The goal of this clinical trial is to learn the efficacy of Mazdutide in treating obese female adults diagnosed with polycystic ovary syndrome (PCOS). The main question it aims to answer is: Does Mazdutide lower the free androgen index (FAI) in obese female adults with PCOS? Participants will take Mazdutide once every week for 24 weeks and visit the clinic once every 4 weeks for checkups and tests.

Start Date21 Oct 2024

Sponsor / Collaborator

Zhongshan Hospital Fudan University

NCT06536023

/ RecruitingPhase 1

A Randomised, Double-blind, Placebo-controlled Trial to Assess Safety, Tolerability and Pharmacokinetics of IBI362 in Chinese Obese Adolescent Subjects

The study is a first-in-pediatric assessment of the safety, tolerability, and pharmacokinetic characteristics of multiple doses of IBI362 in Chinese adolescent subjects with obesity. It employs a multicenter, randomized, double-blind, and placebo-controlled trial design. The study plans to enroll 36 adolescents (aged ≥12 years and <18 years) with obesity who have experienced less than a 5% decrease in Body Mass Index (BMI) after at least 12 weeks of diet and exercise control.

Start Date30 Aug 2024

Sponsor / Collaborator

Innovent Biologics (Suzhou) Co. Ltd.

CTR20242726

/ RecruitingPhase 1

评估IBI362在中国青少年肥胖受试者中多次给药的安全性、耐受性和药代动力学的随机、双盲、安慰剂对照的研究

[Translation] A randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of IBI362 after repeated dosing in obese Chinese adolescent subjects

评估IBI362多次腹部皮下注射的安全性和耐受性，并确定其临床使用的安全剂量范围。

[Translation]

To evaluate the safety and tolerability of multiple abdominal subcutaneous injections of IBI362 and determine its safe dose range for clinical use.

Start Date27 Aug 2024

Sponsor / Collaborator

Innovent Biologics (Suzhou) Co. Ltd.

100 Clinical Results associated with Mazdutide

100 Translational Medicine associated with Mazdutide

100 Patents (Medical) associated with Mazdutide

Literatures (Medical) associated with Mazdutide

01 Jan 2025·Pharmacological Reviews

Emerging pharmacotherapies for obesity: A systematic review

Article

Author: Kokkorakis, Michail ; Chakhtoura, Marlene ; Valenzuela-Vallejo, Laura ; Al Rifai, Jana ; Rhayem, Caline ; Mantzoros, Christos S. ; Mantzoros, Christos S ; Ghezzawi, Malak

The history of anti-obesity pharmacotherapies is marked by disappointments, often entangled with societal pressure promoting weight loss and the conviction that excess body weight signifies a lack of willpower. However, categories of emerging pharmacotherapies generate hope to reduce obesity rates. This systematic review of phase 2 and phase 3 trials in adults with overweight/obesity investigates the effect of novel weight loss pharmacotherapies, compared to placebo/control or Food and Drug Administration-approved weight loss medication, through searching Medline, Embase, and ClinicalTrials.gov (2012-2024). We identified 53 phase 3 and phase 2 trials, with 36 emerging anti-obesity drugs or combinations thereof and four withdrawn or terminated trials. Oral semaglutide 50 mg is the only medication that has completed a phase 3 trial. There are 14 ongoing phase 3 trials on glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) (ecnoglutide, orforglipron, TG103), GLP-1 RA/amylin agonist (CagriSema), GLP-1/glucagon RAs (mazdutide, survodutide), GLP-1/glucose-dependent insulinotropic polypeptide and glucagon RA (retatrutide), dapagliflozin, and the combination sibutramine/topiramate. Completed phase 2 trials on incretin-based therapies showed a mean percent weight loss of 7.4-24.2%. Almost half of the drugs undergoing phase 2 trials were incretin analogs. The obesity drug pipeline is expanding rapidly, with the most promising results reported with incretin analogs. Data on mortality and obesity-related complications, such as cardio-renal-metabolic events, are needed. Moreover, long-term follow-up data on the safety and efficacy of weight maintenance with novel obesity pharmacotherapies, along with studies focused on under-represented populations, cost-effectiveness assessments, and drug availability, are needed to bridge the care gap for patients with obesity. Significance Statement Obesity is the epidemic of the 21st century. Except for the newer injectable medications, drugs with suboptimal efficacy have been available in the clinician's armamentarium. However, emerging alternatives of novel agents and combinations populate the obesity therapeutic pipeline. This systematic review identifies the state and mechanism of action of emerging pharmacotherapies undergoing or having completed phase 2 and phase 3 clinical trials. The information provided herein furthers the understanding of obesity management, implying direct clinical implications and stimulating research initiatives.

