Bexicaserin

Seven abstracts represent data across migraine, childhood-onset epilepsy and multiple system atrophy (MSA), highlighting Lundbeck's biology-driven approach to developing treatments for serious brain diseases Oral presentation of new Phase 1 safety and tolerability data for bocunebart (Lu AG09222), an investigational anti-PACAP monoclonal antibody in migraine prevention Three VYEPTI® (eptinezumab) abstracts include clinical data and new real-world evidence in migraine Neuro-rare pipeline updates feature long-term data for bexicaserin in developmental and epileptic encephalopathies (DEEs), and clinical perspectives on disease progression in MSA VALBY, Denmark, April 13, 2026 /PRNewswire/ -- H. Lundbeck A/S (Lundbeck) today announced that new data across its neurology portfolio will be presented at the American Academy of Neurology (AAN) Annual Meeting 2026, taking place April 18–22 in Chicago, U.S. The presentations span migraine, developmental and epileptic encephalopathies (DEEs) and multiple system atrophy (MSA), and underscore Lundbeck's focus on advancing brain disease treatments where there is significant unmet need. "Neuroscience is reaching an inflection point. Progress in human genetics, biomarker validation, and the understanding of neuro-rare and migraine disease biology is opening new possibilities," said Johan Luthman, EVP and Head of Research & Development at Lundbeck." Our approach is to translate these insights into drug development programs that validate mechanisms early and focus on areas where patients still have few or no treatment options."[i] Among the highlights are new Phase 1 data on bocunebart, a potential first-in-class investigational monoclonal antibody that targets pituitary adenylate cyclase-activating polypeptide (PACAP), a pathway distinct from the calcitonin gene-related peptide (CGRP) mechanism targeted by current preventive migraine therapies. The analysis evaluates the safety and tolerability of bocunebart when administered alongside a gepant, a class of oral CGRP receptor antagonist commonly used in migraine management. Lundbeck will also present data on eptinezumab, an intravenous anti-CGRP preventive treatment for migraine. These include a post-hoc analysis from DELIVER, a randomized Phase 3b trial investigating headache-free periods and patient-reported outcomes in individuals whose migraine had not responded to multiple prior preventive treatments. New interim findings from the ongoing 12-month INFUSE real-world study will report six-month outcomes, including data on migraine-related cognitive symptoms, in patients who had experienced failures with at least one prior anti-CGRP preventive treatment. In rare childhood-onset epilepsy, Lundbeck will present primary 12-month results from the open-label extension of the Phase 1b/2a PACIFIC trial evaluating bexicaserin, an investigational selective 5-HT2C receptor superagonist being studied for the treatment of seizures in DEEs, including Dravet syndrome and Lennox-Gastaut syndrome. Separately, findings will be presented from a Delphi consensus study in MSA, a rare neurodegenerative movement disorder with no currently approved treatment. The Delphi panel examined the appropriateness of expressing treatment effect as a percentage-wise slowing of clinical progression on the Unified Multiple System Atrophy Rating Scale (UMSARS), and the threshold for clinical meaningfulness. Together, these data highlight Lundbeck's expanding neurology pipeline and its continued commitment to advancing treatments for serious brain diseases. Details of Lundbeck presentations at AAN 2026 About migraine Migraine is a complex and incapacitating neurological disease characterized by recurrent episodes of severe headaches typically accompanied by an array of symptoms, including nausea, vomiting, and sensitivity to light or sound.[ii] Not only is migraine painful but also imposes both a social and financial burden. Migraine has a profound impact on patient functioning including relationships with family/friends, leisure activities, household production and work productivity. Migraine is one of the most prevalent neurological diseases for which medical treatment is sought and is considered the leading cause of disability for people under the age of 50 and the 2nd leading cause of disability worldwide.[iii],[iv] Repeated migraine attacks, and often the constant fear of the next one, damage family life, social life and work life. As migraine frequency and severity increase, attacks become harder to control, requiring patients to take more headache medication while experiencing less relief. This cycle contributes to a greater disease burden and, without appropriate preventive management, can lead to further worsening and chronification of migraine.