allow these cookies, you will experience less targeted advertising.

Clinical ResultPhase 3Phase 1Drug ApprovalLicense out/in

30 Jul 2025

·www.prnewswire.com

Alafair Biosciences Receives 510(k) Clearance for VersaCoat™ Tendon Protector and VersaCoat™ Nerve Protector

AUSTIN, Texas, July 30, 2025 /PRNewswire/ -- Alafair Biosciences, a medical device company redefining soft-tissue protection in orthopedic surgery, announced today that it has received two 510(k) clearances from the FDA for VersaCoat™ Tendon Protector and VersaCoat™ Nerve Protector, marketed as a single product, VersaCoat™ Flowable Hydrogel. VersaCoat is a syringe-deliverable gel that provides a protective, gliding surface designed to limit post-operative tethering in surgical procedures involving tendons, ligaments, skeletal muscles, and peripheral nerves (including nerve roots) in patients of all ages. VersaCoat Flowable Hydrogel uses the same proprietary, collagen-free hyaluronic acid and alginate formulation with VersaWrap® Hydrogel Sheet (VersaWrap® Tendon Protector, VersaWrap® Nerve Protector). Hyaluronic acid is essential during the early stages of soft-tissue healing as it supports hydration and reduces inflammation. The alginate component gradually bioresorbs, progressively exposing bioavailable hyaluronic acid throughout the healing process. Both components fully bioresorb without leaving residual material, allowing tissue to return to its pre-injury state. "Post-operative scarring can lead to significant issues for patients, including ongoing pain, limited mobility, and even the need for additional surgery," said Samuel B. Adams, Jr., MD, FAAOS, FAOA, Associate Professor of Orthopedic Surgery at Duke University Medical Center. "In my practice, I've seen VersaWrap consistently reduce these complications and help my patients regain mobility and comfort more quickly. What intrigues me most about VersaCoat is the ability to address larger more complex injuries with a syringe deliverable gel." Building on these clinical benefits, VersaWrap Hydrogel Sheet has rapidly gained recognition as an effective solution for surgeons seeking to minimize post-operative complications and enhance patient recovery. This proven track record has driven strong commercial adoption across multiple specialties, laying a solid foundation for the introduction of VersaCoat Flowable Hydrogel. "VersaWrap Hydrogel Sheet has generated meaningful adoption with more than 30,000 implants and consistent acceptance from surgeons and GPOs," stated John Joyoprayitno, President & CEO of Alafair Biosciences. "By delivering our proven hyaluronic acid and alginate formulation in a flowable format, VersaCoat Flowable Hydrogel responds to surgeon feedback for larger volumes and delivery to hard‑to‑reach tissues, including minimally invasive approaches. This added versatility supports expanded use in a variety of specialties including extremities, sports medicine, and trauma." About Alafair Biosciences, Inc. Alafair is a privately held medical device company developing and marketing an innovative product portfolio based on its proprietary hydrogel technology. The mission of Alafair is to revolutionize surgical care with our versatile hydrogel technology, delivering unparalleled value to patients, surgeons, and healthcare facilities by enhancing soft tissue protection and by elevating patient outcomes. Alafair products are distributed through a dispersed network of independent distributors across the United States. About VersaCoat™ Flowable Hydrogel VersaCoat Flowable Hydrogel (VersaCoat Tendon Protector, VersaCoat Nerve Protector) is an FDA-cleared medical device implant (not tissue) comprising hyaluronic acid (HA) and alginate that provides a gelatinous encasement. VersaCoat Tendon Protector is indicated to manage and protect injured tendons where there is no substantial loss of tendon tissue, to manage and protect surrounding tissues such as ligaments and skeletal muscles, and may encounter structures such as anchors, grafts, staples, and sutures. VersaCoat Nerve Protector is indicated to manage peripheral nerve injuries where there is no substantial loss of nerve tissue. Our innovative technology allows tissues to glide and to remain untethered, thereby reducing reoperations and improving patient outcomes. The gel form is designed to delicately deliver precise volumes onto complex geometries that are difficult to visualize or reach. About VersaWrap® Hydrogel Sheet VersaWrap Hydrogel Sheet (VersaWrap Tendon Protector, VersaWrap Nerve Protector) is an FDA-cleared medical device implant (not tissue) comprising hyaluronic acid (HA) and alginate that provides a gelatinous encasement. VersaWrap Tendon Protector is indicated to manage and protect injured tendons where there is no substantial loss of tendon tissue, to manage and protect surrounding tissues such as ligaments and skeletal muscles, and may encounter structures such as anchors, grafts, staples, and sutures. VersaWrap Nerve Protector is indicated to manage peripheral nerve injuries where there is no substantial loss of nerve tissue. Our innovative technology allows tissues to glide and to remain untethered, thereby reducing reoperations and improving patient outcomes. The sheet form is designed to easily apply an ultrathin, uniform layer or to circumferentially wrap injured tissue. SOURCE Alafair Biosciences, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