01 Dec 2024·Metabolism

Seven glucagon-like peptide-1 receptor agonists and polyagonists for weight loss in patients with obesity or overweight: an updated systematic review and network meta-analysis of randomized controlled trials

Review

Author: Xie, Zeyu ; Deng, Weishang ; Zheng, Guimei ; Cao, Weiling ; Li, Mengting ; Liang, Zhuoru

PURPOSEThis study aimed to provide evidence-based support and a reference for the efficacy and safety of seven glucagon-like peptide-1 (GLP-1) receptor agonists and polyagonists for weight loss in patients with obesity or overweight through a network meta-analysis.METHODSRelevant randomized controlled trials (RCTs) with an intervention duration of at least 16 weeks assessing seven GLP-1 receptor agonists and polyagonists (mazdutide, 6 or 4.5 mg; retatrutide, 12 or 8 mg; tirzepatide, 15 or 10 mg; liraglutide, 3.0 mg; semaglutide, 2.4 mg; orforglipron, 45 or 36 mg; and beinaglutide, 0.2 mg) in patient with obesity or overweight was searched using three databases (Cochrane Library, PubMed, and Embase) from creation to August 30, 2024. The primary outcome was the percentage change in body weight from baseline. Secondary outcomes included changes in waist circumference, hemoglobin A1c, and fasting plasma glucose level from baseline; adverse events, serious adverse events, adverse event withdrawal, and hypoglycemic events. We conducted a frequentist random-effects network meta-analysis to analyze the data extracted from the RCTs using Stata 16.1 software.RESULTSTwenty-seven RCTs of seven GLP-1 receptor agonists and polyagonists and 15,584 patients were included in the network meta-analysis. In terms of efficacy, compared with placebo, retatrutide 12 mg (-22.10 % in body weight and - 17.00 cm in waist circumference), retatrutide 8 mg (-20.70 % and - 15.90 cm), and tirzepatide 15 mg (-16.53 % and - 13.23 cm) were the three most efficacious treatments for reducing body weight and waist circumference. However, these treatments were less effective in patients with type 2 diabetes mellitus (T2DM). In addition, patients with a high body mass index (BMI) or longer treatment cycles exhibited significantly greater weight loss than those with a low BMI or shorter treatment cycles. In terms of safety, patients without T2DM had a higher incidence of adverse events than those with T2DM. None of the interventions increased the incidence of serious adverse or hypoglycemic events (˂54 mg/dL). There was no significant difference in the incidence of adverse event withdrawal for all interventions in head-to-head comparisons. In addition, disparities in race, BMI, and treatment cycles did not significantly increase the incidence of adverse events. Finally, the sensitivity and publication bias analyses indicated that the basic analysis results were reliable.CONCLUSIONRetatrutide (both doses) and tirzepatide exhibited superior efficacy compared to other GLP-1 receptor agonists and polyagonists in reducing body weight and waist circumference. Patients without T2DM, those with a high BMI, and individuals undergoing longer treatment cycles demonstrated significantly greater weight loss and reductions in waist circumference. Dual or triple receptor agonists (GLP-1 plus glucose-dependent insulinotropic polypeptide and/or Glucagon receptor) are more effective for weight loss than GLP-1 receptor agonists.

