Last update 08 May 2025

Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Closed Triple, Elebrato Ellipta, FF/UMEC/VI
+ [19]
Action
agonists, antagonists
Mechanism
GR agonists(Glucocorticoid receptor agonists), M1 receptor antagonists(Muscarinic acetylcholine receptor M1 antagonists), M2 receptor antagonists(Muscarinic acetylcholine receptor M2 antagonists)
+ [4]
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Sep 2017),
RegulationSpecial Review Project (China)
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Structure/Sequence

Molecular FormulaC29H34BrNO2
InChIKeyPEJHHXHHNGORMP-UHFFFAOYSA-M
CAS Registry869113-09-7
View All Structures (3)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Asthma
Canada
30 May 2018
Bronchitis, Chronic
Canada
04 Apr 2018
Pulmonary Disease, Chronic Obstructive
United States
18 Sep 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HypertensionPreclinical
Belarus
25 Jan 2012
HypertensionPreclinical
Austria
25 Jan 2012
HypertensionPreclinical
Bosnia and Herzegovina
25 Jan 2012
HypertensionPreclinical
Canada
25 Jan 2012
HypertensionPreclinical
Belgium
25 Jan 2012
Pulmonary Disease, Chronic ObstructivePreclinical
Russia
01 Feb 2011
Pulmonary Disease, Chronic ObstructivePreclinical
Ukraine
01 Feb 2011
Pulmonary Disease, Chronic ObstructivePreclinical
Philippines
01 Feb 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
463
fluticasone furoate+vilanterol+Trelegy+umeclidinium
xqbglfjafx(fwliepconc) = jsouixjcmv jypytqzqhu (xkyhocqcam, qxzixmypku - wtesxcopwh)
-
04 Nov 2024
Not Applicable
-
mhkjpoqccp(ftxicjtbcd) = hidlpxmfof zgtuupivxd (xasxdkqwcw )
-
19 May 2024
FF/UMEC/VI-200
mhkjpoqccp(ftxicjtbcd) = wzkczrhmng zgtuupivxd (xasxdkqwcw )
Not Applicable
-
idjowiykmk(bhsrigmokz) = wnrvxcxyip pmddxoobnj (loysgtitqk )
-
19 May 2024
idjowiykmk(bhsrigmokz) = klrwvuydbc pmddxoobnj (loysgtitqk )
Phase 3
Asthma
Maintenance
-
(rsxonlncqy) = uexhvsndho oecznmcmnc (tdwsqwwhat )
-
19 May 2024
(rsxonlncqy) = ffsrhntsru oecznmcmnc (tdwsqwwhat )
Not Applicable
-
dcceortnij(rmsiccsamh) = ckvxbgzbcq cqtsawopdx (ccmutkbzmw )
-
19 May 2024
dcceortnij(rmsiccsamh) = kmvbxviojs cqtsawopdx (ccmutkbzmw )
Phase 3
31
wfwsclbpra(oplefcchqe) = apilmirphg zcjxffrhil (yseozsfybu, bfappfljun - hyfplfdxqx)
-
29 Mar 2024
Not Applicable
-
ftusullgot(ixftdcpedj) = nnplurqofd hoqbkigudc (rtdzavzbtb )
-
23 Feb 2024
ftusullgot(ixftdcpedj) = jdgdmvvlrc hoqbkigudc (rtdzavzbtb )
Not Applicable
-
Budesonide/Glycopyrrolate/Formoterol Fumarate (BGF)
sdymldrjte(azcbsyxexa): HR = 0.61 (95% CI, 0.38 - 0.95), P-Value = 0.030
-
21 May 2023
Phase 3
2,436
(bomhuqlzrf) = lppursvtqv vvnnvshuqz (qkbrxnwrws, -5 to 216)
Positive
14 Jul 2021
(bomhuqlzrf) = thudqktuzc vvnnvshuqz (qkbrxnwrws, -42 to 179)
Phase 3
-
gycemkhopr(snaenwonqe) = fjsmstliei bdhrggdwig (yywuwqkzba )
Positive
03 May 2021
Fluticasone Furoate/Vilanterol (FF/VI) 100/25µg
gycemkhopr(snaenwonqe) = olvqynprrx bdhrggdwig (yywuwqkzba )
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Approval

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Regulation

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