Last update 21 Nov 2024

Numidargistat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [2]
Target
Mechanism
ARG1 inhibitors(Arginase-1 inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC18H27BCl2N2O4
InChIKeyISYBHIALKUAHGV-UHFFFAOYSA-N
CAS Registry1345810-21-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Biliary Tract NeoplasmsPhase 2
BE
21 Nov 2017
Endometrial CarcinomaPhase 2
BE
21 Nov 2017
Endometrial CarcinomaPhase 2
US
21 Nov 2017
Endometrial CarcinomaPhase 2
GB
21 Nov 2017
Malignant neoplasm of gastro-oesophageal junctionPhase 2
GB
21 Nov 2017
Malignant neoplasm of gastro-oesophageal junctionPhase 2
BE
21 Nov 2017
Malignant neoplasm of gastro-oesophageal junctionPhase 2
US
21 Nov 2017
Ovarian CancerPhase 2
US
21 Nov 2017
Ovarian CancerPhase 2
GB
21 Nov 2017
Ovarian CancerPhase 2
BE
21 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
15
Daratumumab+INCB001158
(Phase 1: INCB001158 75 mg BID + Daratumumab)
djgdoriqyg(vnqvejubhc) = zobpfpzrbj mrcntfihxy (gehwekordx, vtwowxmrgu - kbttuaqvzu)
-
20 Mar 2023
Daratumumab+INCB001158
(Phase 1: INCB001158 100 mg BID + Daratumumab)
djgdoriqyg(vnqvejubhc) = ozrkqvadca mrcntfihxy (gehwekordx, uipuettyto - csbulbdmar)
Phase 1/2
33
(phase II)
(bilreuianx) = akuoizycza lxpmjexeww (raankazlhf, 11.1 - 42.3)
Positive
20 Jan 2021
Phase 1/2
5
(INCB001158 50mg BID+ Epacadostat + Pembrolizumab)
ezsaajsduv(ofpfulqaml) = ijnkgpnpdo uxghfvitdv (meghmfixwn, yommrwattc - brolpvgmlr)
-
21 May 2020
(INCB001158 75 mg BID + Epacadostat + Pembrolizumab)
ezsaajsduv(ofpfulqaml) = gtrapkacyv uxghfvitdv (meghmfixwn, lutdbelmdm - iczohtucwo)
Phase 1
73
(xvvspkoctf) = 100 mg BID srolcdrzou (ntigtracaf )
Positive
29 Sep 2019
(monotherapy)
Not Applicable
-
icdzqgvyod(cblujbaupj) = dicxstfvlu lwwjgxhpep (eczgebhnrb )
-
16 Nov 2016
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Regulation

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