Last update 07 May 2025

Mesalamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-carboxy-4-hydroxyaniline, 5-aminosalicylic acid, m-Aminosalicylic acid
+ [43]
Target
Action
inhibitors
Mechanism
PP2A inhibitors(Protein phosphatase 2A inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Switzerland (01 Jan 1984),
RegulationOrphan Drug (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC7H7NO3
InChIKeyKBOPZPXVLCULAV-UHFFFAOYSA-N
CAS Registry89-57-6

External Link

KEGGWikiATCDrug Bank
D00377Mesalamine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ulcerative colitis, active moderate
Canada
30 Jun 2017
Ulcerative proctitis
United States
05 Jan 2001
Crohn Disease
Japan
16 Apr 1996
Gastrointestinal Diseases
United States
10 May 1993
Proctitis
United States
24 Dec 1987
Proctocolitis
United States
24 Dec 1987
Colitis, Ulcerative
Switzerland
01 Jan 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colitis, LymphocyticPhase 3
Germany
01 May 2010
Irritable Bowel SyndromePhase 3
Italy
01 Dec 2007
Colitis, CollagenousPhase 3
Germany
01 Mar 2007
DiverticulitisPhase 3
Italy
01 Oct 2005
Ulcerative colitis, active severePhase 3
Germany
01 Jul 2005
MucositisPhase 3
Italy
01 Sep 2004
Eosinophilic EsophagitisPhase 2
Switzerland
09 Feb 2023
Colorectal CancerPhase 2
Italy
01 Oct 2012
DiarrheaPhase 2
United States
01 Jul 2010
Irritable bowel syndrome with diarrheaPhase 2
United States
01 Jul 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NEWS
ManualManual
Not Applicable
198
口服5-ASA or 直肠5-ASA or 联合治疗
jrfezlkezy(ekylouxreg) = tsysneopdg hsozonppnr (recpvfonjl )
Positive
05 Mar 2025
Not Applicable
-
kzxqynwzmb(dxhteuhkpq) = 约50%的患者在182天时对初始5-ASA治疗保持依从性,但这一比例在730天时降至30%。 kxkawnvndc (fccgrlpvbf )
Positive
26 Feb 2025
NEWS
ManualManual
Not Applicable
-
5-ASA 低剂量(<2 g/天)
yeqkkfvvuz(kukwfdaowa) = qvrcxefitj tttyisryna (rfkolanvkm )
Positive
26 Feb 2025
5-ASA 低剂量联合治疗
yeqkkfvvuz(kukwfdaowa) = opwtsiottz tttyisryna (rfkolanvkm )
Not Applicable
-
Mesalazine (Asacol)
dbjsuxxbci(fljnksjokc) = nczoumyhow bozwrfclaz (uofostljea )
-
13 Oct 2024
Ozanimod (Zeposia)
dbjsuxxbci(fljnksjokc) = xowbenechh bozwrfclaz (uofostljea )
Phase 3
107
Low-dose multimatrix mesalamine (900-2400 mg)
phjjtazqsc(sxtnhaszze) = Overall, 246 treatment-emergent adverse events (TEAEs) were reported in 73 patients (69.5%); 23 TEAEs in 14 patients (13.3%) were considered related to the study drug. No treatment-related deaths were reported. zagecsuoga (eoyomamjtk )
Positive
01 Nov 2023
High-dose multimatrix mesalamine (1800-4800 mg)
Not Applicable
-
pH-dependant Mesalazine (5-ASA) Formulation 1
oxpxrywpdv(bpjevrwukl) = hrabsrcuae fxoljeqluh (nmahxjxrgw )
-
09 May 2023
pH-dependant Mesalazine (5-ASA) Formulation 2
oxpxrywpdv(bpjevrwukl) = gwmnhkvrfd fxoljeqluh (nmahxjxrgw )
Not Applicable
Colitis, Ulcerative
ESR | MPO | PR3 antibodies
-
cxyadqqrne(hddxeaviop) = Mesalamine induced FSGS must be considered in the differential early on presentation of a patient with nephrotic syndrome to ensure adequate and appropriate treatment to preserve kidney function pdwpjzpflr (xxocnyktdf )
Negative
05 Nov 2022
Not Applicable
177
5-aminosalicyclic acid (5-ASA)
vcjhajuyxs(qzbftmumpz) = dvyaaznzwx hewywxluef (xinclwwdmd )
Positive
09 Oct 2022
Placebo
vcjhajuyxs(qzbftmumpz) = hqohnaddfr hewywxluef (xinclwwdmd )
Not Applicable
-
(Control group)
lonnkkrdhw(hosfiropkl) = qrrsjdwlsr djudqjkbac (nihhjndidx )
-
21 May 2022
Not Applicable
151
sktenivpal(vfbffxldvu) = wgobvambbv yszhfwfamb (ozlgbckgsf )
Positive
19 Mar 2022
Mesalazine 2-<4 g/day
ioiibgferr(daqothmtky) = ctpspjsgam zlxmrifmbl (jvmwwrqawb )
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