[v] About Vyepti® (eptinezumab) Eptinezumab is a humanized monoclonal antibody that binds to calcitonin gene-related peptide (CGRP) which was purposefully developed for intravenous (IV) administration. The efficacy and safety of eptinezumab 100 mg and 300 mg was investigated in two Phase 3 clinical trials (PROMISE-1 in episodic migraine[vi] and PROMISE-2 in chronic migraine)[vii], where eptinezumab met its primary endpoint of decrease in mean monthly migraine days (MMD) over weeks 1-12 in both episodic and chronic migraine. Furthermore, the clinical trial program demonstrated a treatment benefit over placebo that was observed for both doses of eptinezumab as early as day 1 post-infusion. The safety of eptinezumab was evaluated in more than 2,000 adult patients with migraine who received at least one dose of eptinezumab. The most common adverse reactions (≥2% and at least 2% or greater than placebo) in the clinical trials for the preventive treatment of migraine were nasopharyngitis and hypersensitivity. Approximately 8% of patients on 300 mg, 6% of patients on 100 mg and 6% of patients on placebo in PROMISE-1 and PROMISE-2 experienced nasopharyngitis. In PROMISE-1 and PROMISE-2, 1.9% of patients treated with eptinezumab discontinued treatment due to adverse reactions. VYEPTI (eptinezumab-jjmr) was approved by the U.S. Food and Drug Administration (FDA) for the preventive treatment of migraine in adults in February 2020, and in January 2022, eptinezumab was granted marketing authorization by the European Commission (EC) for the prophylaxis of migraine in adults who have at least four migraine days per month. Today, eptinezumab is launched in more than 30 markets worldwide. INDICATION VYEPTI (eptinezumab-jjmr) is indicated for the preventive treatment of migraine in adults. IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS VYEPTI is contraindicated in patients with serious hypersensitivity to eptinezumab-jjmr or to any of the excipients. Reactions have included anaphylaxis and angioedema. WARNINGS AND PRECAUTIONS Hypersensitivity Reactions: Hypersensitivity reactions, including angioedema, urticaria, facial flushing, dyspnea, and rash, have occurred with VYEPTI in clinical trials and in the postmarketing setting. Most hypersensitivity reactions occurred during infusion and were not serious, but often led to discontinuation or required treatment. Serious hypersensitivity reactions may occur. Cases of anaphylaxis have been reported in the postmarketing setting. If a hypersensitivity reaction occurs, consider discontinuing VYEPTI and institute appropriate therapy. Hypertension: Development of hypertension and worsening of pre-existing hypertension have been reported following the use of CGRP antagonists, including VYEPTI, in the postmarketing setting. Some of the patients who developed new-onset hypertension had risk factors for hypertension. There were cases requiring initiation of pharmacological treatment for hypertension, and in some cases hospitalization. Hypertension may occur at any time during treatment, but was most frequently reported within 7 days of therapy initiation. The CGRP antagonist was discontinued in many of the reported cases. Monitor patients treated with VYEPTI for new-onset hypertension or worsening of pre-existing hypertension, and consider whether discontinuation of VYEPTI is warranted if evaluation fails to establish an alternative etiology or blood pressure is inadequately controlled. Raynaud's Phenomenon: Development of Raynaud's phenomenon and recurrence or worsening of pre-existing Raynaud's phenomenon have been reported in the postmarketing setting following the use of CGRP antagonists. In reported cases with monoclonal antibody CGRP antagonists, symptom onset occurred a median of 71 days following dosing. Many of the cases reported serious outcomes, including hospitalizations and disability, generally related to debilitating pain. In most reported cases, discontinuation of the CGRP antagonist resulted in resolution of symptoms. VYEPTI should be discontinued if signs or symptoms of Raynaud's phenomenon develop, and patients should be evaluated by a healthcare provider if symptoms do not resolve. Patients with a history of Raynaud's phenomenon should be monitored for, and informed about the possibility of, worsening or recurrence of signs and symptoms. ADVERSE REACTIONS The most common adverse reactions (≥2% and at least 2% or greater than placebo) in the clinical trials for the preventive treatment of migraine were nasopharyngitis and hypersensitivity. VYEPTI was approved by the U.S. Food and Drug Administration (FDA) for the preventive treatment of