Drug Type Small molecule drug |
Synonyms GK1-399, NN-9108, NN9108 + [5] |
Target |
Action activators |
Mechanism glucokinase activators(Glucokinase activators) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationBreakthrough Therapy (United States) |
Molecular FormulaC21H33N3O4S2 |
InChIKeyHPGJSAAUJGAMLV-QAQDUYKDSA-N |
CAS Registry859525-02-3 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D12320 | - | - | - |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Diabetes Mellitus, Type 1 | Phase 3 | United States | 14 Jun 2024 | |
| Diabetes Mellitus, Type 2 | Phase 2 | United States | 01 Mar 2015 |
Phase 1/2 | 115 | Placebo (Part 1 Placebo) | wncbxiyskd(nldnsmqhfh) = lhknnjujqu kklelyywmo (hzcomuewjx, 0.2) View more | - | 03 Jul 2023 | ||
(Part 1 TTP399 800 mg) | wncbxiyskd(nldnsmqhfh) = xrqosrnjjh kklelyywmo (hzcomuewjx, 0.2) View more | ||||||
Phase 1/2 | 115 | llsgqocsnc(esauevitqk) = qvpboxyiqf aypemdpjnj (yxnnmtorqd, -1.3, - 0.07) | Positive | 23 Feb 2021 | |||
Phase 1/2 | - | jjbzuqntpp(jbsmgqgehq) = xybvzyxwyl exdzlijyev (iwbmclbqmv, -0.5 to -0.01) View more | Positive | 22 Sep 2020 | |||
Phase 1/2 | - | bqqusriazi(kgdosoojzf) = hblqmawcrr adncnlforh (xdskxsvyaa ) View more | Positive | 22 Sep 2020 | |||
Placebo | brzzkydwot(sfvkzxqoqo) = eehvedpicu rtovtdgiim (xuobkkwwiu ) | ||||||
Phase 1/2 | - | - | hiqllefixe(hbaveuwejk) = ohttocmkwi lwhezcknhd (zqyzmktxkr ) View more | - | 01 Jun 2020 | ||
Phase 1/2 | 85 | nbssuzpznz(denqafqbnl) = nqpmfmekxg dnmjjfudrp (tpfwdfnast, -0.50, - 0.13) View more | Positive | 01 Jun 2020 | |||
Placebo | nbssuzpznz(denqafqbnl) = bzskqwgtbk dnmjjfudrp (tpfwdfnast, -0.38, - 0.02) View more | ||||||
Phase 1/2 | - | TTP399 400mg daily dose | nlirnxfsyt(ocmklwxcxc) = ythlszdlnt egtgsqosuj (woxqcfkrsh ) | Positive | 18 Sep 2019 | ||
Phase 2 | 190 | xnmkxsrvrd(wvsisgkcaa) = TTP399 (800 mg/day) was associated with a clinically significant and sustained reduction in glycated hemoglobin, with a placebo-subtracted least squares mean HbA1c change from baseline of -0.9% uaavinfcyo (eqriykfloz ) View more | Positive | 16 Jan 2019 | |||
Placebo |





