A Phase 1, Two-Part, Double-blind, Placebo-controlled, Randomized Study of the Safety, Tolerability, and Pharmacokinetics of BMS-986278 (Part A) and a Randomized, Double-blind, Positive-controlled, Placebo-controlled, 4-Period Crossover, Thorough QT/QTc Study to Evaluate the Effect of Multiple Doses of BMS-986278 on Cardiac Repolarization (Part B) in Healthy Participants

The purpose of this study is to determine the safety, tolerability, and pharmacokinetics (PK) of high dose of BMS-986278 in healthy participants and to assess the effect of BMS-986278 on the ECG intervals in healthy participants.

Start Date10 Feb 2025

Sponsor / Collaborator

Bristol Myers Squibb Co.

NCT06715683

/ CompletedPhase 1

An Open-label, Randomized, 2-Part, 4-Period, 2-Sequence, Fully Replicated Crossover Study to Assess the Comparative Bioavailability of BMS-986278 To-be-marketed Formulation Compared to the Phase 3 Clinical Trial Formulation in Healthy Participants

This is a trial to evaluate the comparative bioavailability of BMS-986278 to-be-marketed formulation compared to the phase 3 clinical trial formulation in healthy participants.

Start Date12 Dec 2024

Sponsor / Collaborator

Bristol Myers Squibb Co.

NCT06723535

/ RecruitingPhase 1

An Open-Label, Single-Dose, Phase 1 Study to Evaluate the Pharmacokinetics and Safety of BMS-986278 in Participants With Normal Renal Function, Participants With Severe Renal Impairment, and Participants With End-Stage Renal Disease on Intermittent Hemodialysis

The purpose of this study is to assess the effect of severe renal impairment (RI) and end-stage renal disease (ESRD) with intermittent hemodialysis (IHD) on the pharmacokinetics and safety of BMS-986278. This study plans to use a staged design based on RI severity.

Start Date07 Dec 2024

Sponsor / Collaborator

Bristol Myers Squibb Co.

100 Clinical Results associated with Admilparant

100 Translational Medicine associated with Admilparant

100 Patents (Medical) associated with Admilparant

Literatures (Medical) associated with Admilparant

01 Apr 2025·CHEST

Effect of Admilparant, an LPA1 Antagonist, on Disease Progression in Pulmonary Fibrosis

Article

Author: Richeldi, Luca ; Maher, Toby M ; Elpers, Brandon ; Kim, Sinae ; Kreuter, Michael ; Valenzuela, Claudia ; Patel, Aditya ; Wuyts, Wim A ; Hamblin, Mark

BACKGROUND:

Idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) are chronic fibrosing interstitial lung diseases associated with irreversible loss of lung function and early mortality. Admilparant (BMS-986278) is an oral lysophosphatidic acid receptor 1 antagonist under development for treatment of IPF and PPF.

RESEARCH QUESTION:

How does admilparant affect time to disease progression in patients with IPF or PPF?

STUDY DESIGN AND METHODS:

In a phase 2, randomized, double-blind, placebo-controlled study, parallel cohorts of patients with IPF or PPF were randomized separately 1:1:1 to receive 30 mg admilparant, 60 mg admilparant, or placebo twice daily for 26 weeks; background antifibrotics were allowed. The effect of admilparant vs placebo on time to disease progression was assessed post hoc. Disease progression was defined as a composite of relative decline of ≥ 10% in percent predicted FVC (ppFVC), acute exacerbation, all-cause hospitalization, and all-cause mortality. Subgroup analyses were performed based on median ppFVC at baseline. A Kaplan-Meier product-limit approach assessed time to first event of disease progression over 26 weeks.

RESULTS:

In total, 255 patients with IPF and 114 patients with PPF were included. Median ppFVC at baseline was 77.3% and 64.7% in the IPF and PPF cohorts, respectively. Treatment with 60 mg admilparant delayed time to disease progression over 26 weeks compared with placebo in both cohorts of patients (IPF: hazard ratio, 0.54; 95% CI, 0.31-0.95; PPF: hazard ratio, 0.41; 95% CI, 0.18-0.90). A similar trend was observed in the subgroup analysis of patients with ppFVC at baseline either below or above the median value. In both cohorts, the most frequent first event was relative decline of ≥ 10% in ppFVC; no deaths were reported as first progression events.