11 Jun 2025

·www.globenewswire.com

Teleflex Highlights Prostate Health and Quality-of-Life Awareness Through Two Key Public Initiatives During Men’s Health Month

Timed with National Men’s Health Month, the Prostate Monster ad campaign shines a light on quality-of-life issues associated with benign prostatic hyperplasia or BPH—a condition affecting millions of men1—and encourages them to take control of their health. The Teleflex Prostate Education Express, a mobile training and education center, is on a national tour to educate physicians and the community on prostate health quality-of-life issues associated with BPH and the importance of organ spacing to protect against potential rectal side effects in advance of prostate cancer radiation treatment. WAYNE, Pa., June 11, 2025 (GLOBE NEWSWIRE) -- Teleflex Incorporated (NYSE: TFX), a leading global provider of medical technologies, today announced two bold awareness initiatives in conjunction with Men’s Health Month to raise awareness for quality-of-life issues associated with benign prostatic hyperplasia (“BPH”) and the potential rectal toxicity side effects for men who undergo a prostate cancer radiation treatment plan. The initiative includes a new ad campaign featuring the Prostate Monster, and a mobile training and education center—The Prostate Education Express—which is visiting urology practices, hospitals and academic medical centers across major U.S. cities for the remainder of 2025. These activities are focused on educating physicians and the community on the benefits of treatment with the UroLift™ System, the #1 chosen minimally invasive, outpatient treatment for symptoms of an enlarged prostate, or BPH1, and the benefits of organ spacing using the Barrigel™ rectal spacer in advance of prostate cancer radiation therapy.2 The ad campaign airing on cable networks, streaming platforms, and related digital ads, features the unforgettable “Prostate Monster,” a larger-than-life symbol of the everyday disruption BPH can cause in men’s lives—from interfering with sleep to making simple tasks like mowing the lawn or sitting in traffic uncomfortable. The ads direct viewers to UroLift.com, where men can learn more and take the first step toward relief. When the prostate grows, it can press against the urethra and block the flow of urine, leading to symptoms like frequent urination, weak stream, and interrupted sleep.3 More than 500,000 men have been treated with the UroLift™ System in select markets worldwide.4 Despite how common BPH is, many men delay treatment. “So many men suffer silently with symptoms that can seriously affect their quality of life,” said Claus Roehrborn, M.D* professor of urology at UT Southwestern Medical Center and primary investigator on many UroLift™ System clinical studies over the past 12 years. “Men need to know they don’t have to ‘just deal with it.’ The UroLift™ System offers rapid symptom relief without the need for ongoing medications.”5,6 As a traveling classroom, training hub, and community engagement center, the Prostate Education Express provides hands-on UroLift™ System and Barrigel™ rectal spacer simulator training at a practice’s front door. The national tour will support training for general practicing physicians. The truck will also host community health talks to educate men about their prostate health and collaborate with advocacy events to amplify BPH awareness across major U.S. cities including New York City, Los Angeles, Chicago, Houston, Dallas, Atlanta, Miami, Washington, DC, San Francisco, and Philadelphia. “June is Men’s Health Month—a time to shine the spotlight on the unique health challenges men face, including BPH, a non-cancerous progressive health concern that commonly occurs as men age,” said Anthony Parrillo, vice president, Global Marketing, Teleflex Interventional Urology. “Across the U.S., 14.1 million men seek treatment for BPH symptoms annually.1 The national ad and Prostate Education Express initiatives are extensions of our mission to empower the future of healthcare by educating and motivating men to prioritize their prostate health and seek out effective, proven treatment options like the UroLift™ System5 and understand the importance of rectal organ protection in advance of prostate cancer radiation treatment with Barrigel™ rectal spacer2.” A clinical study found that 98.5 percent of men who were treated with Barrigel™ rectal spacer met the primary endpoint of achieving at least a 25 percent reduction in radiation to the rectum.2 Patients who met the primary endpoint averaged an 85 percent reduction in radiation to the rectum, and Barrigel™ rectal spacer is proven superior in the reduction of acute and long-term Grade 2+ GI toxicity at 3 and 6 months compared to control.2 More than 50,000 men have been treated with Barrigel™ rectal spacer, the first and only hyaluronic acid rectal spacer.2,7,8,9,10 For more information about the UroLift™ System, visit www.UroLift.com. About the UroLift™ SystemThe UroLift™ System is a minimally invasive treatment for lower urinary tract symptoms due to benign prostatic hyperplasia (BPH). It is indicated for the treatment of symptoms of an enlarged prostate up to 100cc in men 45 years or older (50 years outside U.S.). The UroLift™ System permanent implants, which can be delivered during an outpatient procedure,11 relieve prostate obstruction without heating, cutting, destruction of, or removing prostate tissue. The UroLift™ System can be used to treat a broad spectrum of anatomies, including obstructive median lobe.12 It is the only leading BPH procedure shown to not cause new onset, sustained erectile or ejaculatory dysfunction.**13-14 A study conducted over 5 years showed a low retreatment rate of about 2-3% per year, or a total of 13.6 percent over the course of the study, demonstrating UroLift™ System durability.5 Most common side effects are temporary and can include hematuria, dysuria, micturition urgency, pelvic pain, and urge incontinence.6 Rare side effects, including bleeding and infection, may lead to a serious outcome and may require intervention. Individual results may vary. The prostatic urethral lift procedure (using the UroLift™ System) is recommended for the treatment of BPH in both the 2021 American Urological Association and 2022 European Association of Urology clinical guidelines. More than 500,000 men have been treated with the UroLift™ System in select markets worldwide.4 Learn more at www.UroLift.com. Caution: Federal (USA) law restricts this device to sale by or on the order of a physician. About Barrigel™ Rectal SpacerBarrigel™ rectal spacer is the first and only hyaluronic acid rectal spacer that separates the prostate from the rectum to protect the rectum during radiation therapy treatment for prostate cancer.2 Barrigel™ rectal spacer is made from Non-Animal Stabilized Hyaluronic Acid (NASHA).16 Hyaluronic acid is a substance naturally present in the human body and is highly biocompatible and fully absorbable. NASHA has a proven history of safety and efficacy in a wide variety of medical applications in men, women and children worldwide.15,17 Barrigel™ rectal spacer has been proven to significantly reduce unwanted side effects from prostate cancer radiation therapy2 and is cleared for rectal spacing in the United States, Australia, and Europe.18 Barrigel™ rectal spacer is indicated for prostate cancer patients with T1-T3b disease. For more information about Barrigel™ rectal spacer, please visit https://barrigel.com/hcp/barrigel-control-matters. Barrigel™ Rectal Spacer Important Safety InformationBarrigel™ rectal spacer is intended to temporarily position the anterior rectal wall away from the prostate during radiotherapy for prostate cancer and, in creating this space, it is the intent of Barrigel™ rectal spacer to reduce the radiation dose delivered to the anterior rectum. Barrigel™ rectal spacer is composed of biodegradable material and maintains space for the entire course of prostate radiotherapy treatment and is intended to be absorbed by the patient’s body over time. Barrigel™ rectal spacer should only be administered by qualified and properly trained physicians with experience in ultrasound guidance and injection techniques in the urogenital/pelvic area. As with any medical treatment, there are some risks involved with the use of Barrigel™ rectal spacer. Potential complications associated with the use of Barrigel™ rectal spacer include, but are not limited to: pain associated with Barrigel™ rectal spacer injection; needle penetration of the bladder, prostate, rectal wall, rectum, or urethra; injection