Drug Type Small molecule drug |
Synonyms BAY 1163877盐酸盐, BAY-1163877 |
Target |
Mechanism FGFRs antagonists(Fibroblast growth factor receptors antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC23H26N6O3S |
InChIKeyHNLRRJSKGXOYNO-UHFFFAOYSA-N |
CAS Registry1443530-05-9 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
FGFR positive Transitional Cell Carcinoma | Phase 3 | US | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | US | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | JP | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | JP | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | AU | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | AU | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | BE | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | BE | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | BR | 31 May 2018 | |
FGFR positive Transitional Cell Carcinoma | Phase 3 | BR | 31 May 2018 |
Phase 2/3 | 175 | gtqwulpsuo(cerbuvloqt) = No rogaratinib-related deaths occurred hnxnglzudd (qmuuymsfag ) View more | Positive | 14 Oct 2022 | |||
Chemotherapy (docetaxel, paclitaxel, or vinflunine) | |||||||
Phase 2 | Squamous non-small cell lung cancer FGFR Overexpression | 15 | bykfpcqcdj(hmyzddzelg) = hyperphosphatemia (60%), diarrhoea (20%), and dry mouth (20%) qigxkagoaq (ueozpgvkgi ) View more | Negative | 28 May 2021 | ||
Phase 2/3 | 175 | stsmkslwih(zlyexsbhqt) = ezytibkrsg noxesnvhhs (kljgngbqcv ) View more | Positive | 19 Feb 2020 | |||
Chemotherapy (docetaxel, paclitaxel, or vinflunine) | stsmkslwih(zlyexsbhqt) = xylhzvxzfa noxesnvhhs (kljgngbqcv ) View more | ||||||
Phase 2 | 260 | wtiqwblcok(bdcjbvtice) = 35% lyxvmfcojz (kuippnukiz ) View more | Positive | 26 May 2019 |