migraine in adults in February 2020. For more information, please see Full Prescribing Information and Patient Information or visit . About the INFUSE study The INFUSE study is an ongoing 12-month, prospective, observational study in the US, assessing real-world effectiveness of IV eptinezumab (100 mg or 300 mg) in adults with migraine who previously failed at least one preventive anti-CGRP. Data were collected digitally at baseline, Day 7, and Months 3, 6, 9 and 12 through participant-reported surveys. The primary outcome was percent of patients with "much" or "very much" improved on the 7-point PGIC scale ("very much improved," "much improved," "minimally improved," "no change," "minimally worse," "much worse," or "very much worse"). Secondary outcomes included monthly headache days and ≥50% reduction in monthly headache days (MIDAS-derived) and number of patient-defined "good days".[viii] About the DELIVER trial DELIVER (NCT04418765) is a Phase 3b, multicenter, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of eptinezumab in patients with chronic or episodic migraine. Chronic migraine was defined as migraine occurring on ≥8 days per month and headache occurring on >14 days, and episodic migraine as migraine occurring on ≥4 days and headache occurring on ≤14 days. All patients had to have experienced failures of two to four prior preventive treatment classes (including: propranolol, metoprolol, topiramate, amitriptyline, flunarizine, valproate, divalproex, candesartan) or botulinum toxin A/B (if documented that botulinum toxin was used for chronic migraine), and at least one failure being due to inadequate efficacy. Patients who experienced failure on a previous treatment targeting the CGRP pathway were excluded from participation. Documented evidence of prior migraine treatment failures was supported by medical records or by physicians´ confirmation specific to each treatment in the past 10 years. About bocunebart Bocunebart is an investigational monoclonal antibody (mAb) with a novel mechanism of action. It was engineered to bind to and inhibit the signaling of pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide implicated in migraine pathophysiology. This mechanism operates through a pathway distinct from that targeted by anti-calcitonin gene-related peptide (anti-CGRP) therapies.[ix] Bocunebart, which met its primary endpoint in the Phase 2b PROCEED trial in February, represents a potential new treatment class and could provide an alternative option for the preventive treatment of migraine. Bocunebart is an investigational mAb, not approved by the US Food and Drug Administration (FDA) or any other regulatory agency, and the efficacy and safety of bocunebart have not been established. About DEEs Developmental and Epileptic Encephalopathies (DEEs) are a group of rare neurodevelopmental disorders that typically manifest in early childhood.[x] These heterogeneous and severe epilepsy syndromes are characterized by refractory seizures and developmental stagnation or regression.x According to the International League Against Epilepsy (ILAE), DEEs currently encompass more than 10 syndromes, including Early Infantile DEE (EIDEE), Infantile Epileptic Spasms Syndrome (IESS), Dravet Syndrome, and Lennox-Gastaut Syndrome with various etiologies among those mainly genetic (e.g., CDKL5, STXBP1, KCNT1, SCN2A). The etiology is unknown in approximately 50% of cases of DEE.x About bexicaserin Bexicaserin is an investigational, oral, centrally acting, highly selective superagonist of the 5- HT2C receptor.[xi] Bexicaserin is being evaluated for the treatment of seizures in participants with any type of DEE in a global Phase 3 clinical program (the DEEp Program). The FDA has granted Breakthrough Therapy designation for bexicaserin for the treatment of seizures associated with DEEs for patients two years of age and older. Bexicaserin has also recently been granted Breakthrough Therapy Designation in China for the treatment of seizures associated with DEEs. Bexicaserin is an investigational compound, not approved by the US Food and Drug Administration (FDA) or any other regulatory agency, and the efficacy and safety of bexicaserin have not yet been established. About multiple system atrophy MSA is a rapidly progressing rare condition that causes damage to nerve cells in the brain. In a person with MSA, an abnormal build-up of the protein α-synuclein is thought to be responsible for damaging the areas of the brain that control balance, movement, and the body's normal functions.i MSA is seriously debilitating and places a high disease burden on patients and their care partners. There is currently no cure for MSA and no available treatment to slow its clinical progression.