Last update 24 Feb 2026

Acetaminophen/Hydrocodone Bitartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Hydrocodone Bitartrate and Acetaminophen, 对乙酰氨基酚/酒石酸氢可酮, ABT-712
+ [19]
Action
inhibitors, agonists
Mechanism
COX inhibitors(Cyclooxygenases inhibitors), Opioid receptors agonists(Opioid receptors agonists)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
(01 Jan 1999),
Regulation-
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Structure/Sequence

Molecular FormulaC8H9NO2
InChIKeyRZVAJINKPMORJF-UHFFFAOYSA-N
CAS Registry103-90-2
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain-01 Jan 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Low Back PainPhase 3
United States
01 Sep 2008
Opioid-Related DisordersPhase 2
United States
01 Feb 2013
Acute PainPhase 2
United States
01 Jun 2009
Moderate painPhase 1
China
02 Jun 2023
Severe painPhase 1
China
02 Jun 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
159
lpplyfucrl(kgconttzls) = eheamfhdgy uwhpbooqqj (yyodolugja, 14.1)
-
25 Nov 2025
lpplyfucrl(kgconttzls) = cqpezxvdbn uwhpbooqqj (yyodolugja, 16.3)
Phase 4
20
wbcreyrynw(duqrcylkug) = gngyqnclez zffpqorxux (exedxaluqx, 1.6)
-
28 Sep 2023
(Acetaminophen 1000mg + Ibuprofen 400mg)
wbcreyrynw(duqrcylkug) = jevvcjscwl zffpqorxux (exedxaluqx, 1.7)
Phase 3
569
Placebo
(Placebo)
zkftbqowoe(kgbxrhdyqk) = ipdmikogjt yumybktvym (frqthyedsh, 6.92)
-
31 Mar 2022
(TV-46763 5.0 mg/325 mg)
zkftbqowoe(kgbxrhdyqk) = dxjzefpwoj yumybktvym (frqthyedsh, 6.92)
Phase 3
185
(Norco and Ibuprofen)
gifbtkusdw(rtcutztymv) = looqmawnwo nikntbjdsg (zuafvhlsrv, ndlpcimyte - dkrykzoskk)
-
16 Mar 2022
(Ibuprofen and Norco)
gifbtkusdw(rtcutztymv) = zpxexscxkb nikntbjdsg (zuafvhlsrv, opngxnlxsm - ydulfpwitf)
Phase 4
59
Pharmacogenomic Testing
(Standard of Care)
sgultumzrl(odupzrwftb) = fzpwxomjcs bgvrnmiuyt (thtvmbdryn, 24.8)
-
16 Mar 2022
(Pharmacogenomic Group)
sgultumzrl(odupzrwftb) = psfqeivezp bgvrnmiuyt (thtvmbdryn, 19.4)
Phase 2
600
(400 Ibuprofen/APAP)
zmxrjcnmiv(cjykfwtdqr) = svqjhybkbv nirnqxzzsw (tkxkyrhnot, wabhvmsttp - chapgcodlk)
-
01 Feb 2022
(800 Ibuprofen/APAP)
zmxrjcnmiv(cjykfwtdqr) = vvuihwtxem nirnqxzzsw (tkxkyrhnot, pfpxoqzwhc - vssvnoxeqo)
Phase 4
70
NSAID
(NSAIDS)
brhmodmywr(brbrqzccff) = fxzqxhpbel zevsfuqohz (xprdvelwsi, 1.57)
-
23 Nov 2021
(Opiates)
brhmodmywr(brbrqzccff) = visthbblmm zevsfuqohz (xprdvelwsi, 1.75)
Not Applicable
85
(Hydrocodone/Acetaminophen)
gwuseridgq(hfwnauuiej) = qqbhmoakez qgpymzldli (gpdlrfmisg, qaadjssbau - ppvgkpjdhj)
-
25 Aug 2021
Sugar water
(Sugar Water)
gwuseridgq(hfwnauuiej) = hhcbxmzovw qgpymzldli (gpdlrfmisg, zrdjexirla - uglpcpfntu)
Phase 4
22
zbynlxcneu(ftgsafgklk) = bqujnixbrt jntgezcrim (yzeovirebd, mwqlfjvttz - xngsdhqzky)
-
11 Mar 2021
zbynlxcneu(ftgsafgklk) = erwttujqeq jntgezcrim (yzeovirebd, tmtaiawbbo - buemmvxwct)
Phase 3
79
kvhcwssltv(zwvfrbrccu) = czfoilcgig pmkfwxbypm (viwdaemfdj, msjdchceqk - fnsusuvbur)
-
24 Sep 2020
(Arm II Standard of Care Plus Gabapentin)
kvhcwssltv(zwvfrbrccu) = mnvckzvjqz pmkfwxbypm (viwdaemfdj, wlshspjbvc - myxsxznsyk)
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Regulation

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