of Barrigel™ rectal spacer into the bladder, prostate, rectal wall, rectum, urethra, or intravascularly; local inflammatory reactions; infection; urinary retention; rectal mucosal damage, ulcers, necrosis; bleeding; constipation; and rectal urgency. More information on indications, contraindications, warnings and instructions for use can be found in the Instructions For Use at www.barrigel.com. Individual results may vary. Caution: Federal (USA) law restricts this device to sale by or on the order of a physician. About Teleflex Incorporated As a global provider of medical technologies, Teleflex is driven by our purpose to improve the health and quality of people’s lives. Through our vision to become the most trusted partner in healthcare, we offer a diverse portfolio with solutions in the therapy areas of anesthesia, emergency medicine, interventional cardiology and radiology, surgical, vascular access, and urology. We believe that the potential of great people, purpose driven innovation, and world-class products can shape the future direction of healthcare. Teleflex is the home of Arrow™, Barrigel™, Deknatel™, LMA™, Pilling™, QuikClot™, Rüsch™, UroLift™ and Weck™ – trusted brands united by a common sense of purpose. At Teleflex, we are empowering the future of healthcare. For more information, please visit teleflex.com. Forward-Looking Statements Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements. Any forward-looking statements contained herein are based on our management’s current beliefs and expectations, but are subject to a number of risks, uncertainties and changes in circumstances, which may cause actual results or company actions to differ materially from what is expressed or implied by these statements. These risks and uncertainties are identified and described in more detail in our filings with the Securities and Exchange Commission, including our Annual Report on Form 10-K. Teleflex, the Teleflex logo, Arrow, Barrigel, Deknatel, LMA, Pilling, QuikClot, Rüsch, UroLift and Weck are trademarks or registered trademarks of Teleflex Incorporated or its affiliates, in the U.S. and/or other countries. All other trademarks are the property of their respective owners. © 2025 Teleflex Incorporated. All rights reserved. References*Paid consultants of Teleflex.**No instances of new, sustained erectile or ejaculatory dysfunction in the L.I.F.T. pivotal study †Study sponsored by Palette Life Sciences, now part of Teleflex. U.S. 2023 estimates based on US Market Model 2023-25 (3-14-23 FINAL), which is in part based on Symphony Health PatientSource® 2018-22, as is and with no representations/warranties, including accuracy or completeness.Mariados NF, Orio PF III, Schiffman Z et al. Hyaluronic acid spacer for hypofractionated prostate radiation therapy: A randomized clinical trial. JAMA Oncol. 2023: e1-e8.†Speakman, BJUI 2014.Management estimate based on product sales as of June 2024. Data on file. Teleflex Interventional Urology.Roehrborn, Can J Urol 2017.Roehrborn, J Urol 2013Mariados N, Sylvester J, Shah D et al. Int J Radiat Oncol Biol Phys (2015).Song D et al, Int J Radiat Oncol Biol Phys (2024).Data on file. As of 10/01/2024Management estimate based on product sales as of January 2025. Data on file. Teleflex Interventional Urology.Shore, Can J Urol 2014Rukstalis, Prostate Cancer Prostatic Dis 2018AUA BPH Guidelines 2003, 2020McVary, Urology 2019Svatos M, Chell E, Low DA, et al. Symmetry, separation, and stability: Physical properties for effective dosimetric space with a stabilized hyaluronic acid spacer. Med Phys. 2024; https://doi-org.libproxy1.nus.edu.sg/10.1002/mp.17292 †Barrigel Injectable Gel Instructions for Use (2022).Restylane® celebrates 25 years of natural-looking results with its signature line of hyaluronic acid fillers. 2021. Available at: https://www.prnewswire.com/news-releases/restylane-celebrates-25-years-of-natural-looking-results-with-its-signature-line-of-hyaluronic-acid-fillers-301388779.html. Accessed Sept 30, 2021.Data on file Teleflex. 2025. MAC03104-01 Rev A Contacts:TeleflexLawrence KeuschVice President, Investor Relations and Strategy Developmentinvestor.relations@teleflex.com610-948-2836 Media Contact:Glenn SilverPartner National Media Relations Specialistglenn.silver@finnpartners.com646-871-8485

