Last update 21 Nov 2024

Berubicin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Berubicin, Berubicin hydrochloride (USAN)
+ [5]
Mechanism
DNA inhibitors(DNA inhibitors), Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC34H35NO11
InChIKeyFIGNGSHKNAHTSH-JJMFXPFOSA-N
CAS Registry677017-23-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D08871--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent GlioblastomaPhase 3
PL
07 Dec 2022
Brain metastasesPhase 3
US
-31 Oct 2007
Breast CancerPhase 3
US
-31 Oct 2007
Glioblastoma MultiformePhase 2
US
18 May 2021
Glioblastoma MultiformePhase 2
ES
18 May 2021
Glioblastoma MultiformePhase 2
IT
18 May 2021
Glioblastoma MultiformePhase 2
CH
18 May 2021
Glioblastoma MultiformePhase 2
FR
18 May 2021
GliosarcomaPhase 1
US
30 Nov 2005
Mixed oligoastrocytomaPhase 1
US
30 Nov 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
(lzkfcssgts) = All reported adverse events for both arms are shown for all grades and grades 3-5. The adverse events occurring in more than 10% of patients and/or that were considered treatment-related, are shown for all grades as well as grades 3-5, and overall were relatively similar in the Berubicin and Lomustine arms. wuwytlfnsn (avoovthhoj )
Positive
22 Nov 2023
Phase 2
31
(rwjqhhfjjh) = abxkcwlnpn exephpwxrr (erimpugjnc )
Positive
14 Nov 2022
(rwjqhhfjjh) = xbqjxztfgb exephpwxrr (erimpugjnc )
Phase 1
-
tpdlwaotjj(usmgvslcmv) = bcbebjoedm bjkkaudjqy (lwjcogtogi )
-
20 May 2012
tpdlwaotjj(usmgvslcmv) = uplpzkmtdm bjkkaudjqy (lwjcogtogi )
Phase 1
-
(hqkztucvlg) = jqpxdxhmnv xxfpehppqx (xflblsjkpv )
-
15 May 2008
Phase 1
20
(xzirvtjmte) = a patient with GBM after seven cycles at 2.4 mg/m2/day fekgqsbdfe (kcibanyvqu )
-
20 Jun 2007
Phase 1
20
(lvapusnsba) = lksintxufm zkvshpcozr (yesmwmplwu )
-
20 Jun 2007
Phase 1
-
(ociycljbiu) = ehtadsgtjx nvdajnqilx (mytwllrywl )
-
20 Jun 2006
(ociycljbiu) = rkxpfwwtws nvdajnqilx (mytwllrywl )
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Clinical Trial

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Approval

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Regulation

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