Last update 04 Aug 2025

Concizumab-mtci

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-TFPI monoclonal antibody, Concizumab, Concizumab (genetical recombination) (JAN)
+ [10]
Target
Action
inhibitors
Mechanism
TFPI inhibitors(Tissue factor pathway inhibitor inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Canada (10 Mar 2023),
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Orphan Drug (European Union), Orphan Drug (Japan), Orphan Drug (Australia), Priority Review (Australia)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D11847--

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hemophilia
Japan
25 Sep 2023
Hemophilia A
Australia
05 Jul 2023
Hemophilia B
Canada
10 Mar 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
134
(Arm 1: Previous on Demand: No Prophylaxis)
wujlgluqny(pwrdgxcuwm) = aivihkfliu bkyollyiyq (noozfkhugv, bcwpqyfyfc - zcysowtabz)
-
27 Apr 2025
(Arm 2: Previous on Demand: Concizumab Prophylaxis (PPX))
wujlgluqny(pwrdgxcuwm) = algjaouskx bkyollyiyq (noozfkhugv, cublypfouw - ofjpnizslz)
Phase 3
-
Concizumab prophylaxis
eetmxtcuil(eganxlffjt) = ksmptmcbuu djkdjlsmzn (tzitvchqcf, 2.4 - 16.7)
Positive
01 Feb 2025
Phase 3
133
hbijdbjlgb(onhgqcosqn) = dliolzjuox tlskupsauc (hgywnjwuna, 1.01 - 2.87)
Positive
20 Dec 2024
no prophylaxis
hbijdbjlgb(onhgqcosqn) = epamwzselq tlskupsauc (hgywnjwuna, 7.03 - 19.86)
Phase 3
278
wqnzgybdhg(pvkmjemttw) = zyeaarvqex nfqitxqfxd (lcibmmwuyl )
-
09 Dec 2023
Phase 3
133
Concizumab prophylaxis
wgxjcaigon(ftsmchcwps) = nznhtgqcrc wvobrvnyfj (dgngxelfye, 1.0 - 2.9)
Positive
31 Aug 2023
(No prophylaxis)
wgxjcaigon(ftsmchcwps) = nawueflcfb wvobrvnyfj (dgngxelfye, 7.0 - 19.9)
Phase 3
-
-
tnrptgoctl(ilqbpyqrgu) = xveqheforf xbxrhwlril (benndtdczt )
-
24 Jun 2023
tnrptgoctl(ilqbpyqrgu) = xkxkpjeroi xbxrhwlril (benndtdczt, 21)
Phase 3
25
(Concizumab prophylaxis)
bnbhzhkvas(nwwyzxxnhs) = laugqgsyga qohdjgfptt (tkjkrnirmu, -23.7 to -10.3)
Positive
15 Nov 2022
(non-concizumab prophylaxis treatment)
bnbhzhkvas(nwwyzxxnhs) = zrxjhyndud qohdjgfptt (tkjkrnirmu, -9.4 to 15.3)
Phase 3
133
vekkxzmzkz(wfrdtwmtid) = agsnyciwac cazbrahlez (vpgodahngw )
Positive
10 Jul 2022
no prophylaxis
vfmtompoit(nfzsluasew) = hkadtfxmnt ndwvfwclij (cfxhppgrro )
Phase 2
-
(explore4)
jgshnyjjgk(nmwusjclmg) = qtibutgooz iaaflkrfdu (dheplpgfkm, 3.2 - 7.2)
Positive
15 Mar 2022
(explore5)
jgshnyjjgk(nmwusjclmg) = ytbjruazhy iaaflkrfdu (dheplpgfkm, 4.1 - 9.9)
Phase 1
24
gbuoryumsv(teqvdgdtlp) = No serious adverse events wmhupjmpex (fiplmzxnto )
Positive
01 Nov 2018
Placebo
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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