Delving into the Latest Updates on Affiliated Hospital of Guangdong Medical University with Synapse

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Urogenital Diseases

Infectious Diseases

Nervous System Diseases

Gene therapy

Trispecific antibody

Small molecule drug

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Disease Domain	Count

Infectious Diseases	2
Immune System Diseases	1
Endocrinology and Metabolic Disease	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Chemical drugs	1
Small molecule drug	1
Trispecific antibody	1
Gene therapy	1

Top 5 Target	Count

NCOA4 x XBP1	1

This study is conducted to evaluate the efficacy and safety of lenvatinib plus sintilimab, transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) and hepatic artery infusion chemotherapy (HAIC) with FOLFOX regemen (LEN+SIN+DEB-TACE+HAIC) versus lenvatinib plus sintilimab and DEB-TACE (LEN+SIN+DEB-TACE) for large hepatocellular carcinoma (> 7cm) with portal vein tumor thrombosis (PVTT).

Start Date01 Apr 2025

Sponsor / Collaborator

Second Affiliated Hospital of Guangzhou Medical University

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100 Clinical Results associated with Affiliated Hospital of Guangdong Medical University

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0 Patents (Medical) associated with Affiliated Hospital of Guangdong Medical University

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2,358

Literatures (Medical) associated with Affiliated Hospital of Guangdong Medical University

31 Dec 2025·Renal Failure

Construction of a C-reactive protein-albumin-lymphocyte index-based prediction model for all-cause mortality in patients on maintenance hemodialysis

Article

Author: Hao, Junfeng ; Luo, Huasheng ; Luo, Hongying ; Huang, Junmin ; Liu, Huafeng ; Chen, Lu ; Xu, Yongzhi ; Wang, Peng

OBJECTIVEThe mortality rate of patients undergoing maintenance hemodialysis (MHD) remains high. The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel biomarker that reflects inflammation, nutritional and immune status, all merged into one single derived parameter. No study has yet linked the CALLY index to survival in hemodialysis. This study aims to explore the correlation between the CALLY index and mortality in MHD patients, and develop and validate a nomogram to estimate the likelihood of death in this population.METHODSThis retrospective cohort study collected data from 436 patients and they were divided into survival group (n = 335) and non-survival group (n = 101). Multivariate logistic regression analysis was used to screen factors associated with death, and nomograms were developed to estimate the risk of death in MHD patients. The discrimination and calibration of nomograms were validated using the area under the receiver operating characteristic (ROC) curve (AUC) and calibration curve. In the study, stratification analysis and covariate adjustment were conducted to explore the correlation between the CALLY index and the mortality of MHD patients.RESULTSIn the final model, logistic regression showed that the CALLY index, creatinine, triglycerides, dialysis duration, absolute neutrophil count, blood urea nitrogen, sodium and ferritin were variables associated with mortality in MHD patients. A nomogram was developed to assess the risk of death in MHD patients. The AUC of the model was 0.821 (95% CI: 0.778-0.861). The results of stratified analysis and calibration model showed that the CALLY index was a protective factor for maintaining the mortality of MHD patients.CONCLUSIONSThe CALLY index is closely related to the mortality of MHD patients. A nomogram constructed based on CALLY index can effectively evaluate the mortality risk of MHD patients.

01 Jul 2025·Genes & Diseases

Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy

Author: Su, Yanyu ; Wu, Dong ; Qiu, Guiqiang ; Huang, Dan ; Wei, Chunhui ; Xie, Yu ; Zhao, Xuanna ; Li, Lixia ; Liu, Weiliang ; Liu, Caixia ; Liang, Yanmei

RNA-binding proteins (RBPs) regulate the generation of circular RNAs (circRNAs) by participating in the reverse splicing of circRNA and thereby influencing circRNA function in cells and diseases, including cancer.Increasing evidence has demonstrated that the circRNA-RBP network plays a complex and multifaceted role in tumor progression.Thus, a better understanding of this network may provide new insights for the discovery of cancer drugs.In this review, we discuss the characteristics of RBPs and circRNAs and how the circRNA-RBP network regulates tumor cell phenotypes such as proliferation, metastasis, apoptosis, metabolism, immunity, drug resistance, and the tumor environment.Moreover, we investigate the factors that influence circRNA-RBP interactions and the regulation of downstream pathways related to tumor development, such as the tumor microenvironment and N6-methyladenosine modification.Furthermore, we discuss new ideas for targeting circRNA-RBP interactions using various RNA technologies.

01 Jun 2025·Pathology - Research and Practice

Regulation mechanism of chemokine CXCL3 in nasopharyngeal carcinoma

Article

Author: Zhai, Shumin ; Huang, Weiyuan ; Zhuang, Jiafeng ; Huang, Jing ; Lin, Peixin ; Yan, Jiecheng ; Jiang, Danxian

Nasopharyngeal carcinoma (NPC), a malignancy arising from the nasopharyngeal mucosal epithelium, remains poorly understood at molecular level. This study identifies CXCL3, a chemokine, as a critical oncogenic driver in NPC through multi-dataset transcriptomic analysis (GSE12452, GSE53819 and GSE61218). CXCL3 was identified to be upregulated in NPC tissues and correlated with tumor progression (P = 0.022) and poor prognosis. Immune infiltration analysis revealed its association with mast cell accumulation and immunosuppressive checkpoints (CD200, CD44 and CD70). Gene Set Enrichment Analysis (GSEA) linked CXCL3 to ECM-receptor-interaction, JAK-STAT and MAPK pathways. Functional assays demonstrated that CXCL3 silencing suppressed the SUNE-1 cells proliferation (P < 0.01), migration, and invasion abilities (P < 0.05), induced G2/M-phase arrest and reduced S-phase populations via MAPK/ERK pathway inhibition (p-ERK1/2, p-P38 and p-STAT3 down-regulated). Immunohistochemistry confirmed elevated CXCL3 expression in NPC tissues (approximately 80 % positivity) versus normal controls (100 % negative). Notably, CXCL3 knockdown impaired tubule formation in vitro, implicating its role in vascular remodeling. These findings establish CXCL3 as a multifaceted regulator of NPC progression through immune microenvironment modulation, MAPK/ERK signaling, and angiogenesis, nominating it as a potential therapeutic target in NPC.

100 Deals associated with Affiliated Hospital of Guangdong Medical University

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100 Translational Medicine associated with Affiliated Hospital of Guangdong Medical University

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Pipeline

Pipeline Snapshot as of 12 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

2

1

Phase 1 Clinical

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2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

KL-HIV-Tri01	HIV Infections More	Phase 1 Clinical
KL-7SHRNA	-	Clinical
Selenium nanoparticles(SeNPs) ( NCOA4 x XBP1 )	Reperfusion Injury More	Preclinical
Pyridine-Thiazole-Pleuromutilin 10b	MRSA - Methicillin resistant Staphylococcus aureus infection More	Preclinical
YSL-12 ( Tubulin )	Neoplasms More	Pending