Last update 01 Nov 2024
LP-118
Last update 01 Nov 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms |
Target |
Mechanism Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors), Bcl-xl inhibitors(Apoptosis regulator Bcl-X inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
Login to view timeline
Related
4
Clinical Trials associated with LP-118A Phase I/II Study to Investigate the Combination of LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory T-ALL/LBL
A Phase I Study on Safety, Tolerance, Pharmacokinetics and Preliminary Efficacy of LP-118 in Patients with Advanced Malignancies
评估口服BCL-2/BCL-XL抑制剂LP-118在中国晚期恶性肿瘤患者的安全性、耐受性、药代动力学特征以及初步疗效的I期临床研究
[Translation] A Phase I clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of LP-118, an oral BCL-2/BCL-XL inhibitor, in Chinese patients with advanced malignancies
100 Clinical Results associated with LP-118
Login to view more data
100 Translational Medicine associated with LP-118
Login to view more data
100 Patents (Medical) associated with LP-118
Login to view more data
1
Literatures (Medical) associated with LP-118Haematologica
LP-118 is a novel B-cell lymphoma 2 / extra-large inhibitor that demonstrates efficacy in models of venetoclax-resistant chronic lymphocytic leukemia
Article
Author: Perry, Elizabeth ; Shen, Yue ; Diaz-Rohena, Daisy Y ; Ravikrishnan, Janani ; Bhat, Seema A ; Anthony, Stephen P ; Chen, Yi ; Chen, Yu ; Wierda, William G ; Satpati, Suresh ; Lapalombella, Rosa ; Misra, Shrilekha ; Mitchell, Andrew ; Woyach, Jennifer A ; Davids, Matthew S ; Sampath, Deepa ; Mo, Xiaokui ; Lozanski, Arletta ; Sanchez, John ; Rogers, KerryA ; Lai, Tzung-Huei ; Kittai, Adam S ; Kaufman, Tierney ; Lozanski, Gerard ; Williams, Charmelle D ; Collins, Mary C ; Jain, Nitin ; Byrd, John C ; Liu, Chaomei ; Muhowski, Elizabeth ; Tan, Fenlai
100 Deals associated with LP-118
Login to view more data
R&D Status
10 top R&D records. to view more data
Login
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Acute Myeloid Leukemia | Phase 1 | US | 23 Aug 2021 | |
| Chronic lymphocytic leukaemia refractory | Phase 1 | US | 23 Aug 2021 | |
| Multiple Myeloma | Phase 1 | US | 23 Aug 2021 | |
| Mycosis Fungoides | Phase 1 | US | 23 Aug 2021 | |
| Myelodysplastic Syndromes | Phase 1 | US | 23 Aug 2021 | |
| Myelofibrosis | Phase 1 | US | 23 Aug 2021 | |
| Refractory Hematologic Malignancy | Phase 1 | US | 23 Aug 2021 | |
| Rhabdoid Tumor of the CNS | Phase 1 | US | 23 Aug 2021 | |
| Small Lymphocytic Lymphoma | Phase 1 | US | 23 Aug 2021 | |
| T-Cell Prolymphocytic Leukemia | Phase 1 | US | 23 Aug 2021 |
Login to view more data
Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Login to view more data
Translational Medicine
Boost your research with our translational medicine data.
login
or
Deal
Boost your decision using our deal data.
login
or
Core Patent
Boost your research with our Core Patent data.
login
or
Clinical Trial
Identify the latest clinical trials across global registries.
login
or
Approval
Accelerate your research with the latest regulatory approval information.
login
or
Regulation
Understand key drug designations in just a few clicks with Synapse.
login
or
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free