INTERPRETATION:

These findings support further evaluation of admilparant as a therapeutic option for patients with IPF or PPF in phase 3 trials.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov; No.: NCT04308681; URL: www.

CLINICALTRIALS:

gov.

13 Mar 2025·JOURNAL OF MEDICINAL CHEMISTRY

Neutral LPAR1 Antagonists for the Treatment of Idiopathic Pulmonary Fibrosis

Article

Author: Wang, Xiaojing

Despite significant advancements in the treatment options for idiopathic pulmonary fibrosis (IPF), the disease remains aggressive and incurable. This viewpoint summarizes the discovery of a neutral, potent, and selective lysophosphatidic acid receptor 1 antagonist for the treatment of IPF. The lead optimization without the cocrystal structure guidance is worth it to highlight.

01 Feb 2025·AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting Autotaxin and Lysophosphatidic Acid in Pulmonary Fibrosis: Admilparant’s Positive Results Show Continued Promise

Communications

Author: Spagnolo, Paolo ; Molyneaux, Philip L.

News (Medical) associated with Admilparant

17 Jun 2025

·www.einpresswire.com

Pulmonologists and Rheumatologists Struggle to Diagnose and Manage CTD-ILD, According to New Research from Spherix Global Insights

Systemic sclerosis and myositis interstitial lung disease subtypes flagged as most difficult to manage; specialists cite lack of effective treatments and diagnostic clarity EXTON, PA, June 17, 2025 (GLOBE NEWSWIRE) -- According to Spherix Global Insights’ newly published Special Topix™: Interstitial Lung Disease in Rheumatology (US) report, both rheumatologists and pulmonologists report significant challenges in diagnosing and managing connective tissue disease-associated interstitial lung disease (CTD-ILD), with systemic sclerosis (SSc) and myositis (IIM) cited as the most difficult subtypes to treat. The research, based on responses from 138 US specialists (n=68 rheumatologists and 70 pulmonologists), highlights persistent unmet needs, diagnostic ambiguity, and a call for more robust and collaborative management strategies. The findings reflect that undiagnosed and misdiagnosed patients make up a substantial portion of the CTD-ILD population, with nearly one-third of rheumatologists and over half of pulmonologists naming differential diagnosis as a key challenge. Specialists underscore a lack of specific biomarkers, logistical biopsy issues, and overlapping symptoms as primary obstacles. “The most definitive test (biopsy) is invasive. It is difficult to find the clinicians who are willing to do it in a timely manner, and to convince the patient it needs to be done.” – Rheumatologist “Ensuring the correct diagnosis to avoid misdiagnosing the type of ILD or source of ILD. I usually employ the assistance of a rheumatologist.” – Pulmonologist “Often it would be difficult to get patients biopsied for logistical reasons, and often the pathology report would not be precise enough.” – Pulmonologist Even once diagnosed, CTD-ILD patients face a treatment landscape with few options to slow or halt disease progression. When asked about the most difficult aspects of management, specialists consistently pointed to a lack of effective and targeted therapies, with SSc-ILD and myositis-ILD receiving the highest unmet need scores. For SSc-ILD specifically, not only is it associated with the most aggressive progression and worst long-term outcomes, but it also presents a uniquely complex therapeutic challenge. The clinical burden is especially pronounced in patients with diffuse cutaneous systemic sclerosis (dcSSc), where the use of corticosteroids is often limited due to the heightened risk of scleroderma renal crisis. This leaves physicians with a narrow band of anti-fibrotic and immunosuppressive options, many of which are perceived as only modestly effective in controlling ILD progression, let alone reversing it. Even therapies with regulatory approval for SSc-ILD, such