A Phase 1, Open-label, Single-arm Study to Investigate the Safety, Tolerability, and Preliminary Efficacy of TNFa and IL-2 Coding Oncolytic Adenovirus TILT-123 in Combination With Lymphocyte-depleting Chemotherapy and Tumor-infiltrating Lymphocytes in Melanoma Patients.

This is an open-label, phase 1 trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with lymphocyte-depleting chemotherapy and TILs in metastatic melanoma patients.

Start Date25 Jun 2025

Sponsor / Collaborator

TILT Biotherapeutics Oy

NCT06125197

/ Active, not recruitingPhase 1

A Phase I Open-Label, Dose-escalation Trial of Tumor Necrosis Factor Alpha and Interleukin-2 Coding Oncolytic Adenovirus (TILT-123) in Combination With Pembrolizumab in Patients With Immune Checkpoint Inhibitor Refractory Non-Small Cell Lung Cancer

This is an open label, Phase 1, dose escalation trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with Pembrolizumab in patients with immune checkpoint inhibitor refractory non-small cell lung cancer.

Start Date23 Jul 2024

Sponsor / Collaborator

TILT Biotherapeutics Oy

[+1]

NCT05222932

/ Active, not recruitingPhase 1

A Phase I Open-Label, Dose-escalation Clinical Trial of Tumor Necrosis Factor Alpha and IL-2 Coding Oncolytic Adenovirus TILT-123 and Avelumab in Solid Tumor Patients (Melanoma and SCCHN) Refractory to or Progressing After Anti-PD(L)1

This is a phase 1, dose-escalation trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with avelumab in patients with advanced solid tumors refractory to or progressing after anti-PD(L)1.

Start Date08 Mar 2023

Sponsor / Collaborator

TILT Biotherapeutics Oy

100 Clinical Results associated with Igrelimogene litadenorepvec

100 Translational Medicine associated with Igrelimogene litadenorepvec

100 Patents (Medical) associated with Igrelimogene litadenorepvec

Literatures (Medical) associated with Igrelimogene litadenorepvec

31 Dec 2026·OncoImmunology

Alistipes and Eggerthella shape the response to oncolytic adenovirus therapy in mice and humans through short-chain fatty acid metabolism

Article

Author: Cervera-Carrascon, Victor ; Basnet, Saru ; Pakola, Santeri Artturi ; Lahti, Leo ; Erawijantari, Pande Putu ; Manuel dos Santos, João ; Karoliina Raatikainen, Sini ; Haybout, Lyna ; Hemminki, Otto ; van der Heijden, Mirte ; Hemminki, Akseli ; Arias, Victor ; Clubb, James Hugo Armstrong ; Kanerva, Anna ; Jirovec, Elise ; Kudling, Tatiana ; Ronkainen, Aki ; Grönberg-Vähä-Koskela, Susanna ; Quixabeira, Dafne Carolina Alves ; Ojala, Nea

Accumulating evidence implicates the microbiome as an important determinant of clinical outcomes in cancer therapies; however, the role of the microbiome in oncolytic virus therapy remains largely unexplored. We investigated the gut microbiome of cancer patients following treatment with the oncolytic adenovirus igrelimogene litadenorepvec (Ad5/3-E2F-d24-hTNF-IRES-hIL2; TILT-123). Baseline fecal samples from phase I clinical trials (NCT04695327 and NCT05271318) were analyzed using shotgun metagenomic sequencing and compared to treatment outcomes. A higher relative abundance of Alistipes was observed in patients with treatment benefit, while elevated Eggerthella was observed with reduced benefit. These associations were validated in a preclinical mouse model where administration of Alistipes shahii improved the efficacy of adenovirus therapy. In addition, enrichment analysis in patient samples showed a positive correlation between higher relative abundance of Alistipes and elevated short-chain fatty acids in both feces and serum, which in turn revealed higher circulating neutrophil counts. Finally, in a case study, we observed that adenovirus treatment resulted in increased Alistipes relative abundance and reduced Eggerthella relative abundance, indicating that adenovirus therapy may beneficially modulate the microbiome. Overall, our findings reveal a novel association between Alistipes, Eggerthella, and the therapeutic response to oncolytic adenovirus therapy, highlighting their potential as biomarkers or targets for microbiome-based interventions such as pre-, pro-, or postbiotics.

