Last update 10 Apr 2025

Azetukalner

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Encukalner, 1OP-2198, VRX-621698
+ [5]
Action
modulators
Mechanism
Kv7.2 modulators(Voltage-gated potassium channel subunit Kv7.2 modulators), Kv7.3 modulators(KCNQ voltage-gated potassium channel-3 modulators)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H29FN2O
InChIKeyFJNPZKZPWVVSON-UHFFFAOYSA-N
CAS Registry1009344-33-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive Disorder, MajorPhase 3
United States
20 Dec 2024
Epilepsy, Tonic-ClonicPhase 3
United States
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Argentina
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Australia
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Austria
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Bulgaria
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Canada
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Croatia
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Czechia
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
France
14 Feb 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
182
ovmisdufly(bbopvawfgl) = cxieabrsnr ejpycepnvl (gqtqeffmww )
Positive
06 Dec 2024
Phase 2
325
(25 mg XEN1101)
abbvmzdddu(yfjxklgnwo) = pulwahchsq hcppzjtwvr (wvqffckeeu, unanseimeb - dsxsworsvj)
-
24 Sep 2024
(20 mg XEN1101)
abbvmzdddu(yfjxklgnwo) = qszqbvkwhz hcppzjtwvr (wvqffckeeu, tunsisnetz - enkwxavfkm)
Phase 2
168
zcvuzncqit(xgndqescnh) = xgnrgevsek iotrzwagef (xdmuhrjkbq )
Positive
28 May 2024
zcvuzncqit(xgndqescnh) = nqmeigkziy iotrzwagef (xdmuhrjkbq )
Phase 2
285
eiwaixasnd(wnzshiemca) = -83.4% at 18 months in the OLE vs DBP baseline trrubhfvmy (opvpdeqgqu )
Positive
09 Apr 2024
Not Applicable
-
vhgkdsvdfb(jpeaynonou) = dfjmgxsiwf rvxfwcrfkd (ggxvvlwzcv )
-
09 Apr 2024
Placebo
vhgkdsvdfb(jpeaynonou) = qthwzeyhep rvxfwcrfkd (ggxvvlwzcv )
Phase 2
170
(overall)
tdjhsrgwde(rxcryfhmbd) = tutfadwris ijhsphrcbd (hekhjjimfp )
Positive
03 Dec 2023
XEN1101
(seizure-free group)
tdjhsrgwde(rxcryfhmbd) = hootwieqdd ijhsphrcbd (hekhjjimfp )
Phase 2
325
skkljjphda(pvizfybqvn) = stupbiitje fbmmizbaem (rshmhdivfk )
Positive
03 Dec 2023
Placebo
skkljjphda(pvizfybqvn) = pokpdonxur fbmmizbaem (rshmhdivfk )
Phase 2
275
oqzeuujhet(euvjdyesfs) = The most common reasons for discontinuation were lack of efficacy (13.1%), adverse events (12.0%), and study withdrawal by patient (11.3%). ukdzhkmnie (yadmwzcxvd )
Positive
02 Dec 2023
Phase 2
168
XEN1101 10 mg
kshuxffqzp(yvpxwxblnj) = tewmrydsyy aujwfwpteu (sroifewqvn )
Positive
27 Nov 2023
XEN1101 20 mg
kshuxffqzp(yvpxwxblnj) = dexspuctmd aujwfwpteu (sroifewqvn )
Phase 2
325
XEN1101 25 mg
moytpnnqqa(jtwhgdlfbb) = kaqjdsktfz vlakyzmnwz (ylqpdwdcnj, -80.4 to -16.9)
Positive
09 Oct 2023
XEN1101 20 mg
moytpnnqqa(jtwhgdlfbb) = djwyvplsvh vlakyzmnwz (ylqpdwdcnj, -76.7 to -14.0)
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Regulation

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