This is an observational, cohort study that will use secondary data to describe the baseline demographics and clinical characteristics in patients who received EVUSHELD as PrEP against SARS-CoV-2 infection/COVID-19 in Japan.
All patients who have a record of administration of EVUSHELD in the database will be included in the study. The index date will be defined as the date of first EVUSHELD administration in the database (Day 0) and the patients will be followed up to 6 months after the index date (Day 1 to 180). The look back period is defined as the 12-month period prior to index date (Day -360 to -1). The exposure of interest will be defined as the administration of EVUSHELD for use as PrEP against COVID-19. As the result of feasibility assessment, sample size of the study expected to be approximately 280.

Start Date06 Dec 2023

Sponsor / Collaborator

AstraZeneca PLC

NCT05465876 / WithdrawnPhase 2IIT

A Multi-Center, Open-Label, Single-Arm Phase II Trial of Antibody Combination EVUSHELD (Tixagevimab and Cilgavimab) to Provide Passive Immunity Against COVID-19 in Vaccine Non-responsive Chronic Lymphocytic Leukemia

Chronic lymphocytic leukaemia (CLL) is a common lymphoid malignancy affecting older adults. CLL patients are immunocompromised by the disease itself and by several of its therapies. It has now been shown that many CLL patients do not mount an antibody response following COVID-19 vaccination and are therefore at risk of COVID-19 infection. Furthermore, patients with hematologic malignancies are known to be at increased risk of severe infection if they do acquire COVID-19 infection.
The purpose of this trial is to document evidence of passive immunity to COVID-19 infection after EVUSHELD administration with serologic and neutralization assays at multiple post administration time points in patients with no response to standard of care vaccination to COVID-19.
This trial will include a single dose of EVUSHELD to be administered, with a 1-year follow-up period, comprising of 8 health status visits.
Blood samples will be taken at screening, baseline and at multiple health status visits over the course of the year for various antibody testing and analysis. T cell reactivity to COVID-19 epitopes will be studied at baseline and again monthly for 3 months in any participants that become infected with COVID-19.

Start Date01 Oct 2023

Sponsor / Collaborator

Sunnybrook Health Sciences Centre

[+1]

NCT05569408 / CompletedNot Applicable

An Observational Study to Assess the Real-world Effectiveness of EVUSHELD™ (Tixagevimab/Cilgavimab) as Pre-exposure Prophylaxis Against COVID-19 Among EVUSHELD-eligible Populations in the United States Department of Defense Healthcare System

An AstraZeneca-sponsored observational, electronic healthcare record (EHR)-embedded retrospective cohort study to assess the real-world effectiveness of EVUSHELD against SARS-CoV-2 infection, COVID-19-related hospitalization, and other COVID-19 related outcomes in the total EUA-eligible patient population treated in DoD Health system.

Start Date10 Aug 2023

Sponsor / Collaborator

AstraZeneca PLC

100 Clinical Results associated with Cilgavimab/Tixagevimab

100 Translational Medicine associated with Cilgavimab/Tixagevimab

100 Patents (Medical) associated with Cilgavimab/Tixagevimab

100

Literatures (Medical) associated with Cilgavimab/Tixagevimab

31 Dec 2024·Human Vaccines & Immunotherapeutics

Immunogenicity and safety of tixagevimab-cilgavimab for COVID-19 pre-exposure prophylaxis in immunocompromised 20 to <40 kg children and adolescents: A pilot, prospective, open-labeled study

Article

Author: Pheerapanyawaranun, Chatkamol ; Copeland, Katherine ; Niyomnaitham, Suvimol ; Charuvanij, Sirirat ; Chokephaibulkit, Kulkanya ; Jansarikit, Laddawan ; Pitisuttithum, Onsiri ; Piyaphanee, Nuntawan ; Rungmaitree, Supattra ; Buaboonnam, Jassada

We evaluated the immunogenicity of 300 mg Tixagevimab-Cilgavimab in immunocompromised children and adolescents who weighed 20 to >40 kg. Six to 18-year-old participants were divided into two groups by body weight and received 300 mg (20 to <40 kg) and 600 mg (≥40 kg) Tixagevimab-Cilgavimab, respectively. Anti-SARS-CoV-2 receptor-binding domain IgG concentrations and pseudovirus neutralizing antibody (NAb) titers were measured at 4, 12, and 24 weeks after administration and compared with reference data from healthy Thai children at 2 weeks after three BNT162b2 vaccinations. Of 59 participants, 49.2% were female, with a median (IQR) age of 12 (9, 15) years; 16 (27.1%) had cancer. NAb titers (95% CI) for the ancestral Wuhan strain were comparatively high for both dosing regimens (16363.2 [13765.9, 19450.5] vs 17768.3 [15539.5, 20316.9] in 20 to <40 kg and ≥40 kg participants, respectively) and significantly higher than reference titers (P < 0.001 for both). NAb titers for Omicron BA.4/5 were on par with the reference for both dosing regimens. Adverse events were mild, well tolerated, and slightly more prevalent in ≥40 kg participants who received full-dose Tixagevimab-Cilgavimab. Minimal waning in anti-RBD IgG concentrations, comparable to the reference, was observed at 12 and 24 weeks after Tixagevimab-Cilgavimab administration for both regimens. We concluded that half-dose Tixagevimab-Cilgavimab in 20 to <40 kg participants generated equivalent antibodies to standard doses in ≥40 kg participants and significantly higher antibodies than three-dose BNT162b2 vaccination. Further study of monoclonal long-acting antibodies in larger cohorts and <6-year-old children are warranted.

04 Nov 2024·JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antiviral effect of Evusheld in COVID-19 hospitalized patients infected with pre-Omicron or Omicron variants: a modelling analysis of the randomized DisCoVeRy trial

Article

Author: Poignard, Pascal ; Guedj, Jérémie ; Lingas, Guillaume ; Peiffer-Smadja, Nathan ; Gaymard, Alexandre ; Ader, Florence ; Massonnaud, Clément ; Bouscambert-Duchamp, Maude ; Beaulieu, Maxime ; Hites, Maya ; Mentré, France ; Carcelain, Guislaine

Abstract:

Background:

The antiviral efficacy of Evusheld (AZD7442) in patients hospitalized for SARS-CoV-2 is unknown.

Methods:

We analysed the evolution of both the nasopharyngeal viral load and the serum neutralization activity against the variant of infection in 199 hospitalized patients (109 treated with Evusheld, 90 treated with placebo) infected with the SARS-CoV-2 virus and included in the randomized, double-blind, trial DisCoVeRy (NCT04315948). Using a mechanistic mathematical model, we reconstructed the trajectories of viral kinetics and how they are modulated by the increase in serum neutralization activity during Evusheld treatment.

Results:

Our model identified that the neutralization activity was associated with viral kinetics. Reflecting the variant-dependent neutralization activity of Evusheld, the antiviral activity of Evusheld was larger in patients infected with pre-Omicron or Omicron BA.2 variants than in patients infected with Omicron BA.1 variant. More specifically, the model predicted that Evusheld reduced the median time to viral clearance compared with placebo-treated patients by more than 5 days in patients infected by pre-Omicron (median: 5.9; 80% PI: 2.1–13.6) or Omicron BA.2 (median: 5.4; 80% PI: 2.0–12.4), respectively. The effect was more modest in patients infected by the Omicron BA.1 variant, reducing the median time to viral clearance by 2 days (median: 2.2; 80% PI: 0.4–8.9).

Conclusions:

Hospitalized patients treated with Evusheld had a shorter median time to SARS-CoV-2 viral clearance. As Evusheld antiviral activity is mediated by the level of neutralization activity, its impact on viral clearance varies largely according to the variant of infection.

01 Oct 2024·VACCINE

“REAl LIfe” observational study on the effectiveness of Evusheld prophylaxis against SARS-CoV-2 omicron variants in vaccine non-responder immunocompromised patients (REALISE)

Article

Author: Novelli, Viola ; Fassio, Federico ; Calvi, Monica ; Pattonieri, Eleonora Francesca ; Meloni, Federica ; Seminari, Elena Maria ; Montini, Simone ; Defrancesco, Irene ; Baldanti, Fausto ; Girardi, Daniela ; Esposito, Giuliana Lucia ; Lilleri, Daniele ; Marena, Carlo ; Codullo, Veronica ; Picasso, Erica ; Bianchessi, Antonio

BACKGROUND:

Infection by SARS-CoV2 has become a challenge, especially for immunocompromised patients who show a weaker humoral response to COVID-19 vaccine. Tixagevimab+cilgavimab (Evusheld) is a combination of human monoclonal antibodies that can be used for pre-exposure prophylaxis to prevent infection or disease by SARS-CoV2.

OBJECTIVES:

Our study aimed to investigate the effectiveness of Evusheld by comparing an Exposed and an Unexposed group.

STUDY DESIGN:

Immunocompromised patients were enrolled in the Evusheld Group between March and September 2022. All patients had anti-spike IgG antibody levels <260 BAU/ml before administration of Evusheld. Blood samples for serological evaluations were collected, and anti-Spike antibodies were tested. For the Unexposed Group, a serologic test was performed at enrollment and a questionnaire was performed after 6 months.

RESULTS:

43 patients received Evusheld pre-exposure prophylaxis and 45 patients not receiving Evusheld were enrolled in the Unexposed group. The median age was 59.0 years in the Evusheld group, and 63.0 in the unexposed group. In the Evusheld group, during the Omicron wave in Italy, 23.3% of subjects developed symptomatic infection compared to 42.2% in the unexposed group. A majority of infections was seen in male respect to female patients. No difference in length of infection between the groups was seen. Antibody level remained higher than the basal threshold at 180 days from enrollment.

CONCLUSIONS:

Evusheld seems to reduce the rate of symptomatic infection in immunocompromised patients. Further data are required to determine whether this prophylaxis may have a longer-lasting effect over time.

News (Medical) associated with Cilgavimab/Tixagevimab

01 Jul 2024

·pipelinereview.com

Sipavibart EMA regulatory submission accepted under accelerated assessment for COVID-19 prevention

Submission based on positive SUPERNOVA Phase III trial data which demonstrated a statistically significant reduction in the incidence of COVID‑19 in an immunocompromised patient population LONDON, UK I July 01, 2024 I AstraZeneca’s Marketing Authorisation Application (MAA) for sipavibart has been accepted under an accelerated assessment procedure by the European Medicines Agency (EMA), for the pre-exposure prophylaxis (prevention) of COVID-19 in immunocompromised patients. Sipavibart is an investigational long-acting antibody designed to provide COVID-19 protection for immunocompromised patients who often do not respond adequately to vaccination alone and remain at high risk of serious outcomes from COVID-19. The EMA’s Committee for Medicinal Products for Human Use (CHMP) granted sipavibart accelerated assessment as it was deemed of major interest for public health and therapeutic innovation. Accelerated assessment aims to reduce the timeframe for the CHMP to review a MAA compared to the standard procedure. The MAA is based on positive results from the SUPERNOVA Phase III trial which demonstrated sipavibart’s safety and efficacy in preventing symptomatic COVID-19 in immunocompromised patients, compared to control, in a variant landscape in which COVID-19 cases captured over the course of the trial were caused by several different SARS-CoV-2 variants. 1 SUPERNOVA is the only Phase III trial that provides efficacy data for COVID-19 pre-exposure prophylaxis exclusively in immunocompromised patients. 2 Prof. Paul Loubet, M.D., Ph.D., MPH, Professor of infectious diseases, University of Montpellier, head of the Infectious and Tropical Diseases department, Nîmes University Hospital, France, and SUPERNOVA trial investigator, said: “The disease burden of COVID-19 remains high for immunocompromised patients who are disproportionately impacted compared to the general population, despite vaccination. With cases expected to rise in the winter months, adding more pressure to stretched healthcare systems, sipavibart has the potential to be an important option for immunocompromised patients who remain at risk, and it has demonstrated COVID-19 protection in a mixed variant environment.” Iskra Reic, Executive Vice President, Vaccines and Immune Therapies, AstraZeneca, said: “Immunocompromised patients currently have no options for COVID-19 protection in Europe beyond vaccination, which often is not sufficient to protect them against serious COVID-19 outcomes. We are pleased that the EMA has accepted this regulatory submission with an accelerated assessment procedure and will work to bring sipavibart to these highly vulnerable patients.” Data from the SUPERNOVA trial will be presented at a forthcoming medical meeting. In addition to the EMA, AstraZeneca is in dialogue with other regulatory authorities on potential authorisation or approval pathways for sipavibart. Notes COVID-19 and the continued unmet need in the immunocompromised population Despite the World Health Organization declaring an end to the pandemic a year ago, COVID-19 remains a significant problem for immunocompromised patients today and severe COVID-19 outcomes can fluctuate significantly throughout the year. People who are immunocompromised including blood cancer patients, those who have organ transplants, those with end-stage renal disease requiring dialysis and those taking immunosuppressive medications typically have an insufficient immune response to COVID-19 vaccination, leaving them at high risk of severe outcomes from COVID-19, even when fully vaccinated. 3-8 Findings from INFORM , a large real-world evidence study, reinforce the ongoing, significant and disproportionate burden of COVID-19 for the immunocompromised compared to the general population. Despite accounting for up to 4% of the INFORM study population, about 25% of COVID-19 hospitalisations, ICU admissions and deaths are borne by immunocompromised patients, even after multiple doses of COVID-19 vaccines. 3 SUPERNOVA SUPERNOVA is a large Phase III, global, randomised, double-blind, placebo-controlled trial assessing the safety and efficacy of sipavibart compared to control (tixagevimab/cilgavimab or placebo) for the prevention of COVID-19, providing the only COVID-19 efficacy data in immunocompromised patients. 2 Positive high-level results from SUPERNOVA showed that sipavibart demonstrated a statistically significant reduction in the incidence of symptomatic COVID‑19 compared to control (tixagevimab/cilgavimab or placebo) in an immunocompromised patient population. 1 The trial met both dual primary endpoints; relative risk reduction of symptomatic COVID-19 caused by any SARS-CoV-2 variant and the relative risk reduction of infections caused by SARS-CoV-2 variants not containing the F456L mutation. 1 SUPERNOVA demonstrated the potential benefit of sipavibart in an evolving variant landscape in which COVID-19 cases captured over the course of the trial were caused by several different SARS-CoV-2 variants. 1 All participants in the trial had an immunocompromising condition and/or were on immunosuppressive treatments, which put them at risk to mount an inadequate immune response to vaccination and at high risk of developing severe COVID-19. Participants enrolled in the study included patients with conditions such as hematologic malignancies, solid organ transplant recipients, hematopoietic stem cell transplants, end stage kidney disease/dialysis, and being within one year of receipt of B cell depleting therapy. 1,2 Sipavibart was generally well-tolerated in the trial and preliminary analyses show adverse events were balanced between the control and sipavibart arms. 1 Sipavibart Sipavibart (formerly AZD3152) is an investigational long-acting monoclonal antibody (LAAB) against COVID-19. Sipavibart was designed to provide broad and potent coverage across Omicron and ancestral viral variants by neutralising spike protein interaction with the host receptor ACE2. 9 Sipavibart was derived from B-cells donated by convalescent patients after SARS-CoV-2 infection. Sipavibart has been engineered using the same antibody scaffold as Evusheld and was optimised with the same half-life extension and reduced Fc effector function and complement C1q binding platform. 9 The reduced Fc effector function aims to minimise the risk of antibody-dependent enhancement of disease – a phenomenon in which virus-specific antibodies promote, rather than inhibit, infection and/or disease. Sipavibart was licensed by AstraZeneca in May 2022 from RQ Biotechnology . AstraZeneca AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca’s innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on social media @AstraZeneca . References 1. AstraZeneca. (16 May 2024). SUPERNOVA Phase III trial of sipavibart long-acting antibody met primary endpoints in preventing COVID-19 in immunocompromised patient population [Press Release]. Las Accessed June 2024 https://www.astrazeneca.com/media-centre/press-releases/2024/supernova-trial-met-covid-19-prevention-endpoint.html . 2. Clinialtrials.gov. Last Accessed June 2024 https://clinicaltrials.gov/study/NCT05648110?term=AZD3152&rank=3 3. Evans RA et al. Impact of COVID-19 on Immunocompromised Populations during the Omicron Era: Insights from the Observational Population-Based INFORM Study. The Lancet Regional Health – Europe . 2023;0(0):100747. doi:10.1016/J.LANEPE.2023.100747 4. Dube S. Continued Increased Risk of COVID-19 Hospitalisation and Death in Immunocompromised Individuals Despite Receipt of ≥4 Vaccine Doses: Updated 2023 Results from INFORM, a Retrospective Health Database Study in England. Poster P0409 at ECCMID 2024. 5. Turtle L. Individuals with Multiple Sclerosis Are at High Risk for COVID-19 Hospitalisation and Death Despite High Rates of Vaccination: Results from the England INFORM Study. Oral Presentation at ECCMID 2024. 6. Meeraus W. High Prevalence of Immunocompromising Conditions Among Patients with Severe Acute Respiratory Infection, Including SARS-CoV-2: Results from a Multicentre, Test-Negative Case Control Study. Abstract #01796 at ECCMID 2024. 7. Meeraus W. Immunocompromise, Cancer and Other Comorbidities in Patients with Severe Acute Respiratory Infection Testing Positive Versus Negative for SARS-CoV-2: A Post Hoc Analysis of COVIDRIVE Data from May 2021 to May 2023. Abstract #01800 at ECCMID 2024. 8. Ketkar A et al. Assessing the Risk and Costs of COVID-19 in Immunocompromised Populations in a Large United States Commercial Insurance Health Plan: The EPOCH-US Study. Curr Med Res Opin. 2023 . 39 (8):1103-1118. 9. Francica JR, Cai Y, Diallo S, et al. 1355. The SARS-CoV-2 Monoclonal Antibody AZD3152 Potently Neutralizes Historical and Emerging Variants and is Being Developed for the Prevention and Treatment of COVID-19 in High-risk Individuals . Open Forum Infect Dis . 2023 Nov 27;10(Suppl 2):ofad500.1192. doi: 10.1093/ofid/ofad500.1192. SOURCE: AstraZeneca

Clinical ResultPhase 3ImmunotherapyVaccine

16 May 2024

·www.fiercebiotech.com

AstraZeneca prepares fresh COVID push to regulators after antibody's phase 3 success

AstraZeneca said its study “demonstrated the potential benefit of sipavibart in an evolving variant landscape in which COVID-19 cases captured over the course of the trial were caused by several different SARS-CoV-2 variants.” While AstraZeneca’s globally used COVID-19 vaccine is leaving the scene, the British Big Pharma is hoping it will be taking a fresh therapeutic option to regulators soon. Results from the phase 3 SUPERNOVA study show that the company’s investigational long-acting antibody (LAA) sipavibart produced a statistically significant reduction in the incidence of symptomatic COVID‑19. The global trial of 3,335 immunocompromised patients saw half receive a 300-mg intramuscular dose of sipavibart and the others receive either AstraZeneca’s previously authorized LAA combo COVID-19 treatment Evusheld or placebo. The study had two primary endpoints: reducing the number of cases of COVID-19 caused by any variant of the virus and the relative risk reduction of infections caused by variants not containing the F456L mutation. SUPERNOVA hit both these goals, said AstraZeneca, although it didn’t provide any details of the data. Still, the Big Pharma said the study had “demonstrated the potential benefit of sipavibart in an evolving variant landscape in which COVID-19 cases captured over the course of the trial were caused by several different SARS-CoV-2 variants.” The participants involved were aged 12 years and over and included patients with blood cancer, organ transplant recipients, patients with end-stage renal disease requiring dialysis, those receiving B-cell depleting therapy within the past year and people taking immunosuppressive medications. “Immunocompromised patients currently have limited or no options for COVID-19 protection and continue to face a significant burden of disease, despite often being fully vaccinated,” AstraZeneca’s executive vice president of vaccines and immune therapies Iskra Reic said in the release. “Sipavibart has the potential to prevent COVID-19 in the immunocompromised and we will now work with regulatory authorities globally to bring sipavibart to these vulnerable patients,” Reic added. Sipavibart was derived from B cells donated by convalescent patients who had previously been infected with COVID-19. The treatment is engineered using the same antibody scaffold as Evusheld. The FDA rescinded its authorization of Evusheld in January 2023 when it became clear it was ineffective against some of the newer variants of COVID-19.

Clinical ResultPhase 3VaccineEmergency Use AuthorizationImmunotherapy

16 May 2024

·firstwordpharma.com

AstraZeneca touts enhanced protection with COVID-19 antibody in immunocompromised people

AstraZeneca on Thursday said the long-acting antibody sipavibart significantly reduced the incidence of symptomatic COVID-19 compared with placebo or its predecessor antibody cocktail Evusheld (tixagevimab/cilgavimab) in a Phase III pre-exposure prophylaxis study involving immunocompromised individuals — a population that accounts for nearly a quarter of cases with worse outcomes.With the positive readout, Astrazeneca is poised to compete against Invivyd's Pemgarda (pemivibart), which recently secured an emergency-use authorisation (EUA) in the US for pre-exposure COVID-19 prophylaxis of immunocompromised patients.“Immunocompromised patients currently have limited or no options for COVID-19 protection…despite often being fully vaccinated,” noted Iskra Reic, EVP of vaccines and immune therapies at AstraZeneca, adding that “sipavibart has the potential to prevent COVID-19” in this vulnerable population.The SUPERNOVA trial randomised 3335 immunocompromised participants to receive either a single 300mg intramuscular dose of sipavibart or a comparator consisting of placebo or Evusheld. The participants included individuals aged 12 years and above, at risk of not adequately responding to active immunisation and at high risk for developing severe COVID-19.Superior protection across variantsTop-line results showed sipavibart met the study’s dual primary endpoints — reducing the risk of symptomatic disease from any SARS-CoV-2 variant and the risk of infections from variants not harbouring the F456L mutation, relative to the comparator. AstraZeneca noted that the protection offered by sipavibart was consistent across the evolving variant landscape throughout the study.In terms of safety, the antibody was well tolerated, with a comparable adverse-event profile between the sipavibart and control arms. Detailed findings will be unveiled at a forthcoming medical conference.AstraZeneca’s Evusheld lost its EUA for pre-exposure prophylaxis in the US early last year, after failing to neutralise circulating SARS-CoV-2 variants in vitro. The drugmaker now intends to engage with regulators to outline the approval process for sipavibart, looking to regain its position in the COVID-19 prophylactics market.

Clinical ResultPhase 3Emergency Use Authorization

100 Deals associated with Cilgavimab/Tixagevimab

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Indication	Country/Location	Organization	Date
COVID-19	US	AstraZeneca PLC	08 Dec 2021

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Indication	Highest Phase	Country/Location	Organization	Date
Coronavirus Infections	Phase 1	US	AstraZeneca PLC	30 Nov 2021