01 May 2026·MOLECULAR THERAPY

Article

Author: Mäenpää, Johanna ; Tohmola, Tiialotta ; Hemminki, Otto ; Hirvenoja, Stella ; Jalkanen, Katriina ; Ojala, Nea ; Clubb, James Hugo Armstrong ; Arias, Victor ; Haybout, Lyna ; Hemminki, Akseli ; Monberg, Tine ; Kanerva, Anna ; Svane, Inge Marie ; Ferrero, Julia Davila ; Kistler, Claudia ; Block, Matthew Stephen ; Salmelin, Natasha ; Alanko, Tuomo ; Kudling, Tatiana Viktorovna ; Manuel Dos Santos, João ; Eleuteri, Arianna ; Jirovec, Elise ; Renkonen, Risto ; Havunen, Riikka ; van der Heijden, Mirte ; Pasanen, Annukka ; Sorsa, Suvi ; Grönberg-Vähä-Koskela, Susanna ; Joenväärä, Sakari ; Basnet, Saru ; Cervera-Carrascon, Victor ; Pakola, Santeri Artturi ; Zahraoui, Sanae ; Quixabeira, Dafne Carolina Alves

The oncolytic adenovirus TILT-123 (Ad5/3-E2F-d24-hTNFA-IRES-hIL2, igrelimogene litadenorepvec) has demonstrated favorable safety profiles in phase 1 clinical trials in patients with advanced solid tumors (these trials were registered at ClinicalTrials.gov: NCT04695327, NCT05271318, and NCT04217473). In this study, we analyzed the serum proteome of patients treated with TILT-123 monotherapy using mass spectrometry, focusing on samples collected during the initial intravenous administration phase. Functional and correlative analyses revealed that IGLV8-61-encoded natural immunoglobulin M (IgM) was associated with reduced neutralizing activity and improved clinical outcomes, as assessed by positron emission tomography imaging and overall survival. Single-cell B cell receptor sequencing enabled profiling of the circulating antibody repertoire and detection of IGLV8-61-expressing clones. Recombinant expression of antibody sequences from a responding patient with a history of hyperlipidemia yielded three pentameric natural IgMs capable of binding both TILT-123 and anionic modified low-density lipoprotein. Further characterization revealed that the IgMs significantly enhanced transduction and promoted cell killing in vitro across multiple cell lines. Blocking studies demonstrated transduction was influenced by Fc receptors pIgR and FcμR. Cross-trial comparisons indicated dyslipidemia as a common feature among responders. Collectively these findings show that dyslipidemia -associated natural IgM enhances the therapeutic efficacy of TILT-123, via antibody-dependent enhancement. These findings may have broader implications for other oncolytic viruses, an emerging class of tumor immunotherapies.

01 May 2026·MOLECULAR THERAPY

Article

Author: Quixabeira, Dafne C A ; Kistler, Claudia ; Kononen, Juha ; van der Heijden, Mirte ; Pakola, Santeri A ; Kudling, Tatiana V ; Färkkilä, Anniina ; Santos, Joao M ; Hemminki, Otto ; Arias, Victor ; Grönberg-Vähä-Koskela, Susanna ; Jirovec, Elise ; Clubb, James H A ; Alanko, Tuomo ; Haybout, Lyna ; Hellesuo, Maria ; Hemminki, Akseli ; Havunen, Riikka ; Jalkanen, Katriina J ; Sormunen, Jorma ; Kemppainen, Jukka ; Cervera-Carrascon, Victor ; Sorsa, Suvi ; Kanerva, Anna

TILT-123 (Ad5/3-E2F-d24-hTNFα-IRES-hIL2, igrelimogene litadenorepvec) is a chimeric oncolytic adenovirus engineered to selectively replicate in tumor cells and express tumor necrosis factor (TNF) and interleukin-2 (IL-2). While oncolytic viruses are commonly administered intratumorally, this approach often restricts practical applicability. Intravenous delivery is less invasive and offers a more practical alternative; however, systemic immune barriers challenge effective tumor targeting. In a cohort of a phase 1 clinical trial, six patients with advanced solid tumors who had exhausted standard treatments received two intravenous doses of TILT-123 (split-dose), per treatment day across seven cycles. Safety was the primary objective, while efficacy outcomes were exploratory and assessed using positron emission tomography/-computed tomography (PET/CT) imaging, along with overall survival. Split-dosing was safe, with chills, fever, fatigue, and lymphocyte reduction being the most common treatment-related events. In imaging, the disease control rate was 83.3% according to PET criteria and 33.3% by RECIST 1.1. The median overall survival was 198 days. Split-dosing increased the area under the curve of TILT-123 and amplified systemic cytokine responses. Proteomic analysis of serum and neutralizing antibody profiling indicated that enhanced humoral immune activity was associated with shorter overall survival. Post-treatment biopsies confirmed virus presence and alterations in immune cell composition. These findings support further evaluation of intravenous TILT-123 administration in clinical trials.

