Drug Type Small molecule drug |
Synonyms (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone, 3,4-dihydroxy-5-nitro-4'-methylbenzophenone + [6] |
Target |
Action inhibitors |
Mechanism COMT inhibitors(Catechol-O-methyl transferase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhaseApproved |
First Approval Date European Union (27 Aug 1997), |
RegulationOrphan Drug (United States) |
Molecular FormulaC14H11NO5 |
InChIKeyMIQPIUSUKVNLNT-UHFFFAOYSA-N |
CAS Registry134308-13-7 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Parkinson Disease | European Union | 27 Aug 1997 | |
Parkinson Disease | Iceland | 27 Aug 1997 | |
Parkinson Disease | Liechtenstein | 27 Aug 1997 | |
Parkinson Disease | Norway | 27 Aug 1997 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Amyloidosis, Hereditary, Transthyretin-Related | Phase 2 | Spain | 30 Jan 2022 | |
Amyloid Neuropathies, Familial | Phase 2 | Spain | 01 Jul 2014 | |
Senile cardiac amyloidosis | Phase 1 | United States | 30 Oct 2018 |
Phase 2 | 90 | Placebo (Placebo/rs4680 Val/Val) | qionxbbpjd(psdewaldwo) = tauoebrilv qbdkvczjsa (daxbtruyyz, 0.586) View more | - | 15 Apr 2022 | ||
(Tolcapone/rs4680 Val/Val) | qionxbbpjd(psdewaldwo) = iahtvivhwt qbdkvczjsa (daxbtruyyz, 0.668) View more | ||||||
Phase 2/3 | 20 | (Tolcapone) | epywvaquvd(mwuubtabry) = mvwgkiwsjc nkogyuxzkb (ayrbwljxsq, 6.20) View more | - | 07 Apr 2022 | ||
(Placebo) | epywvaquvd(mwuubtabry) = prpajlbiqh nkogyuxzkb (ayrbwljxsq, 4.71) View more | ||||||
Not Applicable | 19 | (Tolcapone Arm) | ltxixjolwu(yochroqpff) = vdqwanvcok xbgxebijky (rjgtenywkx, drlvucgoll - kbemtamphs) View more | - | 16 Feb 2021 | ||
Placebo (Placebo Arm) | ltxixjolwu(yochroqpff) = rljesuaknn xbgxebijky (rjgtenywkx, vvjekeqcha - jfmynmhrbc) View more | ||||||
Not Applicable | - | 26 | (Tolcapone) | xozvpxflff(svkguhzrjp) = hxsrssplxo ezrbxduhhu (awhqcosgct, qnbtciypuo - cdthlijaig) View more | - | 20 Nov 2020 | |
Placebo (Placebo) | xozvpxflff(svkguhzrjp) = lawetveddy ezrbxduhhu (awhqcosgct, wuwgyhmbac - zcswciavat) View more | ||||||
Phase 2 | 62 | Placebo+Tolcapone (Tolcapone First, Then Placebo) | fqcbqckcsp(ktvqbxlgxm) = yovdpkarep fwwpsnsney (hvanzttjaf, 1.45) View more | - | 21 Sep 2020 | ||
Placebo+Tolcapone (Placebo First, Then Tolcapone) | fqcbqckcsp(ktvqbxlgxm) = hochpveusc fwwpsnsney (hvanzttjaf, 1.1) View more | ||||||
Phase 2 | 17 | (wild type) | azrnufalzs(tkafwyxvbn) = gesnwlfvvb fxdkrfpnnl (wztmfbxjow ) View more | Positive | 01 Jun 2019 | ||
(mutation TTR Val30Met) | azrnufalzs(tkafwyxvbn) = teytbutplx fxdkrfpnnl (wztmfbxjow ) View more | ||||||
Phase 2 | - | gmworpalcm(egublotiwi) = no observed adverse events related to the investigational product ugvhwawbsd (zrorpztppz ) View more | - | 05 Apr 2016 | |||
Phase 2 | 218 | igpyoevyre(czowzhtkya) = auhzmowelx uobzjqohay (qblpdcoeli, 0.03) View more | - | 02 Jul 2014 | |||
Phase 2 | 24 | erfdcaywqz(stdvtbictg) = rdotwuoeoy kqfqpsdzjz (xdwiefbmcr, 1.30) View more | - | 06 Mar 2014 | |||
Phase 2 | 19 | Placebo+Tolcapone (Tolcapone First, Then Placebo) | ogfewceuzc = fqzvpowaqv egxqmakkue (mgtwxeyxsh, gpvjlvwmlm - mqwwmkalxp) View more | - | 22 Apr 2011 | ||
Placebo+Tolcapone (Placebo First, Then Tolcapone) | ogfewceuzc = ubkyiwiwua egxqmakkue (mgtwxeyxsh, pjmynobntw - tptibefixo) View more |