01 Sep 2024·Indian Journal of Endocrinology and Metabolism

Approved and Emerging Hormone-Based Anti-Obesity Medications: A Review Article

Review

Author: Kalhan, Atul ; Sidrak, Wael R. ; Kalra, Sanjay

AbstractObesity is a heterogeneous, complex, and chronic disease that has a detrimental impact on disability-adjusted life years across the globe. Recent advancements in our understanding of gut-brain communication at the molecular level have driven the development of next-generation anti-obesity medications (AOMs). Glucagon-like peptide-1 receptor agonists (GLP1RAs) remain the front-runners in this rapidly evolving landscape of hormone-based AOMs. Two GLP1RAs, namely Liraglutide and Semaglutide, have been approved by the Food and Drug Administration (FDA) and European Medicine Agency (EMA) for use in clinical practice for weight loss. Three oral GLP1RAs, namely Semaglutide, Danuglipron, and Orforglipron, are undergoing advanced clinical trials in individuals with obesity. Amylin receptor agonist (AMYRA) Cagrilintide, when used alone or in combination with Semaglutide, has demonstrated substantial weight reduction in clinical trials. Tirzepatide, a dual agonist for the glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors, has been observed to be associated with a significant placebo-subtracted weight reduction of 17.8% in a 72-week randomized controlled trial. Novel approaches targeting glucagon signalling have also yielded promising preliminary results. Three long-acting GLP1R/glucagon receptor (GCGR) dual agonists, namely Survodutide, Mazdutide, and Pemvidutide, exhibited significant weight loss in clinical trials. Retatrutide, a GLP1R/GCGR/GIPR tri-agonist, has been associated with a placebo-subtracted weight reduction of -22.1% in a 48-week phase-II trial. As a note of caution, long-term data on such medications’ safety and cardiovascular benefits is yet to be ascertained. Our review provides a comprehensive overview of the approved and emerging hormone-based AOMs, highlighting the diversity of options that might become available in the near future.

News (Medical) associated with Mazdutide

17 Dec 2024

·www.echemi.com

Eli Lilly’s Pirtobrutinib Joins the Race as BTK Competition Heats Up

On December 16, Innovent Biologics and Eli Lilly announced a collaboration agreement for the non-covalent (reversible) Bruton’s tyrosine kinase (BTK) inhibitor, pirtobrutinib, in mainland China. Under this agreement, Innovent Biologics will handle the import, sales, promotion, and distribution, while Eli Lilly will manage R&D and post-market medical affairs. On October 29, Eli Lilly’s pirtobrutinib received approval from the National Medical Products Administration (NMPA) for treating relapsed or refractory mantle cell lymphoma (MCL) in adults who have previously received BTK inhibitor treatments. Currently, the domestic market has five approved BTK inhibitors, including ibrutinib, zanubrutinib, ocatabrutinib, and acabrutinib. Sanofi’s Tolebrutinib and Rilzabrutinib are in Phase III clinical trials, while CT-1530 from Shouyao Holdings is in Phase II. The robust development of BTK inhibitors indicates potential market changes. BTK inhibitors work by targeting the BCR signaling pathway, binding to BTK, inhibiting its phosphorylation, and inducing apoptosis, effectively managing B-cell malignancies. Before BTK inhibitors, lymphoma treatments were limited to chemotherapy, anti-CD20 antibodies, and radiotherapy. Ibrutinib, the first BTK inhibitor, revolutionized B-cell cancer treatment since its 2013 debut and was approved in China in 2017. However, sales of ibrutinib have slowed due to competition from similar drugs. Zanubrutinib, developed by BeiGene, reached $1.297 billion in global sales in 2023, marking the first domestic drug to achieve such success, but it now faces increasing competition. Pirtobrutinib, as the first and only non-covalent BTK inhibitor, intensifies competition in this niche market. It shows potential to overcome resistance to covalent BTK inhibitors and offers a new option for relapsed/refractory MCL patients. To highlight its efficacy, Eli Lilly conducted a head-to-head study in the BRUIN MCL-321 trial. By 2030, pirtobrutinib is projected to capture 60% of the chronic lymphocytic leukemia market, equating to $3 billion in annual sales. With advancing technology and new drug development, the BTK market is expanding rapidly. According to Frost & Sullivan, the global BTK market could reach $20 billion by 2025 and $26.1 billion by 2030. In China, the market size is expected to reach RMB 13.1 billion by 2025 and RMB 22.5 billion by 2030. The growing BTK market has attracted numerous pharmaceutical companies. At least 20 BTK inhibitors are in clinical trials domestically, with Shouyao Holdings, Hengrui Medicine, and Hezheng Pharmaceutical leading the way. Ibrutinib’s core patent will expire on December 28, 2026, and at least 10 companies are preparing generics. This will lead to fierce competition among original drugs, domestic innovations, and generics. BeiGene’s zanubrutinib remains a key product, but new competitors like pirtobrutinib pose challenges. The success of pirtobrutinib in China’s market is worth monitoring. Originally developed by Redx Pharma and acquired by Loxo Oncology, pirtobrutinib was purchased by Eli Lilly for $8 billion in 2019. In March 2022, Innovent Biologics secured Chinese commercialization rights for pirtobrutinib with an initial payment of $45 million. The partnership between Innovent Biologics and Eli Lilly began in 2015 and has expanded through multiple projects. Despite setbacks like sintilimab’s rejection by the U.S. FDA in 2022, their collaboration continues with other initiatives. Their 2019 cooperation on IBI362, a dual GLP-1R and GCGR agonist, is in Phase II/III trials for Type 2 diabetes and weight loss. In March 2022, Eli Lilly’s ramucirumab was approved in China, granting Innovent Biologics exclusive commercialization rights. Additionally, they collaborate on selpercatinib, a RET inhibitor for gene fusion tumors. The cooperation and competition between domestic and multinational pharmaceutical companies are becoming a norm. This model offers a win-win strategy for navigating the global market.

Drug ApprovalAcquisitionPhase 3Phase 2License out/in

19 Sep 2024

·www.pharmaceutical-technology.com

Novo Nordisk and Nanovation sign $600m deal in rare and cardiometabolic diseases

As part of the deal, Novo Nordisk and NanoVation will collaborate on up to seven programmes. Credit: PeopleImages.com – Yuri A via Shutterstock. Novo Nordisk has signed a $600m deal with NanoVation to develop genetic medicines for rare and cardiometabolic diseases. Free Report How is the Biopharmaceutical industry evolving? 2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape. GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects. Access the report to: Benchmark the impact of major themes on the Biopharmaceutical industry. Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents. Evaluate the effects of COVID-19 on the sector. Download the full report to understand what to expect and how to align your strategies for success. Thank you. You will receive an email shortly. Please check your inbox to download the Report. Go deeper with GlobalData Reports NPVM: Innovent Biologics Inc's Mazdutide Reports NPVM: Novo Nordisk AS's Ideal Pump Insulin Data Insights The gold standard of business intelligence. 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Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address. Novo has secured a licence to use NanoVation’s long-circulating lipid nanoparticle (lcLNP) technology for RNA delivery targeting cells outside the liver. Both companies will collaborate on two programmes to develop base-editing therapies for rare genetic diseases, with plans for up to five future targets for cardiometabolic and rare diseases. Under the agreement, Novo is paying an undisclosed upfront fee. The multi-year deal could be worth up to $600m, with NanoVation set to receive research funding eligible for potential milestone payments, as well as tiered royalties on future product sales. Novo has secured several deals in the past few years to maintain its dominant position in the cardiometabolic disease market. The Danish pharma company entered research collaborations with two US cell and gene therapy biotech startups in January, namely Omega Therapeutics and Cellarity. In February 2024, Novo partnered with US-based biotech Neomorph in a collaboration and licensing agreement to discover and develop multiple molecular glue degraders for cardiometabolic disorders and rare diseases. See Also: AstraZeneca’s Fasenra to challenge GSK’s Nucala in rare vasculitis after FDA nod FDA approves Accord BioPharma’s HERCESSI for cancer treatment Novo has also shown its commitment to developing therapies for disorders with unmet needs such as metabolic dysfunction-associated steatohepatitis (MASH). The company’s collaboration with Cellarity involves the development of therapies for MASH, for which there are no treatments approved by the US Food and Drug Administration (FDA). Novo’s Q1 2024 financial results highlighted that the company’s aspiration to expand the use of its blockbuster obesity products to cardiovascular indications has been successful. In March, its obesity drug Wegovy (semaglutide) was approved by the FDA for reducing the risk of cardiovascular diseases in obese or overweight adults. Semaglutide is also marketed as Ozempic in type 2 diabetes. Wegovy generated $4.5bn in sales for Novo in 2023, as per the company’s financials. According to GlobalData analyst consensus forecasts, the drug is set to make $19.4bn in 2030. GlobalData is the parent company of Pharmaceutical Technology. In the announcement accompanying the deal, NanoVation’s co-founder Pieter Cullis said: “Genetic medicine is at a pivotal moment and this partnership marks a major milestone for NanoVation as an innovator in nucleic acid delivery. By combining NanoVation’s expertise in extrahepatic delivery with Novo Nordisk’s expertise in cardiometabolic and rare diseases we have the potential to create truly transformative therapies.” Free Report How is the Biopharmaceutical industry evolving? 2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape. GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects. Access the report to: Benchmark the impact of major themes on the Biopharmaceutical industry. Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents. Evaluate the effects of COVID-19 on the sector. Download the full report to understand what to expect and how to align your strategies for success. Thank you. You will receive an email shortly. Please check your inbox to download the Report. 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License out/inDrug Approval

12 Sep 2024

·www.pharmaceutical-technology.com

EASD 2024: Innovent shows off mazdutide’s efficacy in diabetes and obesity

Mazdutide was developed by Eli Lilly and Innovent acquired the development and commercialisation rights to the therapy in China. Image credit: Alones / Shutterstock. Innovent Biologics has released more data from two Phase III trials evaluating mazdutide in adults with type 2 diabetes (T2D) and obesity. The China-based biotech has presented data from the Phase III GLORY-1 trial (NCT05607680) evaluating the therapy in obese or overweight individuals, along with detailed results from the Phase III DREAMS-2 trial (NCT05606913), which showed mazdutide to be superior to Eli Lilly’s Trulicity (dulaglutide) in managing T2D. The results were presented at the European Association for the Study of Diabetes (EASD) taking place from 9 to 13 September in Madrid, Spain. Mazdutide is a dual agonist of glucagon-like peptide 1 receptor (GLP-1) and human glucagon receptor (GCGR). It was developed by Eli Lilly and Innovent acquired the development and commercialisation rights to the therapy in China. Lilly retains the rights to the drug in all other countries. The Chinese company is currently conducting five Phase III trials evaluating the therapy in Chinese patients with either T2D, obesity or both. The company is also seeking regulatory approval in China for mazdutide in both chronic weight management and glycaemic control in T2D. See Also: Japan approves updated Covid-19 vaccine to tackle JN.1 variant FDA approves Roche’s Tecentriq Hybreza for cancer The EASD presentation was built on data from the randomised placebo-controlled Phase III GLORY-1 trial , which was announced at the American Diabetes Association meeting in June. The trial enrolled 610 Chinese patients who were either overweight or obese. Patients achieved 10.97% and 13.38% reduction in body weight compared to baseline with 4mg and 6mg mazdutide, respectively. At 48 weeks, more than half of patients (50.6%) on high-dose mazdutide reported at least a 15% reduction in body weight. Patients receiving mazdutide also reported an improvement in cardiovascular and kidney functions. Combined analysis of two mazdutide groups showed improvement in systolic blood pressure, triglyceride, cholesterol and low-density lipoprotein (LDL) levels, and a reduction in serum uric acid and alanine aminotransferase levels, compared to placebo. Innovent also presented exploratory data on liver stenosis (fatty liver). The results showed a dose-dependent reduction in liver fat content (LFC). A mean LFC reduction of 7.7% and 13.6% was seen with 4mg and 6mg mazdutide, respectively, compared to 0.8% LFC reduction with placebo. The DREAMS-2 trial evaluated mazdutide as an add-on therapy in 731 Chinese patients with T2D. The therapy was added to the current treatment including metformin, sodium-glucose cotransporter-2 (SGLT2) inhibitors and thiazolidinediones. After 28 weeks, patients in mazdutide 4mg and 6mg groups demonstrated a mean reduction in HbA1c 1.69% and 1.73% from baseline, respectively, compared to a 1.36% HbA1c reduction in the Trulicity group. Furthermore, 71.2% and 74.2% of patients receiving mazdutide 4mg and 6mg achieved HbA1c of less than 7%, compared to 62.1% with Trulicity. The company also highlighted the weight reduction seen by these participants. At 28 weeks, 50.1% and 64.3% of participants with mazdutide 4mg and mazdutide 6mg achieved both a weight reduction of at least 5% and HbA1c of less than 7.0%, compared to 19.4% of participants reporting the same with Trulicity. Innovent also teased improvements in cardiometabolic risk factors, including blood pressure, lipids, serum uric acid and transaminases, adding that it plans to publish the detailed results in peer-reviewed journals.