News (Medical) associated with Igrelimogene litadenorepvec

13 May 2025

·www.globenewswire.com

TILT Biotherapeutics Announces Closing of USD 25 Million Series B Financing

Initiates Phase 2 platinum-resistant ovarian cancer trialHELSINKI, May 13, 2025 (GLOBE NEWSWIRE) -- TILT Biotherapeutics (Tiltbio), a clinical-stage biotechnology company developing intravenously delivered cancer immunotherapies, announces it has raised USD 25.6 million (EUR 22.6 million) in a Series B financing. The financing was supported by existing investors; the European Innovation Council (EIC) Fund, Lifeline Ventures, Finnish Industry Investment (TESI), and Stephen Industries Inc Oy. It will support a Phase 2 clinical trial of Tiltbio’s lead product, TILT-123, in patients with platinum-resistant epithelial ovarian cancer, a Phase 1b trial in melanoma in combination with TILs and other Phase 1b trials. The Company recently published data from its Phase 1a clinical trial (PROTA) in platinum-resistant ovarian cancer in Nature Communications (1), which was also presented at AACR (2). The data showed that treatment was well tolerated with an excellent safety profile and promising efficacy observed in some patients. Disease control was achieved in 64% of evaluable patients (9/14) while the overall response rate was 20% at the highest dose level. Median progression-free survival and overall survival were 98 and 190 days respectively. Interim results from ongoing Phase 1b trials are expected to read out in H2 2026. Tiltbio’s founder and CEO, Akseli Hemminki, said: “We are delighted to have secured our Series B financing and thank our investors for their continued support. We’ve been making good progress in ovarian cancer and this financing will support the roll out of our Phase 2 clinical trials. We’re excited to have already opened the first site in the USA and are looking forward to dosing our first patients soon and opening at least five more sites this year.” He continued, “Ovarian cancer continues to be an unmet medical need despite recent therapies being approved. There are no oncolytic viruses or checkpoint inhibitors currently approved for use in this indication. We are committed to our mission to transform the treatment options for patients with ovarian cancer with TILT-123.” TILT-123 (Igrelimogene litadenorepvec), an oncolytic adenovirus armed with tumor necrosis factor (TNF) and interleukin-2 (IL-2), is designed to enhance the efficacy of T-cell therapies and immune checkpoint blockade. Tiltbio has a collaboration with MSD (Merck & Co., Inc., Rahway, NJ, USA) investigating TILT-123 in combination with KEYTRUDA® (pembrolizumab) in ovarian cancer (NCT05271318). Reference (1) Nature Communications paper: “The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial.”(2) American Association for Cancer Research (AACR) Annual Meeting 2025 poster link: ‘Clinical immunology correlates in platinum resistant or refractory ovarian cancer patients treated with chimeric oncolytic adenovirus encoding TNF and IL-2 (TILT-123) in combination with pembrolizumab’ Notes to Editors About TILT Biotherapeutics TILT Biotherapeutics is a clinical-stage biotechnology company developing cancer therapeutics based on its proprietary oncolytic adenoviruses armed with molecules including cytokines that can activate T cells and destroy cancer cells. The company’s patented TILT® technology can be delivered intravenously, locoregionally, or intratumorally. It modifies the tumor microenvironment and has a broader systemic effect. By making cold tumors hot, it eliminates cancer’s ability to evade immune responses, thereby enhancing immune checkpoint inhibitors or T-cell therapies such as tumor infiltrating lymphocyte (TIL) and CAR T therapies. Over eighty patients have been treated in five international trials sponsored by the company with excellent safety profiles and promising initial efficacy responses observed in some patients. The company’s pioneering approach has been recognized by industry leaders. It has two collaborations with MSD (Merck & Co., Inc., Rahway, NJ, USA) investigating TILT-123 in combination with KEYTRUDA® (pembrolizumab) in ovarian cancer (NCT05271318) and in refractory non-small cell lung cancer (NCT06125197). The company is also collaborating with Merck KGaA (Darmstadt, Germany) and investigating TILT-123 in combination with Bavencio® (avelumab). Based in Helsinki, Finland, and with an office in Boston, the company was established over a decade ago as a spin-out from the University of Helsinki. To date Tiltbio has secured over EUR 72 million in financing from investors including the European Innovation Council (EIC) Fund, Lifeline Ventures, Finnish Industry Investment (TESI), Stephen Industries, angel investors, Business Finland, the EIC Accelerator programme, and the U.S. Department of Defense. Media contacts TILT Biotherapeutics COO Aino Kalervoaino@tiltbio.com Scius CommunicationsKatja Stout+447789435990katja@sciuscommunications.com Daniel Gooch+447747875479daniel@sciuscommunications.com

