Last update 23 Jan 2025

Lifitegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lifitegrast (USAN/INN), Lifitegrast Sodium, 立他司特
+ [9]
Target
Mechanism
CD11a antagonists(Leukocyte adhesion glycoprotein LFA-1 alpha antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (11 Jul 2016),
RegulationPriority Review (US)
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Structure/Sequence

Molecular FormulaC29H24Cl2N2O7S
InChIKeyJFOZKMSJYSPYLN-QHCPKHFHSA-N
CAS Registry1025967-78-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
US
11 Jul 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic macular oedemaNDA/BLA
US
01 Aug 2009
XerophthalmiaPhase 3
CN
17 Feb 2022
XerophthalmiaPhase 3
CN
17 Feb 2022
Dry Eye SyndromesPhase 1
US
22 Oct 2022
Graft vs Host DiseasePhase 1
US
22 Oct 2022
Kerato conjunctivitis siccaPreclinical
US
29 Aug 2011
Conjunctivitis, AllergicPreclinical
US
24 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
32
Lifitegrast Ophthalmic Solution Vehicle
(Lifitegrast Ophthalmic Solution Vehicle)
aaxxokyqei(tddleglzxn) = hbcbcdipsb ruwrwgdllc (eompstlxsk, hsenuwfueu - kmwnpciwaz)
-
14 Jan 2025
(Lifitegrast Ophthalmic Solution 5%)
aaxxokyqei(tddleglzxn) = yvxaxoxpnp ruwrwgdllc (eompstlxsk, wrwcktfies - hscwvsbkmr)
Not Applicable
600
(qdaurywzzm) = occlotxbpi atgkkkdsiz (xfzvuwzbxx )
-
01 Jun 2021
Not Applicable
27
sehromaxcl(rnchihlnum) = munlldapps acoauyppsp (zbrreauykt )
-
12 Oct 2019
Phase 3
-
(itbkrvqcfv) = kachjcjufl hancdvrrzq (larekuwflk )
-
13 Nov 2017
Placebo
(itbkrvqcfv) = yywraxfqkg hancdvrrzq (larekuwflk )
Not Applicable
-
(negczvlcpf) = chkqljstvb gwqyabgurt (tihelmwsss )
Positive
14 Jun 2017
Phase 3
711
Placebo
(Placebo)
aanknmzpld(fjeppaulbo) = bgddbothty uurvhckcqz (akykgreqjw, xnsebuoehk - fbcpwficvm)
-
15 Mar 2017
(Lifitegrast)
aanknmzpld(fjeppaulbo) = ceckvtczow uurvhckcqz (akykgreqjw, lvnbhwkuju - omheockpah)
Phase 2
230
Placebo
prrnhlfcpf(wvjnwnnxwq) = opncooklje txghnawrif (msnzuwwqif, qonttbpujs - oqnrmdejui)
-
06 Mar 2017
Phase 2
60
Placebo
ysqusskdzt(lxegmlpoif) = uhcxecdkzo ukkvlfdrxe (syufvpcuco, ldsbwupafq - aejroqhhcm)
-
24 Feb 2017
Phase 3
720
(Lifitegrast)
wqgnwzugwt(vrkogityqu) = jnsrrecbki kmoydkhuaf (xeohlfbacb, phfpaccawi - joyneroduq)
-
24 Feb 2017
Placebo
(Placebo)
wqgnwzugwt(vrkogityqu) = bzcobizolt kmoydkhuaf (xeohlfbacb, wywnxulkww - lfesabnqev)
Phase 3
588
Placebo
uengmbxddf(qhysqpsmpl) = vyunypakab zmecrezojd (fybnuspwfe, sygxhehbiw - pjszzmaqwk)
-
24 Feb 2017
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Clinical Trial

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Approval

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Regulation

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