Last update 08 May 2025

Nifurtimox

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nifurtimox (USAN/INN)
+ [5]
Target-
Action-
Mechanism-
Inactive Indication
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (06 Aug 2020),
RegulationOrphan Drug (United States), Priority Review (United States), Accelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC10H13N3O5S
InChIKeyARFHIAQFJWUCFH-UHFFFAOYSA-N
CAS Registry23256-30-6

External Link

KEGGWikiATCDrug Bank
D00833Nifurtimox

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chagas Disease
United States
06 Aug 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MedulloblastomaPhase 2
United States
14 Jan 2008
Neuroblastoma recurrentPhase 2
United States
14 Jan 2008
NeuroblastomaPhase 1
China
20 Oct 2021
Chagas DiseaseDiscovery
Colombia
27 Jan 2016
Chagas DiseaseDiscovery
Argentina
27 Jan 2016
Chagas DiseaseDiscovery
Bolivia
27 Jan 2016
Chagas CardiomyopathyDiscovery
Argentina
01 Nov 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
112
butcidybva(kuvsffzlvd) = csmgiarcnn anavzqsyvj (ebailbsgzi, pgaalewlcx - fvnlpaidfo)
-
29 Dec 2022
Not Applicable
3,000
yzfhwypmyq(cgmgqugedx) = rahbgaxwoo nrppjopzeg (yikhfxseyi, 1.0 - 4.5)
-
01 Oct 2021
(No antitrypanosomal treatment)
yzfhwypmyq(cgmgqugedx) = zftcldbnbc nrppjopzeg (yikhfxseyi, 1.0 - 4.2)
Phase 3
330
bwehrutsrr(nkwjyrvfag): difference = 14.0 (95% CI, 3.7 - 24.2)
Positive
07 Jan 2021
placebo
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Clinical Trial

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Approval

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Regulation

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