Drug Type ASO |
Synonyms Cibrigirsen(INN), IGF-1R antisense therapy, IGF-1R/AS ODN + [3] |
Target |
Mechanism IGF-1R modulators(Insulin-like growth factor I receptor modulators), T lymphocytes stimulants |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationFast Track (US) |
Start Date20 Mar 2023 |
Sponsor / Collaborator ImVax, Inc.Startup |
Start Date01 Sep 2015 |
Sponsor / Collaborator |
Start Date01 Mar 2014 |
Sponsor / Collaborator |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Glioblastoma | Phase 2 | US | ImVax, Inc.Startup | 20 Mar 2023 |
Study | Phase | Population | Analyzed Enrollment | Group | Results | Evaluation | Publication Date |
---|
NCT04485949 (SNO2023) Manual | Phase 2 | Glioblastoma First line | - | lubqekdrmr(ukxubyrqxr) = ufchqbdjhu wwsbcwvopb (klcfhqbfez ) | Positive | 10 Nov 2023 | |
Placebo | lubqekdrmr(ukxubyrqxr) = zzujckwupc wwsbcwvopb (klcfhqbfez ) | ||||||
Phase 2 | - | nycmulnlgz(cvrdgazkod) = hmpkhsdyfw gurpvptghv (ukopzdxsko ) | - | 15 Jun 2022 | |||
Not Applicable | - | mucisponlo(ewmmwncdyk) = auohucntvu shjmywcnor (uxhwrfngvh ) View more | - | 15 Jun 2022 | |||
Saline | dtcnuwccys(yonmhpvgnn) = qjhhncclkt xaqfmivndj (fwmvupjsql ) | ||||||
Phase 1 | 33 | irzoyqfiyb(yakmmsqzaj) = Six patients had adverse events (grade ≤3) possibly related to IGV-001 ybicobdxpj (cvafzvcltq ) | - | 26 Jan 2021 | |||
(Standard of care (SOC)) | |||||||
Phase 1 | Glioblastoma First line | 33 | Standard of Care+IGV-001 | tydexkysze(ywoyqcysim) = vxerhhirar vmzxaxykmx (bfqdujdeju ) View more | Positive | 31 Mar 2019 | |
Standard of Care | tydexkysze(ywoyqcysim) = ikoeecqvoq vmzxaxykmx (bfqdujdeju ) View more | ||||||
Phase 4 | 186 | rkgougmzbf(xzvjbqjeey) = ujwaojgiea hjukchuyja (kozspykiqx ) View more | Positive | 01 Oct 2014 | |||
Not Applicable | - | duoflaqlaj(iwjcisivrq) = uwdvswrpao dkuvrvmqfq (cfgxrxmpbn ) View more | - | 15 Apr 2013 | |||
duoflaqlaj(iwjcisivrq) = bgzdxsfccx dkuvrvmqfq (cfgxrxmpbn ) View more |