[xii] Symptoms of MSA usually start between 55 and 60 years of age, and the typical time to death is 8.6 years after symptom onset.xiii Although there are many different possible symptoms of MSA, not everyone who is affected will experience all of them. The symptoms of MSA are wide-ranging and may include muscle control problems, similar to those of Parkinson's disease.xiii Many different functions of the body can be affected, and symptoms can include urinary incontinence, dizziness when standing, balance and gait issues, and falls. MSA is accompanied by reduced capacity to live independently, and death is often due to respiratory problems. Contacts Anders Crillesen Head of Media Relations, Corp. Communication [email protected] +45 27 79 12 86 Jens Høyer Vice President, Head of Investor Relations [email protected] +45 30 83 45 01 About H. Lundbeck A/S Lundbeck is a biopharmaceutical company focusing exclusively on brain health. With more than 70 years of experience in neuroscience, we are committed to improving the lives of people with neurological and psychiatric diseases. Brain disorders affect a large part of the world's population, and the effects are felt throughout society. With the rapidly improving understanding of the biology of the brain, we hold ourselves accountable for advancing brain health by curiously exploring new opportunities for treatments. As a focused innovator, we strive for our research and development programs to tackle some of the most complex neurological challenges. We develop transformative medicines targeting people for whom there are few or no treatments available, expanding into neuro-specialty and neuro-rare from our strong legacy within psychiatry and neurology. We are committed to fighting stigma and we act to improve health equity. We strive to create long term value for our shareholders by making a positive contribution to patients, their families and society as a whole. Lundbeck has more than 5,000 employees in more than 20 countries and our products are available in more than 80 countries. For additional information, we encourage you to visit our corporate site and connect with us via LinkedIn. References: [i] Jellinger KA. J Alzheimers Dis. 2018;62:1141–79 [ii] Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd Edition. 2018. 38(1): p. 1-211 [iii] Steiner TJ, et al. J Headache Pain. 2018;19(1):17 [iv] Leonardi M, et al. J Headache Pain. 2005; 6(6):429– 440 [v] Lipton RB, et al. J Neurol. 2023;270(12);5692–5710 [vi] Ashina M, et al. Cephalalgia. 2020;40(3):241-254 [vii] Lipton RB, et al. Neurology. 2020;94(13):e1365-e1377 [viii] Starling A et al. Poster Presentation: HCOP Annual Conference 2025 [ix] Al-Karagholi, M.AM., Zhuang, Z.A., Beich, S. et al. J Headache Pain 26, 79 (2025). [x] Scheffer IE, et al. Epilepsia. 2025;00:1-10 [xi] Ren A, et al. J Medicinal Chem. 2025;68(11):10599-10618 [xii] Palma JA, et al. Auton Neurosci. 2018;211:15–25 CONTACT: H. Lundbeck A/S Ottiliavej 9, 2500 Valby, Denmark +45 3630 1311 [email protected] This information was brought to you by Cision The following files are available for download: 21% more press release views with Request a Demo

Modern neuroscience research shifts toward precision medicine & digital biomarkers utilizing artificial intelligence to accelerate patient enrollment timelines. "Why are traditional clinical endpoints failing while digital biomarkers are successfully redefining the future of neurological drug development?" - Maximize Market Research ” — Maximize Market Research ROCKVILLE , MD, UNITED STATES, April 3, 2026 / EINPresswire.com / -- The Neurology Clinical Trials Market , valued at USD 6.67 Billion in 2025, is transitioning toward high-value, mechanism-driven research. Projected to expand at a 6.5% CAGR to reach USD 10.36 Billion by 2032, this surge is anchored in Phase II dose-optimization studies targeting neurodegenerative pathways and rare pediatric indications. Current investment cycles prioritize precision medicine to shorten the gap between early stage discovery and confirmatory trials. Get Full PDF Sample Copy of Report: (Including Full TOC, List of Tables & Figures, Chart) @ https://www.maximizemarketresearch.com/request-sample/171139/ Despite a high capital threshold averaging USD 1.5 Billion per neurologic agent, the market remains resilient. This is driven by a robust global pipeline of interventional studies, which secured over 82% of revenue. As sponsors navigate complex CNS delivery challenges, the adoption of biomarker validated endpoints has become the industry standard. This shift significantly reduces the failure at scale risks historically associated with late-phase neuroscience programs, ensuring more sustainable