as Boehringer Ingelheim’s OFEV (nintedanib), garner only measured enthusiasm from treating physicians. While rheumatologists acknowledge nintedanib’s potential to slow functional decline, they note it does little to address the underlying autoimmune pathology. Similarly, mycophenolate mofetil and rituximab remain staples of clinical practice, yet their real-world performance is viewed as inconsistent and difficult to monitor. Across the board, satisfaction ratings for currently utilized agents fall short of expectations, reinforcing a treatment landscape still dominated by trial-and-error approaches. This disconnect between disease complexity and treatment efficacy is fueling demand for dual-acting agents, therapies that can address both systemic autoimmunity and pulmonary fibrosis. Nowhere is this demand more visible than in systemic lupus erythematosus-associated ILD (SLE-ILD), where rheumatologists express growing interest in GSK’s Benlysta (belimumab). Though not currently approved for ILD, belimumab’s immunologic mechanism and expanded label for lupus nephritis have raised hopes that similar benefit may extend to pulmonary manifestations. Across interviews and survey feedback, physicians articulate a desire for treatments that reduce systemic activity while simultaneously preventing fibrotic progression—without the need for an antifibrotic add-on with limited synergy. Looking ahead, specialists are cautiously optimistic about the pipeline. While interest in agents with antifibrotic and immunomodulatory properties is rising, physicians emphasize that what’s most needed is not just another drug, but a paradigm shift—a treatment model that reflects the multifaceted nature of CTD-ILD. As one physician summarized, the goal is to "treat the patient, not just the lungs." In addition to tracking physician sentiment and practice patterns, the study includes target product profile evaluations for several pipeline therapies: Benlysta (GSK), BMS-986278 (Bristol Myers Squibb), Nerandomilast (Boehringer Ingelheim), and Treprostinil (United Therapeutics). These profiles offer manufacturers timely insights into clinical expectations, adoption potential, and differentiation opportunities in an increasingly complex ILD treatment landscape. Special Topix ™ is an independent service that includes access to a report or series of reports based on current events or topics of interest in specialty markets covered by Spherix. About Spherix Global Insights Spherix is a leading independent market intelligence and advisory firm that delivers commercial value to the global life sciences industry, across the brand lifecycle. The seasoned team of Spherix experts provides an unbiased and holistic view of the landscape within rapidly evolving specialty markets, including dermatology, gastroenterology, rheumatology, nephrology, neurology, ophthalmology, and hematology. Spherix clients stay ahead of the curve with the perspective of the extensive Spherix Physician Community. As a trusted advisor and industry thought leader, Spherix’s unparalleled market insights and advisory services empower clients to make better decisions and unlock opportunities for growth. To learn more about Spherix Global Insights, visit spherixglobalinsights.com or connect through LinkedIn . For more details on Spherix’s primary market research reports and interactive dashboard offerings, visit or register here: https://clientportal.spherixglobalinsights.com NOTICE: All company, brand or product names in this press release are trademarks of their respective holders. The findings and opinions expressed within are based on Spherix Global Insight’s analysis and do not imply a relationship with or endorsement of the companies or brands mentioned in this press release. Andy Stankus, Rheumatology Franchise Head Spherix Global Insights 4848794284 andy.stankus@spherixglobalinsights.com Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

