Last update 08 May 2025

Bitopertin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bitopertin (JAN/USAN), Paliflutine
+ [8]
Target
Action
inhibitors
Mechanism
GlyT1 inhibitors(Glycine transporter 1 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC21H20F7N3O4S
InChIKeyYUUGYIUSCYNSQR-LBPRGKRZSA-N
CAS Registry845614-11-1

External Link

KEGGWikiATCDrug Bank
D10186Bitopertin-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SchizophreniaPhase 3
United States
27 Sep 2010
SchizophreniaPhase 3
Bulgaria
27 Sep 2010
SchizophreniaPhase 3
Italy
27 Sep 2010
SchizophreniaPhase 3
Russia
27 Sep 2010
SchizophreniaPhase 3
Japan
27 Sep 2010
SchizophreniaPhase 3
Czechia
27 Sep 2010
SchizophreniaPhase 3
Russia
27 Sep 2010
SchizophreniaPhase 3
Czechia
27 Sep 2010
SchizophreniaPhase 3
Italy
27 Sep 2010
SchizophreniaPhase 3
Bulgaria
27 Sep 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
75
(hcqajlezjx) = nearly all treatment-emergent adverse events were mild to moderate in intensity uavsrwyrcv (kudcolpmmx )
Positive
07 Dec 2024
Phase 2
22
(dgxnanygic) = pwoklosilp rikkcjnyxq (xodfedthpp )
Positive
14 May 2024
Phase 2
75
(xianmvkpyr) = vodphhjzkv ltruxqxmpb (zpoomtnxye )
Met
Positive
01 Apr 2024
(xianmvkpyr) = fbsjivfvqx ltruxqxmpb (zpoomtnxye )
Met
Phase 2
17
(icavtyjvoz) = qneivjlspx kdrgdqfdex (dxafojtkfj, 17)
Positive
11 Dec 2023
Phase 1
29
(zrkbgfittc) = epzummfaci qfoxgokrtb (hznhsaxaxj, 7.4)
Negative
01 Aug 2017
Placebo
(zrkbgfittc) = hnwhircskr qfoxgokrtb (hznhsaxaxj, 11.5)
Phase 3
-
169
(dxspbbuyzz) = mzdfbtrbjh wcozivskxc (zgdoslrjcu )
-
01 Oct 2012
(dxspbbuyzz) = djfqswffqf wcozivskxc (zgdoslrjcu )
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Approval

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Regulation

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