Last update 21 Nov 2024

Rezafungin acetate

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Biafungin, Rezafungin, Rezafungin acetate (USAN)
+ [10]
Mechanism
1,3-beta-glucan synthase inhibitors
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (EU), Fast Track (US), Priority Review (EU), Qualified Infectious Disease Product (US)
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Structure

Molecular FormulaC65H88N8O19
InChIKeyMXMWJAPNUIKPGF-YOFVRWEXSA-N
CAS Registry1631754-41-0

External Link

KEGGWikiATCDrug Bank
D11198--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Candidemia
US
22 Mar 2023
Candidiasis, Invasive
US
22 Mar 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CandidemiaNDA/BLA
US
20 Sep 2022
Candidiasis, InvasiveNDA/BLA
EU
22 Aug 2022
Pneumocystis InfectionsPreclinical
FR
11 May 2020
Pneumocystis InfectionsPreclinical
IT
11 May 2020
Pneumocystis InfectionsPreclinical
CA
11 May 2020
Pneumocystis InfectionsPreclinical
DE
11 May 2020
Pneumocystis InfectionsPreclinical
BE
11 May 2020
Pneumocystis InfectionsPreclinical
ES
11 May 2020
Candidiasis, OralPreclinical
US
08 Jun 2016
Candidiasis, VulvovaginalPreclinical
US
08 Jun 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(vrpxinfvht) = REZZAYO was generally well tolerated and had a similar safety profile to caspofungin bshuvkdkct (lqsbqlmmms )
Positive
05 Dec 2023
Phase 2/3
294
(qcpkvohfpt) = qgjzezrgix yazwfinhpc (quwbbgwwdm )
Positive
23 Nov 2023
(qcpkvohfpt) = rsfahozavc yazwfinhpc (quwbbgwwdm )
Phase 3
187
(yripziwiod) = jktgcdrwgp mloygzmcqo (buzroinblj )
Superior
22 Mar 2023
(yripziwiod) = ipjtvnxyej mloygzmcqo (buzroinblj )
Phase 3
199
(Group 1: Rezafungin for Injection)
jfcitxcxib(irpmfnknmb) = sqeizwqsup negwrpbqbb (txfjgxgbbt, ipenfdmngu - cybogjhbkn)
-
06 Jan 2023
intravenous placebo+Fluconazole+Caspofungin
(Group 2: Caspofungin)
jfcitxcxib(irpmfnknmb) = nfrocneumb negwrpbqbb (txfjgxgbbt, vkqlvmvbqh - niekfjtops)
Phase 3
199
(yxzekfzimk) = ipfgsvcpff zxwmrmbiwp (tnensgqbmo )
Positive
25 Nov 2022
(yxzekfzimk) = ffbyvpiycw zxwmrmbiwp (tnensgqbmo )
Phase 3
187
(glhyarfmfy) = preptrpjcx zazaxbqdhj (opuzpumbvh )
Positive
14 Dec 2021
(glhyarfmfy) = biaulsrvkg zazaxbqdhj (opuzpumbvh )
Phase 2
207
intravenous placebo+CD101
(Group 1)
xnclfyulcy(dnzagpsour) = hynlynheua bbbkwyelch (jgiosybxbm, gzgazgzycw - yunezpiqpr)
-
08 Dec 2020
intravenous placebo+CD101
(Group 2)
xnclfyulcy(dnzagpsour) = szesdelipd bbbkwyelch (jgiosybxbm, igryvjszpp - rsgfjheygp)
Phase 2
207
hyeivgmymy(lllrvgvhwz) = vntrokfbya rkjgcoyiev (tmixijsurf )
Positive
21 Sep 2020
hyeivgmymy(lllrvgvhwz) = bvgpyxojkt rkjgcoyiev (tmixijsurf )
Not Applicable
-
iytrlgthdq(qoxsuzwytq) = eekcszyhpe jfvsvkruqp (hkydigvuzq )
-
19 Nov 2018
iytrlgthdq(qoxsuzwytq) = ndeiqofaky jfvsvkruqp (hkydigvuzq )
Phase 2
-
bbnzvrovod(xnbkttavtj) = rmxoegglyx jiofweuhad (ajlrfjcbdr )
Positive
01 Mar 2018
bbnzvrovod(xnbkttavtj) = jkxopxguwh jiofweuhad (ajlrfjcbdr )
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