R&D trajectories. Neurology Clinical Trials Market: AI-Driven EMR Abstraction Accelerating Enrollment Timelines A critical bottleneck in the Neurology Clinical Trials Market is identifying eligible candidates within complex, unstructured clinical datasets. A landmark study by Cleveland Clinic and Dyania Health demonstrated that medically trained Natural Language Processing (NLP) systems screen patient charts with 96.2% accuracy. By automating the abstraction of structured and unstructured Electronic Medical Record (EMR) data, the platform identified qualified participants for rare disease trials in six days, a process historically requiring over 90 days of manual review. This shift toward Automated Patient Matching fundamentally alters the CNS trial revenue model by reducing Screen Failure rates that typically inflate R&D costs. These 2026 AI frameworks use justification based logic to provide physician interpretable evidence for every inclusion decision. This Clinical Trial Optimization ensures protocol adherence and enhances Diversity, Equity, and Inclusion (DEI) by surfacing eligible patients from community health systems previously overlooked by traditional academic site recruitment. Digital Biomarkers and Continuous Monitoring: Redefining Clinical Endpoints in the Neurology Clinical Trials Market Data collection methodologies within the Neurology Clinical Trials Market are evolving from intermittent, subjective clinical assessments toward high frequency objective Digital Biomarkers. Traditional metrics, including the ALSFRS-R for motor function, are now being augmented by smartphone-derived vocal biomarkers and wearable sensors that capture real-world data. Results from Biogen’s Intuition Study demonstrated how passive sensor data from personal devices can distinguish mild cognitive impairment from normal aging with unprecedented sensitivity. By utilizing multimodal sensors to track gait and speech patterns, sponsors can detect subtle therapeutic signals often missed during sporadic in clinic visits. Following the January 2026 FDA revised guidance on sensor based tools, there is an industry wide surge in Electronic Patient-Reported Outcomes (ePRO) adoption. This transition to Continuous Monitoring ensures that trial designs are more sensitive to disease progression, ultimately reducing the sample sizes required for Phase II efficacy testing and lowering the overall CNS drug development costs. Neurology Clinical Trials Market: Economic Drivers, Capital Restraints, and Breakthrough Opportunities The Neurology Clinical Trials Market is defined by a high-risk economic structure where clinical drivers are validated by record-breaking capital infusions. A primary driver is the surge in neuroscience venture funding; for example, MapLight Therapeutics’ USD 372 Million Series D in late 2025 highlights investor appetite for late stage CNS assets. However, the sector faces a significant restraint in the form of extreme capital intensity. With the average cost per approved neurologic agent reaching a USD 1.5 Billion threshold, sponsors like ScinoPharm are utilizing abbreviated regulatory pathways to bypass traditional financial toxicity. Amidst these costs, opportunities are emerging through Decentralized Clinical Trials (DCT), projected to grow at a 17.7% CAGR. This shift is evidenced by the adoption of no-code clinical software, tackling patient retention hurdles. Furthermore, FDA Breakthrough Therapy Designation granted to Alkermes’ alixorexton for narcolepsy serves as a benchmark for accelerating high-growth neurodegenerative pipelines toward commercialization. Global CNS Research Corridors: High-Tech Discovery in North America vs. Rapid Clinical Scaling in Asia-Pacific Market maturity in the Neurology Clinical Trials Market is currently bifurcated. In the USA, the NIH BRAIN Initiative’s funding for modulation technologies reinforces North America’s 50.8% revenue share. This region remains the epicenter for Phase I pharmacology, supported by Brain Canada’s recent USD 160 Million neuro-innovation injection. Simultaneously, India is emerging as a premier destination for clinical scaling. A landmark shift occurred on March 7, 2026, with the New Drugs and Clinical Trials Amendment. This Prior Intimation pathway slashed CDSCO review timelines from 90 to 45 days. By pairing American high-tech discovery with India’s accelerated approval frameworks and treatment-naive patient pools, global sponsors are effectively halving their global CNS drug development lifecycles. Neurology Clinical Trials Market, Key Players Supernus Pharmaceuticals Adamas Pharmaceuticals Eli Lilly and Company Aurora Health Care AbbVie Inc. Medtronic Zydus Group Athira Pharma Annovis Bio