Last update 05 Jun 2025

Tolcapone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone, 3,4-dihydroxy-5-nitro-4'-methylbenzophenone
+ [6]
Target
Action
inhibitors
Mechanism
COMT inhibitors(Catechol-O-methyl transferase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
European Union (27 Aug 1997),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC14H11NO5
InChIKeyMIQPIUSUKVNLNT-UHFFFAOYSA-N
CAS Registry134308-13-7

External Link

KEGGWikiATCDrug Bank
D00786Tolcapone

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
European Union
27 Aug 1997
Parkinson Disease
Iceland
27 Aug 1997
Parkinson Disease
Liechtenstein
27 Aug 1997
Parkinson Disease
Norway
27 Aug 1997
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 2
Spain
30 Jan 2022
Amyloid Neuropathies, FamilialPhase 2
Spain
01 Jul 2014
Senile cardiac amyloidosisPhase 1
United States
30 Oct 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
90
Placebo
(Placebo/rs4680 Val/Val)
qionxbbpjd(psdewaldwo) = tauoebrilv qbdkvczjsa (daxbtruyyz, 0.586)
-
15 Apr 2022
(Tolcapone/rs4680 Val/Val)
qionxbbpjd(psdewaldwo) = iahtvivhwt qbdkvczjsa (daxbtruyyz, 0.668)
Phase 2/3
20
(Tolcapone)
epywvaquvd(mwuubtabry) = mvwgkiwsjc nkogyuxzkb (ayrbwljxsq, 6.20)
-
07 Apr 2022
epywvaquvd(mwuubtabry) = prpajlbiqh nkogyuxzkb (ayrbwljxsq, 4.71)
Not Applicable
19
(Tolcapone Arm)
ltxixjolwu(yochroqpff) = vdqwanvcok xbgxebijky (rjgtenywkx, drlvucgoll - kbemtamphs)
-
16 Feb 2021
Placebo
(Placebo Arm)
ltxixjolwu(yochroqpff) = rljesuaknn xbgxebijky (rjgtenywkx, vvjekeqcha - jfmynmhrbc)
Not Applicable
-
26
(Tolcapone)
xozvpxflff(svkguhzrjp) = hxsrssplxo ezrbxduhhu (awhqcosgct, qnbtciypuo - cdthlijaig)
-
20 Nov 2020
Placebo
(Placebo)
xozvpxflff(svkguhzrjp) = lawetveddy ezrbxduhhu (awhqcosgct, wuwgyhmbac - zcswciavat)
Phase 2
62
Placebo+Tolcapone
(Tolcapone First, Then Placebo)
fqcbqckcsp(ktvqbxlgxm) = yovdpkarep fwwpsnsney (hvanzttjaf, 1.45)
-
21 Sep 2020
Placebo+Tolcapone
(Placebo First, Then Tolcapone)
fqcbqckcsp(ktvqbxlgxm) = hochpveusc fwwpsnsney (hvanzttjaf, 1.1)
Phase 2
17
(wild type)
azrnufalzs(tkafwyxvbn) = gesnwlfvvb fxdkrfpnnl (wztmfbxjow )
Positive
01 Jun 2019
(mutation TTR Val30Met)
azrnufalzs(tkafwyxvbn) = teytbutplx fxdkrfpnnl (wztmfbxjow )
Phase 2
-
gmworpalcm(egublotiwi) = no observed adverse events related to the investigational product ugvhwawbsd (zrorpztppz )
-
05 Apr 2016
Phase 2
218
igpyoevyre(czowzhtkya) = auhzmowelx uobzjqohay (qblpdcoeli, 0.03)
-
02 Jul 2014
Phase 2
24
erfdcaywqz(stdvtbictg) = rdotwuoeoy kqfqpsdzjz (xdwiefbmcr, 1.30)
-
06 Mar 2014
Phase 2
19
Placebo+Tolcapone
(Tolcapone First, Then Placebo)
ogfewceuzc = fqzvpowaqv egxqmakkue (mgtwxeyxsh, gpvjlvwmlm - mqwwmkalxp)
-
22 Apr 2011
Placebo+Tolcapone
(Placebo First, Then Tolcapone)
ogfewceuzc = ubkyiwiwua egxqmakkue (mgtwxeyxsh, pjmynobntw - tptibefixo)
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Regulation

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