Drug Approval

13 Jan 2025

·www.pharmaceutical-technology.com

Mediar Therapeutics signs licensing deal with Eli Lilly for IPF treatment

The partnership aims to advance the idiopathic pulmonary fibrosis therapy into a Phase II trial. Credit: Andrey_Popov/Shutterstock. Mediar Therapeutics has entered a global licensing agreement with Eli Lilly and Company to progress the human immunoglobulin G1(IgG1) antibody, MTX-463, into a Phase II trial for the treatment of idiopathic pulmonary fibrosis (IPF). Free Report 2022: So far In Venture Capital Global investment in 2022 has been majorly dominated by North America, Europe, and Asia Pacific, whereas the Middle East, and South and Central America have recorded low investments comparatively. In light of this, Europe and North America have been identified as the major destinations for Private Equity and Venture Capital (PE/VC) investments. GlobalData’s whitepaper analyzes which sectors PE/VC firms have been investing in, looking at Technology, Media, and Telecom, with these sectors recording $356 billion and a deal volume of over 10,000 deals in 2022. Healthcare, Financial Services, Business & Consumer Services, and Construction sectors have also seen high investment activity by PE/VC firms, recording a deal value of over $70 billion each. But what can this mean for you? Understand how the Deals Database on GlobalData Explorer can be leveraged to: Track the Aggregate Investment Volumes in PE/VC-Stage firms across geographies and sectors, in addition to viewing the specific deals that drove these volumes Identify the top investors already active in any sector-Geography combinations Assess the Performance of Financial and Legal Advisors, supporting the Dealmaking in any segment of choice (Customizable League tables) Understand what is driving the PE/VC fundraising (Deal Rationale) Consult our full report here and optimize your business strategy. Thank you. You will receive an email shortly. Please check your inbox to download the Report. Go deeper with GlobalData Reports NPVM: Bristol-Myers Squibb Co's BMS-986278 Reports NPVM: Bristol-Myers Squibb Co's CC-90001 Data Insights The gold standard of business intelligence. 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Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address. Mediar will receive $99m, consisting of an upfront payment and near-term milestones, with a further potential $687m from future development and commercialisation, and royalties and net sales milestones from future product sales. In a recently completed Phase I trial of healthy volunteers, the therapy was found to be well-tolerated and to engage’ WNT1-inducible signalling pathway protein 1 (WISP1) at all tested doses. The upcoming Phase II trial will assess the pharmacokinetics, efficacy and safety of the therapy in IPF subjects. Mediar plans to commence the trial in the first half of 2025 and will be responsible for its conduct. Post-Phase II, Lilly is set to take over further clinical development and commercialisation efforts. Mediar Therapeutics CEO Rahul Ballal stated: “This collaboration supports our unique myofibroblast-directed approach to treating fibrotic diseases and our mission to bring first-in-class therapies to patients with high unmet medical need.” In addition to MTX-463, Mediar is independently progressing two other proprietary programmes targeting fibrotic disorders. In a separate announcement, Eli Lilly has revealed its plans to establish a new global capability centre in Hyderabad, India, as reported by The Economic Times . The Lilly Capability Centre India (LCCI) Hyderabad is set to focus on enhancing Lilly’s digital capabilities in areas such as artificial intelligence, automation, software product engineering and cloud computing. Recruitment is already in progress for the centre, which will be operational by mid-2025. It is the company’s second such facility in India, following LCCI Bengaluru’s launch in 2016. In December 2024, Eli Lilly’s Zepbound (tirzepatide) received a label expansion from the US Food and Drug Administration to treat adults with obesity and moderate to severe obstructive sleep apnoea. Free Report 2022: So far In Venture Capital Global investment in 2022 has been majorly dominated by North America, Europe, and Asia Pacific, whereas the Middle East, and South and Central America have recorded low investments comparatively. In light of this, Europe and North America have been identified as the major destinations for Private Equity and Venture Capital (PE/VC) investments. GlobalData’s whitepaper analyzes which sectors PE/VC firms have been investing in, looking at Technology, Media, and Telecom, with these sectors recording $356 billion and a deal volume of over 10,000 deals in 2022. Healthcare, Financial Services, Business & Consumer Services, and Construction sectors have also seen high investment activity by PE/VC firms, recording a deal value of over $70 billion each. But what can this mean for you? Understand how the Deals Database on GlobalData Explorer can be leveraged to: Track the Aggregate Investment Volumes in PE/VC-Stage firms across geographies and sectors, in addition to viewing the specific deals that drove these volumes Identify the top investors already active in any sector-Geography combinations Assess the Performance of Financial and Legal Advisors, supporting the Dealmaking in any segment of choice (Customizable League tables) Understand what is driving the PE/VC fundraising (Deal Rationale) Consult our full report here and optimize your business strategy. Thank you. You will receive an email shortly. Please check your inbox to download the Report. 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Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Phase 2Phase 1License out/in

08 Jul 2024

·www.pharmaceutical-technology.com

Lilly bolsters IBD portfolio with $3.2bn Morphic acquisition

Inflammatory bowel disease, which includes crohn’s disease and ulcerative colitis, are characterised by chronic inflammation of the gastrointestinal tract. Credit: SewCreamStudio via Shutterstock. Eli Lilly has signed a definitive agreement to acquire Morphic Holding for $3.2bn, expanding its inflammatory bowel disease (IBD) portfolio. Free Report How is the Biopharmaceutical industry evolving? 2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape. GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects. Access the report to: Benchmark the impact of major themes on the Biopharmaceutical industry. Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents. Evaluate the effects of COVID-19 on the sector. Download the full report to understand what to expect and how to align your strategies for success. Thank you. You will receive an email shortly. Please check your inbox to download the Report. Go deeper with GlobalData Reports LOA and PTSR Model - MORF-057 in Ulcerative Colitis Reports NPVM: Bristol-Myers Squibb Co's BMS-986278 Data Insights The gold standard of business intelligence. Find out more Related Company Profiles Eli Lilly and Co Takeda Pharmaceutical Co Ltd AbbVie Inc Bristol-Myers Squibb Co DICE Therapeutics Inc View all By GlobalData Submit Country Code * UK (+44) USA (+1) Algeria (+213) Andorra (+376) Angola (+244) Anguilla (+1264) Antigua & Barbuda (+1268) Argentina (+54) Armenia (+374) Aruba (+297) Australia (+61) Austria (+43) Azerbaijan (+994) Bahamas (+1242) Bahrain (+973) Bangladesh (+880) Barbados (+1246) Belarus (+375) Belgium (+32) Belize (+501) Benin (+229) Bermuda (+1441) Bhutan (+975) Bolivia (+591) Bosnia Herzegovina (+387) Botswana (+267) Brazil (+55) Brunei (+673) Bulgaria (+359) Burkina Faso (+226) Burundi (+257) Cambodia (+855) Cameroon (+237) Canada (+1) Cape Verde Islands (+238) Cayman Islands (+1345) Central African Republic (+236) Chile (+56) China (+86) Colombia (+57) Comoros (+269) Congo (+242) Cook Islands (+682) Costa Rica (+506) Croatia (+385) Cuba (+53) Cyprus North (+90392) Cyprus South (+357) Czech Republic (+42) Denmark (+45) Djibouti (+253) Dominica (+1809) Dominican Republic (+1809) Ecuador (+593) Egypt (+20) El Salvador (+503) Equatorial Guinea (+240) Eritrea (+291) Estonia (+372) Ethiopia (+251) Falkland Islands (+500) Faroe Islands (+298) Fiji (+679) Finland (+358) France (+33) French Guiana (+594) French Polynesia (+689) Gabon (+241) Gambia (+220) Georgia (+7880) Germany (+49) Ghana (+233) Gibraltar (+350) Greece (+30) Greenland (+299) Grenada (+1473) Guadeloupe (+590) Guam (+671) Guatemala (+502) Guinea (+224) Guinea - 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Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address. Through the deal – which is expected to close in Q3 2024 – Lilly will inherit Morphic’s lead asset, MORF-057. The candidate is under investigation in two Phase II studies for ulcerative colitis and one Phase II study for Crohn’s disease. The small molecule drug inhibits α4β7, an integrin expressed on some white blood cells. With this deal, Lilly looks to challenge Takeda’s blockbuster drug Entyvio (vedolizumab), which bagged a US Food and Drug Administration (FDA) approval in April 2014 to treat IBD. Entyvio is also an α4β7 inhibitor shown to reduce inflammation in the gut and control symptoms of IBD. However, the oral format of MORF-057, compared to the intravenous and now injectable versions of Entyvio, may open up a new market opportunity for Lilly, with some patients preferring oral medications due to ease. IBD is the umbrella term for two chronic conditions: Crohn’s disease and ulcerative colitis, both of which cause inflammation in the digestive tract. GlobalData estimates that the Crohn’s and ulcerative colitis markets will be worth $25.5bn and $14.7bn by 2032, respectively. GlobalData is the parent company of Pharmaceutical Technology. See Also: How will a Labour government support the UK clinical trials industry? TLC-2716 by OrsoBio for Familial Hypercholesterolemia (Type II Hyperlipoproteinemia): Likelihood of Approval Lilly already has an IBD drug under its belt—anti-interleukin (IL)-23 therapy Omvoh (mirikizumab), which secured FDA approval for treating ulcerative colitis in October 2023. According to GlobalData’s Pharma Intelligence Center, Omvoh will generate $939m in sales in 2030. The IBD field is quite crowded, with AbbVie ’s Humira (adalimumab) being the top earner. However, there is still a potential preference for oral drug formulations like Bristol Myers Squibb ’s (BMS) Zeposia (ozanimod), and AbbVie’s Rinvoq (upadacitinib). In the announcement accompanying the acquisition, Lilly’s chief scientific officer Daniel Skovronsky said: “Oral therapies could open up new possibilities for earlier intervention in diseases like ulcerative colitis, and also provide the potential for combination therapy to help patients with more severe disease.” This latest deal comes after a flurry of high-profile acquisitions from Lilly last year, including DICE Therapeutics for $2.4bn in June 2023 , where it inherited a preclinical oral α4β7 programme. In October 2023, Lilly signed a definitive agreement for the acquisition of radiopharmaceutical company POINT Biopharma for an all-in cash price of $1.4bn. Free Report How is the Biopharmaceutical industry evolving? 2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape. GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects. Access the report to: Benchmark the impact of major themes on the Biopharmaceutical industry. Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents. Evaluate the effects of COVID-19 on the sector. Download the full report to understand what to expect and how to align your strategies for success. Thank you. You will receive an email shortly. Please check your inbox to download the Report. By GlobalData Submit Country Code * UK (+44) USA (+1) Algeria (+213) Andorra (+376) Angola (+244) Anguilla (+1264) Antigua & Barbuda (+1268) Argentina (+54) Armenia (+374) Aruba (+297) Australia (+61) Austria (+43) Azerbaijan (+994) Bahamas (+1242) Bahrain (+973) Bangladesh (+880) Barbados (+1246) Belarus (+375) Belgium (+32) Belize (+501) Benin (+229) Bermuda (+1441) Bhutan (+975) Bolivia (+591) Bosnia Herzegovina (+387) Botswana (+267) Brazil (+55) Brunei (+673) Bulgaria (+359) Burkina Faso (+226) Burundi (+257) Cambodia (+855) Cameroon (+237) Canada (+1) Cape Verde Islands (+238) Cayman Islands (+1345) Central African Republic (+236) Chile (+56) China (+86) Colombia (+57) Comoros (+269) Congo (+242) Cook Islands (+682) Costa Rica (+506) Croatia (+385) Cuba (+53) Cyprus North (+90392) Cyprus South (+357) Czech Republic (+42) Denmark (+45) Djibouti (+253) Dominica (+1809) Dominican Republic (+1809) Ecuador (+593) Egypt (+20) El Salvador (+503) Equatorial Guinea (+240) Eritrea (+291) Estonia (+372) Ethiopia (+251) Falkland Islands (+500) Faroe Islands (+298) Fiji (+679) Finland (+358) France (+33) French Guiana (+594) French Polynesia (+689) Gabon (+241) Gambia (+220) Georgia (+7880) Germany (+49) Ghana (+233) Gibraltar (+350) Greece (+30) Greenland (+299) Grenada (+1473) Guadeloupe (+590) Guam (+671) Guatemala (+502) Guinea (+224) Guinea - 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British (+1284) Virgin Islands - US (+1340) Wallis & Futuna (+681) Yemen (North)(+969) Yemen (South)(+967) Zambia (+260) Zimbabwe (+263) Country * UK USA Afghanistan Åland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos Islands Colombia Comoros Congo Democratic Republic of the Congo Cook Islands Costa Rica Côte d"Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guam Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See Honduras Hong Kong Hungary Iceland India Indonesia Iran Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati North Korea South Korea Kuwait Kyrgyzstan Lao Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, The Former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands Martinique Mauritania Mauritius Mayotte Mexico Micronesia Moldova Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Northern Mariana Islands Norway Oman Pakistan Palau Palestinian Territory Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Puerto Rico Qatar Réunion Romania Russian Federation Rwanda Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Pierre and Miquelon Saint Vincent and The Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and The South Sandwich Islands Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates US Minor Outlying Islands Uruguay Uzbekistan Vanuatu Venezuela Vietnam British Virgin Islands US Virgin Islands Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Kosovo By downloading this case study, you acknowledge that GlobalData may share your information with GlobalData and that your personal data will be used as described in their Privacy Policy Tick here to opt out of curated industry news, reports, and event updates Submit Visit our Privacy Policy for more information about our services, how GlobalData may use, process and share your personal data, including information on your rights in respect of your personal data and how you can unsubscribe from future marketing communications. 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Drug ApprovalAcquisitionPhase 2Biosimilar