Radiation TherapyClinical Result

100 Deals associated with Hyaluronic acid

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KEGG	Wiki	ATC	Drug Bank
D08043	Hyaluronic acid	-	DB08818

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Indication	Highest Phase	Country/Location	Organization	Date
Osteoarthritis, Knee	Phase 2	-	-	01 Jun 2021
Alpha 1-Antitrypsin Deficiency	Phase 1	-	Actelion Pharmaceuticals Ltd.	-
Asthma	Phase 1	-	Actelion Pharmaceuticals Ltd.	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03460158 (CTgov)	Phase 4	-	101	Restylane-L®	uvgtyatqpv(kovflcungr) = eapubsznfp uclpwpmddp (waudwwadah, skmjhjrupl - mtdcktxffm) View more	-	27 Sep 2024
P558 (EBMT2020)	Not Applicable	Hematopoietic stem cell transplantation	32	Hyaluronic Acid Bladder Instillation	jgoskwojdd(mfqouzzdro) = jlrkhjpfmb zojrcitlgm (jhlwlfhutl ) View more	-	29 Aug 2020
P558 (EBMT2020)	Not Applicable	Hematopoietic stem cell transplantation	32	Intravesical Hyaluronic Acid (Conventional Measures (hyperhydration, transfusion support, vesical irrigation))	xipmlecrgr(pgfrtqzkzs) = inaxpxnaoo sjoumqmftr (mhqkkerjek )	-	29 Aug 2020
EULAR2015	Not Applicable	Osteoarthritis	120	Durolane®	vuqxdowptn(ewqcpybejt) = faeykpmepe uohwqnpooz (nkckiwvjaf ) View more	Positive	10 Jun 2015
EULAR2015	Not Applicable	Osteoarthritis	120	Placebo	vuqxdowptn(ewqcpybejt) = sqpzohibji uohwqnpooz (nkckiwvjaf ) View more	Positive	10 Jun 2015
ASCO_GU2012	Phase 2	-	-	Injection of hyaluronic acid (HA)	zmncmvzstt(zdqdhlgenh) = tmnguqnqmd bzzfbmevot (krxgkuvdyu ) View more	-	10 Feb 2012
EULAR2006	Not Applicable	-	204	Suvenyl® (1A, 2.5ml:25mg)	gnshenumcr(hbrzygkcdl) = Severe adverse reactions were not seen emzlsqchuw (ikbhfnegyl )	Positive	21 Jun 2006

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Deal

Boost your decision using our deal data.

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Core Patent

Boost your research with our Core Patent data.

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Clinical Trial

Identify the latest clinical trials across global registries.

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Approval

Accelerate your research with the latest regulatory approval information.

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Regulation

Understand key drug designations in just a few clicks with Synapse.

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AI Agents Built for Biopharma Breakthroughs

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Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

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Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis