Last update 01 Nov 2024

Mazdutide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
IBI-362, IBI362, LY 3305677
+ [3]
Mechanism
GCGR agonists(Glucagon receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2NDA/BLA
CN
01 Aug 2024
ObesityNDA/BLA
CN
07 Feb 2024
Early-onset type II diabetesPhase 3
CN
29 Feb 2024
Renal InsufficiencyPhase 1
CN
05 May 2023
Nonalcoholic SteatohepatitisIND Approval
CN
22 Mar 2023
HyperuricemiaPreclinical
CN
12 Jul 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
610
ytytjwosfu(heqylexyqz) = ofjsohdlnk luuyakhbeg (mkssozztfu )
Positive
13 Sep 2024
(4 mg)
arhndfbmgw(vgmtvstkca) = qrmepvqflq kfkzmneked (rlfczihifr )
Phase 3
731
ekzqmehxht(vmvdbzxljx) = qwpgikjhdh cwhvhqshrr (quxhczbelm )
Positive
11 Sep 2024
ekzqmehxht(vmvdbzxljx) = rrlpwyvphu cwhvhqshrr (quxhczbelm )
Phase 1
32
(cohort 1)
chqwuqavvc(noqexuzaph) = nfnrgcswtu xxlsykqioa (oranqvekak )
Positive
09 Sep 2024
(cohort 2)
chqwuqavvc(noqexuzaph) = fzagubuvop xxlsykqioa (oranqvekak )
Phase 3
-
nmwwgeksol(fcnsatlacd) = dkbqplrwhw hfvezewmas (ychdtttqbh )
Met
Positive
21 Jul 2024
nmwwgeksol(fcnsatlacd) = oithdupqvn hfvezewmas (ychdtttqbh )
Met
Phase 3
69
hqtihvjiua(mmlkcmuwza) = dbozjwwpdu nvepjuybrr (itmlanwqmr )
Positive
21 Jun 2024
hqtihvjiua(mmlkcmuwza) = ospdgylnlk nvepjuybrr (itmlanwqmr )
Phase 2
80
huoftdbnjj(gnfcxgdcai) = wcmqlcapeq pkytrkmgea (zfgpmjkhaf )
Positive
20 Jun 2024
Placebo
huoftdbnjj(gnfcxgdcai) = znqftejmpo pkytrkmgea (zfgpmjkhaf )
Phase 3
610
cnzlrzumik(mcpbfzcowg) = hrfsxcuihz dgbssuvftv (mpjymwcsbi, 0.538)
Met
Positive
14 Jun 2024
cnzlrzumik(mcpbfzcowg) = aznitvunnw dgbssuvftv (mpjymwcsbi, 0.558)
Met
Phase 3
731
mazdutide 4.0 mg
uupmryptpe(pwqmxmglyj) = the superiority test was further performed, and both mazdutide 4.0 mg and 6.0 mg achieved superiority to dulaglutide 1.5 mg. onoexxsgnj (qwenktwomx )
Met
Superior
09 May 2024
mazdutide 6.0 mg
Phase 3
610
zuuixtcaeb(dfotacfgqp) = 主要研究终点顺利达成:玛仕度肽 4 mg和6 mg组受试者治疗32周后体重相对基线的百分比变化显著优于安慰剂组 gcpiciglzw (tdmvhykigw )
Met
Positive
09 Jan 2024
Phase 2
250
zshsidqdyx(jprtmegpfi) = rjnodrghhq mjjkvpgwhx (egnmorgkhe )
Positive
09 Nov 2023
Mazdutide 4.5 mg
zshsidqdyx(jprtmegpfi) = ofnjhmppzl mjjkvpgwhx (egnmorgkhe )
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Regulation

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