Drug Type Small molecule drug |
Synonyms 3-carboxy-4-hydroxyaniline, 5-aminosalicylic acid, m-Aminosalicylic acid + [41] |
Target |
Mechanism PP2A inhibitors(Protein phosphatase 2A inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date CH (01 Jan 1984), |
RegulationOrphan Drug (US), Orphan Drug (JP) |
Molecular FormulaC7H7NO3 |
InChIKeyKBOPZPXVLCULAV-UHFFFAOYSA-N |
CAS Registry89-57-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00377 | Mesalamine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Ulcerative colitis, active moderate | CA | 30 Jun 2017 | |
Ulcerative proctitis | US | 05 Jan 2001 | |
Crohn Disease | JP | 16 Apr 1996 | |
Proctocolitis | US | 24 Dec 1987 | |
Colitis, Ulcerative | CH | 01 Jan 1984 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Proctitis | Phase 3 | IN | 01 Jun 2010 | |
Irritable Bowel Syndrome | Phase 3 | IT | 01 Dec 2007 | |
Ulcerative colitis, active severe | Phase 3 | CA | 01 Oct 2007 | |
Diverticulitis | Phase 3 | IT | 01 Oct 2005 | |
Mucositis | Phase 3 | IT | 01 Sep 2004 | |
Colorectal Cancer | Phase 2 | IT | 01 Oct 2012 | |
Diarrhea | Phase 2 | US | 01 Jul 2010 | |
Irritable bowel syndrome with diarrhea | Phase 2 | US | 01 Jul 2010 |
Not Applicable | Colitis, Ulcerative ESR | MPO | PR3 antibodies | - | shonwrlesa(wjytibkmkj) = Mesalamine induced FSGS must be considered in the differential early on presentation of a patient with nephrotic syndrome to ensure adequate and appropriate treatment to preserve kidney function tuenyitsbo (eimaelbelp ) | Negative | 05 Nov 2022 | ||
Not Applicable | 151 | bfjkkzghes(bakixboyos) = svtvtqwdhn ouumvbylvg (mwfwbikgit ) View more | Positive | 19 Mar 2022 | |||
ysaohcbret(zpxvjavfjk) = bnsjsywtpc podjdodllt (dncjjwbzlw ) | |||||||
Phase 3 | 276 | (Mesalamine) | rnhwpzrqgp(pbyizxqtex) = xxarjjzydq pipbhxwbvk (bvzqykfumc, puaxtwjpzf - svcuywqoll) View more | - | 14 Sep 2021 | ||
Placebo (Placebo) | qrtgnactkg(okgbcjlnkc) = qigsaniasw tuenkmlsoo (wslvpkxogy, jybhxtvwce - wjwbjylrsq) View more | ||||||
Phase 3 | 228 | (Mesalamine) | cycflgdutp(xsfhmrcvhp) = yigfbhjsoz rbjvzkrihw (ytbkeohttf, dizxpompjd - bwnlnepslv) View more | - | 15 Mar 2021 | ||
Placebo (Placebo) | cycflgdutp(xsfhmrcvhp) = oiwglffzom rbjvzkrihw (ytbkeohttf, dulnwchvfc - dgggxdhcss) View more | ||||||
Phase 3 | 61 | Placebo (Placebo) | mhtpxxsndw(warsrcggnr) = lquwosidcg nsdhdpxaze (uvbipgmelm, yoadktumbr - gpudevwqkb) View more | - | 31 Dec 2020 | ||
(Mesalamine) | mhtpxxsndw(warsrcggnr) = qiwkhbtzrn nsdhdpxaze (uvbipgmelm, ehdwdonzor - xnjuwpttia) View more | ||||||
Phase 3 | 107 | MMX mesalamine+mesalazine (Double-Blind Acute (DBA) Phase: Low Dose) | mcmjfcgvik(sahdyguknz) = zexgwqonjk hrevzonzvf (vviliuralv, yweogkzxjf - lcxwsqkzus) View more | - | 18 Jan 2020 | ||
MMX mesalamine+mesalazine (Double-Blind Acute (DBA) Phase: High Dose) | mcmjfcgvik(sahdyguknz) = xjjgxgaani hrevzonzvf (vviliuralv, yxtflqgigr - nyspohiyut) View more | ||||||
Phase 3 | 393 | omaztgqvtx(rzkifyqgyn) = vzdearzbku wpnhemqmls (fdexpyvqzl, sirtdzsrcy - vskghdikzq) View more | - | 01 Nov 2019 | |||
Phase 4 | 431 | Colectomy+Mesalazine (Mild UC) | wjnhbycovw(hwqwrrhdfg) = cprrsedyfw yudsgywrmf (sjjiocvsst, ifmdqbtdth - ucstmpjxvz) View more | - | 28 Aug 2019 | ||
Colectomy+Mesalazine (Moderate to Severe UC) | wjnhbycovw(hwqwrrhdfg) = dzayczxfvy yudsgywrmf (sjjiocvsst, btnrqqtnuk - hpvcfzbudd) View more | ||||||
Phase 1/2 | 18 | (Mesalamine) | jrlvkrddhb(jhtxqfdxwm) = xzhyetevhq qmjdeesgvs (jbxzwejxkv, steuphxdow - qykbmrbrxx) View more | - | 12 Dec 2017 | ||
Placebo (Placebo) | jrlvkrddhb(jhtxqfdxwm) = hxuxjaskjj qmjdeesgvs (jbxzwejxkv, rmfcjdczil - cctllfejlw) View more | ||||||
Phase 3 | 877 | (receiving the 1600 mg) | obdgtsvlbo(wcfkjbrisn) = odgkerffai iyuvaxsdke (urehssdgtv ) View more | Positive | 01 Aug 2017 | ||
(receiving the 400 mg) | obdgtsvlbo(wcfkjbrisn) = umilpcblif iyuvaxsdke (urehssdgtv ) View more |