Phase 2Phase 1Clinical ResultImmunotherapyAACR

13 May 2025

·firstwordpharma.com

Tiltbio nabs $25M to launch mid-stage study of oncolytic virus

Tilt Biotherapeutics raised €22.6 million ($25.6 million) in a series B on Tuesday to advance its experimental oncolytic adenovirus therapy into a Phase II trial for platinum-resistant ovarian cancer (PROC). Armed with TNFα and IL-2, the adenovirus — dubbed TILT-123 — is designed to be given in combination with T cell–based therapies such as tumour-infiltrating lymphocytes (TILs) or checkpoint inhibitors to boost their efficacy. The round, which brings the Finnish biotech's total funding to over €72 million, was backed by the European Innovation Council Fund, Finnish Industry Investment, Stephen Industries Inc Oy and Lifeline Ventures; the latter led Tiltbio's €22-million financing in 2023.Combo dataThe fresh capital comes on the heels of Tiltbio's presentation at the American Association for Cancer Research (AACR) meeting last month.In the PROTA Phase I study, patients with PROC were given TILT-123 in combination with Merck & Co.'s PD-1 inhibitor Keytruda (pembrolizumab). Of 14 evaluable patients, nine achieved disease control (64%); median progression-free survival was 98 days, with a median overall survival of 190 days. In the five-patient high-dose cohort, the drug duo led to an overall response rate of 20%. "Ovarian cancer continues to be an unmet medical need despite recent therapies being approved," CEO Akseli Hemminki said. "We’ve been making good progress in ovarian cancer and this financing will support the roll out of our Phase II clinical trials. We’re excited to have already opened the first site in the US and are looking forward to dosing our first patients soon and opening at least five more sites this year.”Tiltbio is exploring other cancers outside of ovarian. Tuesday's funding will help launch a Phase Ib study dosing TILT-123 in combination with TILs in patients with melanomaThe biotech is also evaluating Keytruda plus TILT-123 in patients with refractory non–small-cell lung cancer. In addition, Tiltbio previously inked a partnership with Merck KGaA to study TILT-123 with PD-L1 inhibitor Bavencio (avelumab).

Phase 2Clinical ResultPhase 1AACR

05 Dec 2024

·www.globenewswire.com

TILT Biotherapeutics Provides Update on International Clinical Trial Progress with Intravenous Delivery Regimen for Cancer Immunotherapies

