Multifunctional pH-responsive films were fabricated via layer-by-layer deposition of gelatin, chitosan, and carboxymethyl cellulose (CMC), incorporating selenium nanoparticles (SeNPs) and beetroot extract (BTE), to monitor and preserve beef freshness. SeNPs were synthesized and characterized via various techniques. BTE exhibited promising functional properties, and films demonstrated a significant color transition from red to yellow across pH 2-14. SeNPs and BTE incorporation enhanced UV resistance, mechanical properties, and reduced water and oxygen permeability. AFM revealed distinct changes in film surface morphology upon the addition of SeNPs and BTE. The films displayed strong antibacterial and antioxidant activities, making them suitable for food packaging applications. Molecular docking simulations indicated strong binding affinities between betalains and gelatin, while CMC stabilized the multilayer structure. These multifunctional films extended beef shelf life and monitored its freshness by transitioning film color upon spoilage, introducing novel nanoparticle-incorporated multilayer films for intelligent packaging and effective preservation of animal-derived food freshness.

01 Apr 2025·Food Chemistry

Preparation, physicochemical characterization, and immunomodulatory activity of ovalbumin peptide–selenium nanoparticles

Article

Author: Liu, Xuanting ; Zhang, Ting ; Xu, Menglei ; Zeng, Yingnan ; Liu, Jingbo ; Lyu, Siwen ; Shang, Xiaomin ; Yang, Qi ; Du, Zhiyang

During the preparation and development of selenium nanoparticles (SeNPs), natural bioactive peptides are added to enhance their physicochemical characteristics and functional properties. Among these properties, immunomodulatory activities, which include activating immune cells to strengthen immunity, constitute the major functions of the immune system. To obtain SeNPs with enhanced immunomodulation, ovalbumin peptide (OP) was used as a stabilizer, yielding OP-SeNPs. The physicochemical properties of OP-SeNPs were characterized. RAW264.7 macrophages were used as a model to investigate the immunomodulatory activity of OP-SeNPs. Results indicate that OP-SeNPs were zero-valent and amorphous, with a particle size of 82.23 ± 1.77 nm. SeNPs demonstrated positive interactions with the -OH, CO, CN, and NH groups of OP. In addition, OP-SeNPs activated RAW264.7 macrophages by increasing NO secretion and enhancing pinocytosis activity, indicating their ability to enhance immunomodulatory effects. Therefore, this study provides a theoretical basis for the construction and characterization of bioactive peptides and SeNP complexes.

04 Mar 2025·Natural Product Research

Selenium nanoparticles improved biochemical and physiological properties and antioxidant systems of savoury under drought stress

Article

Author: Asadi, Mohammad ; Nasiri, Yousef ; Venditti, Alessandro ; Zahedi, Seyed Morteza

To investigate the effectiveness of selenium (Se) and Se nanoparticles (Se-NPs) in improving biochemical and physiological characteristics of savoury in drought stress conditions, a factorial experiment based on the completely randomised design with three replications was used. Results demonstrate that Se-NPs considerably enhanced several biochemical parameters, such as relative water content (RWC), antioxidant enzymes activity, and total soluble protein in drought and normal conditions. At the stress level from 100 to 40% of field capacity, a gradual decrease in chlorophyll and CARs contents was observed and under stress and normal conditions, the application of Se-NPs (10 mg L^-1) led to an increase in the content of pigments. Total soluble protein, total phenolic and flavonoid contents showed significant increases in plants treated with Se-NPs under drought stress. Generally, the use of Se-NPs in drought stress conditions can be effective in improving the growth, biochemical, and physiological characteristics of savoury.

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Indication	Highest Phase	Country/Location	Organization	Date
Ischemic nephropathy	Preclinical	China	Affiliated Hospital of Guangdong Medical University	25 Jul 2024
Reperfusion Injury	Preclinical	China	Affiliated Hospital of Guangdong Medical University	25 Jul 2024
Parkinson Disease	Preclinical	China	South China University of Technology	01 Jul 2024

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