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05166421 (CTgov)	Phase 1	Coronavirus Infections	224	AZD8895+AZD1061 (Treatment A: AZD8895 and AZD1061 (Coformulation, Clonal Cell Line Material))	nirlkpumof(ejbcbwfvst) = wjeeldrbsp jfbbflgcms (mixrpbijxz, clorujvjlf - tbhnmpakmb) View more	-	25 Nov 2024
				AZD8895+AZD1061 (Treatment B: AZD8895 and AZD1061 (Separate Vials, Clonal Cell Line Material))	nirlkpumof(ejbcbwfvst) = fxbgvimgey jfbbflgcms (mixrpbijxz, fqbcewoigi - pdyqbjsygk) View more
NCT05184062 (CTgov)	Phase 2	COVID-19	272	600 mg AZD7442 IV (AZD7442)	zvzaxhsouj(ecinjimopd) = tmwjgqtnix fsuumrarkz (uqdllsxual, ikzgvijnol - hlskdapjih) View more	-	21 Nov 2024
				600mg placebo IV (Placebo)	zvzaxhsouj(ecinjimopd) = rykrpshrra fsuumrarkz (uqdllsxual, nbxfsuuwtp - qarvvouywy) View more
NCT05375760 (ENDURE, CTgov)	Phase 2	COVID-19	251	AZD7442 (AZD7442: 600mg ONCE / 300mg Q3M)	ohmpvsvrzv(kgirogzecs) = vjiynfrioy xtqxesmvls (eoelzmdvdv, sgageokjiz - qkbpmbmgdo) View more	-	23 Oct 2024
				AZD7442 (AZD7442: 1200 mg ONCE / 600mg Q6M)	ohmpvsvrzv(kgirogzecs) = acujdwvvyv xtqxesmvls (eoelzmdvdv, uutbdteihk - hmfizeizlt) View more
NCT04507256 (CTgov)	Phase 1	COVID-19	60	placebo (Pooled Placebo)	lknbrdjlej(nrgsvuotzm) = vwavmfhden bhmhoakfry (tzmnrhxosy, dvqjoiyawa - cuwgplsajh) View more	-	18 Oct 2024
				AZD7442 (AZD7442 300 mg, IM)	lknbrdjlej(nrgsvuotzm) = afgmpuiiwl bhmhoakfry (tzmnrhxosy, ylccztunrg - nwjhrcprxs) View more
NCT05780437 (CTgov)	Phase 3	COVID-19	1,417	AZD7442+Remdesivir (AZD7442 Plus SOC)	ufowyfmuvo(deqmdynlqd) = hnrbmxfzpw mpjltwjhod (rrswzvlfwj, ugknoolgab - rvwddpkkbd) View more	-	30 Jul 2024
				Placebo+Remdesivir (Placebo Plus SOC)	ufowyfmuvo(deqmdynlqd) = vpomebozud mpjltwjhod (rrswzvlfwj, pogutdbtbo - nglscehgsh) View more
NCT04625725 \| NCT04625972 (PROVENT and STORM CHASER, Pubmed)	Phase 3	COVID-19	-	AZD7442 300 mg	gnmvbcttjr(odhtzmuwsk) = igyecvuyho rblpeijkno (ukneaotwgs ) View more	Positive	01 Jun 2024
				Placebo	gnmvbcttjr(odhtzmuwsk) = rohrsmvhpm rblpeijkno (ukneaotwgs ) View more
AASLD2023	Not Applicable	-	1,149	Evusheld	cwlmetxvlh(mznxjmpvzb) = pbllgbbeuk gwdwoyfbzr (qpiuvggyxn ) View more	-	10 Nov 2023
PROVENT study (ICML2023)	Phase 3	Hodgkin's Lymphoma \| B-Cell Lymphoma	101	Tixagevimab-cilgavimab	ccxyeyxqqm(eardflbliq) = kanqjgrgnf vhmrasnosd (ckuyzlrbuf ) View more	Negative	09 Jun 2023
EHA2023	Not Applicable	Hematologic Diseases	202	Tixagevimab-cilgavimab	pszfkreypf(lwytphgkyu) = tfznruochn gwivhpictz (llwatewjrz ) View more	-	08 Jun 2023
NCT04625725 (PROVENT, EHA2023)	Phase 3	Hematologic Neoplasms	93	AZD7442	mrqmaulkxb(zluaoomqdp) = lkqpfhdvpw jhclvktztu (znglavfxng )	-	08 Jun 2023

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