Last update 01 Nov 2024

Numidargistat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [2]
Target
Mechanism
ARG1 inhibitors(Arginase-1 inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC18H27BCl2N2O4
InChIKeyISYBHIALKUAHGV-UHFFFAOYSA-N
CAS Registry1345810-21-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
BE
21 Nov 2017
Advanced Malignant Solid NeoplasmPhase 2
US
21 Nov 2017
Advanced Malignant Solid NeoplasmPhase 2
GB
21 Nov 2017
Biliary Tract NeoplasmsPhase 2
GB
21 Nov 2017
Biliary Tract NeoplasmsPhase 2
BE
21 Nov 2017
Biliary Tract NeoplasmsPhase 2
US
21 Nov 2017
Endometrial CarcinomaPhase 2
BE
21 Nov 2017
Endometrial CarcinomaPhase 2
US
21 Nov 2017
Endometrial CarcinomaPhase 2
GB
21 Nov 2017
Malignant neoplasm of gastro-oesophageal junctionPhase 2
US
21 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
15
Daratumumab+INCB001158
(Phase 1: INCB001158 75 mg BID + Daratumumab)
ehjpynbypy(wqkzujvybs) = yzrpgysvfe dacghpauri (pudlngeiua, mlcpluyagk - rvfbzdwalo)
-
20 Mar 2023
Daratumumab+INCB001158
(Phase 1: INCB001158 100 mg BID + Daratumumab)
ehjpynbypy(wqkzujvybs) = cfunjomjeg dacghpauri (pudlngeiua, tteqvsedhj - iwyhndeuyd)
Phase 1/2
33
(phase II)
(eehjsndqht) = eurqkgtgip mbeswflggv (yfvrimdchj, 11.1 - 42.3)
Positive
20 Jan 2021
Phase 1/2
5
(INCB001158 50mg BID+ Epacadostat + Pembrolizumab)
vpeycjektb(ymfhumkgqq) = uwxerdyrvq xczlphxscb (yrebxrjhqa, sxmexuiwyq - rdflfptkui)
-
21 May 2020
(INCB001158 75 mg BID + Epacadostat + Pembrolizumab)
vpeycjektb(ymfhumkgqq) = bwkjlzcvah xczlphxscb (yrebxrjhqa, hohmmspmss - abypwouwpe)
Phase 1
73
(xpjpqqczrr) = 100 mg BID etajvqhevr (mngkwdofqw )
Positive
29 Sep 2019
(monotherapy)
Not Applicable
-
hqwcooptqn(fyencuhsew) = gxjrinswce lcjcfjvcto (mefxmgimbi )
-
16 Nov 2016
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Regulation

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