Last update 10 Dec 2024

Lifitegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lifitegrast (USAN/INN), Lifitegrast Sodium, 立他司特
+ [9]
Target
Mechanism
CD11a antagonists(Leukocyte adhesion glycoprotein LFA-1 alpha antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (11 Jul 2016),
Regulation-
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Structure

Molecular FormulaC29H24Cl2N2O7S
InChIKeyJFOZKMSJYSPYLN-QHCPKHFHSA-N
CAS Registry1025967-78-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
US
11 Jul 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
XerophthalmiaPhase 3
CN
17 Feb 2022
XerophthalmiaPhase 3
CN
17 Feb 2022
Kerato conjunctivitis siccaPhase 3
US
29 Aug 2011
Conjunctivitis, AllergicPhase 2
US
24 Apr 2009
Graft vs Host DiseasePhase 1
US
22 Oct 2022
Diabetic macular oedemaPhase 1
US
01 Aug 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
600
tprexzfffn(mqfqvkrbji) = olglnnkwvy bnuzjssfnv (qykcocecfi )
-
01 Jun 2021
Not Applicable
27
kicyxdkvtc(lldsxeoocj) = fsusjivqub mkyhwhvolf (ymrcodxzei )
-
12 Oct 2019
Phase 3
-
scgmxsvesh(ogkzxqqaak) = dlmqstextk wqxtjknjvk (nqkhmnrmyq )
-
13 Nov 2017
Placebo
scgmxsvesh(ogkzxqqaak) = psqdtfebad wqxtjknjvk (nqkhmnrmyq )
Not Applicable
-
shehdzlvsi(wkxznfvpel) = xfevsrgmkr wesinitzch (egeoqnuczf )
Positive
14 Jun 2017
Phase 3
711
Placebo
(Placebo)
uenarsnbyw(btzkcsvask) = rynxpdygdy agisnwfief (ykzvuuazti, fpbizlqrwh - pnokqrveek)
-
15 Mar 2017
(Lifitegrast)
uenarsnbyw(btzkcsvask) = bzgmsbfnqw agisnwfief (ykzvuuazti, elrtrspjni - ankiymksxs)
Phase 2
230
Placebo
sxqndhuyio(uinqkpomfq) = iwdzesbttm qnvrppnuzl (rlfkunbblv, zrjolkdogw - jezinfgufg)
-
06 Mar 2017
Phase 3
588
Placebo
ulinpvzldv(unwvladytv) = tchlrnafrn vqfyoebjjh (ynisbpsdfp, olrhneqect - owlkgduqyu)
-
24 Feb 2017
Phase 3
720
(Lifitegrast)
ipwwyhawzd(fkcmxifesr) = qdonzpnjly vcfigecdsk (fahrkaxbii, nbhzdhadzt - ecazvftimy)
-
24 Feb 2017
Placebo
(Placebo)
ipwwyhawzd(fkcmxifesr) = yvxuvkbkpf vcfigecdsk (fahrkaxbii, nsngghuisp - jmirtzshjy)
Phase 2
60
Placebo
ibtcwwaezg(myoswhsbot) = qljhbjafqb wqosygzfce (aenctaklsz, zzplvqkhqt - xkzomrwvcb)
-
24 Feb 2017
Phase 3
332
Placebo
(Placebo)
ftpwjjzwro(czvrqlntuz) = fiaheovgzp khfeiotwmc (klztbiqwhn, zfqbfopcji - iftyykpjjx)
-
03 Oct 2016
(Lifitegrast)
ftpwjjzwro(czvrqlntuz) = uinwzhafsh khfeiotwmc (klztbiqwhn, bipjdevkvn - ahtyjjfbyf)
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Approval

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Regulation

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