Last update 20 Mar 2025

Acetaminophen/Hydrocodone/Promethazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Target
COXs x H1 receptor x Opioid receptors
Action
inhibitors, antagonists, agonists
Mechanism
COX inhibitors(Cyclooxygenases inhibitors), H1 receptor antagonists(Histamine H1 receptor antagonists), Opioid receptors agonists(Opioid receptors agonists)
Therapeutic Areas
Nervous System DiseasesOther Diseases
Active Indication-
Inactive Indication
Acute PainDrug-induced nausea and vomitingNausea+ [2]
Originator Organization
Charleston Laboratories, Inc.Charleston Laboratories, Inc.
Active Organization-
Inactive Organization
Charleston Laboratories, Inc.Charleston Laboratories, Inc.
Drug Highest PhasePendingNDA/BLA
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC22H29NO10
InChIKeyZICRJLQTAUVSDU-NSJZFRMTSA-N
CAS Registry34195-34-1
View All Structures (3)

Related

2
Clinical Trials associated with Acetaminophen/Hydrocodone/Promethazine
NCT03657810
/ CompletedPhase 3
A Randomized, Double-Blind, Placebo- and Active-Controlled Study to Determine the Efficacy and Safety of CL-108 5 mg (Hydrocodone 5 mg/Acetaminophen 325 mg/Promethazine 12.5 mg) as a Treatment for Moderate-to-Severe Acute Pain and the Prevention of Opioid-Induced Nausea and Vomiting (OINV) Following Orthopedic Surgery
NCT01780428
/ CompletedPhase 3
A Double-Blind, Randomized, Placebo-Controlled, Multiple-dose Multi-Center Phase III Study of the Safety and Efficacy of Cl-108 in the Treatment of Moderate to Severe Pain
100 Clinical Results associated with Acetaminophen/Hydrocodone/Promethazine
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100 Translational Medicine associated with Acetaminophen/Hydrocodone/Promethazine
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100 Patents (Medical) associated with Acetaminophen/Hydrocodone/Promethazine
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100 Deals associated with Acetaminophen/Hydrocodone/Promethazine
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute PainNDA/BLA
United States
Charleston Laboratories, Inc.Charleston Laboratories, Inc.
02 Aug 2017
Drug-induced nausea and vomitingNDA/BLA
United States
Charleston Laboratories, Inc.Charleston Laboratories, Inc.
02 Aug 2017
VomitingNDA/BLA
United States
Charleston Laboratories, Inc.Charleston Laboratories, Inc.
01 Jan 2013
NauseaNDA/BLA-
Charleston Laboratories, Inc.Charleston Laboratories, Inc.
-
PainNDA/BLA-
Charleston Laboratories, Inc.Charleston Laboratories, Inc.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Clinical Trial

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Approval

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Regulation

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