Data Presented at ESMO-IO supports the potential of personalized treatment strategies to improve clinical trial outcomesHELSINKI, Finland, Dec. 05, 2024 (GLOBE NEWSWIRE) -- TILT Biotherapeutics (TILT), a clinical-stage biotechnology company developing intravenously delivered cancer immunotherapies, announces it will be presenting data at the European Society of Medical Oncology Immuno-Oncology Congress (ESMO-IO) 2024. The oral presentation discloses the impact of different biological features on treatment efficacy in patients treated with the oncolytic virus Igrelimogene litadenorepvec or ‘TILT-123’(1). The study used single-cell sequencing analysis to identify immunological markers in peripheral blood mononuclear cells that were related with better outcomes, including higher baseline levels of cytotoxic effector cells. Additionally, TILT-123 treatment supported the formation of immunological memory. TILT will also present data relating to the fully intravenous dosing of TILT-123 (2). These findings have the potential to support future clinical development strategy. In addition, TILT is progressing its plans for international Phase II trials of TILT-123 in ovarian cancer, to be administered intravenously, and expects Phase Ib clinical results by H2 2025. TILT Biotherapeutics’ founder and CEO, Akseli Hemminki, said: “This year we’ve made significant progress in the clinical development of TILT-123, and have now treated over 60 patients in five international trials, including our first patients in leading US cancer centres. Our data, presented at ESMO-IO this month, provides further support on the mechanism of action of our oncolytic immunotherapy. Our progress in IV administration, alongside our manufacturing process scale up work, supports our mission to make TILT-123 accessible to patients with hard-to-treat solid cancers.” TILT-123, an oncolytic adenovirus armed with tumor necrosis factor alpha (TNFα) and interleukin-2 (IL-2), is designed to enhance the efficacy of T-cell therapies, including immune checkpoint blockade or adoptive cell transfer. TILT’s approach uses oncolytic viruses to selectively replicate in and lyse cancer cells, while simultaneously stimulating immune responses towards the tumor. Reference (1) ESMO-IO Abstract 353: “Single-cell profiling of peripheral blood mononuclear cells from patients treated with oncolytic adenovirus armed with TNFα and IL-2 revealed pre-existing immunity as a predictor of therapy outcomes”. (2) ESMO-IO Abstract 458: “Effect of split intravenous dosing of oncolytic adenovirus TILT-123 on normal tissue versus tumor macrophages and virus bioavailability in patients with advanced solid tumors”. Notes to Editors About TILT Biotherapeutics TILT Biotherapeutics is a clinical-stage biotechnology company developing cancer therapeutics based on its proprietary oncolytic adenoviruses armed with molecules including cytokines that can activate T cells and destroy cancer cells. The company’s patented TILT® technology can be delivered intravenously, locoregionally, or intratumorally. It modifies the tumor microenvironment and has a broader systemic effect. By making cold tumors hot, it eliminates cancer’s ability to evade immune responses, thereby enhancing T-cell therapies such as immune checkpoint inhibitors, tumor infiltrating lymphocyte (TIL) therapy, and CAR T therapies. TILT’s lead asset, TILT-123 also known as Igrelimogene litadenorepvec, is a 5/3 chimeric serotype adenovirus armed with two human cytokines: TNF alpha and IL-2. Over sixty patients have been treated in five international trials sponsored by the company with promising initial efficacy responses observed in some of the patients. The company’s pioneering approach has been recognized by industry leaders. It has two collaborations with MSD (Merck & Co., Inc., Rahway, NJ, USA) investigating TILT-123 in combination with KEYTRUDA® (pembrolizumab) in ovarian cancer (NCT05271318) and in refractory non-small cell lung cancer (NCT06125197). The company is also collaborating with Merck KGaA (Darmstadt, Germany) and investigating TILT-123 in combination with Bavencio® (avelumab). Based in Helsinki, Finland, and with an office in Boston, the company was established over a decade ago as a spin-out from the University of Helsinki. It has funding from Lifeline Ventures, Finnish Industry Investment (TESI), angel investors, Business Finland, the European Innovation Council, and the U.S. Department of Defense. Media contacts TILT BiotherapeuticsCOO Aino Kalervoaino@tiltbio.com Scius CommunicationsKatja Stout+447789435990katja@sciuscommunications.com Daniel Gooch+447747875479daniel@sciuscommunications.com

ImmunotherapyClinical Study

100 Deals associated with Igrelimogene litadenorepvec

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Indication	Highest Phase	Country/Location	Organization	Date
Platinum-Resistant Fallopian Tube Carcinoma	Phase 2	United States	TILT Biotherapeutics Oy	17 May 2022
Platinum-Resistant Fallopian Tube Carcinoma	Phase 2	Finland	TILT Biotherapeutics Oy	17 May 2022
Platinum-Resistant Ovarian Carcinoma	Phase 2	United States	TILT Biotherapeutics Oy	17 May 2022
Platinum-Resistant Ovarian Carcinoma	Phase 2	Finland	TILT Biotherapeutics Oy	17 May 2022
Platinum-Resistant Primary Peritoneal Carcinoma	Phase 2	United States	TILT Biotherapeutics Oy	17 May 2022
Platinum-Resistant Primary Peritoneal Carcinoma	Phase 2	Finland	TILT Biotherapeutics Oy	17 May 2022
Platinum-Sensitive Fallopian Tube Carcinoma	Phase 2	United States	TILT Biotherapeutics Oy	17 May 2022
Platinum-Sensitive Fallopian Tube Carcinoma	Phase 2	Finland	TILT Biotherapeutics Oy	17 May 2022
Platinum-Sensitive Ovarian Carcinoma	Phase 2	United States	TILT Biotherapeutics Oy	17 May 2022
Platinum-Sensitive Ovarian Carcinoma	Phase 2	Finland	TILT Biotherapeutics Oy	17 May 2022

