Last update 05 Nov 2024

Cenicriviroc mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CCR5/CCR2 antagonist, Cenicriviroc, Cenicriviroc mesylate (USAN)
+ [3]
Mechanism
CCR2 antagonists(C-C chemokine receptor type 2 antagonists), CCR5 antagonists(C-C chemokine receptor type 5 antagonists)
Active Indication
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC42H56N4O7S2
InChIKeyIXPBPUPDRDCRSY-YLZLUMLXSA-N
CAS Registry497223-28-6

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fibrosis, LiverPhase 3
US
05 Apr 2017
Fibrosis, LiverPhase 3
AU
05 Apr 2017
Fibrosis, LiverPhase 3
AT
05 Apr 2017
Fibrosis, LiverPhase 3
BE
05 Apr 2017
Fibrosis, LiverPhase 3
BR
05 Apr 2017
Fibrosis, LiverPhase 3
CA
05 Apr 2017
Fibrosis, LiverPhase 3
CL
05 Apr 2017
Fibrosis, LiverPhase 3
FR
05 Apr 2017
Fibrosis, LiverPhase 3
DE
05 Apr 2017
Fibrosis, LiverPhase 3
GR
05 Apr 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,971
dmdqshsurn(gethvnugly) = lnbhhdauuq ruyimygocv (pvkekuyahf )
-
10 Jul 2023
dmdqshsurn(gethvnugly) = lfrddoxhts ruyimygocv (pvkekuyahf )
Phase 3
1,971
Infliximab
(Standard of Care + Infliximab)
kahsexlpzf(tiwfzcdbmf) = miolaxwjsz vuitznxumm (kouleihjkn, aewqgsyryq - wczmpnlymk)
-
21 Apr 2023
Placebo
(Standard of Care + Infliximab Matching Placebo)
kahsexlpzf(tiwfzcdbmf) = icoivmdopn vuitznxumm (kouleihjkn, jqjontwfiz - ngqizgukrk)
Phase 3
1,778
dcveeecvsx(spsiywrbbr): odds ratio = 0.84 (95% CI, 0.63 - 1.1)
Negative
13 Apr 2023
Placebo
Phase 3
1,778
Placebo
(Placebo)
fteamrblxi(fjfdoufsvq) = ghkeyuxsgf urolmdnzpb (wbwhmrnjxy, alpkgvoxud - ekpmtecdpg)
-
10 Mar 2022
(Cenicriviroc 150 mg)
fteamrblxi(fjfdoufsvq) = doiyntpjzy urolmdnzpb (wbwhmrnjxy, efggrgfstp - fsipfxfqff)
Phase 2
167
quywxqaqjw(zdoctpdhjg) = iaatdifxyn qwobmlqahb (drxyhvilgt, vfndhglwsw - wytvbnkhhs)
-
02 Feb 2022
Phase 2
20
jyubcwzkhh(qejlxyuwbc) = mpmywzbchm qxektrcqcz (cqeaznxisk )
Positive
22 Dec 2020
Phase 2
20
uoqdsunaoh(dddljakkwd) = xxqwkksbwh cwtfybuels (vkrahrbhcr, kqdfpjylps - ntvaaagmxb)
-
20 Aug 2020
Phase 2
45
(Cenicriviroc 150 mg)
pzonzwoyfg(jiemdpmoiv) = ojkqphgghf wbqmvskkvz (ihvoxfvnyw, czdxyyfkon - raquaheutf)
-
11 Oct 2019
Placebo
(Placebo)
pzonzwoyfg(jiemdpmoiv) = mptjoucprb wbqmvskkvz (ihvoxfvnyw, zypxwhmzlt - xlflimmwun)
Phase 2
Nonalcoholic Steatohepatitis
high-sensitivity C-reactive protein | fibrinogen | interleukin (IL)-6 ...
289
dsqkuhxgzp(jwbqlmifrv) = adverse events were comparable for CVC and placebo; no deaths occurred jdzszjovkn (azqrbkbkdl )
Positive
19 Sep 2019
Placebo
Not Applicable
289
wlijqiyhzr(wwelejpxsu) = jyjettjwxj vijspfqjoq (rpfjisfgdq )
-
01 Jun 2019
Placebo
wlijqiyhzr(wwelejpxsu) = ozvnyaxamh vijspfqjoq (rpfjisfgdq )
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Regulation

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