Biogen Merck & Co. IQVIA Covance Medpace AstraZeneca Get Full PDF Sample Copy of Report: (Including Full TOC, List of Tables & Figures, Chart) @ https://www.maximizemarketresearch.com/request-sample/171139/ Decentralized Clinical Trials (DCT): Revolutionizing Patient Retention in the Neurology Clinical Trials Market Operational frameworks in the Neurology Clinical Trials Market are pivoting toward Decentralized Clinical Trials (DCT) to mitigate chronic patient attrition. Growing at a 17.35% CAGR, this evolution is headlined by the Medable and Google Cloud collaboration, which integrates AI-driven remote monitoring into hybrid study designs. By utilizing Televisits and In Home Clinical Services, sponsors are removing the geographic barriers that historically limited enrollment in Multiple Sclerosis and Parkinson’s research. This Patient-Centricity shift ensures continuous data flow through connected sensors, directly improving the statistical power of Longitudinal Health Data while halving the traditional site-visit burden for mobility impaired cohorts. Neurology Clinical Trials Market Segmentation: Analyzing Phase-Specific Trends and Therapeutic Breakthroughs Segmentation in the Neurology Clinical Trials Market is currently dominated by Phase II studies, critical for safety monitoring and dose optimization. In the Epilepsy segment capturing 25.4% of market share, real-world progress is evidenced by Lundbeck’s data on bexicaserin, which demonstrated a 60.2% median seizure reduction. Simultaneously, the Neurodegenerative segment is seeing a surge in Phase III confirmatory trials. High-profile milestones, including the FDA PDUFA date for Biogen’s subcutaneous lecanemab, highlight a shift toward disease-modifying Alzheimer’s care. By prioritizing biomarker-confirmed amyloid buildup, these segments are moving toward high-probability molecules, reducing long-term capital risk. By Phase Phase I Phase II Phase III Phase IV By Study Design Interventional Observational Expanded Access By Patient Population Pediatric Patients Adult Patients Geriatric Patients By Route of Administration Oral Intravenous Subcutaneous Intrathecal Transdermal By Indication Huntington's Disease Epilepsy Parkinson's Disease (PD) Stroke Traumatic Brain Injury (TBI) Amyotrophic Lateral Sclerosis (ALS) Muscle regeneration Others By End User Hospitals Research Institutes Contract Research Organizations (CROs) Academic Medical Centers Get access to the full description of the report @ https://www.maximizemarketresearch.com/market-report/neurology-clinical-trials-market/171139/ Analyst Perspective Future growth in the CNS clinical research sector is increasingly tied to Mechanism Driven Evidence rather than traditional symptomatic endpoints. Industry analysts highlight that pipelines are pivoting toward rare pediatric neuro-disorders and orphan indications, where the FDA’s Rare Pediatric Disease Priority Review Voucher (PRV) program acts as a primary financial catalyst. By leveraging Natural History Studies to serve as external control arms, biotech firms are successfully navigating the high-risk Phase II/III transition. This shift toward biomarker-validated cohorts is essential for stabilizing R&D expenditures within the neuroscience study landscape while accelerating the delivery of precision therapies to underserved patient populations. FAQ’s What is the projected valuation for this therapeutic research sector? Ans. The global revenue is expected to reach nearly USD 10.36 Billion by 2032, expanding at a 6.5% CAGR from its 2025 base of USD 6.67 Billion. Which therapeutic segment holds the largest share in 2026? Ans. The Epilepsy and Neurodegenerative segments (specifically Alzheimer’s) dominate, driven by a surge in Phase III confirmatory trials and new Breakthrough Therapy Designations. How is AI impacting patient enrollment timelines? Ans. AI-driven EMR abstraction has reduced patient screening from 90 days to just six days, significantly lowering Screen Failure rates and total CNS drug development costs. 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We provide high-impact, data-driven strategic intelligence to navigate industrial shifts and secure market dominance Domain Focus: Healthcare Our research deciphers the global transition toward precision recruitment and digital biomarker integration. We analyze the intersection of AI-driven EMR abstraction and decentralized trial frameworks, evaluating high-value structural shifts across the Neurology Clinical Trials Market. Lumawant Godage MAXIMIZE MARKET RESEARCH PVT. LTD. +91 96073 65656 akash.r@maximizemarketresearch.com Visit us on social media: LinkedIn Instagram Facebook X Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.