Last update 23 Mar 2025

[68Ga]FAPI-46

Overview

Basic Info

Drug Type
Diagnostic radiopharmaceuticals, Radionuclide Drug Conjugates (RDC)
Synonyms
68 Ga FAPI 46, 68Ga-FAPI-46, [68Ga]Ga-FAPI-46
+ [2]
Target
Action
antagonists
Mechanism
FAP antagonists(Fibroblast activation protein alpha antagonists)
Inactive Indication-
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC41H57F2N11O9
InChIKeySDBGUEFOSXNKBX-HKBQPEDESA-N
CAS Registry2374782-04-2
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant Pleural MesotheliomaPhase 2
Denmark
25 Jan 2025
Gastrooesophageal junction cancerPhase 2
Denmark
15 Feb 2024
Ovarian CancerPhase 2
Denmark
17 Nov 2023
Colitis, UlcerativePhase 2
Netherlands
31 Aug 2023
Crohn DiseasePhase 2
Netherlands
31 Aug 2023
FibrosisPhase 2
Netherlands
31 Aug 2023
Pancreatic Ductal AdenocarcinomaPhase 2
United States
02 May 2022
Alveolitis, Extrinsic AllergicPhase 1
United States
16 Nov 2021
Idiopathic Interstitial PneumoniasPhase 1
United States
16 Nov 2021
PneumoconiosisPhase 1
United States
16 Nov 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
61
(Glioblastoma without sarcomatous differentiation)
kyfamgqjrp(qbpcgujjgz) = bmqfrxzdnc rfwtgsrjqf (zmqpjglsmd )
-
11 Nov 2024
(Gliosarcoma)
kyfamgqjrp(qbpcgujjgz) = ffpusxujcf rfwtgsrjqf (zmqpjglsmd )
Not Applicable
Gliosarcoma | Glioblastoma
Fibroblast-activation-protein (FAP)
61
(Glioblastoma without sarcomatous differentiation)
bpflymywsj(fgdywtsjib) = lnhaeznicy kvnmzjsqml (gednwapavb )
-
17 Oct 2024
(Gliosarcoma)
bpflymywsj(fgdywtsjib) = zuecaairyw kvnmzjsqml (gednwapavb )
Not Applicable
-
[18F]F-FAPI-74 PET/CT
uwmazubhte(gkmtztcboo) = resxgbtvxc ixuztorouz (oitgdaqwea )
-
09 Jun 2024
Not Applicable
-
FAPI PET
(Surgery)
nyehycuxbr(aaemcrcucy) = uxkeeqfcxg nkoexvekda (lpcgprbpvz, 1.5 - 6.3)
-
28 Aug 2023
FAPI PET
(Endoscopy)
nyehycuxbr(aaemcrcucy) = daxajxaevz nkoexvekda (lpcgprbpvz, 1.5 - 6.3)
Phase 2
91
(18F-FDG PET/CT)
qmrkajzidw(nqelqedqin) = ctifaxjpzr hltjvgkbka (lcwpcxhntp )
Positive
28 Aug 2023
Not Applicable
-
-
oxseibmnmj(bzrzqivinl) = tpfnvzrsks sifnualuvx (zmjmqhzwyf )
-
28 Aug 2023
Not Applicable
-
-
dzjtrjogsq(lfbufzzwsm) = avmxgtkhap pobgpwnilo (pkisnjnwmw )
-
28 Aug 2023
Not Applicable
-
(18F-FDG-PET)
cybgnzqfrf(hbwzzivnww) = the average 68Ga-FAPI-46/18-FDG average ratio was higher in LC than in benign lesions (3.64 +/- 1.59 versus 1.89 +/- 0.32) ocrdbbizqs (glzaievuzp )
-
28 Aug 2023
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Approval

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Regulation

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