Last update 07 Nov 2024

Mesalamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-carboxy-4-hydroxyaniline, 5-aminosalicylic acid, m-Aminosalicylic acid
+ [41]
Target
Mechanism
PP2A inhibitors(Protein phosphatase 2A inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CH (01 Jan 1984),
RegulationOrphan Drug (US), Orphan Drug (JP)
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Structure

Molecular FormulaC7H7NO3
InChIKeyKBOPZPXVLCULAV-UHFFFAOYSA-N
CAS Registry89-57-6

External Link

KEGGWikiATCDrug Bank
D00377Mesalamine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ulcerative colitis, active moderate
CA
30 Jun 2017
Ulcerative proctitis
US
05 Jan 2001
Crohn Disease
JP
16 Apr 1996
Proctocolitis
US
24 Dec 1987
Colitis, Ulcerative
CH
01 Jan 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ProctitisPhase 3
IN
01 Jun 2010
Irritable Bowel SyndromePhase 3
IT
01 Dec 2007
Ulcerative colitis, active severePhase 3
CA
01 Oct 2007
DiverticulitisPhase 3
IT
01 Oct 2005
MucositisPhase 3
IT
01 Sep 2004
Colorectal CancerPhase 2
IT
01 Oct 2012
DiarrheaPhase 2
US
01 Jul 2010
Irritable bowel syndrome with diarrheaPhase 2
US
01 Jul 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Colitis, Ulcerative
ESR | MPO | PR3 antibodies
-
shonwrlesa(wjytibkmkj) = Mesalamine induced FSGS must be considered in the differential early on presentation of a patient with nephrotic syndrome to ensure adequate and appropriate treatment to preserve kidney function tuenyitsbo (eimaelbelp )
Negative
05 Nov 2022
Not Applicable
151
bfjkkzghes(bakixboyos) = svtvtqwdhn ouumvbylvg (mwfwbikgit )
Positive
19 Mar 2022
ysaohcbret(zpxvjavfjk) = bnsjsywtpc podjdodllt (dncjjwbzlw )
Phase 3
276
(Mesalamine)
rnhwpzrqgp(pbyizxqtex) = xxarjjzydq pipbhxwbvk (bvzqykfumc, puaxtwjpzf - svcuywqoll)
-
14 Sep 2021
Placebo
(Placebo)
qrtgnactkg(okgbcjlnkc) = qigsaniasw tuenkmlsoo (wslvpkxogy, jybhxtvwce - wjwbjylrsq)
Phase 3
228
(Mesalamine)
cycflgdutp(xsfhmrcvhp) = yigfbhjsoz rbjvzkrihw (ytbkeohttf, dizxpompjd - bwnlnepslv)
-
15 Mar 2021
Placebo
(Placebo)
cycflgdutp(xsfhmrcvhp) = oiwglffzom rbjvzkrihw (ytbkeohttf, dulnwchvfc - dgggxdhcss)
Phase 3
61
Placebo
(Placebo)
mhtpxxsndw(warsrcggnr) = lquwosidcg nsdhdpxaze (uvbipgmelm, yoadktumbr - gpudevwqkb)
-
31 Dec 2020
(Mesalamine)
mhtpxxsndw(warsrcggnr) = qiwkhbtzrn nsdhdpxaze (uvbipgmelm, ehdwdonzor - xnjuwpttia)
Phase 3
107
MMX mesalamine+mesalazine
(Double-Blind Acute (DBA) Phase: Low Dose)
mcmjfcgvik(sahdyguknz) = zexgwqonjk hrevzonzvf (vviliuralv, yweogkzxjf - lcxwsqkzus)
-
18 Jan 2020
MMX mesalamine+mesalazine
(Double-Blind Acute (DBA) Phase: High Dose)
mcmjfcgvik(sahdyguknz) = xjjgxgaani hrevzonzvf (vviliuralv, yxtflqgigr - nyspohiyut)
Phase 3
393
omaztgqvtx(rzkifyqgyn) = vzdearzbku wpnhemqmls (fdexpyvqzl, sirtdzsrcy - vskghdikzq)
-
01 Nov 2019
Phase 4
431
Colectomy+Mesalazine
(Mild UC)
wjnhbycovw(hwqwrrhdfg) = cprrsedyfw yudsgywrmf (sjjiocvsst, ifmdqbtdth - ucstmpjxvz)
-
28 Aug 2019
Colectomy+Mesalazine
(Moderate to Severe UC)
wjnhbycovw(hwqwrrhdfg) = dzayczxfvy yudsgywrmf (sjjiocvsst, btnrqqtnuk - hpvcfzbudd)
Phase 1/2
18
(Mesalamine)
jrlvkrddhb(jhtxqfdxwm) = xzhyetevhq qmjdeesgvs (jbxzwejxkv, steuphxdow - qykbmrbrxx)
-
12 Dec 2017
Placebo
(Placebo)
jrlvkrddhb(jhtxqfdxwm) = hxuxjaskjj qmjdeesgvs (jbxzwejxkv, rmfcjdczil - cctllfejlw)
Phase 3
877
(receiving the 1600 mg)
obdgtsvlbo(wcfkjbrisn) = odgkerffai iyuvaxsdke (urehssdgtv )
Positive
01 Aug 2017
(receiving the 400 mg)
obdgtsvlbo(wcfkjbrisn) = umilpcblif iyuvaxsdke (urehssdgtv )
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Regulation

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