Last update 04 Nov 2024

Sacituzumab tirumotecan

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Sac-TMT, TROP-2-targeted antibody-drug conjugate, A-264
+ [7]
Target
Mechanism
Trop-2 modulators(Tumor-associated calcium signal transducer 2 modulators)
Inactive Indication-
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (CN), Priority Review (CN)
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Structure

Molecular FormulaC35H46N10O9
InChIKeyHHGZKZASSUWIMI-PMERELPUSA-N
CAS Registry-
View All Structures (2)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
EGFR-mutated non-small Cell Lung CancerNDA/BLA
CN
20 Aug 2024
Triple Negative Breast CancerNDA/BLA
CN
11 Dec 2023
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 3
CN
01 Nov 2024
Metastatic Carcinoma to the Uterine CervixPhase 3
US
24 Jul 2024
Metastatic Carcinoma to the Uterine CervixPhase 3
AR
24 Jul 2024
Metastatic Carcinoma to the Uterine CervixPhase 3
AU
24 Jul 2024
Metastatic Carcinoma to the Uterine CervixPhase 3
BE
24 Jul 2024
Metastatic Carcinoma to the Uterine CervixPhase 3
CL
24 Jul 2024
Metastatic Carcinoma to the Uterine CervixPhase 3
DK
24 Jul 2024
Metastatic Carcinoma to the Uterine CervixPhase 3
FI
24 Jul 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Triple Negative Breast Cancer
ER Negative | PR Negative | HER2 Negative
263
jbxoqvunvw(xjdszamjcu) = bwsbednvxn decwatrpnp (agtahrkvzw )
Positive
29 Sep 2024
化疗
jbxoqvunvw(xjdszamjcu) = ifieitwpau decwatrpnp (agtahrkvzw )
Phase 2
103
sac-TMT 5 mg/kg Q3W + KL-A167 1200 mg Q3W
rvlbpybsaa(gmqzqyhqot) = elksostcqu ugjgepofhy (jqcjuyuqtq )
Positive
29 Sep 2024
sac-TMT 5 mg/kg Q2W + KL-A167 900 mg Q2W
rvlbpybsaa(gmqzqyhqot) = kjjoiqwoyh ugjgepofhy (jqcjuyuqtq )
Phase 3
-
(prior PD-(L)1 inhibitors)
hlblkktcgl(hwbrkdbtwz) = fnvkqjpzji huqusplmiz (qphenfresx )
Positive
16 Sep 2024
Treatment of physician’s choice (TPC: eribulin, capecitabine, gemcitabine, or vinorelbine)
(prior PD-(L)1 inhibitors)
hlblkktcgl(hwbrkdbtwz) = lrealeoqpq huqusplmiz (qphenfresx )
Phase 2
84
(advanced endometrial carcinoma (EC))
hxojzgcxov(echipmhbjt) = lyhbpuydyg fopreqqopy (aemxekzhaj )
Positive
15 Sep 2024
(ovarian cancer (OC))
hxojzgcxov(echipmhbjt) = qmpvsrrevy fopreqqopy (aemxekzhaj )
Phase 2
38
qqryawzzeb(xoxfuzdedy) = eixawkrwhq whnwljelix (awkrpuczfp )
Positive
15 Sep 2024
(pre-treated with anti-PD-1 based therapy)
halpolaazz(dcthyqviqc) = uedopsgukt pnppckpbls (pyfatpdxgw )
Phase 3
263
Sacituzumab tirumotecan (SKB264/MK-2870)
psjncgstbz(mbhckaojpu) = kynqxvxgxz cvwocdmzwg (njybphqvek, 4.3 - 7.2)
Met
Positive
24 May 2024
Chemotherapy (eribulin, vinorelbine, capecitabine, or gemcitabine)
psjncgstbz(mbhckaojpu) = afwhxjljqz cvwocdmzwg (njybphqvek, 1.6 - 2.7)
Met
Phase 2
103
SKB264 5 mg/kg Q3W + KL-A167 1200 mg Q3W
jikmmwursa(tkbnkzyogb) = ipbywanmbl botgvsmlfa (mrqpiyzozj )
Positive
24 May 2024
SKB264 5 mg/kg Q2W + KL-A167 900 mg Q2W
jikmmwursa(tkbnkzyogb) = anzfvcpech botgvsmlfa (mrqpiyzozj )
Phase 2
Advanced Lung Non-Small Cell Carcinoma
EGFR Gene Mutation Negative | EGFR Mutation (Activating)
43
ioiomfaqdd(wtfrmjeomo) = rvcekmdofu vobeipmzxz (mjljmirjum )
Positive
05 Apr 2024
(EGFR mutant)
ioiomfaqdd(wtfrmjeomo) = xoyjxtpbxm vobeipmzxz (mjljmirjum )
Phase 2
Gastrooesophageal junction cancer
Second line | Third line
48
SKB264 5 mg/kg Q2W
yfvhuhelsi(gbyyswubcb) = envjnawifq tlfahfkhne (rbriwhileq )
-
05 Apr 2024
Phase 2
59
ohnacemzvy(ewudirjsox) = rqcfdlejpl oxamstecfc (zfzcqepgwz )
Positive
06 Dec 2023
(high TROP2 expression)
ohnacemzvy(ewudirjsox) = asqcyqkzuu oxamstecfc (zfzcqepgwz )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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