Delving into the Latest Updates on Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid with Synapse

Primary objective: To evaluate the effectiveness of stannous galactosyl human serum albumin diethylenetriamine pentaacetate for injection in clinical liver function assessment; Secondary objective: To evaluate the safety of stannous galactosyl human serum albumin diethylenetriamine pentaacetate for injection in liver function assessment.

Start Date09 Jun 2021

Sponsor / Collaborator

Peking Union Medical College Hospital

[+1]

CTR20191555

/ CompletedPhase 1

99mTc-GSA注射液在中国健康志愿者体内的药代动力学和安全性的I期临床研究

[Translation] Phase I clinical study on the pharmacokinetics and safety of 99mTc-GSA injection in Chinese healthy volunteers

主要目的：评估锝[99mTc]半乳糖酰人血清白蛋白二亚乙基三胺五乙酸盐（99mTc-GSA）注射液在健康志愿者体内的药代动力学特征；次要目的：评估锝[99mTc]半乳糖酰人血清白蛋白二亚乙基三胺五乙酸盐（99mTc-GSA）注射液单次给药在健康受试者中的安全性和耐受性。

[Translation]

Primary objective: To evaluate the pharmacokinetic characteristics of technetium [99mTc] galactosyl human serum albumin diethylenetriamine pentaacetate (99mTc-GSA) injection in healthy volunteers; Secondary objective: To evaluate the safety and tolerability of single-dose technetium [99mTc] galactosyl human serum albumin diethylenetriamine pentaacetate (99mTc-GSA) injection in healthy subjects.

Start Date29 Nov 2019

Sponsor / Collaborator

Peking Union Medical College Hospital

[+1]

JPRN-UMIN000035026

/ RecruitingNot ApplicableIIT

Predictive of liver function after Stereotactic body radiotherapy using 99mTc-GSA hepatobiliary schinchigraphy - Predictive of liver function after SBRT using hepatobiliary schinchigraphy

Start Date27 Nov 2018

Sponsor / Collaborator

Asahi University

100 Clinical Results associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

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100 Translational Medicine associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

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100 Patents (Medical) associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

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284

Literatures (Medical) associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

01 Mar 2025·Food Chemistry

Enhancing colonic health with encapsulated grape seed anthocyanins: Oral capsule for Colon-targeted delivery

Article

Author: Wang, Hongchao ; Niu, Ben ; Pei, Zhangming ; Tian, Fengwei ; Zhao, Jianxin ; Gao, Wenyu ; Li, Feng ; Lu, Wenwei

Grape seed anthocyanins (GSA) offer health benefits and protect against diseases, including colitis. Its unpleasant smell and instability prevent widespread application. Antisolvent pretreatment GSA was encapsulated in chitosan-phytic acid 3D gel network. SEM and X-ray diffraction results demonstrate that pretreatment reduces GSA particle size and exhibits amorphous structure. FTIR confirmed they were physically encapsulated and not covalently bound. Its subsequent simulations digestion and fermentation showed only 26.69 % upper digestive tract leakage and altered gut microbiota and metabolites profile. In DSS-induced colitis model, it ameliorated the symptoms, including diarrhea, bloody stools, weight loss, and DAI score. Additionally, it regulates colitis mice pro- and anti-inflammatory cytokines, modifies cecum and colon SCFA profile, improves intestinal barrier, and restores colonic cell redox equilibrium. Collectively, GSA ameliorates experimental colitis via inhibiting TRL4/NF-κB and activating Nrf2 signaling pathway. In conclusion, we propose our GSA capsule can effectively deliver an intact parent form of GSA to the colon and has the potential to be a colonic health strategy.

01 Jan 2025·Clinical Immunology

Sympathetic nerve promotes renal fibrosis by activating M2 macrophages through β2-AR-Gsa

Article

Author: Li, Qian ; Zhang, Chunjiang ; Liu, Lele ; Han, Min ; Cai, Yang ; Deng, Yuanjun ; Zhang, Tianjing ; Xu, Gang