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04217473 (ASCO2026)	Phase 1	Metastatic melanoma epidermal and hepatocyte growth factors (EGF and HGF respectively) \| MDSCs \| young memory T cells (CD27+CD28+CD8+) ... View more	17	TIL therapy + igrelimogene litadenorepvec	ugoqaikxcr(blvxxlqmls) = not observed wgpazenals (wadvdajghb )	Positive	29 May 2026
NCT04217473 (TUNINTIL, SITC2025)	Phase 1	Refractory Melanoma	17	TILT-123 + TILT-123filtrating Lymphocytes	iavosthbrx(lyborzfftw) = 29% xlhywxheox (hzwznakjtj ) View more	Positive	05 Nov 2025
NCT05271318 (PROTA, ESMO 12025 \| ESMO 22025)	Phase 1	Platinum-Resistant Ovarian Carcinoma	15	TILT-123 + pembrolizumab	btaeybpayb(aevzstorsf) = qmicaapoae lxbszhicic (kjefmhfyyt ) View more	Positive	17 Oct 2025
NCT04695327 (TUNIMO, ESMO2025)	Phase 1	Advanced Malignant Solid Neoplasm	6	TILT-123	qzbvlavqnu(svnysuobcu) = Treatment was safe, with flu-like symptoms peaking on day 8. iqboaobxli (comhztlnvp )	Positive	17 Oct 2025
NCT04695327 (ESMO_IO2025)	Phase 1	Solid tumor IGLV8-61 IgM	58	TILT-123 (solid tumors)	gzmvjmvxsz(zzkytcsvql) = gdshkydizl npqpcpidpy (cvvuisnhbr )	Positive	12 Oct 2025
NCT04695327 (ESMO_IO2025)	Phase 1	Neoplasms	39	igrelimogene litadenorepvec (Split-dose intravenous administration (sdIV))	wskkayocze(rkmuwrdxtr) = nwwgxgunzr fkdnzltxpd (mxplmvlhjv ) View more	Positive	12 Oct 2025
NCT04695327 (ESMO_IO2025)	Phase 1	Neoplasms	39	igrelimogene litadenorepvec (Intratumoral administration (IT))	wskkayocze(rkmuwrdxtr) = uufyefmlab fkdnzltxpd (mxplmvlhjv ) View more	Positive	12 Oct 2025
NCT04695327 (TUNIMO, ESMO_IO2025)	Phase 1	Advanced Malignant Solid Neoplasm	6	TILT-123 + Metronomic Cyclophosphamide	tpybwaefwm(kutnisftoi) = Four grade 4 adverse events occurred related to TILT-123; three lymphocyte count decreases, and one white blood cell decrease. Regarding CP, two lymphocyte count decreases qkbvxwojon (sqqevlmoum ) View more	Positive	12 Oct 2025
NCT04217473 (TUNINTIL, ASCO2025)	Phase 1	Refractory Melanoma anti-Ad neutralizing antibodies \| lymphocyte count	17	TILT-123	dpnkdpveos(qpfvrlbddg) = bcrhdzzdmu lohbcvzhmp (isbhiqhcxj ) View more	Positive	30 May 2025
NCT04217473 (TUNINTIL, ASCO2025)	Phase 1		17	oncolytic adenovirus TILT-123 (ACT-TILs)	dpnkdpveos(qpfvrlbddg) = lahzqlcjth lohbcvzhmp (isbhiqhcxj )	Positive	30 May 2025
NCT05271318 (PROTA, AACR2025)	Phase 1	Platinum-Resistant Ovarian Carcinoma lymphocyte count positive \| prothrombin INR \| anti-adenovirus neutralizing antibody (nAb) titer	15	TILT-123 + Pembrolizumab	fseajstavc(bpukjewiks) = okbnsudmkb dkewzdrbmx (eqemkavywu ) View more	Positive	28 Apr 2025
NCT04695327 \| NCT05271318 \| NCT04217473 (TUNINTIL \| TUNIMO \| PROTA, Pubmed \| J Exp Clin Cancer Res)	Phase 1	Advanced Malignant Solid Neoplasm	52	TILT-123 3 × 10^9 VP	jcnfelfuzw(rfknzaxmsi) = cbmumgmahk gvbnwtmfhy (ugyljfxezy )	Positive	06 Nov 2024
	Phase 1	Advanced Malignant Solid Neoplasm	52	TILT-123 4 × 10^12 VP	jcnfelfuzw(rfknzaxmsi) = snupzszaba gvbnwtmfhy (ugyljfxezy )	Positive	06 Nov 2024

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