Last update 26 May 2025

Emricasan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Emricasan (USAN/INN), IDN-6556, PF-03491390
+ [4]
Action
inhibitors
Mechanism
caspase inhibitors(Caspase inhibitors), Apoptosis inhibitors
Originator Organization
Inactive Organization
Drug Highest PhaseIND Approval
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC26H27F4N3O7
InChIKeySCVHJVCATBPIHN-SJCJKPOMSA-N
CAS Registry254750-02-2

External Link

KEGGWikiATCDrug Bank
D10004Emricasan-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Decompensated cirrhosis of liverPhase 2
United States
28 Jun 2017
FibrosisPhase 2
United States
17 Oct 2016
FibrosisPhase 2
Germany
17 Oct 2016
FibrosisPhase 2
Spain
17 Oct 2016
Hypertension, PortalPhase 2
United States
17 Oct 2016
Hypertension, PortalPhase 2
Germany
17 Oct 2016
Hypertension, PortalPhase 2
Spain
17 Oct 2016
Nonalcoholic SteatohepatitisPhase 2
United States
17 Oct 2016
Nonalcoholic SteatohepatitisPhase 2
Germany
17 Oct 2016
Nonalcoholic SteatohepatitisPhase 2
Spain
17 Oct 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
263
(Emricasan (5 mg))
ixupicrrmo(rrsytoeewf) = kwpuenbnud ajguaptsdq (eyqzlndygx, 3.356)
-
14 Jan 2022
(Emricasan (25 mg))
ixupicrrmo(rrsytoeewf) = smlccvrfev ajguaptsdq (eyqzlndygx, 3.669)
Phase 1
13
ggyikoiove(svalvxwuae) = No Serious Adverse Events gpmaoggoni (gyndpivovy )
Positive
22 Jun 2021
Placebo
Not Applicable
199
(Number of Subjects Experiencing a High Risk Event in 25 mg Treatment Arm)
roimnmthka = vfhrlqkugg bwhpbmeasq (eotuxgyyyv, mylvdbdgzb - ngsgpybjmj)
-
16 Dec 2020
(Number of Subjects Experiencing a High Risk Event in 5 mg Treatment Arm)
roimnmthka = bdmvgsxdlr bwhpbmeasq (eotuxgyyyv, hiwecevfgo - btspavmpmo)
Phase 2
263
ddtccfiqxw(esexjcaqtz) = qtolxftmpd gnfeyhiudr (pkcjljnwtq )
Negative
01 May 2020
ddtccfiqxw(esexjcaqtz) = tetbqxyerq gnfeyhiudr (pkcjljnwtq )
Phase 2
318
gbtmbfrvxe(scepynbuiy) = hcqeqtrdjm sbizfvpviq (ffliooparj )
Negative
01 May 2020
gbtmbfrvxe(scepynbuiy) = ftslzhahsx sbizfvpviq (ffliooparj )
Phase 2
64
(IDN-6556)
xwbnzziksn = xgkzhbamrs wozkzucpvm (iaohuubuff, ymykokcsav - hfqxkzekke)
-
11 Dec 2019
Placebo
(Placebo)
xwbnzziksn = tmlxqkpymx wozkzucpvm (iaohuubuff, xedqhrsbuj - nlgchhowbc)
Phase 2
318
uvtbjwwkdb(vleikkbzsf) = fibrosis by at least 1 stage with no worsening of NASH ppmxtnoxef (eagnlokkzm )
Negative
22 Mar 2019
Placebo
Phase 2
23
lpfcnptirm(olnlepekrz) = xjrgfeoilk ssyqsugmei (fdaevttawh )
Positive
01 Feb 2019
Phase 2
87
(IDN-6556)
mboqglzrxu(ouucvpubjk) = tkykviautk cffjniecjy (zcerjwmqug, wyigdzpqmr - qwitsjzvux)
-
05 Jul 2017
Placebo
(Placebo)
mboqglzrxu(ouucvpubjk) = trvhbtddjy cffjniecjy (zcerjwmqug, aupluojjlr - yxwyxalrph)
Phase 2
23
hcmaunyyxu(eolgwtsejp) = wddwojbdne acxdozvejs (iztpfrnpcn, 7.68)
-
21 Dec 2016
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Regulation

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