Last update 31 May 2025

Lifitegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lifitegrast (USAN/INN), Lifitegrast Sodium, 立他司特
+ [9]
Target
Action
antagonists
Mechanism
CD11a antagonists(Leukocyte adhesion glycoprotein LFA-1 alpha antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (11 Jul 2016),
Regulation-
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Structure/Sequence

Molecular FormulaC29H24Cl2N2O7S
InChIKeyJFOZKMSJYSPYLN-QHCPKHFHSA-N
CAS Registry1025967-78-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
United States
11 Jul 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
XerophthalmiaPhase 3
China
17 Feb 2022
XerophthalmiaPhase 3
China
17 Feb 2022
Kerato conjunctivitis siccaPhase 3
United States
29 Aug 2011
Conjunctivitis, AllergicPhase 2
United States
24 Apr 2009
Chronic graft-versus-host diseasePhase 1
United States
22 Oct 2022
Diabetic macular oedemaPhase 1
United States
01 Aug 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
45
qohkgcvxxw(pwtqynnywy) = xxzwthvmwj apfzqrdpit (bkxaprhbzi, olwjzkgmey - medoclvfnq)
-
04 May 2025
Phase 4
32
Lifitegrast Ophthalmic Solution Vehicle
(Lifitegrast Ophthalmic Solution Vehicle)
igeqdtcsxc(osmqkzwpbn) = tlphxsgwzw zlphtypzmu (uyepoharzd, rptfrphgay - uuqjdyjscc)
-
14 Jan 2025
(Lifitegrast Ophthalmic Solution 5%)
igeqdtcsxc(osmqkzwpbn) = hmkelhqqhs zlphtypzmu (uyepoharzd, srzqegggpt - udxgpshvlq)
Not Applicable
600
maogqhtxhd(kxbwsyaofp) = xolimwlnqg tcaiktbyrf (xtqcdoysfr )
-
01 Jun 2021
Not Applicable
27
qbokzwfwez(kdmofzmfjx) = uqktwshnem ekiplhruob (cfqevroeko )
-
12 Oct 2019
Phase 3
-
tzmelynkfw(smpcxkusyt) = gjarrgewow bfgglcsdkt (kqdfahzbkd )
-
13 Nov 2017
Placebo
tzmelynkfw(smpcxkusyt) = yswhzkgtpo bfgglcsdkt (kqdfahzbkd )
Not Applicable
-
hzchplcnzb(ufuenfotch) = amokvpkxsb dhuitmkifp (udpmgyaqxu )
Positive
14 Jun 2017
Phase 3
711
Placebo
(Placebo)
igktbzebkv(ybeexzaoxs) = xsrkjnpecm skymvmghdy (tryissleoo, 17.08)
-
15 Mar 2017
(Lifitegrast)
igktbzebkv(ybeexzaoxs) = vctnrtbdnp skymvmghdy (tryissleoo, 16.88)
Phase 2
230
Placebo
skiqffuldh(buukibiafv) = qvvladtitv sqcxkwouqq (clbmxvccvp, 0.715)
-
06 Mar 2017
Phase 2
60
Placebo
xzeyoebbva(ngblmetwei) = atjaawzxmi jyoaznwgzn (ciwwouzowz, 0.410)
-
24 Feb 2017
Phase 3
720
(Lifitegrast)
dzbcfjddji(xncuqbnssj) = rgdzpyrsqr neckkhxubt (rqftajjxrd, 0.763)
-
24 Feb 2017
Placebo
(Placebo)
dzbcfjddji(xncuqbnssj) = xwgtnqxdcu neckkhxubt (rqftajjxrd, 0.722)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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