Clinical ResultPhase 3VaccineDrug Approval

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetes Mellitus, Type 2	NDA/BLA	CN	Innovent Biologics (Suzhou) Co. Ltd.	01 Aug 2024
Obesity	NDA/BLA	CN	Innovent Biologics (Suzhou) Co. Ltd.	07 Feb 2024
Early-onset type II diabetes	Phase 3	CN	Innovent Biologics (Suzhou) Co. Ltd.	29 Feb 2024
Renal Insufficiency	Phase 1	CN	Innovent Biologics (HK) Ltd.	05 May 2023
Nonalcoholic Steatohepatitis	IND Approval	CN	Innovent Biologics (Suzhou) Co. Ltd.	22 Mar 2023
Hyperuricemia	Preclinical	CN	Innovent Biologics (Suzhou) Co. Ltd.	12 Jul 2023

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05607680 (GLORY-1, NEWS) Manual	Phase 3	Overweight \| Obesity	610	Mazdutide	(dzivqyfkxk) = tfqabttvgy vvgvrxnxtb (hgepbugndk ) View more	Positive	13 Sep 2024
				Mazdutide (4 mg)	(lsrywfpmtt) = ckpdceqfnj zgnopkyocu (obahdhfyij ) View more
NCT05606913 (DREAMS-2, EASD2024) Manual	Phase 3	Diabetes Mellitus, Type 2	731	mazdutide 4mg	(gtadjlyymw) = nfxoxqcnyz cchxkozhxn (lqwpucebao ) View more	Positive	11 Sep 2024
				mazdutide 6mg	(gtadjlyymw) = bgincuwlng cchxkozhxn (lqwpucebao ) View more
NCT05623839 (EASD2024) Manual	Phase 1	Overweight \| Obesity	32	Mazdutide (cohort 1)	(lxyseqvzmj) = qmjclgscer cuxhfnkjij (jurywpsvtv ) View more	Positive	09 Sep 2024
				Mazdutide (cohort 2)	(lxyseqvzmj) = kuppianrcm cuxhfnkjij (jurywpsvtv ) View more
NCT05628311 (DREAMS-1, PRNewswire) Manual	Phase 3	Diabetes Mellitus, Type 2	-	Mazdutide 4 mg	(hmrzdhbcvq) = eafngsobsx bmdxhaevui (jiqrancxvm ) Met	Positive	21 Jul 2024
				Mazdutide 6 mg	(hmrzdhbcvq) = sjlmxjnknr bmdxhaevui (jiqrancxvm ) Met
NCT05607680 (GLORY-1, ADA2024) Manual	Phase 3	Overweight \| Obesity	69	Mazdutide 4mg	(aqwzmyvdrs) = bnsfzqlchd dprpdffewm (nmkvprpipn ) View more	Positive	21 Jun 2024
				Mazdutide 6mg	(aqwzmyvdrs) = rsgccgxjzy dprpdffewm (nmkvprpipn ) View more
NCT04904913 (ADA2024) Manual	Phase 2	Obesity	80	Mazdutide	(mhyysawujh) = ijiqpbkrdy zdcqdbovms (yohmnqbzgs ) View more	Positive	20 Jun 2024
				Placebo	(mhyysawujh) = rwxfeswzne zdcqdbovms (yohmnqbzgs ) View more
NCT05607680 (GLORY-1, ADA2024) Manual	Phase 3	Overweight \| Obesity	610	mazdutide 4 mg	(slebmlhejf) = otighjxyrh azktodyvog (putawpsjtn, 0.538) Met View more	Positive	14 Jun 2024
				mazdutide 6 mg	(slebmlhejf) = bsgbxoeidx azktodyvog (putawpsjtn, 0.558) Met View more
NCT05606913 (DREAMS-2, Corporate Publications) Manual	Phase 3	Diabetes Mellitus, Type 2	731	mazdutide 4.0 mg	(lsdpjhguva) = the superiority test was further performed, and both mazdutide 4.0 mg and 6.0 mg achieved superiority to dulaglutide 1.5 mg. ltdagvptpn (rbkvukmrfz ) Met View more	Superior	09 May 2024
				mazdutide 6.0 mg
NCT05607680 (GLORY-1, Corporate Publications) Manual	Phase 3	Overweight \| Obesity	610	玛仕度肽 4 mg	(dtsbhiivaw) = 主要研究终点顺利达成：玛仕度肽 4 mg和6 mg组受试者治疗32周后体重相对基线的百分比变化显著优于安慰剂组 tkfgbeqewr (lrpsxntwrz ) Met View more	Positive	09 Jan 2024
				玛仕度肽 6 mg
NCT04965506 (Literature) Manual	Phase 2	Diabetes Mellitus, Type 2	250	Mazdutide 3 mg	(ccblialkck) = zgxnaomcll sgqwzyigir (cqsvylcrfn ) View more	Positive	09 Nov 2023
				Mazdutide 4.5 mg	(ccblialkck) = uncevdqnes sgqwzyigir (cqsvylcrfn ) View more

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