Sympathetic nervous system overactivation is directly related to renal fibrosis. This study focused on the role of and mechanism by which sympathetic signaling regulates macrophage activation, as well as the contribution to renal fibrosis. Renal denervation alleviated tubular necrosis, tubulointerstitial fibrosis, and macrophage accumulation induced by unilateral ureteral obstruction and ischemia-reperfusion injury. In vitro, norepinephrine (NE) promoted macrophage alternative (M2) polarization by activating β2-adrenergic receptor (β2-AR) and heterotrimeric G stimulatory protein α-subunit (Gsa). The effects of NE-induced macrophage M2 polarization were blocked by a β2-AR selective antagonist and Gsa siRNA. Importantly, ablation of Gsa in macrophages alleviated tubulointerstitial fibrosis, macrophage accumulation, and M2 polarization in the renal ischemia-reperfusion injury model. Sympathetic nervous system overactivation regulates M2 polarization in macrophages as an important neuroimmune mechanism of renal fibrosis. The β2-AR-Gsa signaling pathway was responsible for NE-induced macrophage M2 polarization, which may be a therapeutic target for renal fibrosis.

01 Dec 2024·Computer Methods and Programs in Biomedicine

ECG classification based on guided attention mechanism

Article

Author: Cai, Wenjie ; Liu, Wenjing ; Huang, Yangcheng ; Yin, Ziyi ; Wang, Mingjie ; Hu, Shuaicong

BACKGROUND AND OBJECTIVEIntegrating domain knowledge into deep learning models can improve their effectiveness and increase explainability. This study aims to enhance the classification performance of electrocardiograms (ECGs) by customizing specific guided mechanisms based on the characteristics of different cardiac abnormalities.METHODSTwo novel guided attention mechanisms, Guided Spatial Attention (GSA) and CAM-based spatial guided attention mechanism (CGAM), were introduced. Different attention guidance labels were created based on clinical knowledge for four ECG abnormality classification tasks: ST change detection, premature contraction identification, Wolf-Parkinson-White syndrome (WPW) classification, and atrial fibrillation (AF) detection. The models were trained and evaluated separately for each classification task. Model explainability was quantified using Shapley values.RESULTSGSA improved the F1 score of the model by 5.74%, 5%, 8.96%, and 3.91% for ST change detection, premature contraction identification, WPW classification, and AF detection, respectively. Similarly, CGAM exhibited improvements of 3.89%, 5.40%, 8.21%, and 1.80% for the respective tasks. The combined use of GSA and CGAM resulted in even higher improvements of 6.26%, 5.58%, 8.85%, and 4.03%, respectively. Moreover, when all four tasks were conducted simultaneously, a notable overall performance boost was achieved, demonstrating the broad adaptability of the proposed model. The quantified Shapley values demonstrated the effectiveness of the guided attention mechanisms in enhancing the model's explainability.CONCLUSIONSThe guided attention mechanisms, utilizing domain knowledge, effectively directed the model's attention, leading to improved classification performance and explainability. These findings have significant implications in facilitating accurate automated ECG classification.

100 Deals associated with Technetium(99mTc) Galactosyl Human Serum Albumin Diethylenetriamine Pentaacetic Acid

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R&D Status

Approved

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Indication	Country/Location	Organization	Date
Diagnostic agents	JP	Nihon Medi-Physics Co., Ltd.	03 Jul 1992

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Liver Diseases	Phase 1	CN	Beijing Shihong Pharmaceutical Co., Ltd.	09 Jun 2021
Liver Diseases	Phase 1	CN	Peking Union Medical College Hospital	09 Jun 2021
Contrast agents	Phase 1	CN	Chinese Academy of Medical Sciences	24 Mar 2021
Contrast agents	Phase 1	CN	Beijing Shihong Pharmaceutical Co., Ltd.	24 Mar 2021

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EANM2018	Not Applicable	Fibrosis, Liver	49	99mTc-GSA (Planar scintigraphy)	oewizxwdsk(laqqeoykqk) = jokaagjpfj inmtgqalmu (flpclngeni, 7.0)	Positive	18 Sep 2018
SNMMI2016	Not Applicable	-	-	99mTc-GSA (Normal group)	edyszjtjyr(kzbxsrwsmo) = znokxggric rmjbicjgrx (aitpaqghxf, 5.1)	-	24 May 2016
SNMMI2016	Not Applicable	-	-	99mTc-GSA (Mild liver dysfunction group)	edyszjtjyr(kzbxsrwsmo) = fxqswvzbqo rmjbicjgrx (aitpaqghxf, 4.4)	-	24 May 2016