100 Deals associated with Admilparant

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Indication	Highest Phase	Country/Location	Organization	Date
Progressive fibrotic interstitial lung disease	Phase 3	United States	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	China	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	Japan	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	Argentina	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	Australia	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	Austria	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	Belgium	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	Brazil	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	Canada	Bristol Myers Squibb Co.	25 Oct 2023
Progressive fibrotic interstitial lung disease	Phase 3	Chile	Bristol Myers Squibb Co.	25 Oct 2023

Clinical Result

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT06025578 (ALOFT-PPF, ATS2025)	Phase 3	Progressive pulmonary fibrosis	-	Admilparant 60 mg	tmmbhzxoth(qwnhkvintb) = observed in 13/42 (31.0%) patients gcisbnlrsy (fdvkgcyunq ) View more	Positive	16 May 2025
				Admilparant 120 mg
NCT04308681 (Pubmed \| Am J Respir Crit Care Med) Manual	Phase 2	Idiopathic Pulmonary Fibrosis \| Progressive fibrotic interstitial lung disease	-	Admilparant 30mg	rwlmurbvzk(ymdfavdbut) = Diarrhea occurred at similar frequencies in admilparant arms versus placebo qkonzcgvsf (znfbimcigh ) View more	Positive	11 Oct 2024
				Admilparant 60mg
NCT04308681 (ALOFT, Corporate Publications) Manual	Phase 2	Progressive fibrotic interstitial lung disease	122	BMS-986278 30 mg	rorpjozfhj(rbdtcvkaex) = nqkimaomhv jopotfhoxv (ojyqgiszvc ) View more	Positive	09 Sep 2023
				BMS-986278 30 mg	rorpjozfhj(rbdtcvkaex) = qpivzvahdb jopotfhoxv (ojyqgiszvc ) View more
NCT04308681 (Corporate Publications) Manual	Phase 2	Idiopathic Pulmonary Fibrosis	276	BMS-986278 30 mg	waqlpcdbfy(dgqawawbfg) = efqeudmcak ejsedeofpi (ecifuaumih, -1.8 to 1.4) Met View more	Positive	22 May 2023
				BMS-986278 60 mg	waqlpcdbfy(dgqawawbfg) = fwocdinbei ejsedeofpi (ecifuaumih, -0.1 to 3.0) Met View more
ATS2023	Not Applicable	Idiopathic Pulmonary Fibrosis	-	BMS-986278 30mg	nleobrhokn(izrkagzwtf) = 5%, 8%, 11% ewluebkehw (vtdymrecmy ) View more	-	21 May 2023
				BMS-986278 60mg
NCT04308681 (Pubmed \| J Med Chem)	Phase 2	Lung Diseases	278	BMS-986278	afydubqpkl(cycjzqoksr) = yrxbmdzyki nlpvrsremo (vbgkunjxuq )	-	28 Oct 2021
ERS2020	Not Applicable	-	15	BMS-986278	wclrwvmwdn(ctzzcthkut) = wpnxnnfoxs qdntpqpkdt (kyjnosfqzq )	-	07 Sep 2020
IM027-009 \| BMS-986278 (ERS2019)	Phase 1	-	-	BMS-986278	rewvkhrfqu(jparwnslbh) = the most common AE was headache mpydeoltnx (hahampfhcf ) View more	Positive	28 Sep 2019

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