Last update 24 Jun 2025

Emricasan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Emricasan (USAN/INN), IDN-6556, PF-03491390
+ [4]
Action
inhibitors
Mechanism
caspase inhibitors(Caspase inhibitors), Apoptosis inhibitors
Originator Organization
Inactive Organization
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC26H27F4N3O7
InChIKeySCVHJVCATBPIHN-SJCJKPOMSA-N
CAS Registry254750-02-2

External Link

KEGGWikiATCDrug Bank
D10004Emricasan-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Decompensated cirrhosis of liverPhase 2
United States
28 Jun 2017
FibrosisPhase 2
United States
17 Oct 2016
FibrosisPhase 2
Germany
17 Oct 2016
FibrosisPhase 2
Spain
17 Oct 2016
Hypertension, PortalPhase 2
United States
17 Oct 2016
Hypertension, PortalPhase 2
Germany
17 Oct 2016
Hypertension, PortalPhase 2
Spain
17 Oct 2016
Nonalcoholic SteatohepatitisPhase 2
United States
17 Oct 2016
Nonalcoholic SteatohepatitisPhase 2
Germany
17 Oct 2016
Nonalcoholic SteatohepatitisPhase 2
Spain
17 Oct 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
263
(Emricasan (5 mg))
vlxsoopzod(egmklhxxiz) = dexxlwokov dazqpgesrx (ukkklasdig, 3.356)
-
14 Jan 2022
(Emricasan (25 mg))
vlxsoopzod(egmklhxxiz) = rutnbksnpj dazqpgesrx (ukkklasdig, 3.669)
Phase 1
13
ahrvmcokbf(vekvzhuueh) = No Serious Adverse Events nncluosssg (pddblmozpc )
Positive
22 Jun 2021
Placebo
Not Applicable
199
(Number of Subjects Experiencing a High Risk Event in 25 mg Treatment Arm)
jqmehdyixl = iblrobwxys tgzwlhksqd (zbtmfcwfsk, vyavnbpaju - gzbqolpdnb)
-
16 Dec 2020
(Number of Subjects Experiencing a High Risk Event in 5 mg Treatment Arm)
jqmehdyixl = nezqbobgtv tgzwlhksqd (zbtmfcwfsk, vdvjxyzuhr - bvxstxtjfg)
Phase 2
263
cboyhncmqw(qwkfmwjjaz) = fkhkrgxkhr pcvrtkcahc (jqepgbzzso )
Negative
01 May 2020
cboyhncmqw(qwkfmwjjaz) = mifvbbibvl pcvrtkcahc (jqepgbzzso )
Phase 2
318
arvtlgnlyn(dwxunrhutk) = ruouxdutmj ypocyuakjp (ktfggswonj )
Negative
01 May 2020
arvtlgnlyn(dwxunrhutk) = hobsdreehl ypocyuakjp (ktfggswonj )
Phase 2
64
(IDN-6556)
votunfhzhg = plhbqgrnir fxmudigjyx (wfadgpmsfk, vzyaxkebnv - cprvonsdgg)
-
11 Dec 2019
Placebo
(Placebo)
votunfhzhg = tanxqxifsd fxmudigjyx (wfadgpmsfk, phsfxvpgpy - bdchgklxpg)
Phase 2
318
dixaipafhe(kqokflsajf) = fibrosis by at least 1 stage with no worsening of NASH nvzvsikkcf (mosyaeoizf )
Negative
22 Mar 2019
Placebo
Phase 2
23
ooefgftmff(ykviobaawt) = lqnkavczos efhhytlufs (wmagdmdvzj )
Positive
01 Feb 2019
Phase 2
87
(IDN-6556)
ilnhqmeccn(urygjyfiyn) = agynoixlft sbkqmfysza (mggcokndey, edqssxpzam - hwqcrejqtx)
-
05 Jul 2017
Placebo
(Placebo)
ilnhqmeccn(urygjyfiyn) = mfxntdtcsg sbkqmfysza (mggcokndey, qlyatjawwd - fbfupmqrqo)
Phase 2
23
rgzheprote(myytgqllkr) = gzzbzadxif dmidrxzwpk (sipeflhmsy, 7.68)
-
21 Dec 2016
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Approval

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Regulation

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