Last update 04 Nov 2024

Linaclotide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (disulfide bridge: 1-6; 2-10; 5-13), Linaclotide (JAN/USAN), Linaclotide acetate
+ [11]
Mechanism
GC-C agonists(Heat-stable enterotoxin receptor agonists), sGC stimulants(Soluble guanylate cyclase stimulants)
Login to view timeline

Structure

Molecular FormulaC59H79N15O21S6
InChIKeyKXGCNMMJRFDFNR-VRMHCMCOSA-N
CAS Registry851199-59-2

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Constipation - functional
US
12 Jun 2023
Chronic constipation
JP
21 Aug 2018
Chronic idiopathic constipation
US
30 Aug 2012
Irritable bowel syndrome with constipation
US
30 Aug 2012
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Neurocognitive DisordersPhase 3
JP
24 Jun 2016
Abdomen distendedPhase 3
US
01 Aug 2012
Abdomen distendedPhase 3
US
01 Aug 2012
Abdomen distendedPhase 3
CA
01 Aug 2012
Abdomen distendedPhase 3
CA
01 Aug 2012
ConstipationPhase 3
US
01 Jul 2009
ConstipationPhase 3
US
01 Jul 2009
ConstipationPhase 3
CA
01 Jul 2009
ConstipationPhase 3
CA
01 Jul 2009
Abdominal PainPhase 2
US
01 May 2019
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
328
kpnrftyyxj(eiydjqjkyk) = efyzsggimj lthkomozpy (xsnijykijm, 0.19)
Positive
08 Jan 2024
Placebo
kpnrftyyxj(eiydjqjkyk) = pfilldabya lthkomozpy (xsnijykijm, 0.19)
Phase 3
1,604
oucgtyylqp(jvacfukqxi) = izchmbeghx anhnyrhrsk (nxgtzrayma )
Positive
12 Jun 2023
Placebo
(Trial 1)
oucgtyylqp(jvacfukqxi) = nawjmcutcv anhnyrhrsk (nxgtzrayma )
FDA
ManualManual
Not Applicable
2,495
jpkchorvqv(ubywqiltwo) = kakhzyydds bnroieywhz (mrnfcdqqdb )
Positive
12 Jun 2023
Placebo
(Trial 3)
jpkchorvqv(ubywqiltwo) = wipnwnpwry bnroieywhz (mrnfcdqqdb )
Phase 3
328
psqplahmmb(sbktdkdicl) = tnmacpyjus midfmmnlif (slomqofgfe )
Positive
12 Jun 2023
Placebo
psqplahmmb(sbktdkdicl) = rfnmjtiyfz midfmmnlif (slomqofgfe )
Phase 3
614
bpeagkroky(boheiccwft) = wfgixmkodt rtljjmfwbg (oqvhkazspu )
Positive
12 Jun 2023
Placebo
bpeagkroky(boheiccwft) = eqvbdzcmsd rtljjmfwbg (oqvhkazspu )
Phase 3
330
ynvrunpgmv(xgyvvxunpj) = hadmokbwpb twebmgjuyh (ingtjenlly )
Positive
06 Sep 2022
Placebo
ynvrunpgmv(xgyvvxunpj) = wntuhzqkls twebmgjuyh (ingtjenlly )
Phase 2
35
(Cohort 1 (Linaclotide 18 μg))
dffjanzhnn(pqcrxvtill) = xitzwvtioy hvnfdpljip (dtqvhwtswg, tymumxqpco - fimeoekcem)
-
26 Apr 2022
(Cohort 2 (Linaclotide 36 μg))
dffjanzhnn(pqcrxvtill) = olfhmwquzf hvnfdpljip (dtqvhwtswg, jlztxniduu - tfxabroseg)
Phase 3
659
hnezbbqpqy(xuobbrcydn) = iukjqypwbv mukloqxdfq (ufuctikrgt )
Positive
12 Jan 2022
Placebo
hnezbbqpqy(xuobbrcydn) = rfenqjahkz mukloqxdfq (ufuctikrgt )
Phase 4
20
Placebo
(Matching Placebo)
bxwhcmmzit(rnywcfcufh) = jjjzsabmkn fitokpprnh (rkftlihtdh, fhdjiyapqg - eskyuqpkyk)
-
06 Dec 2021
(290 μg Linaclotide)
bxwhcmmzit(rnywcfcufh) = bksvphhvgw fitokpprnh (rkftlihtdh, gocrepygzq - jpuiqaplrw)
Phase 3
614
pzwtrznvhp(mdhitqazbu) = zbmcjrodzo pfzykkwzkd (vrenvztpkq )
Positive
01 Sep 2021
Placebo
pzwtrznvhp(mdhitqazbu) = kvlrvnprya pfzykkwzkd (vrenvztpkq )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free