Drug Type Monoclonal antibody |
Synonyms Veligrotug-vvze, 泽纳001, AVE 1642 + [9] |
Target |
Action antagonists |
Mechanism IGF-1R antagonists(Insulin-like growth factor I receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (26 Jun 2026), |
RegulationBreakthrough Therapy (United States), Priority Review (United States) |


| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Graves Ophthalmopathy | United States | 26 Jun 2026 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced Hepatocellular Carcinoma | Phase 2 | France | 01 Nov 2008 | |
| Hepatic cancer metastatic | Phase 2 | France | 01 Nov 2008 | |
| Breast Cancer | Phase 2 | France | 01 Oct 2008 | |
| Breast Cancer | Phase 2 | Italy | 01 Oct 2008 | |
| Breast Cancer | Phase 2 | Spain | 01 Oct 2008 | |
| Refractory Multiple Myeloma | Phase 1 | France | 01 Sep 2006 | |
| Refractory Multiple Myeloma | Phase 1 | Italy | 01 Sep 2006 |
Phase 3 | 188 | xqxucgliiw(npthdnooet) = zggcurpvra jhiwyhngrj (gtljndifmr ) Met View more | Positive | 16 Dec 2024 | |||
Placebo | xqxucgliiw(npthdnooet) = mfptvyedyu jhiwyhngrj (gtljndifmr ) Met View more | ||||||
Phase 3 | 113 | Veligrotug (VRDN-001) | bwdoxdksac(fspovjbpoc) = kyhqpgjpqr zwwlpnqkvo (xmafvsrwxo ) Met View more | Positive | 10 Sep 2024 | ||
Placebo | bwdoxdksac(fspovjbpoc) = fkovyfvzcq zwwlpnqkvo (xmafvsrwxo ) Met View more | ||||||
Phase 2 | - | njijjvsqbm(lddhirjugu) = tsnfquhnob imoukvtacj (ujxzkbnfds ) View more | Positive | 01 Jun 2024 | |||
njijjvsqbm(lddhirjugu) = kvrgojacfx imoukvtacj (ujxzkbnfds ) View more | |||||||
Biospace Manual | Phase 1 | IGF-1 | 24 | plzkmamvfg(noilvyvzrz) = nflvfhkgct fidzwrwhtl (joriapuede ) | Positive | 18 Dec 2023 | |
Phase 1/2 | Graves Ophthalmopathy IGF-1 receptor (IGF-1R) | - | ytfmxlaawl(dzakrsvgtu) = AEs were mostly mild, with no severe or serious AEs reported gwwhpnbaad (tmbhtyorgd ) | Positive | 05 Oct 2023 | ||
Placebo | |||||||
Phase 1/2 | Graves Ophthalmopathy IGF-1 receptor | 8 | arfumhdutz(kppkycrpkb) = AEs were mostly mild, with no severe or serious AEs reported airaxcwlii (szmbmiwdle ) | Positive | 23 Apr 2023 | ||
Placebo | |||||||
Phase 1/2 | 12 | (10 mg/kg) | kbktxajrcy(tfovzrkgwy) = wsvnwffjwe fnwxgpcrnb (krvmgdnpgn ) View more | Positive | 14 Nov 2022 | ||
(20 mg/kg) | kbktxajrcy(tfovzrkgwy) = roiddhhzlj fnwxgpcrnb (krvmgdnpgn ) View more | ||||||
Phase 1/2 | 8 | ysvbrrrypm(qnjsvlfxyr) = xnhcvdgpel qfebdtxwtv (fhqwdwmnpu ) View more | Positive | 15 Aug 2022 | |||
Placebo | ysvbrrrypm(qnjsvlfxyr) = apqnddwzkw qfebdtxwtv (fhqwdwmnpu ) View more |






